Izikhokelo malunga nezizathu zeCFS
Yintoni ebangela ukugula okungapheliyo kwesifo? Umbuzo onzima! Nangona uphando oluninzi, iingcali azikwazanga ukuyiphonononga nangayiphi na isizathu esisodwa. Abanye bakholelwa ukuba isifo esingapheliyo sisifo ( ME / CFS ) sinokubangelwa kwizinto ezininzi eziza kunye ndawonye phantsi kweemeko ezifanelekileyo. Ezi zinto zingabandakanya:
- Izinto zobomi
- Inkqubo yesantya ephakathi (CNS) kunye ne-hormone engafanelekiyo
- Intsholongwane okanye olunye unyango
- Isistim somzimba esingaqhelekanga
- Iimeko ezixinezelekileyo
- Ukubonakaliswa kwiibhox
Akunjalo wonke umntu onamami / i-CFS unalo lonke le miba eqhubekayo. Basenokuba neentlangano zabo, ngenxa yezizathu ezithile, ezikhokelela kwimeko. Ngenxa yokuba ukudibanisa izinto ezahlukeneyo kunokubangela iimpawu ezahlukeneyo kunye noshintsho emzimbeni, iingcali zichonga iindidi okanye iinqununu ze-ME / CFS. Ekugqibeleni, i-subgrouping inokukunceda wena kunye nodokotela wakho ubone indlela engcono yokuphatha ngayo.
Izinto zobomi
Uphando lwe-ME / CFS kunye namajethi afakelwe kwi- hypothalamic-pituitary-adrenal (HPA) i-axis kunye ne-sympathetic system. I-axis i-HPA ilawula ukulala kwakho, impendulo yokuxinezeleka, nokuxinezeleka.
Kuphando olwenziwe ngo-2006 olupapashwe kwi- Pharmacogenetics , abaphandi bajonga i-DNA elawula indlela umzimba wakho uphatha ngayo ingozi, ukulimala kunye nokuxinezeleka, kwaye bafumana ukuhluka okufanayo okuza kuqikelela nge-ME / CFS ngama-76 ekhulwini ngokunembile.
I-CDC ibiza ngokuthi "ubungqina bokuqala bokukholelwa kwimeko yezinto eziphilayo zokuphelelwa yintsholongwane engapheliyo." Sekunjalo, abaphandi babengenakukwazi ukuphawula iimpawu zezofuzo okanye ukuchonga indlela ukutshintsha kwathonya ngayo iimpawu.
Olunye uphando lubonisa ukungabikho komzimba kwi-ME / CFS echaphazela ukusebenza komzimba, ukuxhumana kwamaseli, kunye neendlela ezisebenzisa ngayo iiseli.
Zonke ezi zinto zibonisa ukuba abanye abantu banokuthi bazalwe ngokwemizimba yabo kwi-ME / CFS-ngamanye amagama, banokufumana ukuba ngababangela abaqokelelweyo abakhoyo. Ngokomzekelo, ukuba umntu ohlala esichengeni ngexesha elixinzelelekileyo kwaye emva koko ubonakala kwi-virus ethile okanye i-toxin, baya kuphuhlisa i-ME / CFS. Nangona kunjalo, umntu onokwenziwa kwemfuyo eyahlukeneyo, ke, uza kuvela kwimeko efanayo kwaye abe kakuhle.
CNS neeHormones
Njengoko kukhankanywe ngasentla, abanye abantu abane-ME / CFS banokungaqhelekanga kwi-axis ye-HPA. Abaphandi banomdla ngakumbi kwezinye iikhemikhali kunye ne-hormone ezilawulwa yi-HPA axis:
- I-neurotransmitter iyatshintsha
Ama-neurotransmitters ayenemichiza edibanisa imiyalezo kwingqondo yakho. Uphando luye lwabonisa ukuba abanye abantu abane-ME / CFS banamanqanaba angabonakaliyo e-neurotransmitter ezithile (i- serotonin kunye ne- dopamine ). Abaphandi bazama ukuchazela indima le engafanelekanga idlala kwi-ME / CFS. - Ukunyanzeliswa kwehommoni
Iingcali ziyazi ukuba izinga le-hormone ye-cortisol yokuxinezeleka liphantsi kwii-ME / CFS izigulane, kwaye bakholelwa ukuba oku kungenza kube nzima ukujamelana noxinzelelo-nokuba ngumzimba (njengokusuleleka okanye ukuthintela) okanye ngengqondo. Ukutshintshwa kweCortisol kunceda abanye, kodwa akusiyo yonke, izigulane ze-ME / CFS. Ngophando lwango-2008, abafazi abane-ME / CFS banamazinga angamazantsi e-cortisol ngelixa amadoda ayenayo i-ME / CFS ayenzanga, enokukunceda ukuba uchaze ukuba kutheni imeko ixhaphake kakhulu kubafazi.
