I-Melatonin iye yaziwa ngokuqhelekileyo njengonyango lwe- jet lag nokulala . Ihlabathi lezokwelapha elidibanisa ngokunyuka licebisa ukuba ngabafazi abanomdlavuza wesibele , kunye ne- fibromyalgia kunye nesifo esingapheliyo sokukhathala . Kodwa i-melatonin ifumana inzala enkulu yokuba ikwazi ukuchaphazela i-thyroid kunye namahomoni.
I-Melatonin yi-hormone ngokwayo, eveliswa yi-pineal gland, eyinto encinci yegland ekhoyo kwingqondo.
I-pineal gland ithathwa njengomlawuli oyintloko wewashi lomzimba wethu, kuquka iwashi yethu yosuku lwe- circadian osixelela xa silala nalapho sivusa, kunye newashi lexesha elide lexesha eliphilayo elichazela iimpawu ezinkulu ze-hormonal, njengokuba ukungena ekufikeni nasekukhuleni .
I-pineal gland ilawula iziqulatho ze-circadian ngokukhupha i-melatonin, i-hormone eveliswa ngokuyinhloko ebusuku. Ukuhlanganiswa kweMelatonin kunye nokukhululwa ngokuyinhloko kukhuthazwa bumnyama.
Ngokusekelwe kwendima yayo kwingqungquthela ye-circadian nokulala, i-melatonin iye yaziwa ngokubanzi njengoncedo lokulala eluncedo, njengonyango lokunceda ukukhusela i-jet lag kunye nokusetha iwashi lomzimba kwinqanaba elitsha lexesha, kunye nabasebenzi basebusuku abanenkinga yokulala.
Kwakunjengokuncedisa ubuthongo okokuqala ndaqala ukusebenzisa i- melatonin ebusuku xa ndandisoloko ndihamba . Ndaye ndavuka ngokuphindaphindiweyo, kwaye kaninzi ndingakwazi ukulala kwakhona. Emva koko, xa ndavuka ekuseni, ndandiziva ndiziva ndikhulile.
Ndaqala ukuthatha umthamo ophantsi we-melatonin (3 mg), endiwathatha malunga ne-11 ntambama, malunga neyure ngaphambi kokuba ndihlale ndilele. Emva kweveki, ndaqaphela ukuba ndivusa ngaphantsi, kwaye xa ndenza, ndakwazi ukujika ndibuye ndilale ngokulula. Kulungile, ndandisuka ekuseni ndiziva ndihlaziyekile kwaye ndinamandla, ngomsindo omkhulu.
Eminye into emangalisayo, ngokuqinisekileyo ndivuke imizuzu embalwa phambi kwe-alamu. (Ngokuqinisekileyo akulona uphawu, njengoko ndandisoloko ndiyinto yalabo bantu ababethe i-bar snooze ngezihlandlo ezininzi, kwaye emva koko, bezitshitshisa ngokugqithiseleyo ebhedeni. Ngoko ke, ukuvuka ngaphambi kokuba i-alamu, ivakale, yayingavamile!)
Ngeli xesha ndiqalise i-melatonin, ndaye ndakuhlala kwimizuzu yam. Ndinexesha elidlulileyo kwiminyaka emibini, kwaye bekuye iinyanga ezintlanu ukususela kwimizuzu yokugqibela yokuhamba kwimihla . Ndandifake ixesha lokutshisa ngokushisa usebenzisa i-supplement ebizwa ngokuba yiRoyal Maca , kwaye ukutshisa okutshisayo kwaphelile. Ndandibonile ugqirha wam, owafumanisa ukuba ndinezinga eliphezulu kakhulu le- FSH kunye ne-LH- iimpawu ezingabonisa ukuphela komntu kwintombazana engenawo amaxesha-kwaye amazinga e- estrogen kunye nama-progesterone aphantsi. Ngoko ugqirha wam kunye nobabini ndacinga ukuba ndise-menopaus e-konke okufunekayo kukuza kwiinyanga ezili-12 ezipheleleyo ngaphandle kwexesha, kwaye kuya kuba yinto esemthethweni. Kwaye oko kwenzeka emva koko kwamangalisa.
