I-TSH Ngaba Uvavanyo oluPhambili lokuThengisa nokuLawisisa umsebenzi we-Thyroid
Ukutolika amazinga e-TSH akusiyo intuitive, ngoko awukho wedwa xa uzibuza ukuba iinqanaba lakho le-thyroid lithetha ukuthini , kwaye ngokukodwa iinqanaba eziphezulu zezantsi zeTSH zithetha ntoni unyango.
Ngokomzekelo, unokubuza ukuba kutheni ugqirha wakho ufuna ukunciphisa endaweni yokunyusa imithi yakho ye-thyroid xa iziphumo zakho ze-TSH ziphantsi, okanye, ngokukodwa, kutheni ugqirha wakho ukwandisa imithi yakho ye-thyroid xa i-TSH yakho iphakamileyo.
Qiniseka ukuba ngelixa libonakala libuyela ngasemva, konke kuyaqondakala xa ukhangela i-biology ye-thyroid hormone production.
Thyroid Basics
I- thyroid gland yenza i-hormone ye-thyroid. Xa isebenza ngokufanelekileyo, i-thyroid yakho inxalenye yempendulo ye-loop ne-pituitary gland equka amanyathelo amanani athile:
- Okokuqala, i-pituitary yakho iyayiqonda inqanaba le-hormone ye-thyroid ekhishwa kwigazi.
- I-pituitary yakho ikhupha i-hormone yesithunywa esikhethekileyo: i-thyroid evuselela i-hormone (TSH). Indima ye-TSH kukukhuthaza i-thyroid ukuba ikhulule i-hormone ye-thyroid.
- Xa i-thyroid yakho, nangona isiphi isizathu-ukugula, uxinzelelo, ukuhlinzwa, okanye ukuphazamiseka, umzekelo-ayikho okanye ayikwazi ukuvelisa i-hormone ye-thyroid eyaneleyo, i-pituitary yakho ibona amanqanaba athatywayo we-hormone ye-thyroid kwaye ishukunyiswa kwisenzo ngokwenza i-TSH, oko ke kubangela i-thyroid yakho ukwenza i-hormone engaphezulu ye-thyroid. Le yimizamo yokukhupha ukuphakamisa amanqanaba e-hormone ye-thyroid kwaye ubuyisele inkqubo eqhelekileyo.
- Ukuba i-thyroid ingasebenzi kwaye ivelisa kakhulu i-hormone ye-thyroid ngenxa yezifo, okanye ithatha iqondo eliphezulu kakhulu lemithi ye-hormone ye-thyroid -i-pituitary senses yokuba kukho i-hormone ye -roid ejikelezayo kwaye iyancipha okanye icimise ukuveliswa kwe-TSH. Oku kwehla kwi-TSH yinjongo yokubuyisela ukujikeleza amazinga e-hormone ye-thyroid.
Ukutolika amazinga eTSH
Xa uqonda ezi zinto ziseko ze-thyroid, kulula ukuqonda ukuba yi-TSH ephantsi kunye ne-TSH ephezulu ibonakalisa umsebenzi wakho we-thyroid.
Ekubeni i-TSH iphakamisa ama-hormone e-thyroid kwaye igcina inkqubo ngokulinganisela okuqhelekileyo:
- I-TSH ephakamileyo ibonisa ukuba i-thyroid yakho ingasebenzi (i-hypothyroid) kwaye ingenzi umsebenzi wayo wokuvelisa i-hormone ye-thyroid eyaneleyo. I-TSH ethe xaxa isebenza ekuvuseleleni i-thyroid yakho ukuvelisa i-hormone ephezulu ye-thyroid.
- I-TSH ephantsi ibonisa ukuba i-thyroid yakho iyingozi kakhulu (hyperthyroid) kwaye ivelisa i-hormone ye-thyroid. I-pituitary gland igxininisa i-TSH ukuze i-thyroid ingenzi nto ngakumbi.
Ngaba i-TSH ethembekileyo?
Ngexesha lokuxilongwa, uninzi oogqirha basebenzisa uvavanyo lwe-TSH ukuvavanya umsebenzi wakho we-thyroid kwaye ugqibe ikhosi efanelekileyo yokunyango.
Kodwa ke, phawula ukuba ezinye iingcali zivakalelwa kukuba zithembela kuphela kwi-TSH, ngaphandle kokuvavanya amanqanaba ajikelezayo ama-hormone e-thyroid, njenge-thyroxine yamahhala (T4), abanako ukufumanisa iingxaki ze-thyroid ezingcolileyo.
Ngokomzekelo, i-T4 yamahhala ekongezeni kwi-TSH iphinda ihlolwe ukuba ugqirha ugxeka i-thyroid ingozi evela kwizifo ze-pituitary gland okanye hypothalamus. Ngokufanayo, ukuba i-TSH iyinto eqhelekileyo, kodwa umntu unempawu zokuba i-hyperthyroid okanye i-hypothyroid, i-T4 yamahhala inokukhangela.
