I-Beta i-Amyloid Protein, i-Plaque, ne-Alzheimer's

Iprotheni ye-Beta-amyloid kunye ne- plaque - le miqathango emibini enxulumene nengqondo ishintsha kwisifo se-Alzheimer. Ufuna ukwazi ngaphezulu? Nazi iinyaniso ezi-9 kuwe:

1. Ukwakhiwa kweprotheni ye-beta-amyloid kwingqondo kuthathwa njengesinye sezibonakaliso zesifo se-Alzheimer . (Olunye uphawu oluphawulekayo luyi- neurofibrillary tangles .) Ezi proteins ze-beta-amyloid ziyahlanganisana ukuze zenze i-insoluble (ayikwazi ukuchithwa) iiplates ngaphandle kwe-neurons.

1. Iiprotheni ze-Beta-amyloid nazo zakha kwi- synapses kwaye ziphazamise ukuxhatshazwa kwiseli enye ukuya kwenye ingqondo.
2. Ngaphambi kokuba iqela le-beta-amyloid likhulu ngokwaneleyo ekuthiwa yi- plaque , ezi proteins zenza i- oligomers kuqala . I-Oligomers isanqunyulwa (iyakwazi ukuchithwa), amaqela amancinci e-beta-amyloid.
3. Nangona iiplati sele zichongwe njengenye yezinto ezibangelwa yi-Alzheimer's, abaphandi baye bathetha ngoku le mibuzo, ukuchonga ii-oligomers ezichazwe ngasentla njengokuba mhlawumbi sisinye seziphumo eziphambili ekuthintela ukunxibelelana ukusuka kwiseli yeseli. Esinye isizathu ngenxa yale nto kukuba abanye abantu bane-plaque ekwakheni ingqondo, kodwa abanalo izifo zesifo se-Alzheimer .
4. Ukongezelela, olunye uphando luye lwabonisa ukuba utshintsho lwezinto ezinengqiqo luqala ukuqala ngaphambi kweeprotheni ze-beta-amyloid ezivela kwiindawo ezinkulu zeplate.
5. Inzululwazi ifumene iiprotheni ze-beta-amyloid ngaphezu kweminyaka eyi-100 edlulileyo. Baqale bachongwa nguDkt. Alois Alzheimer ngo-1906.

1. I-Beta-amyloid inxalenye yeprotheyini ekhudlwana ebizwa ngokuba ngumprotheni we-amyloid .
2. Iingcaphulo ezinomdla: "Uninzi lwazinzulu lucinga ukuba iiplates ngokwenene inokuba yinto yokugqibela yecala yengqondo ukufumana le-beta-amyloid enobubi kude neurons" (i-Alzheimer's Disease Education and Referral Centre).
3. Uphando oluqhutywe kwiziko le-UC Davis Alzheimer's Health Centre lifumene ukuba isistim somzimba siphendule ngendlela efanayo kwiplani njengoko yenza kwiibhaktheriya, okubangela ukuvuvukala kwengqondo eyonakalisa i-neurons. Ukuvuvukala kwengqondo kudibene nesifo se-Alzheimer.

Imithombo:

_{I-Alzheimer's Association. Uvavanyo lwe-Alzheimer Iimvavanyo ezijoliswe kwi-Beta-Amyloid kunye ne "Hypothesis" yama-Amyloid .}

_{I-Alzheimer's Association. Emininzi Ngeentlobo.}

_{I-DANA Foundation. I-Amyloid-Beta 'i-Oligomers' inokuthi idibanise ne-Alzheimer's Dementia. Julayi 12, 2010.}

_{Isizwe seSizwe sokuguga. Isifo se-Alzheimer's Education and Referral Centre. NgoJanuwari 22, 2015.}

_{I-Stanford Medicine. Izazinzulu Zichaza Indlela i-Beta-amyloid Ngayenza ngayo i-Alzheimer's. Septemba 2013.}

_{Inkqubo yezempilo ye-UC Davis. I-Alzheimer-ebangela i-Amyloid kunye ne-Bacteria Trigger Impendulo efanayo ye-Immune response.}