Kwiinyanga ezimbini emva kokuba ndiqalise i-melatonin, ixesha lam libuyele. Kwaye xa bebuya, babeqhelekile. Babengenamandla ngokungaqhelekanga, njengokuba babekade bekhulile. Umbala wawuqhelekileyo kwaye mhlawumbi umangalisa bonke, baqala ukuza rhoqo iintsuku ezingama-28, ezingenakwenzeka kwiminyaka emininzi.
Andizange ndidibanise ngokukhawuleza i-melatonin ngokubuya komjikelezo oqhelekileyo wokuya esikhathini. Kodwa akukho nto yatshintshwa kwi-regimen yam, ndimele ndizibuze ukuba iimeko eziqhelekileyo zokuhamba kwimizi kwimizi ye-perimenopausal / i-menopausal yayiyimpembelelo eyaziwayo ye-melatonin. Ndacacisa uphando. Kwaye kwakuba ndifumanise uDkt. Walter Pierpaoli, kunye nokucinga kwakhe okuthakazelisayo kunye nokwenza umququzelelo kwi-melatonin.
Melatonin kunye neHormones zethu
Ugqirha waseNtaliyane uWalter Pierpaoli, MD, wakhupha umva ngo-1996 kunye nokukhululwa kwencwadi yakhe emhlabeni wonke, Isimangaliso seMelatonin: UkuLungiswa kweMvelo, ukuLwa kwezifo, ukuLwabelana ngesondo-Ukuphucula iHormone .
Le ncwadi yayingcono kakhulu, kwaye iMalatonin Miracle yeDkt. Pierpaoli yazisa amaMelika kwi-melatonin, eyayisanda kufumaneka kwi-counter e-US kwiminyaka embalwa ngaphambili, kwaye iindima zayo njenge-sleep aid, i-jet lag remedy, i-enhancer immune, kunye mkhuhlane we-antioxidant.
Kodwa le ncwadi yayingeyona yimizamo yexesha elilodwa nguDkt. Pierpaoli. Kwiminyaka emininzi, uphando kunye nokufunda i-melatonin kunye nemiphumo yayo.
Emva kokufunda incwadi kaDkt. Pierpaoli, ndandifunda iphepha lokuphanda elibambelele kulo, i-Annals 2005 ye-New York Academy of Sciences, ebizwa ngokuba yiTshintsho lokuguga: Ukuhlaziya i-Clock Pineal . Olu hlobo lwe-Annals lubonisa amanqaku amaninzi neengcali kunye nophando olwenziwe ngophando lwe-melatonin, kuquka neengxelo eziliqela ezivela kuDkt. Pierpaoli. Ndandivuyela ukuthetha noDkt. Pierpaoli ngokwabo, ukuba ndifunde kabanzi malunga neengcamango zakhe malunga ne-melatonin kunye ne-hormone ye-thyroid.
Ndafunda ukuba abaphandi abaninzi bacinga ukuba i- melatonin ininzi ngaphezu kwe-hormonal sleep aid. Kunoko, bayicinga ukuba i-melatonin ibe yinkqubo ye-chemical mediator esebenzayo ngeendlela esingayiqondi ngokupheleleyo, kodwa ukuba uDkt Pierpaoli nabanye bafunda ngokubanzi.
Oko uDkt. Pierpaoli achaza kwincwadi yakhe kunye nokufunyaniswa ngophando kukuba i-pineal gland ikhiqiza i-melatonin engaphantsi nangaphezulu njengoko sineminyaka yobudala, kodwa ukuba i-melatonin yongezwa xa amazinga e-melatonin ehla ngokwenyama, ezinye iziphumo zokuguga zinganciphisa, zime, okanye utsho, uDkt. Pierpaoli, utshintshile. UDkt. Pierpaoli ukholelwa ukuba i-melatonin ingakwazi ukuvumelanisa nje kuphela iziqulatho ze-circadian zokujikeleza kwe-sleep-end kodwa inkqubo ye-endocrine iyonke.
