Ukuqonda i-Fibromyalgia kunye neM ME / CFS iziyobisi
Xa ufunda malunga neendlela zokwelapha ze- fibromyalgia kunye nesifo esingapheliyo , kufuneka ufumane igama elithi "reuptake inhibitors." Lichaza uhlobo lwe-anti-depressant oluqhelekileyo, oluquka imithi ye-fibromyalgia evunyiweyo ye- FDC Cymbalta (duloxetine) no- Savella (milnacipran) .
Kodwa ngaba uyaqonda ukuba yintoni i-reuptake ithetha?
Xa uqala ukufunda malunga ne-reuptake inhibitors, kunokudideka-siyazi ukuba le miqathango ikholelwa ukuba iquka amaqondo aphantsi eekhemikhali zengqondo ze-serotonin kunye ne-norepinephrine, ngoko kuthatha into ebenza ukuba izithintele izandile.
Inkcazo yale nto ibandakanya isigama esicacisayo sezokwelapha esininzi sisayi kuqonda. Ngezantsi, uzakufumana ukuphazamiseka kweli nkqubo ngolwimi olulula ukuluqonda.
Yintoni iRuptake?
Okokuqala, ncinane malunga nendlela ubuchopho bakho busebenza ngayo:
Iintsholongwane zakho zobuchopho (neurons) ziyahlukana ngeengcambu ezincinane. Xa ubuchopho bakho buhambisa imilayezo esuka kwi-neuron enye ukuya kwelinye, ibopha ezo zikhefu ngokukhupha iikhemikhali ezikhethekileyo ezibizwa ngokuba yi-neurotransmitters ukuba zithwale umyalezo.
Emva kwexesha, isikhala phakathi kweeseli sithinteka kakhulu kunye neurotransmitters ezininzi ezisetyenziswayo. Kufana nokuvula i-imeyile yakho kunye nokuphelisa imfumba ye-envelopes ezingenanto-ezi mvulophu zibalulekile ekufumaneni i-imeyili kuwe, kodwa awusayifuni.
Ingqondo yakho ihlambulule umonakalo ngokubuyisela kwakhona i-neurotransmitters ukuze ibuyiswe kwakhona. Ixesha lonyango lelo liphinda liphinde libuye.
Ngoku masenze lula kwaye senze isinyathelo esilandelayo:
Khawucinge nje ngesicangci esasigxininci ngasemva kwesitulo segumbi lokudlela. Ufuna ukufikelela etafileni, ngoko uphonononga umgca wewebhu ngapha kwekhasi.
Akufanele abe neengxaki ekufikeni kwindawo eya kuyo, kodwa umtsalane ophumayo egumbini uqhubeka ejikeleza eso sihlandlo aze aqhube i-web phambi kokuba isicabangca singagqiba uhambo.
Ngoku, khawucinge ukuba umntu utshintsha isantya kwi-fan ukuze i-oscillates slowly. Oko kunika isikhala kwisithuba esaneleyo sokuwela umda phambi kokuba ibhulophu ibhujiswe.
Isicabangca sisigijimi, i-web ingummiselo we-neurotransmitter, kwaye umtshini uphinde uphinde uphinde uphinde uhlawule. Xa uphucula i-reuptake, umyalezo unelungelo lokwenzela i-neurotransmitter ukuya apho uya khona. I-reuptake inhibitors ayinyuli inani le-neurotransmitter engqondweni yakho, kodwa iyakwandisa inani lexesha elitholakalayo. Oku kunceda imiyalezo ifike apho ihamba khona.
I-Reuptake Isebenza njani Kithi
Abaphandi bacacisa ukuba ubuchopho babantu abane-fibromyalgia, isifo esingapheliyo yokugula, kunye nezinye ezininzi izifo zengqondo ziba namazinga aphantsi angama-neurotransmitters okanye asebenzise i-neurotransmitters ngokufanelekileyo. Oku kuthiwa yi-neurotransmitter dysregulation, kwaye kukholelwa ukuba yinyameko ezininzi zeempawu zethu, kubandakanya inkohlakalo yengqondo kunye nokukhulisa intlungu .
Uphando lubonisa ukuba ukuphuculwa kwe-reuptake kunceda ukunciphisa iimpawu kwiqela elininzi labantu abanezifo.
I-older reuptake inhibitors yanciphisa inkqubo yazo zonke i- neurotransmitters, ezakhokelela kwimiphumo eninzi engafunekiyo. I-reuptake ye-inhibitors yanamhlanje icwangcisa i-neurotransmitters ethile-ngakumbi i-serotonin kunye ne-norepinephrin. Babizwa ngokuba:
- I-serotonin i-reuptake inhibitors (iSRRIs)
- I-Serotonin-norepinephrine reuptake inhibitors (i-SNRIs)
Nangona la mayeza ayibangela iingxaki ezimbalwa kuneemichiza endala, zisenalo uluhlu olude lweziphumo. Ingxenye yengxaki kukuba asinalo ukulahleka kwe-neurotransmitter kuwo wonke ummandla wengqondo, ngoko ke amayeza angathuthukisa ukuhanjiswa kwendawo enye ngelixa ephazamisa kwelinye.
Nangona kunjalo, uhlobo olutsha lwe-SSRI lukhulayo olunokubonelela ngokukhululeka ngemiphumo embalwa ngokujoliswa kwiseli yengqondo efumana umyalezo we-neurotransmitter. Lelo lisele libizwa ngokuba yi-receptor, kwaye i-receptor nganye yenzelwe ukufumana kuphela imilayezo ethunyelwe ngamanye ama-neurotransmitter. Okubalulekileyo, i-receptor iyisikhiya. Kuphela izixhobo zeekhemikhali ezilungileyo zingazivula.
Esi sigqirha esitsha sisebenzisa izixhobo zamakhemikhali ezifanelwe ukukhohlisa ama-receptors athile ekuvula, okwenza kube lula ukuba imilayezo iqhutywe ukusuka kwiseli yeseli. Ubuncinane isilwanyana esinye salolu hlobo-i-Viibryd (i-vilazodone)-ngoku samkelwe ukudakumba eMelika. (Nangona kunjalo, akuzange kuphandwe malunga ne-fibromyalgia okanye isifo esingapheliyo.
Funda kabanzi malunga nokusetyenziswa kwezi ziyobisi kwiimeko zethu:
Ukubona iimpawu ezinxulumene nokungaphumeleli kwe-neurotransmitter, kunye neendlela zokonyango, funda:
Imithombo:
Iintsimi, R. Douglas, Ph.D. (2009) Elinye iBongo. ENew York: uSimon & Schuster.
Goldstein, J. Alasbimn Journal2 (7): Epreli 2000. AJ07-5. "I-Pathophysiology kunye noTyango lweSyndyrdom Syndrome kunye nezinye izifo ezibangelwa yi-Neurosomatic Disorders: I-Treatment Cognitive kwiPilisi."
Smith AK, et al. Psychoneuroendocrinology. 2008 Feb; 33 (2): 188-97. Ukuhlolwa kobuGenesis kwenkqubo ye-serotonergic kwi-syndrome engapheliyo.
2008 IYunivesithi yaseMary Medical University yase-Maryland. Onke Amalungelo Agciniwe. "Isifo Sokunyamekela Isifo"