I-Melatonin kunye nendlela enokunceda ngayo i-Sleep and Sundowning Problems kwi-Alzheimer's
Isifo se-Alzheimer sisifo esibulalayo, kodwa unyango olulodwa olufana ne-hormone melatonin lunakho ukuphucula iimpawu ezinzima ezifana nokulala nokulala.
I-Alzheimer kunye ne-Melatonin
I-Melatonin ineendima ezininzi emzimbeni, kodwa kubaluleke kakhulu kumgaqo wokulala. I-Melatonin ikhiqizwa engqondweni ngengqondo yepineal. Le ngqungquthela ikhupha iqondo layo le-melatonin ngentsasa, kwaye i-hormone ibonakala iyincedo ekutshintsheni kweenguqu esizibiza ngokuthi silele.
Uphando luye lwazisa ixesha elide ukuba amazinga e-melatonin ahlawule ngokwemvelo kunye nobudala, kodwa abantu abanesifo se-Alzheimer banamazinga aphantsi kakhulu - ngamanye amaxesha kuphela isiqingatha kangangoko abantu abaneminyaka efanayo abanalo isifo. Kwakhona, ukuphazamiseka kokulala kudla ngokuba ngumqondiso we-Alzheimer's. Kwiminyaka yakutshanje, uphando oluthile luchaze iingenelo zokuncedisa i-melatonin, kungekhona nje kuphela ekunciphiseni iingxaki zokulala ze-Alzheimer, kodwa nangokuhlwa kwelanga.
UkuSundowning kubhekisela ekuphazamiseni kokuziphatha okuqhelekileyo kwisifo se-Alzheimer kwaye kudla ukuvela kwangokuhlwa. Ngenxa yezizathu ezingenakucaca, abantu abaninzi abane-Alzheimer's exhibition banda ukudideka , ukuxhalabisa , ukukhathazeka kunye nokunyanzelisa ekupheleni kosuku. Ngokombutho we-Alzheimers's Association, malunga nesihlanu kwabantu abane-Alzheimer's disease baya kuba namaxesha okutshona kwelanga, ngokuqhelekileyo kwizigaba eziphakathi kwesi sifo.
UkuSundowning kuthatha inkokhelo kulabo abane-Alzheimer kunye negalelo elikhulu kumxhasi wokukhathazeka nokukhathala. Ngenhlanhla, kukho ubungqina bokuthi i-melatonin inokukunceda ekuhambeni kwelanga kunye nokuphazamiseka kokulala.
Ezinye iinzuzo zeMelatonin kwi-Alzheimer's
I-Melatonin inokuba nezinye iindzuzo. I-antioxidant enamandla, eyenza ukulwa nokuphazamiseka kweekhemikhali eziyingozi ezingonakalisa iiseli.
Kubonakala kunempawu ezithile ze-neuroprotective, zithetha ukuba inceda ukukhusela iisilini kunye neengqondo zeseli kumonakalo. Kukho ubungqina bokuthi ukungakwazi ukusebenza kwe-melatonin kudlala indima ekudakaleni.
Ezinye iingcamango zibonisa ukuba i-hormone inokuphucula ukuphazamiseka kwengqiqo , nangona abaphandi bagxininisa ukuba umphumo uphelelwe kwaye i-melatonin "ayilona" isifo "se-Alzheimer's". Abanye abaphandi bayalumkisa ukuba impembelelo yehomoni iya kuba yincinci kwi -Alzheimer's late-late .
Abaphandi baye baqala ukuhlakulela "i-melatoninergic" okanye izidakamizwa zoluhlobo olunexesha elide kwaye zineethagethi ezithe ngqo. Ngokomzekelo, iRozerem (i-ramelteon) iphumelele ukugunyazwa kwe-FDA yokunyangwa kwexesha elide lokuphazamiseka kokulala. Kodwa kude kube ngoku, akukho mayeza e-melatonin aphuhliswe ngokuthe ngqo kwisifo se-Alzheimer okanye sundowning.
Okukwintsusa
Izifundo ezininzi zesayensi kufuneka zenziwe ngokusetyenziswa kwe-melatonin kwisifo se-Alzheimer ukuqonda ngokwenene inzuzo yaso (okanye kungenjalo).
Kodwa ekubeni i-melatonin ikwahlulwa njengesongezelelo, iyafumaneka ngaphandle kwemvume. Oko kushiwo, ngaphambi kokuba unike ihomoni kumntu onolwazi lwe-Alzheimer, kufuneka udibane nodokotela wakhe, oya kuba nako ukunquma ukuba kunengqiqo.
Imithombo:
I-Alzheimer's Association. "Iingxaki zokulala nokuSundowning
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INKCAZELO: Ulwazi olukule ndawo lusezinjongo zemfundo kuphela. Akufanele isetyenziswe njengendawo yokunyamekelwa ngumntu ogqirha. Nceda ubone ugqirha wakho ukuze ufumane unyango kunye nonyango malunga nayiphi na impawu okanye imeko yonyango .