UDkt. Pierpaoli uthi ukubonelela nge- melatonin eyongezelelweyo , kwi-dose ka-3 mg ebusuku, kuvumela ukuba i-pineal gland ithi "ukuphumla" ukuthetha, kwaye ikhusela i-pineal gland ekugugeni, okuye kuyanciphisa inkqubo yokuguga kwezinye iimbumba kunye namalungu. Ingqungquthela yokuphikisana, kodwa uDkt Pierpaoli nabanye baye baqhuba izifundo ezithakazelisayo ezibonisa ukuba uye kwenye into.
Kwimibhalo yakhe, uDkt. Pierpaoli uchaza izifundo zezilwanyana ezifumene ukuba izilwanyana ezindala eziphathwayo kunye ne-melatonin zibuyele kwii-hormone ze-thyroid eziqhelekileyo. Amagundane ayeneminyaka engama-24 ubudala kwaye aphathwa nge-melatonin, iinyanga ezingama-24 zilingana neminyaka engama-75 ubudala kubantu, zazinamaqanda aphindwe kabini ubukhulu beengceba ezingaphendulwanga, zibonisa umsebenzi wesini osemtsha. UDkt. Pierpaoli wabuye watyalela iintlanzi zepineal zegundane eliguga kwiigundane ezincinci, kwaye ngokufanayo. Iigundane ezincinci kunye neengqungquthela ezindala zepayini zakhula zonke iintlobo zezifo ezinxulumene nokuguga, zaza zaba namandla kakhulu kwaye zavutha, zaza zafa kakhulu kuncinci. Amagundane endala kunye neengqungquthela ezincinci zenza ikhwebu, athola amandla, ahlakulele isondo sokuvuselelwa ngokwesondo, kwaye ahlala, ngokwemyinge ixesha elide ukuba ukuba ngaba ngabantu, bebebe namandla, abakhutheleyo, abasempilweni kunye nabasemsebenzini ngokugqithiseleyo. yobudala.
Kodwa yintoni echaze ukuba ukubuyela kwam emangalisa kwimizila eqhelekileyo yokuya esikhathini kwakunomxholo wase-Itali oqhutywe nguDkt. Pierpaoli owayejonga kumabhinqa angama-42 ukuya ku-62, abavavanya imiphumo yemihla ngemihla ye-3 mg ye-melatonin eyakhiweyo kwiinyanga ezintandathu. Olu pho nonongo lufumene ukuba i-melatonin yandise amazinga e-estrogen kunye nomsebenzi we-thyroid. Abafazi abaneminyaka engaphantsi kwe-50 basebenzisa i-melatonin nabo banciphise i-hormone ye-luteinizing (LH) kunye namazinga e-hormone ( stimulating hormone ) avuselela (FSH) ngenxa ye-melatonin. Kwamanye amabhinqa amancinci, ukujikeleza kwexesha eliqhelekileyo kwabuyiselwa. Yaye ke, ngokumangalisayo, inani labasetyhini ababesele bexhomekeke kwimizimba yomnxeba baze babuyele kwixesha eliqhelekileyo lokuya esikhathini. Ngokukodwa, ngokutsho kukaDkt. Pierpaoli kunye nabaphandi bakhe, i-dose melatonin i-down dose-okanye kwezinye iimeko, ngokubonakalayo iguqula iinguqu ze-endocine ezenzeka ngexesha lokuziyeka.
Ngokubhekisele kwi-thyroid, i-melatonin ayibonakali ukutshintsha amazinga e- TSH kodwa inceda ukuququzelela ukuguqulwa kwe-T4 ukuya kwi-T3 , okubangele ukunyuka kwamazinga eT3 kwiqela lokufunda.
