Izinzuzo zezeMpilo, Ukusetyenziswa, iingcebiso kunye nokunye
Yintoni iMelatonin?
Ukuveliswa ngokwemvelo emzimbeni, i-melatonin iyimodmoni enceda ukulawula imizimba yokulala kunye namahomoni ahlukahlukeneyo emzimbeni. Yenziwe kwi-amino acid tryptophan.
Umzimba uvelisa i-melatonin ngexesha lobumnyama (ukulungiselela ukulala) kwaye inqanda ukuvelisa ngexesha lokukhanya. Ngokwabanye abaxhasi, ukuthatha i-melatonin ngesimo se-melatonin isongezelelo isongezelelo kunokunceda ukuphucula ubuthongo.
Ngama-1970 kunye nee-1980, uphando malunga nemiphumo ye-melatonin ekulala kwakhokelela ekusebenziseni ukunyuka kwe-supplemental melatonin njengenye indlela yokunyangwa kwezifo zokulala. Phakathi kwee-1990, ukugqithiswa kwe-melatonin isongezelelo se-jet lag kwaye ezinye izifo ezinxulumene neminyaka zakhula ngokuphawulekayo.
Ukusetyenziswa kweMelatonin
Ngenye iyeza, i-melatonin izongezo zisetyenziselwa ukulungelelanisa umjikelezo womzimba wokulala kwaye kuthiwa uncedise ezi nkxalabo zempilo ezilandelayo:
- Ijet lag
- Ukungabikho
- Ukuphazamiseka kokulala ngenxa yokusebenza komsebenzi
- Ukulahla i-Sleep Phase Syndrome
- Ukungabikho kokungafihli-nxu lumene nokukhathazeka kwengxaki (hydactivity disorder) (ADHD), i-autism, ukukhubazeka kwesiberebhu kunye nobumfama.
- Ukuncedwa ngokulala emva kokuyeka imithi ye-benzodiazepine
- Ukunciphisa imiphumo emibi yokuyeka ukutshaya
- Ukungazinzi ngenxa yokusetyenziswa kweyeza (umz. Beta-blockers)
Abanye abaxhasayo bathi i-melatonin inokulwa nezinye iifom zesifo somhlaza kunye nokunciphisa ezinye iziphumo zechemotherapy.
Ukongeza, i-melatonin kuthiwa uncedise ukusileleka ezihambelana nezimo ezithile ezifana ne-Alzheimer's disease, ukudandatheka, kunye ne-schizophrenia.
Izinzuzo zezeMpilo zikaMelatonin
Nanku ukujonga ngokuthe ngqo ukusetyenziswa kwe-melatonin kwilinye iyeza kunye neenzuzo zezempilo:
1) Jet Lag
Ukuhamba kwimiba yexesha kukuphazamisa isigqi senkcazo.
Ubungqina bokuqala bubonisa ukuba izongezelo ze-melatonin zinokunciphisa iimpawu ezithile ze-jet-lag, ngakumbi kubantu abahamba ngasempuma kunye / okanye abawela iindawo ezinhlanu okanye ngaphezulu. I-Melatonin inokuphucula ukulumka emini, ukuhambelana kokuhamba, kunye nokuncinci, ukukhathala komini.
Iziphumo ezibalaseleyo zibonakala zenzeka xa i-melatonin isongezelelo iqaliswa ngosuku lokuhamba kwaye ithathwa ngexesha lokulala elifunwayo kwindawo oya kuyo. Ngokuqhelekileyo kuthathwa iintsuku eziliqela.
Idibeneyo: 5 IziNyango zeNdalo zokuKhusela iJet Lag .
2) Ukusalalisa
I-Melatonin ibonakala iyancipha ixesha elithathayo ukulala, kodwa kuphela malunga nemizuzu eyi-12 (ngokutsho kwesifundo esinye). Izifundo ezininzi zibonisa ukuba ixesha elifanelekileyo lokuthatha izithako ze-melatonin liphakathi kweesigama kunye neyure kunye neeyure ezimbini ngaphambi kwexesha lokulala elifunwayo. Kukho ubungqina obubonisa ukuba i-melatonin inokuba luncedo kubantu abadala, mhlawumbi ngenxa yokuba banokuba ne-melatonin encinane emzimbeni wabo. Izifundo ezininzi ziye zincinci kwaye zifutshane kwixesha, kufuneke uphando olungakumbi.
