Yiyiphi imisebenzi abayenzayo, Ziziphi iingxaki ezingabangela
I-GABA kunye ne-glutamate yi- neurotransmitters- abathunywa beemvakalelo kwingqondo yakho. Omnye uyanqabisa, omnye uyakhuthaza, kwaye kufuneka bahlale belinganisana. Ngoko kwenzeka ntoni ukuba lo mgangatho uphonswa?
Olunye uphando lubonisa ukungalingani kwezi zinto zimbini zingadlala indima kwi- fibromyalgia (i-FMS). Uphando aluncinci ngokubandakanyeka kwabo kwi- syndrome engapheliyo ( ME / CFS ), kunye nezifundo ezithile ziphendulela ubungqina bokutshatyalaliswa kwezinto kunye nabanye abafumani nto.
Ubunjani Bakho
Ubomi bomntu bunzima kakhulu. I-neurotransmitter nganye yenza imisebenzi eyahlukeneyo, kwaye iyanxibelelana kunye ne-neurons yakho (iiseli zengqondo) ngendlela enzima esiyiqondi kakuhle.
Sekunjalo, siyaqhubeka sifunda ngakumbi malunga nengqondo kunye nabaphandi baye bakwazi ukudibanisa i-neurotransmitter ethile engavumelekanga kwizifo ezithile okanye iimpawu ezithile. Baye bafumanisa iindlela zokutshintsha umsebenzi we-neurotransmitter kwaye banokubona imiphumo eyiyo ekhoyo kwizifundo zophando.
Ingqondo ingumququzeleli osebenzayo, ngokuqhelekileyo usebenzisa enye i-neurotransmitter ukwenza enye. Lo msebenzi wenza unengqiqo eninzi xa uthetha nge-neurotransmitters nemisebenzi eyahlukileyo, njengeGABA kunye ne-glutamate. I- serotonin eyaziwa bhetele kunye neel melatonin yinye umzekelo, njengokuba i-norepinephrine kunye ne-dopamine. Bonke abo baxhamli be-neurotransmitters bakholelwa ukuba balawulwa kule miqathango.
Xa enye i-neurotransmitter kwibini iphumelele, ingaphonsa enye enye ibhalansi, ngokunjalo.
Glutamate
I-Glutamate yinto enomdla wengqondo yakho. Enye yemisebenzi yayo eyintloko kukuba kufumaneke ezinye iiseli zobuchopho. Iyabakhuthaza ukuze bakwazi ukwenza izinto ezibalulekileyo ezifana nokufunda ulwazi olutsha okanye ukwenza izikhumbuzo-ezinye izinto apho kubandakanywa khona i-glutamate.
Nangona kunjalo, u-cheerleader ongazange ayeke ukwenza ukuba uphethe izinto uyacaphukisa emva kwexeshana. Uninzi lwezinto ezikhuthazayo akuyona into enhle, njengokuba nabani na abanxilisayo bekhofi banokukuxelela. Kwezinye iimeko, i-glutamate ingaba yinto ebizwa ngokuba yi "excitotoxin," oku kuthetha ukuba ngamanye amaxesha kubonakala ngaphezu kwe-neurons baze bazibulale.
Ikhono lokubangela ukufa kweeseli zobuchopho kutheni i-glutamate ikholelwa ukuba ibandakanyeka kwezinye izifo zengqondo eziphazamisayo ezifana nesifo se-Alzheimer kunye ne- amyotrophic lateral sclerosis (i-ALS okanye isifo sikaLou Gehrig.) (Qaphela: i-FMS kunye ne-ME / CFS kube yingozi.)
Kwi-FMS, uphando lubonisa amanqanaba aphezulu aphezulu e-glutamate kwinxalenye yengqondo ebizwa ngokuba yi-insula okanye i-cortex ene-insular. Abaphandi bahamba bejonge khona ngenxa yokuba loo ndawo ichaphazeleka kakhulu kwiintlungu kunye nemvakalelo, eziyinxalenye ebalulekileyo yale mqathango. I-insula nayo ibandakanyeka ekubonweni kweengqondo, izakhono zezithuthi, ukuxhalabisa, ukuphazamiseka kokutya kunye nokulutha.