Amaphesenti angama-96 eentlobo zowesifazane ekufundeni abathathile i-melatonin yabika ukusabalalisa okwenziwe ukusaxhala kwasekuseni, uphawu oluqhelekileyo kubasetyhini be-perimenopausal kunye ne- menopausal . Abasetyhini babe nezikhalazo ezimbalwa malunga nokutshisa okutshisa, iintliziyo ezincinci, kunye nomgangatho omhle kunye nobude bokulala.
Nangona le nto yayingazange isifundo esikhulu, senziwa ngokugqithiseleyo, kwaye icetyiswa ukuba i-melatonin inokudlala indima ebalulekileyo kwimimiselo ye-hormonal kwi-perimenopausal kunye ne-menopausal, kwaye mhlawumbi nangakumbi kulabo abanokungalingani kwe-thyroid.
UDkt. Pierpaoli uvakalelwa kukuba ukunyuka kwe-melatonin eyenzekayo kwii-forties zowesifazane inokuba ngumqondiso we-hormonal oxelela umzimba ukuba uqalise ukuguquka kwe-perimenopausal. Siyazi ukuba kubasetyhini besuka kwi-40 ukuya kwi-44, i-melatonin iyancipha kakhulu. Okuthakazelisayo kukuba, le ngongoma esoloko iqala ukuqala kwexesha. Inqaku elilandelayo elibalulekileyo le-melatonin liyancipha lisuka kwiminyaka engama-50 ukuya kuma-54, malunga nexesha apho ixesha lokuya esikhathini liyeke ukulungelelanisa kuninzi lwabasetyhini.
Iingqungquthela zikaDkt. Pierpaoli ezithandekayo zanikwa inkxaso kunye neziphumo zengxelo ka-2008 echazwe kwiphepha leMenuopause. Okokufundwa kwafumanisa ukuba i-pineal gland, nge-melatonin, ibandakanyeka kwiindlela ezilawula ukuqala kokuphuma kwesisu, kwaye ngokugcina amazinga aphezulu e-melatonin, ukuqala kokumisa isikhashana kungancishiswa.
UDkt Pierpaoli, ngaphandle kombuzo, ummeli onzondelelo kwi-melatonin. Ugqirha ngokwakhe uyindoda enhle yokulwa nokuguga, engaphezu kwama-80, amandla, nokugcina ishedyuli esichengileyo yemisebenzi, uphando, ukuthetha, ukubhala, nokujikeleza ihlabathi. UDkt. Pierpaoli uthe ukuba uya kubuya emva koko ekwazi oko awaziyo, wayeya kuqalisa ukuthatha i-melatonin malunga nama-30 ubudala.
UDkt. Pierpaoli uyagcina ukuba i-melatonin yenza njenge-adaptogen ye-hormonal, ikunceda ukunciphisa i-horrenone, i-thyroid kunye ne-hormone yokuzalana, nokugcina ubusuku bobusuku, nyanga zonke, kunye nexesha lokuphila kwama-hormone. UDkt. Pierpaoli ukholelwa ukuba i-melatonin yandisa ubuninzi bama-receptor kwiimveliso ezijoliswe njengezifuba, isisu, kunye nama-ovari, kunye nokuphucula ubuzwe babo.
Ezinye zezinye iziphumo ze-melatonin ezichazwe nguDkt. Pierpaoli ziquka:
- Unceda ukulinganisela amazinga e-cortisol
- ikhusela i-atrophy yama-ovari, isondo kunye nesisu
- kwandisa ukwanda
- iphakamisa i-HDL ("entle") i-cholesterol
- unciphisa uxinzelelo lwegazi
UDkt. Pierpaoli uthi:
I-Melatonin ayikho i-hormone ngokwayo, kodwa ngokwenene "intombikazi yazo zonke ihomoni," ehlola kwaye iqondise yonke "i-orchestra ye-hormonal".