Bona ii- 14 zoNyango zoMzimba zokuLawula ukuNyunjwa .
3) Umsebenzi weShift
Nangona umsebenzi wokushiya ubusuku uphazamisa isigqirha se-circadian, kukho ubungqina obuncinane obuxhasa uxhalelo lokuba i-melatonin inokulungisa utshintshi lokulala kubantu abasebenza ebusuku baze balele emini.
Akubonakali ukuphucula ubuthongo emva komsebenzi wokutshintsha okanye ukuphucula uqwalaselo ngexesha lomsebenzi wokutshintsha.
4) Iingxaki zokulala ezidibanisene nobumfama
I-Melatonin inokuphucula ukuphazamiseka kokulala kubantu abangaboniyo.
5) Ukunciphisa i-Sleep Phase Syndrome
I-Melatonin ihlolwe ngabantu abane-syndrome yesigaba sokulala. Uphando lucebisa ukuba ukutya rhoqo kwiiveki ezine kunokuphucula ubuthongo, ngokunciphisa ixesha elifunekayo lokulala nokuphucula ixesha lokulala. Nangona kunjalo, ngaphaya komnyaka omnye wokuyeka izibonelelo, ukubuyela kumaphethini okulala kwangaphambili kunyango kuye kwaphawulwa.
6) Iingxaki zokulala ezidibene neengxaki zoPhuhliso
Kukho izifundo eziphambili kunye neengxelo zecala ekusebenziseni i-melatonin kubantwana abaneengxaki ezibangelwa ubunzima bokulala, ezifana neengxaki ze-autism, izifo zokugula, okanye ukuhlutha. Izifundo ezenziwe ngoku kude zibonisa ukuba i-melatonin inganciphisa ixesha lokulala kunye nokulinda ixesha lokulala. Nangona kunjalo, iziphumo zecandelo kunye nokukhuselwa kwexesha elide okanye eliqhelekileyo lokusetyenziswa kwe-melatonin kubantwana abaziwa.
Yiya kwiphepha 2 ukuze ufunde ngezinye iinkxalabo zokukhusela ...
Imijelo
Nangona uphando lubhekiselele ekusebenziseni i-melatonin ukuya kwiinyanga ezimbini, iziphumo ezibi kunye nokukhuselwa kwexesha elide okanye ukusetyenziswa rhoqo kwe-supplementary melatonin abaziwayo. Ezinye iingcali ziqwalasela amanani aqhelekileyo afumaneka kwi-supplementary melatonin, i-3 ukuya ku-5 i-milligrams, ukuba iphakame kakhulu kwaye ithi ixabiso kwi-0.1 ukuya kwi-0.5 milligrams ingqiqo.
Ukuxhaswa kweMelatonin akufanele kuthatyathwe ngabantwana okanye abaselula, njengoko kukho inkxalabo yokuba i-melatonin isongezelelo ingachaphazela kakubi ukuphuhlisa i-gonadal. Amanqanaba aphezulu e-melatonin anokuba nefuthe lokuvimbela i-ovulation. Abasetyhini nabancinci nabasetyhini abazama ukukhulelwa kufuneka baphephe ukusebenzisa i-melatonin.
Imiphumo emibi ye-melatonin ingabandakanya ukulala, intloko, isisu, amaphupha acacileyo, ukuguquka kwemiva emfutshane, kunye nokunciphisa okwethutyana kwingqalelo kunye nokulinganisela. Abantu akufanele baqhube okanye basebenzise umatshini iiyure ezintlanu emva kokuthatha i-melatonin. I-Melatonin inokubangela iziqhwenga zesisu, isisongela, kunye nokuhlanza, uxinzelelo lwegazi olungaphantsi, kunye neenqabileyo, i-hallucinations okanye i-paranoia.
I-Melatonin inokunyusa umngcipheko wegazi, ngoko akufanele isetyenziswe ngabantu abasebenzisa i-warfarin (i-Coumadin®) okanye ezinye iyeza ezichaphazela ukuguqulwa kwegazi, okanye ngabantu abanokuphazamiseka kwegazi.
I-Melatonin ichaphazela ukuveliswa kwamanye amahomoni.
Ukwanda kwesikhumba sesilisa kunye nokunciphisa isibalo sembewu kuye kwabikwa. I-Melatonin inokuchaphazela ushukela wegazi kunye namazinga e-insulin.