- Iimpawu zesigcawu eziphazamisayo
Iwashi yakho ye- circadian (inxalenye ye-HPA axis) ilawula umjikelezo wakho wokulala. Ubungqina bubonisa ukuba kwabanye abantu abane-ME / CFS eli lixesha lilahliwe, mhlawumbi sisiganeko sengqondo okanye esicinezelayo, kwaye umzimba awukwazi ukufumana isigqi esifanelekileyo. Abantu abanele ngxaki kubonakala bechitha ixesha elide kwinqanaba lokuhamba ngokukhawuleza (REM) lokulala, okwenzekayo xa uphupha. Abantu kule nkqutyana ye-ME / CFS bafumana uncedo olungakumbi kwiimithi zokulala kunabantu abasemagqunyeni, ngokutsho kweengcali.
Izifo
Uninzi lweempawu kunye neempawu ze-ME / CFS zifana nezo zigulo zentsholongwane, ngoko ke uphando oluninzi lujolise kwiimeko zokungena kwintsholongwane okanye ezithintekayo.
Abaphandi baye bahlola iingcamango ezintathu ezinxulumene nosuleleko, nangona akukho nanye ibonakaliswe:
- Intsholongwane okanye iibhaktheriya zichaphazela umzimba kwaye zonakalisa isistim somzimba. Umonakalo uyaqhubeka ukudala iimpawu ezifana ne-virus okanye ibhaktheriya.
- Emva kokusuleleka, isenzo esingaqhelekanga sisistim somzimba sokukhusela isigciwane senza intsholongwane eyayingasasebenzi ukuba ivuselele kwakhona.
- Impendulo yomzimba kwiintsholongwane zentsholongwane ivela kubantu abanokukhutshwa.
Ngelixa bonke abantu abane-ME / CFS babonisa iimpawu zentsholongwane, baninzi. Iziqendu ezininzi zobungqina zixhasa inkolelo yokuba ezinye i-ME / CFS ibangelwa ubuncinci inxalenye yintsholongwane:
- Uxhumano lwe-Enterovirus
Kwisifundo se-2007, abantu abane-ME / CFS babenokuba ngamathuba amane kunabantu abanempilo ukuba babe nobungqina be- enteroviruses kwiisisu zabo zesisu. Ukungena kwi-entryoviruses kubangelwa izifo zesisu, kwaye iimpawu ze-ME / CFS zihlala ziqala emva kohlobo lwesifo. - Rnase L
Umzimba wakho usebenzisa i-enzyme Rnase L ukubulala iintsholongwane ezihlasele iiseli zakho, kwaye izigulane ze-ME / CFS zihlala ziphezulu kwi-Rnase L. - Umbulali weNdalo (NK) Iiseli kunye neeseli
Amaseli e-NK & T e-immune system ahlasela ama-cell-infected cells, kwaye abantu abane-ME / CFS bahlala benokukhubazeka imisebenzi ye-NK kunye ne-T kunye neenombolo, ezibonisa ukuba umzimba ongapheliyo unokuzixhalabisa kwaye uziphazamise. - IAndibodies
Abantu abane-ME / CFS banamanqanaba aphezulu e-antibodies ezininzi ezibangelwa ukusuleleka ezibangelwa ukukhathala nezinye iimpawu ze-ME / CFS. Ezi ziphilayo ziquka ezo zenza i-candida (imvubelo), uhlobo lwe-herpesvirus yabantu (HHV-6), isisisi, i-parvovirus kunye ne- Epstein-Barr . Abaphandi abazange bakwazi ukubonisa ukuba nayiphi na yezi zizathu ezibalulekileyo ze-ME / CFS. - Ukuqala kokugula
Amaphesenti angama-80 e-ME / CFS amacala aqala ngokukhawuleza emva kwesimo esifana nomkhuhlane. - Ukuqhambuka kwamaqela
Ngelixa i-CDC ingaqinisekisile ukugqabhuka kwamagqabantshintshi, iingxelo zabantu abaninzi kwindlu efanayo, indawo yokusebenzela, kunye noluntu oluphuhlisayo i-ME / CFS ngexesha elifanayo alinakuvakala.
Abanye abaphandi bacetyisa ukuba utshintsho kumaqanda asemngciphekweni emathunjini angadlala indima ekuphuhliseni i-ME / CFS.
Nangona kunjalo, ububungqina obonakalayo bubaleka ngokubhekiselele kwi-theory. I-ME / CFS ayibonakali isasazeka ngomxholo ochanekileyo, abantu abanalo abakubonakaliyo, kwaye-nangona zifundo ezicwangciswe kakuhle - abaphandi abazange bakwazi ukudibanisa i-ME / CFS naluphi na isifo esithile.