Uphando luye lwadibanisa amanqanaba aphezulu e-glutamate kunye nokudakumba kunye nomsebenzi ophantsi kwengqondo kwiabantu abane-type 1 yeswekile. (I-glutamate inokufumaneka kwi-glucose, esoloko iphezulu kwi-diabetes.) Ubuncinane isifundo esisodwa se-FMS sicebisa ukuba ukunciphisa amanqanaba e-glutamate kunokunciphisa intlungu.
Ingqondo engaphezulu kwe-glutamate ikholelwa ukuba ibangela iimpawu ezininzi, kubandakanywa:
- i-hyperalgesia (ukukhulisa intlungu, into ebalulekileyo yeFMS)
- uxhalaba
- ukungazinzi
- Iimpawu ezifana ne-ADHD, njengokungakwazi ukugxila
Kwimi / i-CFS, abanye abaphandi baphoxisa ukuba umsebenzi we-glutamate uphantsi, oko kuthetha ukuba ingqondo ayifumaneki ngokwaneleyo. Nangona kunjalo, le ntembeko ayisekelwe ngokubungqina.
Ukholo lwe-glutamate engqondweni lukholelwa ukuba lubangela iimpawu ezibandakanya:
- kulala
- iingxaki zoxinzelelo
- ukuphelelwa kwengqondo
- amandla aphantsi
GABA
IGABA imele i-gamma-amino-n-butyric acid. Ingqondo yakho isebenzisa i-glutamate ukuvelisa iGABA.
Umsebenzi oyintloko we-GABA kukuhlaziya ingqondo yakho.
Kwakhona kubandakanyeka ekulaleni, ukuphumla, umgaqo wokuxhalaba kunye nomsebenzi wemisipha.
I-GABA ikholelwa ukuba iphantsi okanye ayisebenzisi kakuhle kwiFMS. Kulolu hlobo, uphando alukhombisi ukuba i-GABA idityaniswe kwi-ME / CFS.
Ngenxa ye-GABA kunye nobudlelwane obusondeleyo be-glutamate, iimpawu zeengqondo ze-GABA zinokufana, okanye ziyahlukana nazo, ezobuchopho buyi-glutamate.
Ukufumana ukulinganisela
Ukuba ukrokrela iGABA / glutamate dysregulation kubangela ezinye iimpawu zakho, xela ugqirha malunga nalo. Kukho izidakamizwa, izongezelelo, kunye neenguqu zokutya ezingakunceda ufumane ibhalansi elungileyo. Ungahlola ezo zikhetho apha:
Imithombo:
UHannestad U, Theodorsson E, uEvengård B. Iphephabhuku yamazwe ngamazwe okhemikhali yonyango. 2007 Feb; 376 (1-2): 23-9. Epub 2006 Julayi 14. i-beta-Alanine kunye ne-gamma-aminobutyric acid kwi-syndrome engapheliyo.
Harris RE, kunye. al. Arthritis kunye ne-rheumatism. 2009 Oct; 60 (10): 3146-52. I-glutamate ephakamileyo ye-fibromyalgia idibene neentlungu zokulinga.
Harris RE, kunye. al. Arthritis kunye ne-rheumatism. 2008 Mar; 58 (3): 903-7. Amanqanaba amandla e-glutamate ngaphakathi kwe-insula adibaniswa nokuphucula kwiindawo ezininzi zeentlungu kwi-fibromyalgia.
> Lyoo IK, kunye. al. IiNqoloba zengqondo jikelele. 2009 Aug; 66 (8): 878-87. I-altutate-glutamate-glutamine-gamma-aminobutyric izinga le-acid kunye nokubhekiselele ekusebenzeni kwengqondo ephantsi kunye neempawu ezixinzelelekileyo kwi-type 1 yeswekile yesifo sikashukela.
Murrough JW, kunye. al. I-NMR kwi-biomedicine. 2010 Julayi; 23 (6): 643-50. Ukwandisa i-lactate ye-ventricular kwi-syndrome engapheliyo i-syndrome eyalinganiswa no-1H IM imaging kwi-3.0 T. II: ukuthelekiswa nengxaki enkulu yokudandatheka.