Yintoni i-Glutamate?
Inkcazo:
I-Glutamate luhlobo lwengqondo yengqondo ebizwa ngokuba yi- neurotransmitter , oko kuthetha ukuba inceda ukuhambisa imiyalezo ecaleni kwengqondo. Ngokuqhelekileyo kubandakanyeka ekufundeni nasekukhunjweni. I-glutamate ikwabandakanyeka kwiintlobo ezininzi zeengxaki zegazi.
Eyaziwayo Njenge: L-glutamic acid, glutamic acid, L-glutamate
Uhlala Udibaniswe Nge: Glutamine
I-Glutamate yenza imisebenzi efunekayo kwingqondo yakho.
Ithathwa njenge-neurotransmitter ye-excitatory, oku kuthetha ukuba ivuselela indawo kwingqondo okanye kwezinye iindawo zenkqubo ye-nervous. Olu hlobo lokuvuselela luyinxalenye ebalulekileyo yenkqubo yokufunda, ngoko ke, ngaleyo ndlela, i-glutamate yinto enhle.
Nangona kunjalo, ezininzi i -glutamate ayikho into oyifunayo. Kwezinye iimeko, ingaba yinto ebizwa ngokuba yi-excitotoxin. "I-Toxin" ayidla ngokuba lizwi elihle, kwaye ngokuqinisekileyo alikho ithemba kulo mzekelo. Kwindima yayo njenge-excitotoxin, i-glutamate inokugqithisa ngakumbi iiseli zengqondo.
Ukuba amanqanaba aphakamileyo angakhange ahlolwe, le ngxaki ye-neurotransmitter inokugqithisa kakhulu loo maseli ade athathe amanyathelo kwaye enze ukuzibulala kwamaselula ukwenzela ukukhusela iiseli ezizungezile. (Cinga nje ngokuba uthatha inyolo ebolayo ukuze ukubola kungasahlali kumazinyo eduze kwayo.)
Amaseli emzimbeni wethu afe ngexesha lonke, kwaye uninzi lwawo lunokutshintshwa. Kodwa i-glutamate iyaqhuba ukuzibulala, nokuba kunjalo, i-neurons.
Ingqondo yakho ayikwazi ukwenza amatsha ukuba atshintshe abo abalahlekileyo, ngoko kubalulekile ukugcina bephilile kwaye bakhuselekile.
Indima yeGlutamate njenge-excitotoxin ikholelwa ukuba ibandakanyeka kwiintlobo ezahlukeneyo zezifo ezinjenge-multiple sclerosis, isifo se-Alzheimer kunye ne- amyotrophic lateral sclerosis (eyaziwa njenge-ALS okanye isifo sikaLou Gherig).
I-glutamate dysregulation ikwacatshangelwa ukuba yinto ebonakalayo ye- fibromyalgia kunye nesifo esingapheliyo sokugula , nangona le miqathango ingabonwa njenge-neurodeergenerative.
Glutamate & Fibromyalgia
Uphando lubonisa ukuba abantu abane-fibromyalgia banamaqondo aphezulu ngokugqithiseleyo okugutamate kwingingqi yengqondo ebizwa ngokuba yi-insula okanye i-cortex. I-insula ibandakanyeke kakhulu ekusebenzeni intlungu kunye nemvakalelo. Amanqanaba aphezulu e-glutamate yinkqubo yokuba lo mmandla wengqondo ungasigxina ngokwemfuneko kule meko.
I-insula nayo ibandakanywa kuyo:
- iingqondo
- uxhalaba
- izakhono zokuhamba
- nqwenela
- zokutya izifo
- umlutha
Kwi-fibromyalgia, ingeniso yongcamango ingakhula, ekhokelela ekugqibeleni . Ukuxhalabisa ngumbonakaliso oqhelekileyo / imeko edibeneyo. Izakhono zeenqwelo zithuthi zingenakukhubazeka, ezikhokelela ekujonganeni neengxaki kunye nokuwa . Ukuphazamiseka kokutya kunokugqithisa kakhulu kubantu abane-fibromyalgia, ngokunjalo.
