I-oncologist yakho inokunyusa ama-injection ye-Neupogen ukuba unayo i-chemotherapy yomhlaza wesifuba. Iyintoni injongo yale engxube, yenziwa njani, kwaye yintoni na iziphumo ezingamanzi onokuzifumana?
Sibanzi
I-Neupogen (i-filgrastim) isilwanyana esinikwe abantu abafumana i-chemotherapy abanesifo esiphantsi se-neutrophil (i-neutrophil -eyenziwa yi-neutropenia .) I-neutrophils yintsholongwane yegazi elimhlophe elinceda ukukhusela intsholongwane.
I-Neupogen isebenza ngokuvuselela umongo weethambo ukwandisa umveliso weeseli ezimhlophe zegazi. Yisilwanyana esicacileyo esivame ukunikezwa njengesibhendu (injection.)
I-Neupogen inokwenziwa ngokukhawuleza emva kokuba i-chemotherapy enokuthi yanciphise kakhulu inani lakho le-neutrophil (njenge-dose ephindwe kabini i-Cytoxan kunye no-Adriamycin.) Ngamanye amaxesha unokunikwa ukuba iimvavanyo zegazi zakho zibonisa ukuba i-white cell count count, ngokukodwa ukubala kwakho kwe-neutrophil, liphantsi ngokwaneleyo ukubeka ingozi enkulu ekukhuleni isifo.
I-Neupogen kubantu abane-Cancer Cancer
I-Chemotherapy isifo somhlaza wesifuba sithinta zonke iiseli ezahlula ngokukhawuleza emzimbeni wakho, kubandakanywa neeseli emathambo esifuba ezenza amangqamuzana egazi ezimhlophe, iiseli ezibomvu zegazi kunye neeplatelet. Xa zonke iiseli zegazi ziyancitshiswa, zithunyelwa njengokunciphisa umongo we-bone kusuka kwikhemotherapy.
Ngelixa abantu bangakha iqondo eliphantsi leeseli ezibomvu (i- chemotherapy-induced anemia ) kunye neeplatelet (i-thothecytopenia-eyenziwa yi-thrombocytopenia) yinto ephantsi ye-neutrophils (i-neutrophil-eyenziwa yi-neutropenia) eyenza ingozi enkulu.
Ngexesha le-chemotherapy, i-oncologist yakho iya kujonga rhoqo iCBC yakho.
I-Neupogen isebenza njani
Ngokuqhelekileyo, umzimba wakho uvelisa iprotheni ekhuthaza ukuveliswa kwe- neutrophils kwinkqubo ebizwa ngokuba yi- hematopoiesis . Kodwa ngexesha le-chemo lomdlavuza webele, umzimba wakho awukwazi ukwenza ngokwaneleyo le protein. I-CBC yakho ingabonisa ukuba izibalo zakho zegazi ze-neutrophil ziphantsi kwaye awuyi-neutropenic.
Iinjongo ze-Neupogen ziya kukhulisa imveliso ye-neutrophils yakho. Unokuziva u-aches kunye nentlungu yesifo ngelixa le nkunkuma isebenza, kodwa kunokunceda ukucinga ukuba isistim somzimba sakho sakha kwakhona kwaye siqina ngakumbi ekukhuseleni impilo yakho.
Lawulo
Uya kuba neelayijeni ye-Neupogen rhoqo imihla yonke kude kubekho iseli legazi elimhlophe libale ukubuyela kumanqanaba aqhelekileyo. Xa kunikezelwa ngokufanelekileyo, ezi injections aziyi kulimaza. Esi sidakamizwa sinokunikwa ngokunyuswa kwe-intravenous (IV).
Imiphumela
Akuyena wonke umntu oza kuba nemiphumo emibi kwi-Neupogen, kodwa iintlungu zombini kunye nomkhuhlane ziqhelekile. Intlungu iya kuvakalelwa njengento ejulile kwimimandla yomzimba wakho apho ininzi yeeseli zakho zegazi zenziwe, njengefabhethi yakho, imilenze yakho ephezulu kunye ne-pelvis yakho.
