Itheknoloji entsha yepromerme yenza inkqubela engcono yesikhumba
Yonke into entsha okanye ukuphumelela ngandlela-thile ichaza imvelaphi yayo kumsebenzi wabanye. Amachiza amatsha kunye namaxwebhu amasha amayeza awafani. Ukuba unako ukuphucula ukwakhiwa kolunye usosayensi, kwaye ukuhamba kwakho kusebenza ngakumbi, kulungele ngakumbi kwaye kuphephile, mhlawumbi uye kwenye into.
Kungekudala, amaninzi amaninzi ajikeleze iindaba ezintsha zesikhumba se-ibuprofen esaphuhliswa ngabaphandi kwiYunivesithi yaseWarwick kunye neenkampani zabo ezincinci iMedherant.
Kubonakala ukuba le nkqubo yokunikezelwa kwepakti iyona nto inamandla, iyancipha kwaye ihambisa imichiza ngakumbi kunokuba nayiphi na into esingazange sinamathele emzimbeni wethu.
Yintoni Ibuprofen?
Ibuprofen (cinga i-Advil okanye i-Motrin) yi- NSAID (izidakamizwa ezichasayo ezingekho komzimba) ezingaphazamisekanga i-cyclooxygenase-1 (COX-1) kunye ne-cyclooxygenase-2 (COX-2) enzymes ngaloo ndlela iphazamise ukuvelisa i-prostaglandin. Ngokuphazamisa i-prostaglandin synthesis, ibuprofen inceda ukunciphisa intlungu, ukuvutha kunye nomkhuhlane. Ingqalelo, ezinye i-NSAID ziquka i-aspirin kunye ne-naproxen.
Iingcali zicinga ukuba ngaphezu kokuphazamisa ukuveliswa kwe-prostaglandin, ibuprofen inokulwa nokutshabalala ngokuchaphazela igazi ngezinye iindlela, kuquka ukuguqulwa komsebenzi we-lymphocyte, ukuvinjelwa kwe-chemotaxis, ukuvimbela ukuhlanganiswa kwe-neutrophil okanye ukusetyenziswa, kunye nokunciphisa amanqanaba e-cytokine.
Yintoni Ibuprofen Eyisebenzisayo?
Ibuprofen isetyenziselwa ukunciphisa umkhuhlane kunye nokuphatha iintlobo kunye neentlungu ezahlukeneyo, ezinjengezo zibangelwa yintloko, ukulimala emva, isifo se-arthritis, isifo sezinyo kunye nokuya esikhathini.
Okuthakazelisayo, ii-NSAID ezifana ne-ibuprofen zinyanga kakuhle ekuphatheni intlungu yeethambo zamathambo. Ngaphezu koko, ibuprofen inokudibaniswa ne-opioids (njenge-hydrocodone) ukunyanga ubuhlungu obukhulu.
Ibuprofen ilawulwa njani?
Imizila eyahlukeneyo yolawulo ikhona kwi-ibuprofen, kuquka iipilisi, i-injection kunye ne-gels.
Ulawulo lwe-ibuprofen nge-patch luveli kwaye lubhetele kunokuba isetyenziso sisebenzisa iigel. Ibuprofen gels zihlaziye kwaye azidilizi imithi rhoqo.
Nazi ezinye izibonelelo ezicetywayo ze-ibuprofen kunye ne-teknoloji ye-polymer ephezulu:
- I-teknoloji entsha ivumela iqhosha ukuba lilayishwe ngamayeza angamahlanu ukuya kwezi-10. Ngamanye amazwi, iipesenti ezingama-30 zesisindo sepakti yonyango.
- Ukukhululwa kwamachiza emzimbeni kuhambelana kwaye kusebenza kwiiyure eziyi-12. Okwangoku, abantu abaphezulu kwi-dobu ephezulu ye-ibuprofen bangadinga ukuginya iipilisi nganye iiyure ezine.
- Isiqwenga sinamathele ngakumbi, siguquguqukayo, sikhululekile kwaye sichaphazele ngaphezu kwezinye iindawo. Ukongezelela, isiqalo sishiya esele sincinci kwaye sincinci kwaye sisobala.
I-pipoti ye-ibuprofen yenzelwe ukusebenzisa iteknoloji entsha ye-polymere eyenziwe yinkampani ebizwa ngokuba yi-Bostik kunye nelayisenisi yokusetyenziswa kwe-transdermal nguMedherant.
Izicelo ezenzekayo ze-New Patch ingaba ngumdlalo-ukutshintsha
NgokweMedherant, ezininzi zeentlungu zokunceda iintlungu ezikhoyo zifumanekanga iipilisi ze-painkiller kwaye kunoko zikhulule ukushisa (cinga menthol). Ngaloo ndlela, le mibadala yamandulo ayiphelelanga ekusebenziseni kwabo. Isiqalo esitsha se-ibuprofen sesidlali sinobuchule ngeendlela ezininzi.