Ezinye iidokotela eMelatonin
UDkt Pierpaoli akayena kuphela ummeli we-melatonin. Ingcali kunye ne-hormone ingcali ye-hormone uDavid Brownstein, MD , icebisa ukuba i-melatonin "ikhuselekile ngokukodwa," kwizigulane ezininzi. UDkt. Brownstein uthi:
I-dose ephantsi ye-melatonin ingaba yinxalenye ebalulekileyo yokuncedisa ihomoni. Akukona nje kuphela ukubaluleka ukulala, kodwa kuncedo ekuncedeni amanye amahomoni, kwaye ngokukodwa, ukuguqulwa kweT4 kuya ku-T3 ukuguqulwa.
UDkt. Jacob Teitelbaum , osebenza kunye nesifo esingapheliyo sesifo , i-fibromyalgia kunye nezigulane ze-thyroid , uvakalelwa kukuba ukuphumelela kwe-melatonin kunokusuka ekubeni nakho ukukhuthaza ukulala okusemgangathweni. UDkt Teitelbaum uthi:
Kwenzeka ntoni xa ungenalo ukulala, ukhupha yonke inkqubo. Ukulala ngokufanelekileyo kukubuyisela umsebenzi we-hypothalamic. Kwaye i-melatonin, ubuncinci, ukuncedisa ukuphucula umgangatho wokulala. Kwaye, ngaphezu koko, kwi-hormone yonke inkqubo, i-pineal ingabonwa njengenkokeli ye-orchestra yonke. Ukuba ilukhuni, yonke inkqubo ye-hormonal ingaba ludenge.
Ukuxhaswa noMelatonin
Ungongeza njani nge melatonin?
Incomo kaDkt. Pierpaoli kukuthatha i-3 mg ye-melatonin ekhutshwa ngexesha, ngo-11 ntambama okanye iyure ngaphambi kokuba ulale, nantoni na ngaphambili. Oku kukuvumela ukuba ube "ne-melatonin" xa ixesha lomzimba liza kuvelisa.
Iziphumo eziphambili kwiincwadi ezivela kwi-dose e-melatonin ephantsi zibonakala ngathi ziphunga zentsasa, iiphupha ezicacileyo kunye neendlobongela, okanye intloko elula emva kokusetyenziswa kwipesenti encinci yabasebenzisi. Oku kuyimpawu yokuba unokufuna ukubuyela kwiqondo eliphantsi .
Ngokwe-hormone nengcali ye-thyroid uRichard Shames, MD:
Unokufuna ukuqala nge-3 mg, uze ubone ukuba unokufumana inzuzo efanelekileyo ukuya kwi-2 mg, kwaye mhlawumbi u-1 mg. Umbono wam oqhelekileyo kukuba umthamo we-1 mg awuyi kubangela intloko kunye nokudakumba njengempembelelo yecala.
Kukho akukho paphando olude olupapashwe ixesha elide lokuhlola idatha ye-dose e-melatonin ephantsi. Kodwa bonke oogqirha endithe ndathetha nabo, baninzi abasebenzisa i-melatonin ye-dose ephantsi kwaye bayincoma kwizigulane, banomuvo wokuthi kusekelwe kwiziphumo zentshukumo zexesha elifutshane, asikwazi ukufumana nayiphi na ingxaki ngokusetyenziswa kwexesha elide. i-melatonin i-dose ephantsi. Kodwa uMelatonin akufanele asebenziswe ngabasetyhini abakhulelweyo okanye abalahlayo.
Ukuba unomdla ekuncediseni i-melatonin, emva kokuba uthethe nodokotela wakho, khetha uphawu lwakho ngokuchanekileyo. Ufuna ukuqinisekisa ukuba ufumana i-melatonin ye-bakala ecocekileyo, i-pharmaceutical, kunye neengcali zibonisa ukuba usebenzisa kuphela i-melatonin yokwenziwa kunye ne-melatonin evela kwizilwanyana.