Ngokuqhelekileyo, unyango aluyadingeki kwintlungu yethambo kodwa uthetha nodokotela wakho ngaphambi kwexesha. Unokuthi uncome ukuba uthathe iTylenol (acetaminophen) okanye i-Advil (ibuprofen) kodwa, ekubeni imithi ingakwazi ukusebenzisana okanye ibeke iingxaki ukuba isibindi sakho okanye iintso zakho zingasebenzi kakuhle, kubalulekile ukucima oku kwangaphambili. Abantu abaninzi bafumanisa ukuba ukuthumba kwindawo yokuhlambela ngokufudumele kunceda ukunciphisa ubuninzi beentlungu.
Xa Ufanele Ubize Ugqirha wakho
Iimpendulo zingahle zenzeke kwaye kufuneka ubizele ugqirha wakho ngokukhawuleza ukuba ufanele uhlakulele:
- Indlela yokuphefumula (ukuvumba ukuphefumula, ukuvuvukala kobuso, imilomo, ulwimi okanye umqala, ukugqithisa ukusabalalisa umzimba wakho)
- Intlungu zesisu
- Intlungu
Kumele ubize ugqirha wakho ukuba uyaphawula intlungu yesifuba, iintlungu zentliziyo, okanye ukukhathala okungavamile okanye ukunyaniseka.
Mngcipheko
I-Neupogen isilwanyana esiphephile kakhulu esetyenziselwa ezininzi iintlobo ze-neutropenia. Ngokuqhelekileyo akukho miphumo ebuthathaka okanye isigxina kule nkunkuma. Naziphi na iziphumo eziphambili ozifumanayo ziya kuphelisa kwaye ziphelise xa uyeka ukufumana izibhamu ze-Neupogen. Kukho iimeko zokuphuka kwamapeni okubangelwa ukufa, nangona oku kunqabile kakhulu.
Ngubani omele aphephe le Michiza
Ungathathi le nkunkuma ukuba:
- Ukhulelwe okanye uncelisa
- Uhlaselwa kwi-Neupogen
Iingcebiso
Ngaphambi kwejoyi yakho yokuqala ye-Neupogen, ugqirha wakho uya ku-oda iiCBCs rhoqo ukuze afumane amanqanaba eeplatelet zakho, amangqamuzana egazi abomvu kunye namhlophe kunye neutrophils. Njengoko unyango luqhubeka, qhubeka nokuhlolwa kwegazi okulandelayo. Ezi zibalulekileyo njengoko zihlola ukusebenza kwe-Neupogen kwaye ukuba ufumana idilesi efanelekileyo.
Ukuba unonyame okanye ukhulelwe, xubusha oku ngogqirha wakho ngaphambi kokuba uthathe u-Neupogen. Akukho zifundo ezaneleyo ezenzelwe ukucacisa umphumo walesi sidakamizwa ngobisi lwebele okanye kumntwana wesisu.
Ngaphantsi
I-Neupogen (okanye i-Neulasta ) inokuphumelela kakhulu ekwandiseni izinga le-neutrophils emzimbeni wakho ukunciphisa umngcipheko wokusuleleka. Kubalulekile ke ke ukuba uqaphele kwaye usebenzise amanyathelo anganciphisa umngcipheko wakho wokusuleleka xa usuhlobo lwe-chemotherapy olufana nokuhlamba izandla kunye nokuphepha ukunxibelelana nabagulayo.
> Imithombo:
> Lee, K., Kim, J., Lee, M. et al. Isifundo esi-Randomized, Multicenter, iSigaba II / III sokuQinisekisa iDose efanelekileyo kunye nokuHlola indlela yokuPhatha kunye noKhuseleko lwePegteograstim kwi-Chemotherapy-i-Neutropenia echaphazelekayo ngokuthelekiswa ne-Pegfilgrastim kwizigulane ze-Breast Cancer: KCSG PC10-09. Unonophelo loNcedo kwiCancer . 2016. 24: 1709-1717.