I-Melatonin inokuchaphazela ukusebenza komzimba. Ayaziwa ukuba kuya kubachaphazela njani abantu abaneemeko ezizimeleyo ezifana ne- multiple sclerosis , i- psoriasis , isifo se-Crohn , i- rheumatoid arthritis , i- lupus , kunye nohlobo lwe-1 lweswekile.
Akufanele kuthatyathwe ngabafakeli bokufakelwa.
Ukuxhaswa kweMelatonin kungadlukisayo iimpawu kubantu abanexinzelelo, ngoko abantu abanexinzelelo kufuneka basebenzise i-melatonin phantsi kweliso lomnikezeli wezempilo. Inokunyusa umngcipheko wokubanjelwa kwabantu kubantu abaneengxaki zokungena. I-Melatonin iphulwe phantsi kwesibindi, ngoko abantu abanesifo sesibindi bangadinga ukukhusela i-melatonin.
I-Melatonin inokusebenzisana neziyobisi kunye nezibonelelo ezifana ne:
- Umxinzelelo ophezulu wegazi
- Iziyobisi ezithintela umzimba wokuzivikela, njenge-cyclosporine
- Amachiza okuxhatshazwayo
- I-Corticosteroids (esetyenziselwa iimeko ezivuthayo ezifana ne-arthritis)
- I-Benzodiazepines, njenge-diazepam kunye nezinye iziyobisi ezibangelwa ukutshatyalaliswa
- Izitshalo ezibangela ukulala okanye ukulala, ezifana nekava kava kunye ne- valerian
- Wort John's wort
Ukusebenzisa iMelatonin yezeMpilo
Kubalulekile ukuba uqaphele ukuba ukuphatha unyango kwaye ukuphepha okanye ukulibazisa ukunakekelwa okuqhelekileyo kunokuba nemiphumo emibi. Unokufumana iingcebiso ekusebenziseni izongezo apha , kodwa ukuba ucinga ngokusetyenziswa kwe-melatonin nayiphi na injongo, qinisekisa ukubonisana nomboneleli wakho oyintloko.
Imithombo:
Buscemi N, Vandermeer B, Hooton N, et al. Ukusebenza kunye nokukhuselwa kwe-melatonin engapheliyo kwezifo zokulala eziphambili. Uhlalutyo lweemeta. J Gen Intern Med 2005; 20: 1151-8.
UFischer, S., uSmolnik, R., uHerms, M., Born, J., noFehm, uHL uMelatonin uphucula kakuhle i-neuroendocrine yobugcisa bokulala kubantu abangaboniyo. J Clin Endocrinol.Metab 2003; 88 (11): 5315-5320.
Gringras P, Gamble C, Jones AP, kunye al; I-MENDS Study Group. UMelatonin ngenxa yeengxaki zokulala kubantwana abaneengxaki ze-neurovelopvelopmental: i-trialbo elawulwa yinto elawulwa yinto elawulwayo. BMJ. 2012 uNgo-5; 345: e6664.
UJames M, u-Tremea MO, uJones JS, uKrohmer JR. Ngaba i-melatonin ingathuthukisa ukulungelelaniswa nobusuku? U-J Emerg Med 1998; 16: 367-70.
Jan, JE, Hamilton, D., Seward, N., Fast, DK, Freeman, RD, kunye noLaudon, M. Uvavanyo lwezonyango lwe-melatonin elawulwe ngokulawulwa kwabantwana abaneengxaki zokujikeleza ukulala. J Pineal Res 2000; 29 (1): 34-39.
Nagtegaal JE, Laurant MW, Kerkhof GA, et al. Iimpembelelo ze-melatonin ngobuninzi bobomi kwizigulane nge-syndrome yesigaba sokulala esibambezelekayo. J Psychosom Res 2000; 48: 45-50.
Standard Standard. "Melatonin" Mayoclinic.com. Ifikelele ngo-Oktobha 3, 2007.
PDRHealth. "Melatonin" Ifikeleleke ngo-Oktobha 3, 2007.
Rossignol, DA kunye noFrye, RE Melatonin kwiimeko ze-autism iziphazamiso: ukuhlaziywa okucwangcisiweyo kunye nokuhlaziywa kwemeta. Dev.Med.Child Neurol. 2011; 53 (9): 783-792.
Sack RL, Brandes RW, Kendall AR, et al. Ukuxhaswa kwee-circadian izhyhythm by melatonin kubantu abangaboniyo. N Engl J Med 2000; 343: 1070-7.
Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onelayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.