Ukudibanisa izihluthulelo ezibini ezingaphezulu kwe-counter-counter
Ngokuqhelekileyo, oogqirha bazama ukunciphisa i- polypharmacy okanye ukuvezwa kwakho kwiimithi ezigqithisileyo okanye ezingaphezulu. Ngaloo ndlela, ukuba uthetha ngesifo somqala esifuna i-antibiotics, uya kufumana umyalelo wolu hlobo lwe-antibiotic ayikho imithi yee-antibiotics ezininzi. Kodwa ngaba le khokelo isebenza kwimirhumo yokuhlunguphazeleka kwangoko, kunye na?
Ngakumbi malunga nePolypharmacy
Izizathu zokuphepha kwe-polypharmacy phakathi kwamagqirha zininzi.
Okokuqala, amayeza amaninzi awuthathayo, umngcipheko omkhulu wemiphumo emibi okanye ukusebenzisana kweziyobisi. Imithi eyahlukeneyo inokusebenzisana nezindlela ezininzi eziyingozi.
Okwesibini, nanini na kunokwenzeka, ugqirha uzama ukumisela imithi ephethe isifo kwaye ifike kwingcambu yokugula. I-Polypharmacy ngokuqhelekileyo ibonisa indlela eyahlukeneyo yokukhupha iimpawu zesifo endaweni yokujongana nesifo ngokwazo.
Okwesithathu, njengoko kwimeko yokusetyenziswa kakubi kwe-antibiotic, i-polypharmacy inokubeka ingozi kwimpilo yoluntu. Ngokukodwa, ukuthatha ezininzi iintsholongwane kunye nokugqitywa kwinkqubo yokonyusa ukwandisa amathuba okuba iibhaktheriya ezinganyangekiyo zingasasazeka phakathi kwabantu abaninzi. Iibhaktheriya ezinokungasebenzisi iziyobisi ziindaba ezimbi kuba zichasene unyango kunye namayeza aqhelekileyo.
Ukholo olulodwa kwisikhokelo esiqhelekileyo sokuphepheka kwe-polypharmacy kukusetyenziswa ngokuthe ngqo kwamachiza athile enjenge-acetaminophen (iTylenol) kunye ne-ibuprofen (Motrin).
La mayeza awaphazamisani. Ukongezelela, unyango lwentlungu bunzima kwaye ukudibanisa i-acetaminophen kunye ne-ibuprofen kunokuncedisa ukunciphisa ubuhlungu obukhulu nxamnye nokugweba imithi ye-opioids. Ukusetyenziswa kakubi kwe-opioid kuphakama, kwaye ngoku siphezu kweengxaki ze-opioid.
I-note, i-opioids yimishanguzo eneempembelelo eziyingozi ezibandakanya ukudandatheka nokuphefumula kunye nokusetyenziswa kokusetyenziswa kakubi.
Ngaphezulu, ezinye iifom e-opioid ezifana ne-Vicodin okanye i-Norco zidibaniso ze-hydrocodone-acetaminophen, kwaye, ngoko, xa zithathwa ngeTylenol, ezi zi-opioids zingabandakanya ukukhanya kwe-acetaminophen. I-acetaminophen kakhulu inokubangela ukulimala kwesibindi.
Tylenol
I-Tylenol luhlobo lwe-analgesic olutshintsha indlela esibone ngayo intlungu kwaye linciphisa izinga lokushisa kwemizimba yethu (oko kukuthi, i-antipyretic). Ngokuqhelekileyo kudibaniswa namanye amayeza ukuphuhlisa iintlobo ezahlukeneyo zentlungu.
Nangona indlela eyiyo yeTylenol ayinakucaciswa, siyakholelwa ukuba le mayeza asebenza ngokuvimbela i-cyclo-oxygenase (ngokuyinhloko i-COX-2). Ngenxa yokuba i-Tylenol isetyenziselwa inxalenye yesibindi, abantu abaneengxaki zesibindi kufuneka bakuphephe le nkunkuma xa kunokwenzeka.
Motrin
I-Motrin yiphilisi echasayo yokutshabalala (NSAID), efana neTylenol, ifake imiphumo yayo kwi-cyclo-oxygenase ngokunjalo ukuvimbela i-prostaglandin synthesis. Iprostaglandins idibanisa intlungu, ukuvuvukala kunye nomkhuhlane.
Inhibition in prostaglandin synthesis iphinda ivelise i-vasoconstriction kunye nokukhubazeka kwe-renal okungabangela ukuhluleka kwezintso. Ngaloo ndlela, abantu abaneengxaki zeengtso kufuneka baxakeke kuMotrin.