Ngamanye amaxesha uva ukuba i-melatonin ayilunyanzelwanga kubantu abanezifo ezizimelayo , kwaye kulabo bafazi abaneengxaki ze- thyroid ngenxa yokuzimela ngokuzenzekelayo isifo seHashimoto okanye iGraves, oku kungathi kunzima. Kusengumcimbi ophazamisayo. Kodwa ndacela uDkt. Pierpaoli ngale nto, kwaye wathi kwakukho icala elilodwa elikude apho i-melatonin idibaniswa khona ne-hepatitis. Uthe ukukhathazeka akunakunqununu, ukuba i-melatonin ibonakala iyakunceda umsebenzi we- immune ukusebenza ngokufanelekileyo, kungekhona ngaphezu komsebenzi, njengokuba abacebisi bathetha. UDkt Pierpaoli - kunye nabanye oogqirha abathetha nabo-banomuzwa wokuthi i-melatonin inceda izifo ezizimele. Wachaza ukuba kutheni udliwano-ndlebe awanikezela kwiiNkqubo zoKhuselo lwaMazwe ngamazwe, i-Pharmacy yase-UK:
Ngokuphathelene nokuzimela komzimba, i-melatonin kufuneka isetyenziswe kwizifo ezizimeleyo ngenxa yokuba iya kubuyiselwa ukuphendula kwamagciwane okuqhelekileyo kunye namandla omzimba wokuzivikela omzimba ukuqonda i-antigen "anti". Siye sabona ukufumana ngokupheleleyo! I-etiology yazo zonke izifo ezizimele ezichaphazela ulusu, izilonda, igazi kunye naziphi na izicubu zisekelwe kubuncinci okanye zikwazi ukukwazi ukubona izicubu zomzimba zethu, ngoko ke zikhuphe ukuphendula ngokuzenzekelayo. Ukuguga ngokwayo kuninzi inkqubo efihlakeleyo, efihlakeleyo neyikhohlakeleyo ekhokelela ekubeni i-vasculitis (isifo se-slot), i-autoantibodies kunye nomhlaza. Umsebenzi wethu weminyaka engama-40 uye waholela ekuboniseni ukuba ukukhuselwa komzimba kuphantsi kokulawulwa kwe-hormonal. I-Melatonin ayinakunyusa ukuhlanganiswa kwe-autoantibodies ezinobundlobongela, ngokuchaseneyo iya kuqhubela phambili ekuphulukisweni kwezinto ezisemgangathweni ze-hormonal kunye nokuqalisa inkqubo ye-autoimmune.
Imithombo:
Díaz, Beatriz López; Llaneza, Plácido Coto. "Umgaqo we-Endocrine wekhosi yokuhamba komzimba ngomlomo we-melatonin: ingxelo yecala lokuqala." Ukunquma kwexesha . 15 (2): 388-392, Matshi / uEpreli 2008.
UParry, uBarbara, kunye. al. "Ukwandiswa kweMelatonin kunye nokuchithwa kwexesha elidlulileyo kwixinzelelo lweMenopausal: Indima yeminyaka edluleyo yokuxhoma kwexesha, i-Follicle-stimulating hormone, ixesha lokulala, kunye ne-Index Mass Mass" Umbhalo we-Clinical Endocrinology & Metabolism . Ishicilelwe kwi-intanethi: Julayi 02, 2013 kwi-Intanethi
I-Pierpaoli, uWalter "Ukuguqula ukuguga: Ukulungiswa kwakhona kwexesha lePineal Clock." Disemba 2005, uWiley-Blackwell. I-intanethi.
Toffol, Elena et. al. "I-Melatonin kwintombi yase-perimenopausal kunye ne-postmenopausal: imibutho eneemvakalelo, ubuthongo, iimpawu ze-climacteric, kunye nomgangatho wobomi," Ukunquma kwesikhashana . NgoMeyi 2014 - Umqulu 21 - Isiqendu 5 - p 493-500