Isaziso malunga ne-XMRV
Ngo-2009, abaphandi be-Whittemore Peterson Institute (WPI) banyathelisa uphando kwiphephancwadi ye- Sayensi ephakamisa ukuba unxibelelwano phakathi kwe-XMRV, i-retrovirus esanda kufumanisa, kunye ne-ME / CFS. Bafumene i-XMRV malunga nama-67% eesampuli zegazi ukusuka kwii-ME / CFS izigulane. Bakufumanisa kwakhona kwi-3% yokulawulwa kwempilo.
Nangona kunjalo, uphando olulandelayo aluphumelelanga ukuqinisekisa ubungqamaniso, kubandakanya isifundo esikhulu esibandakanya umphandi oyintloko we-WPI. Olunye uphando lucetyiswa indlela apho ukungcola kubenokudala iziphumo ezingamanga kwisifundo sokuqala. Ekupheleni konyaka ka-2011, i-XMRV yecawa yayiye yonke-kodwa ilahliwe.
Inkqubo yomzimba
Izifundo eziliqela zibonise ukungenakunyani kwiistim e-immune zabantu abaneM ME / CFS, kodwa abaphandi abafumananga umzekelo ongenamkeleko. Phakathi kwezona zinto zixhaphake kwaye zikhuselekile ngokuzikhusela komzimba.
Ezinye iingxelo zixelile ukuba uninzi lwezigulane ze-ME / CFS zithintela kwizinto ezifana ne-pollen, ukutya kunye nezitye ezifana ne-nickel kunye ne-mercury.
Oku kukhokelela kwingcamango yokuba izilwanyana zingabangela inqununu yokungaqhelekanga kwe-immune ekhokelela kwi-ME / CFS. Enye imfundiso kukuba ukunyamezela, uxinzelelo kunye nokusuleleka kunokunxulumanisa nokukhupha ikhemikhali ebizwa ngokuthi i-adenosine triphosphate (ATP), egcina amandla kwiiseli. Ezinye izigulane ze-ME / CFS zibonisa ubungqina bokwehla kwe-ATP.
Ezinye izigulane ze-ME / CFS zinamanqanaba aphakamileyo yezinto ezibizwa ngokuthi i- cytokines , ezithandwa yizinzululwazi zingabangela iimpawu ze-ME / CFS, kubandakanywa ukukhathala kunye nama-actic muscle. Izifundo ezahlukahlukeneyo zichaze ukungalingani kwamatriki kwi-ME / CFS, kodwa ezinye iingcali azizange ziqinisekisile i-T cell kunye ne-cytokine engafanelekiyo.
Isifo sengqondo sokunyuka esingapheli sibonakala sinezinto ezimbalwa ezifana nezifo ezizimeleyo ezifana ne- lupus okanye i- multiple sclerosis , apho i-immune system ihlasela ngokungafanelekanga amalungu enempilo emzimbeni. Umzimba ophandayo wophando uphakamisa ukuba i-ME / CFS inokuzimela.
Ukuxinezeleka
Abaphandi bakholelwa ukuba ukwakheka kwengqondo, ubuntu kunye neemeko zentlalo zinokuchaphazela nokuba uya kuphuhlisa i-ME / CFS, kodwa abayiqondi ngokupheleleyo ubudlelwane obunzima phakathi kwabo.
Nangona le miba mhlawumbi ayisona sizathu esibalulekileyo seM ME / CFS, banokudlala indima ekwenzeni ukuba nithinteke.
Qaphela: I-ME / CFS ayithathwa njengesifo sobungundoqo seengqondo, kwaye ukungenaM ME / CFS kuthetha ukuba umntu unobuthakathaka kwengqondo okanye akakwazi ukuhlangabezana nezinto. Nangona maxa wambi kudibaniswa nokuxinezeleka kweklinikhi, i-ME / CFS yimeko ecacileyo.
Amachiza / amachiza
Kwinqanaba elithile, ukukhathala okungapheli kunye nentlungu kudibaniswa nokutyhila kwiikhemikhali ezahlukeneyo kunye neengxube zendalo. Ezi ziquka i-solvents, i-pesticides okanye isinyithi esinzima. Nangona kunjalo, ngenxa yokuba abaninzi bethu baye bavelelwa kwezi ntlobo zeekhemikhali ngexesha elithile, kunzima ukulandelela phantsi ukuba zeziphi iingxaki. Imeko ebizwa ngokuba yi- multiple chemical sensitivity (MCS) ibangela ezininzi iimpawu ezifanayo njengeM ME / CFS, kwaye ezi zimbini zikholelwa ukuba ziimeko ezixubileyo .
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