Kwinqaku edibeneyo, kwezinye iincwadi, i-Motrin ingabangela izilonda zesisu kunye negazi.
Ukudibanisa ezimbini
Okuthakazelisayo, nangona isenzo esiqhelekileyo, uphando oluncinane luye lwenziwe ukuhlola ulawulo lwe-Tylenol noMotrin.
Olunye uphando oluthe lwaqala ekuqaleni kwesihloko lwenziwe kubantwana. Nangona kunjalo, kunzima ukudweba i-correlates ngqo phakathi kweentlungu kunye nokukhululeka komkhuhlane kubantwana xa kuthelekiswa nawabantu abadala. Ngokukodwa, abantwana abayalelwe iTylenol kunye noMotrin ngenxa yentlungu kunye nomkhuhlane badla ngokufumana le mayeza njengamayeza athile.
Iziphumo ezisuka kwelinye uphando olutsha olupapashwe kwiBritish Journal of Anesthesia lubonisa ukuba xa iTylenol neMotrin zithathwa ndawonye (ngohlobo lokuxuba oluxubileyo olubizwa ngokuba yi-Maxigesic) ngezigulane ezandula zonyango ngomlomo, le nhlanganisela ibangela ukukhululeka kwentlungu.
Ngokufanayo, iziphumo eziphononongwa ngokuphononongwa kwezilingo ezilawulwe ngononophelo kwaye zishicilelwe kwi- Medicine Pain zibonisa ukuba "ukuhlanganiswa kweparacetamol [acetaminophen] kunye ne-NSAID yayisebenza ngakumbi kuneparacetamol okanye i-NSAID yedwa kwi-85% kunye ne-64% yezifundo ezifanelekileyo, ngokulandelanayo."
Okukwintsusa
Ngoko kubonakala ngathi-ngokungafani nokuhlanganiswa kwe- aspirin kunye ne-Motrin , ezo zombini ii-NSAID-ukuthatha i-acetaminophen kunye ne-ibuprofen kunye ngokukhuselekileyo nangokusebenzayo.
Kodwa ngaphambi kokuba usebenzise izihluthulelo zakho zentlungu, ndiya kulungelelanisa le mpendulo ngamagxa amathathu.
Okokuqala, ukuba unengxaki yesibindi okanye izintso, akufanele uthathe i-acetaminophen okanye i-Motrin (oko kukuthi, i-NSAID), ngokulandelanayo.
Okwesibini, ii-analgesics ezinjenge-Tylenol okanye i-Motrin zenzelwe ukusetyenziswa kwexesha elifutshane kuphela. Nceda ukhumbule ukuba intlungu ayikho nje uphawu kodwa luphawu lokulimala okanye isifo. Ukuba intlungu yakho iyaqhubeka, kufuneka ufune ugqirha.
Okwesithathu, unako ukudlula ngaphezulu iTylenol kunye noMotrin ngaloo ndlela wenze into efanelekileyo ngakumbi ukuba ube namayeza asemgangathweni ala mayeza ahlolwe ngugqirha.
> Imithombo:
I-Borazan NH, i-Furst DE. Izidakamizwa ezingavumelaniyo nezidakamizwa, izifo-Ukuguqula izidakamizwa ze-Antirheumatic, i-Nonopioid Analgesics, kunye nezidakamizwa ezisetyenziswe kwiGout. Ku: Katzung BG, Trevor AJ. eds. I-Basic & Clinical Pharmacology, 13e . New York, NY: McGraw-Hill; 2015. Kufumaneka ngo-Oktobha 11, 2015.
Cliff KS et al. Ukudibana neParacetamol (i-Acetaminophen) kunye ne-Nonsteroidal Anti-inflammatory Drugs: Uhlolo lokuHlola oluCwangcisiweyo lweCandelo loPhulo lweZakhono zoPhulo oluPhezulu oluPhambili. Uphulo lweMpilo . 2010. > https://doi.org/10.1213/ANE.0b013e3181cf9281
Ulonyulo lwe-AF et al. I-Acetaminophen kunye ne-Ibuprofen yoNcedo lokuPhukisa emva koPhando lwe-Oral kuBantu abadala: Uvavanyo oluLungisiweyo oluHlangeneyo. IBritish Journal of Anesthesia . 2010. https://doi.org/ > 10.1093 / bja / aep338
Olson KR. Isahluko 4. I-Acetaminophen. Ku: Olson KR. eds. Ukutyhefuza nokugqithiswa kweDrug, 6e . New York, NY: McGraw-Hill; 2012.