Iingxaki zokuxhatshazwa yizona zixhaphaza kakhulu izidakamizwa ze- fibromyalgia kunye nesifo esingapheliyo , kodwa le klasi yeziyobisi inomngcipheko omkhulu wemiphumo emibi, kwaye uluhlu lweempembelelo ezinokuthi lube lude.
Isiza esibizwa ngokuba nguViibryd (vilazodone) sithembisa ukubonelela ngemiphumo embalwa emibi, kwaye uphando lwezonyango lubonisa ukuba kuncinci amathuba okubangela ukunyusa ubunzima nokuxhatshazwa ngokwesondo-ezibini iziphumo ezivame ukukhokelela abantu ukuba bahambe kwezinye izidakamizwa.
I-Viibrid eyahlukileyo njani?
I-Viibrid luhlobo lwe-anti-depressant olubizwa ngokuba yi-SSRI (i-serotonin ekhethiweyo yokubuyisela inhibitor). Kodwa iViibrid iyahlukileyo kuba ijolise ngaphezu kokuphinda ihlaziywe.
I-reuptake yinto yokugcina indlu yengqondo. Xa enye i-neuron (inkolelo yesilongo) ithumela umyalezo komnye, yenza njalo ngamakhemikhali abizwa ngokuba ngama- neurotransmitters , kwaye i- serotonin ibaluleke kakhulu kuthi, njengokuba singenayo ngokwaneleyo okanye singayisebenzisi kakuhle.
Xa une-serotonin ephantsi (okanye nayiphi na i-neurotransmitter), umyalezo osithunyelweyo usebenzisa awunalo amandla okwaneleyo okufumana kwi-neuron enye ukuya elandelayo. Kufana ne-tennis ekhonzayo engenamandla ukufumana ibhola ngaphaya kwenetha. Inkwenkwe yebhola ekhuphayo ukuqokelela le bhola engabonakaliyo yenza umsebenzi wokubuyisela kwakhona-ukukrazula i-serotonin esebenzayo ukuze kungabonakali izinto.
Izidakamizwa ezenza ukuba i-reuptake igxinwe igcine loo nkwenkwe yebhola (ngokwenene iseli kunye ne-presynaptic neurons) ukususa i-neurotransmitter nokunika ixesha elide lokuthumela umyalezo walo.
Okwangoku, sibheke kwelinye icala lenkundla yentenethi. Kuthiwani ngomntu onqamle umnatha, i-neuron efumana umyalezo? Lelo lisele ineemceivers, kwaye i-receptor nganye yenzelwe ukufumana kuphela imilayezo esuka kwii-neurotransmitters ezithile. Ngokuyisiseko, i-receptor ivalwe, kwaye kuphela izixhobo zecikhali ezifanelekileyo ezingayivula.
I-Viibryd ijolise i-receptors ethile ye-serotonin enezihluthulelo ezifakwe kunye nokuziqhelanisa ekuvulekeni, okwenze kube lula ukuba imiyalezo ibonakale ukusuka kwiseli yeseli.
Oko sikubonayo kukuba njengokuba izidakamizwa ziba zizodwa ngakumbi ngale ndlela, ziyaqhubeka zisebenza ngempembelelo embalwa. Ngokungena kwiindlela ezithile kunye neendlela ezilinganiselwe ukuba iingqondo zisebenza, zinokujolisa bhetele ingxaki engundoqo kunokuba utshintshe ummandla wemimandla emikhulu yengqondo elawula izinto esizifuni ukuzenza kunye nazo.
Studies
Kuze kube ngoku, iViibrid ayizange ifundwe yonke into ye-fibromyalgia okanye isifo esingapheliyo.
Izifundo, kuquka ezinye ezinkulu, zibonisa ukuba i-Viibrid isebenza ngokubhekiselele kwingxaki enkulu yokudakumba kunye neengxaki ezixhalabisayo, zombini eziqhelekileyo kubantu abane-fibromyalgia kunye nesifo esingapheliyo. Uphando lubonisa ukuba ukunyamezeleka.
Uphando olushicilelwe ngo-2017 alufumananga nxaxheba kwimisebenzi yesondo kubantu abadala.
Imiphumela
Ngoxa iViibrid ibonakala ibeneemiphumo ezimbalwa kunezinye iziyobisi eklasini, oko akuthethi ukuba i-side effect effect. (Akukho nkunkuma.)
Kwizilingo, iimpembelelo eziqhelekileyo zibandakanya
- isifo sohudo
- isicaphulelo
- ukungcola
- kulala
- iindlovu / amaphupha angaqhelekanga
- ukuhlanza
Ukuba ucinga nge-Viibryd, qiniseka ukuba uthethe ugqirha kunye nekhemistiya malunga neengozi kunye neenzuzo.
Ugqirha wakho kunye nekhemistiya unokukunceda uqaphele ukusebenzisana okungalunganga kunye namanye amayeza kunye nezongezelelo ezithathayo.
> Imithombo:
> Clayton AH, Durgam S, Li D, et al. Iimpembelelo ze-vilazodone ekusebenzisaneni ngokwesondo kubantu abadala: iziphumo ezivela kwisifundo esilawulekiweyo, esisi-blind, se-placebo esilawulwayo. I-psychopharmacology yamazwe ngamazwe. 2017 Jan; 32 (1): 27-35.
> Durgam S, Chen C, uGommoll CP, et al. Ukuphucula iiklasi kwisifo esibuhlungu kwizigulane ezineengxaki ezinkulu eziphazamisekileyo ziphathwe nge-vilazodone: ukuhlaziywa kwe-post hoc ezine ezilingo ezilawulwa yi-placebo. Izifo ze-Neuropsychiatric kunye nonyango. Ngomhla we-2016 uMdluli wesi-2: 12: 3073-3081. eCollection 2016.
> Shi L, Wang J, Xu S, Lu Y. Ukusebenza kunye nokunyamezela kwe-vilazodone yesifo esixhalabisayo esikhulu: ubungqina besigaba se-III / IV zilingo ezilawulwa ngoncedo. Uyilo lweziyobisi, uphuhliso kunye neyeza. 2016 Novemba 25; 10: 3899-3907. eCollection 2016.