I-Glutamate ikhona kwiindawo zomzimba ngaphandle kwenkqubo ye-nervous, apho isebenza njengehomoni. Kule nxaxheba, kunokubangela intlungu.
Ucwaningo lwango-2016 lubonisa ukuba umzimba unokunciphisa intlungu ye-glutamate enabantu abane-fibromyalgia, enokukunceda ukucacisa ukuxhamla okungaqondakaliyo phakathi kwalo mqathango nokuzikhandla .
I-Glutamate kwiSyndrome Syndrome
Izifundo zahlula ukuba i-glutamate dysregulation inendima ekungaphelelweni kwesifo esingapheliyo, imeko leyo ibandakanya ukugqithiswa kwemizwa, ukuxhala, kunye nokuhamba / ukulinganisela iingxaki .
Ngokwahlukileyo kwi-fibromyalgia, ke, uphando lubonisa ukuba amanqanaba e-glutamate aphantsi kwiindawo ezithile zobuchopho. Oku kunengqiqo xa ucinga ngengqondo yenkohlakalo ehambelana nesi sifo, equka iingxaki zokufunda.
Kananjalo sinokubakho ubungqina bokuthi isifo esingapheliyo sesisu singabandakanya iizakhi ezinxulumene ne-glutamate dysregulation.
I-Monosodium Glutamate
Njenge-amino acid, i-glutamate iyinxalenye ye-monosodium glutamate (MSG), esetyenziswa kwamanye amayeza kunye ne-additive food.
Inokuthi inxulumene neminye imiba yezempilo engathintekiyo.
Abanye abasebenzi bezempilo bayakholelwa ukuba i-MSG inokulimaza kubantu abane-fibromyalgia, ngelixa abanye bakholelwa ukuba akunjalo. Abanye abantu bathi ukuphelisa i-MSG kwizidlo zabo kuncedise ukunciphisa iimpawu ze-fibromyalgia kunye nesifo esingapheliyo sokugula, kodwa ezi zibango azixhaswanga yi-sayensi yezokwelapha.
I-glutamate kunye namanye ama-Neurotransmitters
Unokuzibuza ukuba ingqondo yakho iqhubana njani namanqanaba aphezulu e-glutamate. Inesisombululo-esinye i-neurotransmitter ebizwa ngeGABA. Umsebenzi we-GABA uwukuzolalisa ingqondo yakho emva kokuba i-glutamate ivule yonke into.
Kubalulekile ukuba iGABA kunye namanqanaba e-glutamate ahlalisane kunye, kodwa oko akunjalo kwimeko yokugula okuhlobene ne-glutamate.
Ezinye i-neurotransmitters ezibandakanyeka kule miqathango ziquka:
UHannestad U, Theodorsson E, uEvengård B. Iphephabhuku yamazwe ngamazwe okhemikhali yonyango. 2007 Feb; 376 (1-2): 23-9. i-beta-Alanine kunye ne-gamma-aminobutyric acid kwi-syndrome engapheliyo.
Harris RE, kunye. al. Arthritis kunye ne-rheumatism. 2009 Oct; 60 (10): 3146-52. I-glutamate ephakamileyo ye-fibromyalgia idibene neentlungu zokulinga.
Kuratsune H, Yamaguti K, Lindh G, et al. NeuroImage. > 2002 Nov; 17 (3): 1256-65. Iindawo zeBongo ezibandakanyeka ekukhathazeni ukukhathala: ukunciphisa i-acetylcarnitine ingene kwingqondo.
> Martins DF, Siteneski A, uLudtke DD, et al. I-molecular neurobiology. 2016 Sep. 13. [I-Epub phambi kokushicilela] Ukubhukuda kwamanzi okunciphisa umgangatho wokunciphisa ukunciphisa i-nociception eyenziwa yi-glutamate ngokusetyenziswa kwe-protein-coupled receptors ezivimbela i-protein kinase a-phosphorylated.
Smith AK, Fang H, Whistler T, et al. Neuropsychobiology. > 2011; 64 (4): 183-94. Izifundo zokuguqula i-genomic zichonga ubudlelwane be-GRIK2 kunye ne-NPAS2 ene-syndrome engapheliyo.