I-TSH ayinelanga ngokwaneleyo ukujonga i- hypothyroidism ngexesha lokukhulelwa , kungakho i-T4 kunye / okanye i-T4 iyonke ihlolwe kwakhona.
Ngokuxhomekeka kwiimeko zeklinikhi, ezinye iimvavanyo ze-thyroid ezingathi zihlolwe ziquka i-triiodothyronine (T3), ibuyele i-T3 , kunye novavanyo lwe-antibody.
IiRang Reang Ranges
I-hitch enkulu ekunxibelelanisweni kwe-TSH ukuya kwi-hypothyroidism kunye ne-hyperthyroidism yinto engavumelaniyo kwihlabathi lezonyango ngokubhekiselele kwinqanaba lokubhekisela kwi-TSH.
Amanqanaba angaphantsi kwe-0.4 athatyathwa ubungqina obunokwenzeka be-hyperthyroidism, kwaye amanqanaba angaphezu kwe-5.0 ahlolisiswa ubungqina obubonakalayo be-hypothyroidism, kodwa ezinye iingcali zivale ukuba lolu luhlu lubanzi kwaye lufanele lucaciswe ukuya ku-0.4 ukuya ku-2.5mU / L.
Ukuqwalasela unyango ngokusekelwe kwi-TSH
Xa uphathwe nge-hypothyroidism kunye neziyobisi zentsholongwane ye-thyroid, oogqirha baya kuzama ukunyanga kumayeza "okuqhelekileyo" okubhekiselele kwi-TSH esuka kwi-0.3 / 0.5 kwi-low-end, ukuya ku-3.0 / 5.0 esiphakamileyo.
Ngoko, xa uhambe ukuhlola kwaye i-TSH yakho ingena ngaphantsi kwexesha eliqhelekileyo (oko kuthetha ukuba i-TSH ixhaswa kuba ama-hormone e-thyroid sele ephakamileyo), ugqirha wakho unokufuna ukunciphisa umthamo wakho we-hormone ye-thyroid ngenxa yokuba sele u-hyperthyroid . Oku kungenxa yokuba ukukhutshwa ngokugqithisileyo kwe-TSH (oku kuthetha ukuveliswa kwe-hormone ephezulu ye-thyroid) kunokunyusa umngcipheko womntu we-fibrillation ye-atrial (intliziyo ye-arrhythmia) okanye i-osteoporosis.
Kwaye ukuba uvavanyo lwakho lwe-TSH lulapha ngaphezu kwesiqhelo, abanye oogqirha baya kufuna ukwandisa umlinganiselo wakho we-hormone ye-thyroid, kuba amazinga angaphezu kwesiqhelo acingelwa ukuba yi-hypothyroid (engasebenzi).
ILizwi
Isishwankathelo, uvavanyo lwe-TSH ngabagqirha be-blood test ikakhulukazi basebenzisa i-hypothyroidism kunye ne-hyperthyroidism kunye nokujonga unyango lwe-hormone ye-thyroid (xa kufuneka).
Nangona iimeko zonyango, njengokukhulelwa okanye ezibhedlele, zingadinga ukuba i-T4 neT3 zilinganiswe, ukuqonda ingcamango engundoqo yezinga eliphezulu okanye eliphantsi le-TSH lithetha ukuba umsebenzi wakho we-thyroid ungumzimba wento ofuna ukuyifumana.
Oko kwathiwa, ukuba unemibuzo malunga nomsebenzi wegazi we-thyroid, qiniseka ukuba ubuze ugqirha wakho.
> Imithombo:
> Bahn, R., Burch, H, Cooper, D, et al. I-Hyperthyroidism kunye Nezinye izizathu zeTrorotoxicosis: Izikhokelo zoLawulo lwe-American Thyroid Association kunye ne-American Association of Clinical Endocrinologists. I-Endocrine Practice. I-Vol 17 No. 3 ngoMeyi / ngoJuni 2011.
> Braverman, L, Cooper D. Werner & Ingbar's The Thyroid, 10 Edition. WLL / Wolters Kluwer; 2012.
> Garber, J, Cobin, R, Gharib, H, kunye. al. "Izikhokelo zeCliniki zoLwazi lwe-Hypothyroidism kubantu abadala: I-Cosponsored yi-American Association of Clinical Endocrinologists kunye ne-American Thyroid Association." I-Endocrine Practice. I-Vol 18 No. 6 uNovemba / Disemba 2012.
> Ross DS. (2017). Uvavanyo lweLebhan ye-thyroid. Ku: UpToDate, Cooper DS (Ed), UpToDate, Waltham, MA.