Ubungqina bendima ekuHlaleni koKhathala okungapheliyo
Intsholongwane ye-Epstein-Barr (EBV) ilungu leentsapho ze-herpesvirus kwaye enye yeentsholongwane eziqhelekileyo zomntu. Sekuyisikhathi eside ixhunyaniswe ngentsholongwane yokugula okungapheliyo ( ME / CFS ), nabanye abaphandi bathi yinto ebalulekileyo yecausal xa abanye bathi akubandakanyeki kwesi sifo nonke.
Abo ba kholelwa ukuba uqhagamshelwe kaninzi baxoxa malunga nokuvuselelwa kwakhona.
Zonke i-herpesvirus zihlala kwiinkqubo zakho ngonaphakade, kodwa ngokubanzi zihlala zihlala zilele kakhulu ixesha. Xa ziba zikhuthele, iiseli ezikhethekileyo kumasosha omzimba, kuquka i- B-cell kunye neeseli ze- T , ngokuqhelekileyo abanalo ingxaki yokugodla kwakhona kwakhona.
Uninzi lwabantu alukwazi nokuba le nkqubo iqhubeka. Kungenxa yokuba i-B kunye ne-T-cell, kwisistim somzimba sokuzikhusela, ukhumbule intsholongwane kwaye iyakwazi ukuhlanganisa ngokukhawuleza umkhosi wamagciwane okuyigcina.
Ukuba i-immune system ayisebenzi kakuhle, nangona kunjalo, inokwenza ukuba intsholongwane ithole inqanaba kumanqanaba aphinde akugulise. Xa oko kwenzeka, kubizwa ngokuthi ukuvuselelwa kwakhona.
Ubungqina bokubuyiselwa kwakhona
Sinobubungqina bokubuyisela i-typothesis ye-EBV yokuqalisa kwakhona kwezinye iimeko ze-ME / CFS. Uphando olushicilelwe ngo-2014 lugxininisa loo ngcamango.
Kule sifundo, oososayensi bafumene ubungqina bokuba ii-B kunye ne-T zeeseli zabantu abaninzi abanesi sifo abazange bakwazi ukukhumbula i-EBV, oku kuthetha ukuba intsholongwane ebenziwa kwakhona iya kuba ngcono ukuphucula, ukuvelisa nokudala iimpawu.
Abaphandi bafumene le memori ekhunjulwayo imemori yamastim e-immune angama-76 ekhulwini labathathi-nxaxheba abangaphezu kwama-400. Le yipesenti yepesenti.
Kanye nokubonisa oko kunokubangela nokugcina ezinye iziganeko ze-ME / CFS, abaphandi bathi lo msebenzi ungakhokelela kumakishi wokuxilongwa okude. (Okwangoku, asinalo vavanyo lovavanyo lokuxilongwa kwe-ME / CFS , ngoko kuyaqhubeka ukuxilongwa kokukhutshwa.)
Okungakumbi Nge-Epstein-Barr Virus
I-EBV iyingozi ebalulekileyo. Kuyaziwa ngokubangela ukuba i- mononucleosis echaphazelekayo , ebizwa ngokuba yi-mono okanye "isifo sokubanga." Iimpawu zeMono ziquka:
- Ukukhathala okukhulu
- Umqala obuhkungu
- Intloko
- Fever
- Iintsimbi zomzimba
- I-lymph nodes
- Ukuqonda ukukhanya
- Ukuqhawukelwa ngumphefumlo
Ukubuyisela kwi- mono kuyaziwa ukuba kuthathe ixesha elide, kwaye ukuphindaphinda kubonakaliswe ukukhathala okukhulu.
Abanye abaphandi baye bade bakholelwa ukuba akukho into eyenzeka ngokungazenzisiyo ukuba nazo ziyimpawu ze-ME / CFS. Nangona kunjalo, inxalenye enkulu yabemi ithatha i-EBV emizimbeni yabo kwaye inani elincinci lala bantu liphuhlisa i-ME / CFS. Oku kuye kwaphazamisa iinzame zokuchazela indlela i-EBV inokubangela ngayo ukugula.
Olu pho nonongo lubonakala ukuba lunqobe le ngxaki, nangona kunjalo, ukunika impendulo yalo mbuzo. Ayiphenduli imibuzo malunga nokuba kutheni amanye amasosha omzimba abonakala engaboniyo le ntsho longwane, nangona kunjalo. Esi sihloko sophando olusasa, njengoko sifumana indlela yokulungisa ubuphofu.
EBV Studies zangaphambili
Olunye uphando lubonisile ukuba inani elincinane lamatyala e-ME / CFS amantombazana ayeza kudala kwiinduli ze-mono, kwaye ezininzi iintsholongwane oogqirha abangabonakaliyo kwi-mono zifanelwe i-ME / CFS.
Kubonakala ngathi i-EBV eyingozi ixabayo, mhlawumbi iyakubangela ukugula ixesha elide. (Funda kabanzi malunga neziphumo ezivela kuCort Johnson kwiMpilo ephakamileyo.)
Ukongeza kwi-mono, i-EBV inxulumene neentlobo ezithile zomhlaza, ezinokuchaza iziganeko eziphezulu zezifo ezichaphazeleka ngumhlaza nokufa ukuba ezinye iingcali ze-ME / CFS zibika ukuba ziye zaphawula. I-EBV inokudlala indima kwi- multiple sclerosis . Olunye uphando lubonisa ukuba lunokulinganisa i- leukemia .
Akukho nanye kule nto ichanekileyo, nangona kunjalo. Sisekho indlela ende yokuya xa ifika kwi-EBV okanye nayiphi na intsholongwane njengento ebangela i-ME / CFS.
ILizwi
Ngolu hlobo olutsha lokufunyanwa kwememori yeselula, sinokuzalisa i-gap ephawulekayo yolwazi malunga nendlela i-EBV inokubangela ngayo i-ME / CFS kunye negalelo kwiimpawu eziqhubekayo.
Nangona kusetyenziswe umsebenzi ogqithisiweyo ukuqinisekisa ukuba lolu cwaningo luyakwenza ukuba oogqirha baninzi baxelele imithi echasene nentsholongwane (njenge-valacyclovir okanye i-valganciclovir) kwizigulane ze-ME / CFS ezinezinga eliphezulu ze-EBV.
> Imithombo:
> Chhabra P, uMthetho AD, Sharma U, et al. I-Epstein-barr igciwane lesandulela ngculaza ebonakalayo njenge-leukemia ephazamisayo: ingxelo yamatyala amabini kunye nokuhlaziywa kweencwadi. Umbhalo wamaNdiya we-hematology kunye nokunyelwa igazi. 2014 Mar; 30 (1): 26-8.
> Loebel M, Strohschein K, Giannini C, et al. Impendulo ye-EBV-B kunye ne-T-cell emelekileyo kwizigulane ezine-syndrome ezingapheliyo. PLoS One. 2014 Jan 15; 9 (1): e85387. eCollection 2014.