Iimvavanyo zengqondo ezichasayo ezingenakuvuthayo, ezibizwa ngokuba yi-NSAID (ezibizwa ngokuba ngama-sayds), ezinye zezigulane eziqhelekileyo eziqhelekileyo, ngokukodwa kwizigulane ezineemeko zomzimba ezifana ne-arthritis, bursitis, kunye ne-tendonitis. Ezi zonyango zifumaneka kwi-counter-counter (umzekelo i-Ibuprofen, i-Motrin, i-Aleve) okanye njengemithi (umzekelo, iCelebrex, DayPro, iRelafen).
Ii-NSAID zisebenza kakuhle kwiintlungu zentlungu (analgesia) kunye nokunciphisa ukuvuvukala (okuchasayo).
Indlela Abasebenza ngayo
Amachiza asebenzayo ekunciphiseni ukuvuvukala afikelele kwiindidi ezibini ezibalulekileyo:
- I-Steroids (umz. ICortisone )
- Imithi engekho-Steroidal Anti-Inflammatory Medication (NSAIDs)
Iidakamizwa ze-Steroid ezisetyenziselwa unyango lwe-inflammation yi-hormone yemvelo eyenziwa ngumzimba obizwa ngokuba yi-cortisol. Kukho nezinye iintlobo ze-steroids (kubandakanywa ne-cholesterol kunye ne-hormone yesondo), kodwa le nxalenye yesithathu yinyango enamandla yokuchasana. Imithi ye-Steroid inokunikezwa ngomlomo, ngokwasetyenjini, okanye njengengxube ekhoyo , njengoko isetyenziswa ngokuqhelekileyo kumathambo.
Ii-NSAID zisebenza ukuvimba umphumo we-enzyme ebizwa nge-cyclooxygenase. Le enzyme ibaluleke kakhulu kwimveliso yomzimba yeprogaglandines. Yi-prostaglandin eyenza ukuvuvukala nentlungu kwimeko efana ne-arthritis okanye i-bursitis. Ngenxa yoko ngokuphazamisana nomsebenzi we-cyclooxygenase, unciphisa umveliso we-prostaglandin, kwaye unciphisa intlungu kunye nokuvuvukala okuhambelana nale miqathango.
Elula, akunjalo?
Ewe, kukho ngaphezulu. Iprostaglandins nayo ineminye imisebenzi ebalulekileyo emzimbeni. Olunye uhlobo lwe- prostaglandin (zininzi iintlobo) zincedisa umgca wesisu kunye nomkhuhlane okhuselayo (obizwa ngokuba yi-gastric mucosa). Xa abantu bethatha imishanguzo ye-NSAID, ukuveliswa kolukhuseleko lwamanzi luyakuncitshiswa, kwaye abanye abantu basengozini yokuphucula izilonda zesisu.
I-Newer / Prescription I-SASA ingcono?
Kwiminyaka emininzi edluleyo, amanye amayeza entsha afike kwiimarike; Ezi zibizwa ngokuqhelekileyo njenge- COX-2 inhibitors . Khumbula, zonke i-NSAID zisebenza malunga ne-cyclooxygenase (COX). I- NSAID zendabuko (umzekelo i-Ibuprofen, i-Motrin, i-Aleve) isebenzisana no-COX-1 kunye ne-COX-2. I-COX-1 kunye ne-COX-2 ziintlobo zombini ze-cyclooxygenase enzymes ezisebenza emzimbeni wakho. Amachiza amatsha (umz. Celebrex) asebenza ngokubanzi malunga ne-COX-2, kwaye avumele i-COX-1 isebenze ngokuqhelekileyo. Ngenxa yokuba i-COX-1 ibaluleke kakhulu ekuveliseni i-lining block in gut (igastric mucosa), le NSAID ezitsha zikholelwa ukuba zingekho phantsi komngcipheko wokubangela izilonda zesisu.
Oko kwathiwa, ii-NSAID ezitsha zingaboniswa ukuba zisebenze nantoni na engcono kwi-enzyme ye-COX-2. Ngoko ke, ii-inxitors ze-COX-2 zinenzuzo yokuba nokuba nemiphumo embalwa yecala, kodwa kungekhona imiphumo engcono kwimpawu.
I-Effact Side-Effects ye-NSAID
Ii-NSAID zingafumaneka kwi-counter-counter-counter, kodwa oko akuthethi ukuba banakho ngaphandle kweempembelelo ezibi. I-side-effect eyona ndawo ixhaphakile isisu. Isizathu salokhu kucatshangelwa ukuba ngenxa yempembelelo kwisilingi sesisu. Ukuba ukucaphuka kunzima, kunokukhokelela kwizilonda zamachiza , kunye neengxaki ezinzima.
Ngaphambi kokuba uqale ukuthatha imishanguzo ye-NSAID kufuneka uxoxe nodokotela wakho. Qiniseka ukuvumela ugqirha wakho ukuba azi malunga nezinye iingxaki zonyango ozinayo, ingakumbi ingozi yexinzelelo, isifo se-asthma, isifo okanye isisu. Ukongezelela, vumela ugqirha wakho azi ezinye iimichiza onokuzithatha, kwaye ukuba unayo nayiphi na into eyaziwayo yokunyanga imithi.
I-SASA ayifanele isetyenziswe ukuba:
- U khulelwe
- Uncelisa
- Unembali yesilonda sesisu
- Uthabatha amayeza omzimba wegazi
Ii-SAs kufuneka zisetyenziswe kuphela ngaphantsi kwe-CLOSE ulawulo lwangonyango ukuba:
- Unayo i-asthma
- Unengxaki yesibindi
- Unengxaki yeentliziyo
- Unengxaki zeengtso
Ngaphantsi: Ngaba i-NSAID ikhuselekile?
Amachiza okungaxhasi-mzimba angakhuselekanga kwaye anokusebenza kakuhle. Iziphumo ezininzi ziyakwazi ukufezwa kunye nokusetyenziswa ixesha elifutshane. Oko kwathiwa, la mayeza anemiphumo emihle kwaye ayinakusetyenziswa ngumntu ngamnye. Ngelixa abaninzi abantu abanesimo esibangela ukuvuvukala banokufumana i-NSAID ukuba luncedo, kufuneka uxoxe njalo nodokotela wakho ukuba ucinga ukuqala enye yale myeza.
Imithombo:
Berger, RG "I-Nonsteroidal Anti-inflammatory Drugs: Ukwenza okukhethekileyo" J. Am. Acad. IOrn. Ukupheka, ngo-Okthoba 1994; 2: 255 - 260.
van Tulder MW, et al. "Izidakamizwa ezingezange-inflammatory anti-inflammatory for pain-back back