Ingaba le Nveli yeMveli ingaba i-MEND ye-Alzheimer's Mind?
Olunye uphando lubangalisa indlela ye-MEND njengendlela efanelekileyo yokunyanga, kunye nokutshintsha, iimpawu zesifo se-Alzheimer.
Isifo se-Alzheimer sisimo esinyukayo esichaphazela malunga nama-5.3 yezigidi zaseMerika. Izimpawu zayo ziquka ukulahleka kwememori, ukudideka, ukuphazamiseka , kunye neengxaki zokunxibelelana. Ukhohlo olungaphendulwanga, i-Alzheimer iholele ekupheliseni ukubola kweengqondo kunye nomzimba, kunye nokufa ngokugqibeleni.
Ngelishwa, izidakamizwa ezininzi zokuphatha isifo se-Alzheimer ziye zavavanywa kule minyaka elishumi edlulileyo kwaye ngoku ngoku aphumelelanga ukwenza umbahluko omkhulu kwizilingo zabo zonyango. Enyanisweni, i-Alzheimers's Association ichaza isifo se-Alzheimer njengesona kuphela sezizathu ezilishumi zokufa ngaphandle kokunyanga okanye unyango olululo. Kuphela kuphela amachiza avunyelwe yi-Food and Drug Administration (FDA) ukuphatha i-Alzheimer, kwaye ukuphumelela kwabo kunzima.
Nangona kunjalo, kwiphononongo epapashwe ngoJuni 2016, iqela labaphandi libika ukuba linokutshintsha loo nto. Uphononongo lubonisa ukuphucula okubonakalayo-kwinqanaba lokuba ababhali babhala "ukuguqulwa" kweempawu-kubantu abaye bafunyaniswa ukuba bane-Alzheimer's or mental cognitive impairment . (Ukukhubazeka okunzulu kwengqondo yimeko apho kuncipha ukucinga nokukhumbula imemori.
Ukwandisa ingozi yokuba i-Alzheimer iya kuphuhliswa.) Ngaphezu koko, abaphandi baxelele ukuba ukuphuculwa kwengcamango kuhlale kuzinzile ngelixa abathathi-nxaxheba besifundo baqhubeka nokulandela indlela ye-MEND.
Yintoni i-MEND? Kutheni Kungasebenza?
I-MEND isisigxina esiphakamisela ukukhuliswa komzimba nge-neurodegeneration.
Injongo yesicwangciso se-MEND kukujonga izinto ezininzi zempilo yomntu, kunokufuna imichiza yommangaliso ejolise kwindawo enye, njengeprotheyini ye- betyloid eyakhayo kwaye ivelise iiplathi kwiibongo zabantu abane- Alzheimer's .
Abaphandi be-MEND baqhathanisa indlela yabo yezinye izifo ezingapheli ezifana nomhlaza, i-HIV / AIDS kunye nesifo senhliziyo. Ukunyangwa ngempumelelo kwezi meko kudla ngokuquka ukuphuhliswa kwendlela yohlobo lwe-cocktail olubandakanya udibaniso lwamachiza kunye nokungenelelo kwezonyango ezizimeleyo ngokwemiqathango ethile yomntu ngamnye.
Ngokufanayo, xa sibona oko kubangela isifo se-Alzheimer , abaphandi abaninzi bacinga ukuba akunakwenzeka ukuba kukho enye into ebangela uxanduva. Kungenzeka ukuba izinto ezininzi zifaka isandla ekuphuhliseni ii-Alzheimer kunye nezinye iintlobo zemeko yokugula komzimba .
Ukudibanisa izinto ezininzi kubonakala kunengqiqo kunye nokuba sijonga njani iindlela ezahlukeneyo (ezifana nokutya , ukuzivocavoca umzimba kunye nokuzivocavoca kwengqondo ) ziye zabonisa impumelelo ethile ekuphuculeni ukusebenza komqondo . Ukuba iindlela ezihlukeneyo zidibeneyo, kunokwenzeka ukuba inqanaba eliphambili lokuphatha i-Alzheimer iya kufezwa kwindlela nganye inokujolisa kwimiba eyahlukileyo yezinto ezibangela, okanye igalelo ekunciphiseni ukuqonda.
Ezinye zeendawo eziza kuhlolwa yi-MEND kunye neethagethi zibandakanya:
- Amanqanaba e-Homocysteine
- Amanqanaba e-Vitamin B12
- Ukulala
- Ukutya
- Igazi lezinga leshukela
- Ukuzilolonga
- Ukuchonga kunye nokunyangwa kwe-apnea yokulala
- Ukuxinezeleka
Uphando loPhando
Abathathi-nxaxheba abalishumi baye babandakanyeka kulolu pho nonongo. Ekuqaleni kweso sifundo, ngamnye wabo wafumana ukuxilongwa kwe-Alzheimer's or incogmentary dispairment. Iimvavanyo zixhaswa ziinkalo ezahlukeneyo kubandakanya umqulu wengqondo wengqondo , i- MRIs , i-PET, uvavanyo lwe-Stroop , amanqanaba e-homocysteine, uvavanyo lwe-digit span , uvavanyo lweememori oluphicothiweyo, i- MMSE , iingxelo zokunciphisa ukukhumbula imemori kunye nokufumana ingxaki yokufumana amagama .
