Iyeza elibizwa ngokuthi i-mirogabalin linika ithemba lokuphucula impawu ngeempembelelo ezimbalwa kunezinto ezikhoyo zonyango lwe- fibromyalgia (FMS) . Kusasa kakhulu ukuba wazi ngokuqinisekileyo, nangona kunjalo.
I-Mirogabalin yilwaphulo lokulinga elona lilungu lesithathu "lentsapho" yonyango oluqhelekileyo kuluntu lwaseFMS. Abaxhamli bayo bangamaNeurontin (gabapentin) kunye neLyrica (pregabalin) , ebizwa ngokuba yi "son of Neurontin."
I-Neurontin neLyrica zizonke izidakamizwa zokulwa neentambo eziye zafunyanwa zisebenzayo ngenxa yentlungu yesifo sikashukela . I-Lyrica yabe ivunyiwe yi-FDA ye-FMS ne-Neurontin ihlala ichongwe kwi-ileyile. Ziye zisetyenziselwa ezinye iintlobo zentlungu, kubandakanywa intlungu emva kokuhlinzwa kunye ne- posturalpe neuralgia .
Noko ke, i-Mirogabalin iye yaphuhliswa ngokukodwa ngengqondo ye-neuropathic kunye ne-FMS.
Indlela iMirogabalin isebenza ngayo
Ngokomenzi weziyobisi waseJapan u-Daiichi Sankyo, i-mirogabalin ibophelela kumacandelo e-calcium kwingqondo, njengokuba iLyrica ne-Neurontin. Nangona kunjalo, i-mirogabalin kuthiwa ibopha ngokukhethekileyo kuneLyrica, enokubangela ukuba kube nemiphumo embalwa yecala.
Okwangoku, imiphumo emibi ingabangela ingxaki enkulu eLyrica, Neurontin, nakwezinye iziyobisi zeFMS. Enyanisweni, abaninzi abantu bayeke ukuthabatha la mayeza ngenxa yabo. Ukuba ukulindela kwangaphambili kubambe kwaye i-mirogabalin inikeza intlungu yesiphumo kunye neempendulo ezimbi, kuya kuba yinto enkulu kubantu abanalo meko.
I-Mirogabalin nayo ikholelwa ukuba ihlala ixesha elide kuneLyrica, oku kuthetha ukuba kunokufuneka ukuba kuthathwe ngaphantsi. Ucwaningo lukaJanuwari 2016 lucebise ukuba i-dose yemihla ngemihla ingcono kakhulu ekunciphiseni iziphumo zecala.
I-Fibromyalgia ne-Neuropathy
U-Daiichi Sankyo okwangoku uqhuba isifundo somntu onesiwaka kwi-mirogabalin ye-FMS.
Oko kukufunda ngokukodwa (kunye nokubiza) ngokukhawuleza kwenkqubo, ebonisa ukuba inkampani inethemba ngeziphumo.
Izifundo zeziyobisi zidla ngokuthelekisa amachiza kwindawo ye-placebo, kodwa lo ubeka i-mirogabalin intloko ukuya entloko eLyrica.
Uphando olupapashwe ngo-2014 lucebisa ukuba i-mirogabalin ibonise isithembiso njengonyango lwe-diabetes peripheral neuropathy.
Uphando olutshanje luqikelele ukuba i-mirogabalin ingaba ngamaxesha angama-17 anamandla ngaphezu kweLyrica; Nangona kunjalo, abanye abaphandi baye bagxeka ukuyila.
Isistim
Amanqanaba afanelekileyo e-miragabalin ayikasekwa. Uphando olufumene i-potenti e-17 ekhankanywe ngasentla iqikelele ukuba i-dosage ingaba ngu-17.5 mg okanye iphantsi, xa kuthelekiswa ne-150 mg yeLyrica yansuku zonke.
Izifundo ze-Neuropathy zisebenzisa 15 mg, 20 mg, okanye 30 mg.
Ububungqina bokuqala bubonisa ukuba ama-dosage aphantsi angadingeka kulabo abaneengxaki eziphambili okanye ezinzima zeengxaki.
Iziphumo eziPhakathi kunye nezilumkiso
Imiphumo emihle inokwenzeka nanoma yiphina imishanguzo kwaye uluhlu olupheleleyo lwaso alukwaziwa de emva kokuba beye kwiimarike iminyaka embalwa.
Okwangoku, uphando lucebise ukuba i-mirogabalin inokudibaniswa ne:
- ukungcola
- kulala
- ukulala ixesha elide
- intloko
I-Mirogabalin Iya Kufumaneka nini?
Uphando lwezokwelapha yinkqubo ephosakeleyo kakhulu. Ngethuba lokuqala lokuzama ukuqaliswa ngo-2015, kwaye kubandakanywa nenani elikhulu labathathi-nxaxheba, asinakuzilindela ukubona iziphumo zeeminyaka embalwa.
Ukuba i-mirogabalin iyaqhubeka ibonisa isithembiso kwaye isicelo seNtsha seDrug siya phambi kwe-FDA, kunokuthatha enye iminyaka emibini ukuba ivunyiwe okanye iyanqatshwa.
Nangona kukhuthazwa ukwazi ukuba unyango oluneengxaki ezinokuthi lube nempembelelo embalwa lube kwixa lethu elizayo, kufuneka siqhubeke sifuna uphando olwangoku olusinceda silungise iimpawu.
> Imithombo:
> Boston Clinical Trials. "Yintoni Ethembisa Ngayo Nge-Mirogabalin? Iimbono zonyango kwi-Fibromyalgia yethu entsha." Onke Amalungelo Agciniwe.
> I-Calandre EP, i-Rico-Villademoros F, i-Slim M. I-Expert review ye-neurotherapeutics. 2016 Julayi 7: 1-15. [I-Epub phambi kokuprinta] i-Alpha2delta ligands, i-gabapentin, i-PGB kunye neMGB: ukuhlaziywa kwe-pharmacology yabo yekliniki kunye nokusetyenziswa kwezilwanyana.
> Inkampani ye-Daiichi Sankyo, Limited. "U-Daiichi Sankyo Uvakalisa izigulane zokuQala kwiiNqanaba eziPhakamileyo, eziNinzi zeSizwe ezi-3 ze-MIrogabalin." Onke Amalungelo Agciniwe.
> Hutmacher MM, et al. I-Journal ye-pharmacology yeklinikhi. 2016 Jan; 56 (1): 67-77. Ukubonakaliswa kwempendulo-mpendulo yemilinganiselo yemihla ngemihla yeentlungu, kunye nezoxinzelelo kunye nokungazinzi, i-mirogabalin (i-DS-5565) kwizigulane ezineentlungu zesifo sikashukela se-paripheral neuropathic.
> Iimvume ezintsha zeDrug. "Mirogabalin." Onke Amalungelo Agciniwe.
> Vinik A, et al. Ukunyamekela ngesifo sikashukela. 2014 Dec; 37 (12): 3253-61. Ukusebenza kunye nokukhuselwa kwe-mirogabalin (i-DS-5565) yokunyanga intlungu yesifo sikashukela i-neuropathic intlungu: i-random, i-double-blind, i-placebo- kunye ne-active-control-controlled control------study-phase-study study 2.
> Yin OQ, et al. I-Journal ye-pharmacology yeklinikhi. 2016 Feb; 56 (2): 203-12. Uhlobo lwe-pharmokokinetic yoluntu kunye nokulinganisa ukuhlola ukuphazamiseka kwemithwaba ye-renal kwi-pharmacokinetics ye-mirogabalin.