Ukuqwalasela iMbandela yeBlue White
I-Microglia zinamaseli amancinci kwinkqubo yesantya ephakathi (CNS), equlethwe yingqondo yakho kunye nentambo yomgudu. Ngelixa bancinci, banendima enkulu yokudlala: bayona mgca wokuqala wokukhusela kwi-CNS.
Igama elithi "glia" ngokwezwi nezwi lithetha "iglue." Iiseli ze-Glial zivela kwiifom ezininzi kwaye zenza imisebenzi ehlukeneyo yokuxhasa i-neurons, kuquka ukucoceka kweekhemikhali ezisetyenzisiweyo (inkqubo ebizwa ngokuba yi-reuptake) kunye ne-insulating neurons (njenge-sheels ye-myelin), ebalulekileyo ukuba isebenze ngokufanelekileyo.
(Ukulimala kwi-myelin sheaths yinto ebalulekileyo ye- multiple sclerosis .)
Umncinci uthetha "encinci," ngoko "microglia" ngokwezwi nezwi lithetha iiseli ezincinci zelili.
I-Microglia iyakwazi ukuhamba ngokukhululekileyo ingqungquthela kunye nomqolo womgca kwiindawo apho kukho ukulimala okanye intsholongwane. Xa belapho, bakhonza njenge-alarm system ngokuguqula ezinye iinxalenye zesistim somzimba kwi-ingxaki ukuze umzimba wakho uzame ukuwulungisa. Ijog yabo ayiyenzi xa kuvuselwa i-alamu, nangona kunjalo. I-Microglia yindawo ebalulekileyo yempendulo kwingxaki.
Njengaye nezinye iintlobo zokuphendula ngomzimba, umsebenzi we-microglial ungakhokelela ekuvukeleni. Ukuvuvukala kuyimfuneko ebalulekileyo yenkqubo yokuphilisa, ngoko ngaloo ndlela, into enhle. Ukuba ingaba yinto engapheliyo, kodwa ukuvuvukala kunokukhokelela kwiingxaki ezininzi zempilo ngaphaya kweentlungu kunye nokungahambi kakuhle.
Kwizazinzululwazi zonyango, i-microglia yinto efumaneka ngokutsha kwaye kukho nto esingayiqondiyo ngabo.
Nangona kunjalo, uphando luye lwabonisa ukuba babandakanyeka phantse kuzo zonke izifo zesifo segazi.
I-Microglia neBroin Fog
Kwi-fibromyalgia ne-chronic fatigue syndrome, i-microglia ingaba yinto eninzi yezinto eziphilayo ezibandakanyekayo ekusebenziseni ingqondo engqondweni (i-fiber fog okanye ingqondo yobuchopho.) Abanye abaphandi bacinga ukuba ubukho bee-molecule ezithile kwi-brains bethu bungafumana i-microglia ivuselele kwaye iyenze, eyenza ukuvuvukala kwendawo kunye nokuphazamisa indlela yethu ingqondo isebenza ngayo kuloo ndawo.
Uphononongo luka-2014 lubonisa ukuba ukusebenza okungapheliyo kwe-microglial emgodini kunokuba noxanduva, ubuncinane inxalenye, kwiintlobo ezimbini ezibuhlungu ezingavamile kwi-syndrome engapheliyo: i- hyperalgesia kwiimisipha kunye ne- allodynia engumatshini . Ezi zombini iintlobo zentlungu zizinto eziphambili ze-fibromyalgia ngokunjalo.
I-Hyperalgesia kukukhuliswa kwentlungu yinkqubo yesantya esisiseko, ngokuyinhloko "ukujika umthamo." Kungenxa yoko ulwaphulo lubuhlungu kakhulu, kwaye intlungu emva kwakho ngaphambi kokuba ugula ngokugqithiseleyo yaqhuma ngakumbi xa i-fibromyalgia okanye isifo esingapheliyo sisifo.
I-Allodynia intlungu evela kwinto eqhelekileyo ayibangeli intlungu. I-allodynia ye-mechanical intlungu ibangelwa ngqo ngokunyakaza. Oko kuthetha ukucoceka okulula okanye into encinane njengoko ukugqithisa kwengubo ekhanda lakho kunokubangela intlungu.
Olunye uphando lubonisa ukuba i-microglia ikwabandakanyeka kwi-allodynia yentlupheko (intlungu ebuxininini obunzima, njengobunqunu) kwaye inokuba negalelo okanye idale intlungu ngeendlela ngaphandle kokuvuvukala. (Ziziphi iindlela ezenziwa ngabaphandi?)
Uphando lwe-genetic kubantu abane-fibromyalgia lubonisa ukuba kungenzeka ukuba iizakhi ezithile zithintela intlungu ngokunyusa umsebenzi we-microglia emgodini.
Ezi zifundo asinceda nje ukuba siqonde oko kubangela iimpawu ze-fibromyalgia kunye nesifo esingapheliyo, kodwa sisincede sibone iithagethi zophando kunye nezokwelapha ezizayo. Ubuncinane isicatshulwa esisodwa esakholelwa ukuba sinciphise umsebenzi we-microglia- low-dose naltrexone -has wathabatha ingqalelo ngophando malunga nale miqathango. Eli seziyobisi sele liye kwiimarike kodwa ngoku lingagunyaziswanga ukuba lisebenziswe kule miqathango, ngoko kufuneka limiselwe ngaphandle-ilebula.
Imithombo:
UGraeber MB, uChristie MJ. Neurology. 2012 kuMatshi; 234 (2): 255-61. Iinkqubo ezininzi ze-microglia: igalelo lomgcini wesango kwiintlungu.
Ukukhanya KC, et al. Uphando lwezobuhlungu kunye nonyango. 2012; 2012: 427869. I-Genetics kunye nomzobo womzimba obandakanya uxinzelelo kunye noxinzelelo kwi-fibromyalgia kunye nangaphandle kwe-comorbid epronic fatigue syndrome.
Tambuyzer BR, uPonsaerts P, uNowen EJ. Umbhalo we-biyocyte biology. 2009 Mar; 85 (3): 352-70. I-Microglia: abalondolozi bamasango e-central system ye-nervous immunology.
I-theoharides TC, kunye ne-al. Imida kwi-neuroscience. 2015 Julayi 3; 9: 225. Ubunongo "inkungu," ukuvuvukala nokukhuluphala; Imiba ephambili yeengxaki ze-neuropsychiatric ziphuculwe yi-luteolin.
Yasui M, et al. Glia. 2014 Sep; 62 (9): 1407-17. Imodeli yesifo esingapheliyo yokunyamekela i-allodynia kunye ne-hyperalgesia ye-muscular nge-activated microglial activation.