Abathathi-nxaxheba baphinde bavavanywa ukuba bachonge ukuba ngaba ngabaphathi bezityalo ze-APOE4 . I-APOE4 igalelo landisa amathuba okuba umntu ahlakulele isifo se-Alzheimer, kodwa asiyikuqiniseka.
Umntu ngamnye kwabayishumi abandakanyekayo kulolu pho nonongo uthathe inxaxheba kwisicwangciso sonyango esibandakanyekayo esithintela izixhobo ezininzi ngokwemiqathango yazo yokuvavanya. Ezinye zezikhokelo zazo zibandakanya ukwandisa ubungakanani babo bokulala ubusuku bonke, ukuthatha i- melatonin (ukwongezelela ngokwemvelo ) ukuphucula ubuthongo, ukuphucula ukutya kwabo ukunciphisa iswekile , gluten, inyama kunye nokutya okulula, nokwandisa iziqhamo, imifuno , i-blueberries kunye nokungabikho kwezolimo iintlanzi, ukuzila ukudla ngaphambi kokulala ebusuku ngenxa yeeyure ezingama-3 kunye neehora ezili-12 ngobusuku, ubuthongo bemihla ngemihla ye- vitamin D3 , C kunye / okanye i-E, imihla ngemihla ye- citicoline , ucoceko lwamazinyo oluphuculweyo , amayeza ecocoti kunye ne- curcumin ( i-tumeric) , unyango lwe-hormone, ukulawulwa kwengcinezelo efana no-yoga, ukuzivocavoca umzimba rhoqo kunye nokuzilolonga kwengqondo rhoqo.
Iziphumo
Umntu ngamnye kwabayishumi abandakanyekayo kulolu phofu wabona ukuphucula okuphawulekayo ekuqondeni kwabo, ngokusekelwe kwiingxelo zabo kunye neyabathandekayo babo, kwakunye neziphumo zokuvavanywa kwengqondo. Ezi mphuculo zazikuthi ekupheleni kokufunda, abaninzi abathathi-nxaxheba abazange bahlangabezane neempendulo zokuxilongwa kwe-Alzheimer okanye ukukhubazeka kwengqondo. Ukongezelela, ukusebenza kwabo kwengqondo kuhlale kuzinzile kwiminyaka emine ngoku, eli lixesha elide kunabo bonke abantu abaye babekwe kule protocol. Olu phuculo olugcinwe ngokubhekiselele lugqithwa xa lithetha ngonyango lwe-Alzheimer's disease.
Eminye imizekelo yokuphuculwa okuphawulekayo kulolu cwaningo iquka umlinganiselo we- Mini Mental State Exam (MMSE) wama-23 (okuya kubonisa isifo esifanelekileyo se-Alzheimer) esiye sa phucula ukuya kuma-30 (amanqaku aphelileyo), amanqaku angama-MMSE angama-22 aphuculweyo angama-29 , kunye nokwanda okwenene ngobukhulu be-hippocampus kwingqondo yomnye wabathathi-nxaxheba. Olu phofu luchaze ukuba umqulu womntu we- hippocampal waqala nge-17 percentile kwaye wanda ukuya kuma-percentile angama-75. Oku kuphawulekayo kuba i-hippocampus yindawo kwindawo yengqondo ehlotshaniswa nokukwazi ukukhumbula ulwazi, kunye nobukhulu obuncinci bunxulumene nememori enciphise.
Ekugqibeleni, ngaphambi kokuthatha inxaxheba kulolu cwaningo, ininzi yabathathi-nxaxheba babe neengxaki emsebenzini okanye ekhaya ezihlobene nokusebenza kwazo kwengqondo. Ekupheleni kwesi sifundo, abaninzi babenokuphucula ekusebenzeni kwabo emsebenzini nasemakhaya.
Ucwaningo olufanayo olufanayo
Ngo-2014, uphando olulinganayo luqhutywe nguDale E. Bredesen kwaye lwapapashwa kwincwadi yokuguga . (UBredesen wayengomnye wabalobi besifundo esashicilelwe ngo-2016.) Uhlolisiso luka-2014 lwabandakanya abathathi-10 abathathi-nxaxheba be-Alzheimer, ukuphazamiseka kwengqondo engqondweni okanye ukuphazamiseka kwengqondo . I-MEND protocol yayisetyenziswe kubo ngabanye bala bantu, kunye nabo bonke abaye bafumana ulwazi lokuphucula ukuqonda. Umntu weshumi, intlonelo esesifo se-Alzheimer's disease , saqhubeka nokuhla naphezu kwe-MEND protocol.