Okokuqala kuba iqhosha lingabonakali, lisebenza ixesha elide kwaye lulula ukuyisebenzisa, luya kubonisa ukuba luncedo ngokwenene kwizigulane ezithile zezigulane ezifana nabagijimi kunye nabantu abaneengxaki zokunamathela kwamachiza . Ngokomzekelo, umgijimi angasebenzisa i-patch kwindawo yenkxalabo okanye ukuxhamla kwizithuba zeeyure, okanye umntu osebenzisa amayeza amaninzi unokuba neepilisi ezingaphantsi zokukhathazeka ngazo.
Okwesibini, ngokugqithisa isisu nokukhupha amayeza ngokuchanekileyo kwesikhumba, i-ibuprofen patch ingayi kubangela ukuba kungabikho nto isisu esichukumisayo, into echaphazelekayo echaphazelekayo kulawo manqanaba aphezulu e-NSAID yomlomo.
Okwesithathu, iteknoloji esetyenziselwa ukuphuhlisa le patch inokhetho lokuhambisa ezinye iindidi zonyango-imithi, efana ne-ibuprofen, yayingenakukhunjulwa ukulawula ulawulo. Ingqalelo, ezinye iintlungu ezixhaswa nazo zilawulwa kwifom yefatchanyl (i-opioid) kunye ne-lidocaine (i-anesthetic ye-anesthetic), kwaye kuya kuba lunomdla ukubona ukuba le teknoloji entsha yekripthi ingaphucula ukulawulwa kwezi zi yobisi.
Ngaba iIbuprofen ineempembelelo ezimbi?
Ibuprofen ithengiswa kwi-counter kwaye umngcipheko weempembelelo ezibi ziphantsi. Isithukuthezi esiswini sisona siphumo esibi kakhulu kwi- NSAID ezifana ne-ibuprofen. Ezinye iziphumo ezinobungozi ze-ibuprofen zibandakanya ukuphuma kwegazi (njengokwakheka kwengqondo okanye ukushaywa kwesisu) kunye nesilonda esiswini.
Khangela eli nqaku malunga nendlela ama-NSAID axhunyiwe ngayo kwiimvavanyo ezingabonakaliyo kwiintsana.
Njengoko kukhankanywe ngaphambili, abenzi be-ibuprofen iqhosha elitsha bathi nge-patch yabo, akukho mngcipheko wesisu ngenxa yonyango ngenxa yesikhumba kungekhona ngesigxina sesisu.
Nangona kunjalo kwiimeko ezinqabileyo, ibuprofen inokubangela ukuhlambalaza, ama-hives kunye nezinye izikhumba. Abantu abanembali ye- atopy , okanye abo "baxhatshazwayo" kwaye baxhamla kwi-eczema, i-hay fever kunye ne-asthma ye-allergic, banokuthi bangabi ne-ibuprofen. Nangona kunjalo, abantu abangenazo i-atopy baye bahlakulela i-ibuprofen.
I-pipoti ye-ibuprofen ingakumbi ekubetheni i-market kwaye ayiyikuvunyelwa kwe-FDA. Okwangoku, kukho uphando oluncinane olupapashwe kwi-patch-ininzi yento esiyaziyo ivela kwimpapasho yeendaba, udliwano-ndlebe kunye neengxelo zeendaba-kwaye siya kufuneka sibone idatha yangaphambili ngaphambi kokuba siqonde ngokuqinisekileyo oku kuveliswa okutsha. Ngokomzekelo, ngokucacileyo ukuba i-dose eyongeziweyo kunye nokugcinwa kweengcambu ze-ibuprofen i-patch ingayinceda ngandlela-thile ukuguquka kwesikhumba kulabo abachasayo kwi-NSAID.
Ukujonge phambili, uMdindi, umenzi we-ibuprofen patch, ulindele ukuba inkqubo yakhe yokuhambisa iziyobisi iza kusetyenziswa ukulawula ezinye iziyobisi kunye ne-over-counter-counter-counter-counter-counter-counter. Ngokomzekelo, uMedherant uzama i-methyl salicylate ipaki. (I-meteth salicylate iyona isithako esisebenzayo esiseBENGAY.)
Imithombo
I-athikili ebizwa ngokuthi "Ukuchithwa kwe-hypersensitivity-type hypersensitivity kusuka kwi-ibuprofen" ngu-E Nettis kunye nabalobi ababambisene nabo abapapashwe kwi- Allergy ngo-2003.
Ukungena okubizwa ngokuthi "Ibuprofen" kwiCandelo leDrug Monographs kwicandelo loLwazi lokuFikelela.