Inhlonipho ephakamileyo yeT3 ixhamle kwiSifo soMzimba
Ungazivumi wodwa xa ungazange uvevanywe ngokuhlolwa kwegazi okubizwa ngokuba yi-reverse T3 (rT3), eyaziwa ngokuba yi-reverse triiodothyronine. Olu luhlolo lwegazi aluqhelekanga ngokugqithiswa ngabagqirha be-thyroid, ngaphandle kwelokugula kwesifo esibi (cinga ngomntu ogonywe esibhedlele).
Makhe sijonge ukujonga ngokukhawuleza kule vavanyo legazi le-thyroid, kwaye ingxoxo ijikeleze intsingiselo yayo yangempela.
Yintoni echasayo T3?
I-RT3 yi-metabolite ye-T4 (thyroxine). Ngokuqhelekileyo, xa i-T4 ilahlekile i-athomu ye-iodine-inkqubo ebizwa ngokuba yi-monodeiodination, okanye i-T4 kuya kwi-T3 ukuguqulwa-iba yi-triiodothyronine (T3), i-hormone esebenzayo ye-thyroid.
Kodwa kwezinye iimeko, umzimba ugcina amandla ngokuguqula i-T4 esikhundleni salo ku-rT3, ifomu engasebenziyo ye-T3 engakwazi ukuhambisa i-oksijini namandla kumaseli, njengoko i-T3 yenza.
Ukulinganisa iT3
I-RT3 ingalinganiswa nokuhlolwa kwegazi olulula.
Ngokuqhelekileyo uyalelwe odokotela, ngaphandle kwimeko yokugula kakubi, izigulane ezibhedlele ezifunyenwe ukuba zibe neemvavanyo ze-thyroid eziqhelekileyo-ngokuqhelekileyo i-TSH ephantsi okanye eqhelekileyo, i-triiodothyronine ephantsi (T3) kwaye mhlawumbi i-thyroxine ephantsi (T4).
Ukuze ukwazi ukutolika ngokuthe ngileyo kwezi ziphumo (qinisekisa ukuba umntu ogule ngokugqithiseleyo unesifo se-hypothyroid okanye unesifo se-non -roidroid), i-rT3 ithathwa.
Syndrome ye-Nonthyroidal
Ukugula okungenayo i-nonthyroidal, eyaziwa ngokuba yi-euthyroid-illness syndrome, ibhekiselele kumgangatho ophantsi we-thyroid umsebenzi ovavanyo olufunyenwe kwisimo sokugula kakubi kumntu ongenakho ukuxilongwa kwe-thyroid. Emva kokubuyiselwa kwisifo esibi, iziphumo zovavanyo lwe-thyroid kufuneka zenzeke.
Kwi-nonthyroidal disease syndrome, i-rT3 idla ngokuphakanyiswa, ngenxa yokunciphisa umzimba komsebenzi othile we-enzyme. Phakathi kwe-hypothyroidism, i-rT3 iphantsi.
Ngaloo ndlela, izinga eliphezulu le-RT3 kwisimo sogulane olunzulu lunceda oogqirha bangafuni ukuxilongwa kwe-hypothyroidism.
Ngenxa yokuba kukho ukugula okungapheliyo, i-thyroid hormone diminution is considered as a protective mechanism (okanye mhlawumbi i-artifact, ngokwezinye iingcali), oogqirha abacebisi ngokubanzi unyango.
Nangona kunjalo, isigqibo sokuba ingagqirha isifo esingenayo i-nonhyroidal isaphikisana. Ezinye iingcali zikholelwa ukuba i-nonthyroidal illness syndrome ibonisa ukuba i-hypothyroidism yintshu ekhoyo. Ngoko, bakholelwa ukuba umntu kufuneka aphathwe nge-thyroid i-hormone esikhundleni (okanye nakwiimeko zokukhupha i-hypothalamic) ukuba amazinga e-thyroxine angaphantsi kwinqanaba elithile.
Ukuhambela phambili, kubalulekile ukuqaphela ukuba ngaphandle kokugula okukhulu, ezinye iimeko zezempilo ezingabangela ukugula okungenayo i-nonthyroidal ziquka:
- Nxuwa
- Ukuhlinzwa
- Umtsalane we-bone
- Ukuhlaselwa yintliziyo
- I-coronary artery ispass grafting
Umbono weMicrotherapy Integration kwi-rT3
Kuyafaneleka ukuphawula ukuba ezinye iingcali ze-hormone ezidibeneyo zinombono ohlukileyo wendima kunye nenani le-rT3, ikholelwa ukuba amanqanaba aphakamileyo we-RT3 (nangona i- TSH, i-Free T3 kunye ne-Free T3 ixabiso lingabakho kwi-standard reference reference ) ingabonakalisa ingxaki ye-thyroid kumgangatho wamaselula-imeko ebizwa ngezinye izikhathi ngokuthi "i-hypothyroidism yeselula."
Kulo mbono odibeneyo, i-rT3 ephakamileyo ingabangela ukunyamezela okungapheliyo ngokomzimba okanye ngokomzwelo, ukukhathala kwamadraal , izinga lokunciphisa i-iron ferin (igcinwe isinyithi), ukugula okukhulu kunye nokulimala, kunye nezifo ezingapheliyo, phakathi kwezinye izinto.
Ngokutsho kwabasebenzi bokudibanisa, enye yeendlela eziphambili zokujongana ne-RT3 ephakamileyo kunye "ne-hypothyroidism yeselula" ngonyango lwe-thyroid kunye neyeza elineT3.
ILizwi
Umyalezo wokubuya ekhaya uwukuthi intsingiselo echanekileyo okanye ukuchazwa kwe-rT3 isacatshulwa ngaphandle. Ngethemba, uphando olongezelelweyo kunyango (okanye kungenjalo) lwezigulane ezigulayo ezinamazinga aphezulu e-TT3 ziya kwenziwa (njengoko kungakhange kuphandwe kwizifundo ezinkulu, ngezifundo ezingenamsebenzi).
> Imithombo:
> DeGroot LJ, uCrousos G, Dungan K, et al., Abahleli. (2015). UMzantsi Dartmouth (MA): MDText.com, Inc. &
> Ross DS. (2017). Umsebenzi weKroyroid kwi-non -roidroid. Cooper DS, ed. Isemgangathweno. Waltham, MA: UpToDate Inc.
> Van den Berghe G. Ukugula okungenayo i-thyroidal kwi-ICU: isifo esinobuso obuhlukileyo. Thyroid. 2014 Oct; 24 (10): 1456-65.