Ingxelo yocwaningo ifumene utshintsho olubalulekileyo kunye oluphawulekayo emva kokuba i-MEND protocol isetyenziswe-ukukwazi ukusebenza ngempumelelo emsebenzini. Kwachaza ukuba abantu abathandathu kwabayishumi bekuye kwafuneka bayeke imisebenzi yabo okanye babe neengxaki ezibalulekileyo emsebenzini wabo ngenxa yengxaki zabo ezinengqiqo. Emva kokubandakanyeka kwabo ngendlela ye-MEND, bonke abayisithupha bakwazi ukubuyela emsebenzini okanye abanolwazi oluphawulekayo ukuphucula ukusebenza kwengqondo kwimisebenzi yabo.
I Pros
Ngokucacileyo, le mpu melelo (kunye neyokuqala, ngokunjalo) ekuguquleni inkqubela ye-Alzheimer's disease kubathathi-nxaxheba bayayinomdla kwaye inokubakho inxaxheba enkulu kwimigudu yethu yokunyanga, ukunyanga nokukhusela isifo se-Alzheimer. Ukongezelela, imbono emva kokufundwa kokukwazi ukudibanisa imiba eyahlukileyo yento esele siyayazi ngayo ngempilo yengqondo ibonakala ingqiqo, ngokukodwa inikwe ukungaphumeleli kweminye imvavanyo yeeklinikhi zonyango olululo.
Umxhasi
Nangona iziphumo zikhuthaza kakhulu, kukho abanye kwizenzululwazi ezibuza lo mboniso njengento engacacanga kwaye ikhethiweyo kuba akusiyo uphando oluphangaleleyo oluphindiweyo. Uphando oluphindiweyo kabini na apho abaphandi, okanye abathathi-nxaxheba, bayazi ukuba ngubani ofumana unyango. Ithintela ukuba kungenzeka ukuba iziphumo zophando zichaphazela ukunyanzelisa kwabaphandi, kunye nokuba kungenzeka ukuba abathathi-nxaxheba bachatshazelwa yimpembelelo ye-placebo (apho bafuna ukuphucula kwaye ngoko benza).
Abanye baphinde bahlalutye isifundo ngenxa yokuba asichazi ukuba zezifundo zikhethwe njani izifundo zezifundo, kwaye ubungakanani besampula buncinane kakhulu kwi-10 kuphela. Yaye, xa iimvavanyo ezifanayo ziphinda ziphindwe, kukho ukuthambekela kovavanyo- abathabathayo ukuphucula ukusebenza kwabo.
Kukho nkxalabo yokuba abaphandi bafuna ukubeka ingqalelo kwiziphumo zophando kuba i-MEND protocol ibonakaliswe kwaye ithengiswa nguMasibisi njengendlela yokunikezela ngeenkonzo zonyango apho bangafikelela khona iziqinisekiso zabo baze banikeze iprotocol kwizigulane zabo.
Abaphandi ababandakanyeka kulolu cwaningo baqaphele ukuba le protocol iyinkimbinkimbi kwaye kunzima ukuyilandela. Enyanisweni, bachaza kwinkcazo yolu cwaningo ukuba akukho nxaxheba kwabafundi abawalandela ngokupheleleyo imiyalelo ye-MEND protocol.
Ekugqibeleni, kuyathakazelisa ukuqaphela ukuba ininzi yabathathi-nxaxheba bobabini zifundo bebancinci kunabaninzi abafumana i-Alzheimer kunye nezinye iintlobo zeengqondo. Oku kungaphakamisa umbuzo wokuba i-MEND protocol ingasebenza kakuhle xa isetyenziswe kubantu abaneminyaka yobudala, okanye ukuba incinci yabafundi bathatha inxaxheba kwimpumelelo ye-MEND indlela.
Yintoni elandelayo?
Nangona le mibuzo neengcamango, iziphumo zolu cwaningo zikhuthaza. Bagxininisa imfuneko yokuhlaziya kwakhona indlela yethu yokunyanga kwesifo se-Alzheimer, kwaye banikezela nethemba kwindawo apho uphumelele kakhulu.
Uphando oluqhubekayo kule ndawo kunye neqela elikhulu labathathi-nxaxheba ngolu vavanyo lwezonyango olulawulwayo linyathelo elilandelayo elibalulekileyo ekuqaliseni ukuphumelela okwenyaniso kwindlela yesifo se-Alzheimer ..
Imithombo:
Ukuguga. 2014 Sep; 6 (9): 707-717. Ukuguqulwa kokuncipha kwengqondo: Inkqubo yonyango yolwaphulo. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221920/
Ukuguga. 06/12/16. Ukuguquka kokuncipha kwengqondo kwi-Alzheimer's disease. http://www.impactaging.com/papers/v8/n6/full/100981.html#bibl_1
I-EMBO yeMilcular molecular. 2013 Juni; 5 (6): 795-798. Isizukulwana esilandelayo kwisizukulwana se-Alzheimer's disease. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779441/
Ukusebenzisa iiLebhu. I-MEND Protocol.
ZeBlog Blogs. NgoJuni 24, 2016. Iprotocol ye-MEND ™ yesifo se-Alzheimer: Iyeza elisebenzayo kwi-steroids? (kwakhona) http://scienceblogs.com/insolence/2016/06/24/the-mend-protocol-for-alzheimers-disease-functional-medicine-on-steroids-visisited/