Ukuba ungumfazi onamaqondo aphantsi okanye aphakamileyo ye-hormone thyrotropin (eyaziwa ngokuba yi- thyroid evuselela i-hormone , okanye i-TSH) unomngcipheko ophezulu we- Alzheimer's disease . Iziphumo zaxelwa kwiphepha lezonyango, i- Archives of Internal Medicine .
Uphando
Kuhlolisiso olukhulu, oluqhutywe njengenxalenye yoFundo lwe-Framingham olusekelwe kuluntu, izigulana ezi-2,000 ziye zahlolwa ngezikhathi ezithile ngenxa yengqondo yexesha elidlulileyo kwixesha elingaphezulu kweminyaka elishumi.
Eli qela laphinde lalandelwa malunga nama-13 iminyaka. Ngethuba lexesha elilandelelweyo, i-209 yezigulane zafundwa zizifo zesifo se-Alzheimer. Kwimabhinqa, amazinga e-TSH ayexhomekeke kakhulu kwi-Alzheimer's disease. Enyanisweni, kubafazi abanezinga le-TSH elingaphantsi kwe-1.0 okanye ngaphaya kwe-2.1, bekukho ngaphezulu kokuphindwe kabini kwandisa ingozi yesifo se-Alzheimer. Okuthakazelisayo, akukho buhlobo obunjalo obubonakala kumadoda.
Abaphandi abazi ukuba iinguqu ze-thyroid kunye ne-TSH ziyenzeka ngaphambi okanye emva kokuqala nokuxilongwa kwesifo se-Alzheimer. Akwazanga kwakhona indlela yesayensi okanye yezinto eziphilayo emva kobudlelwano. Kodwa ke, bancomela ukuba uphando olongezelelweyo luqhutyelwe ukuchonga ukuba kukho nayiphi na impembelelo kunyango okanye ukukhusela.
Mhlawumbi oko kubaluleke kakhulu ukufumanisa, nangona kunjalo, ukuba iziphumo zafana, nokuba ngaba izigulane zafumanisa ukuba zinesifo se-thyroid kwaye zithatha imishanguzo ye-hormone ye-ormic substitution.
Impawu yokusebenza ibonakala njengezinga le-TSH.
Nangona ukulinganiswa kwe-hyperthyroidism okanye i-hypothyroidism kungabangela iingxaki ezinengqiqo, kunye nobunzima bokukhumbula, ukucinga nokufunda, ezi zibonakaliswa zibuyiselwa ngonyango olufanelekileyo lwe-thyroid. Olu cwaningo, nangona kunjalo, lucelomngeni imfundiso yemveli yokuba iingxaki ze-thyroid ziyisisombululo esiphendulwayo sokukhubazeka kwengqondo.
Kunoko, iziphumo zophando zibonisa ukuba ukungalingani kwintsebenzo ye -roid kungabangela ukuba kubekho umngcipheko wokuhlaselwa kwesifo se-Alzheimer.
Omnye wabalobi bokufunda, uDkt. Zaldy Tan, utshele iMedscape:
Kwakunomdla ukufumana ukuba amazinga aphantsi kunye aphezulu ahlanganiswa nesifo se-Alzheimer. Into yokuba ubuchopho buzama ukugcina amanqanaba e-thyroid kwibala elincinci lingacetyiswa ukuba ukuba lusebenze ngokufanelekileyo, kufuneka ligcinwe kuloluhlu kwaye ukuya ngaphantsi okanye ngaphezulu apha akuyona into enhle.
Akucaci ukuba amazinga e-TSH adala i-Alzheimer's, ukukhusela i-Alzheimer's, okanye ukuba isifo se-Alzheimer ekugqibeleni sichaphazela i-TSH. Uphononongo lwalugcinwe kwaye aluzange luvandlakanise. Iingcali zibonisa ukuba ukuphendula ngokunyanisekileyo kungonakaliswa yisifo se-Alzheimer, okanye ukuba iimeko ze-hormone ze-thyroid zingaba negalelo ekuveliseni isifo se-Alzheimer's disease.
Enye ingcamango enomdla ngababhali abafundayo ibonisa indima yokuba i-hormone ye-thyroid idlala ekulawuleni imbonakalo ye-gene ebizwa ngokuba yiprotroprotector protein (APP), enegalelo kwi-Alzheimer's. Kungenzeka ukuba ukungalingani kwe-hormone ye-thyroid kunokukhokelela kwimibandela kunye nokulawulwa kwe-APP, oko kwandisa ingozi ye-Alzheimer's.
Ukuqhubela phambili ulwalamano phakathi kwe-thyroid, amazinga eTSH kunye nesifo se-Alzheimer. Uphando olunjalo, kodwa ke luya kugqiba ukubonelela ngezizathu ezizwakalayo zoluntu lwezobugqirha ekugqibeleni lifumane i-TSH yolwazi olubanzi.
Lo mbandela uphuzululwe. Ngo-2002, i-American Association ye-Clinical Endocrinologists (AACE) inconywe ukunciphisa isalathiso seTSH ukusuka kwi-0.5 ukuya kwi-5.0 mIU / L, ngokubanzi kwi-0.3 ukuya ku-3.0, kunye noMbutho kaZwelonke we-Clinical Biochemistry uncetyise umda we 2.5. Nangona abanye oogqirha kunye ne-endocrinologists bexela iziphakamiso, i-AACE yashiye le ngcebiso, kwaye ii-laboratories kunye noogqirha baqhubeka bevavanya uvavanyo lwegazi lwe-thyroid ngokwe-0.5 ukuya kwi-5.0.
ILizwi
Okwangoku, okwangoku, olu pho nonongo lubonelela ubungqina obungqina bokuthi, kwizigulane ezithola unyango lwe-thyroid, i-target target ye-TSH nqanaba ngelixa amayeza kufuneka abe phakathi kwe-1.0 ukuya ku-2.0, ngaphandle kokuba ezinye izinto zihamba phambili. (Ngokomzekelo, ezinye izigulane zomdlavuza we-thyroid zigcinwa kwiinkqubo ezixinzelelekileyo zonyango lwe-thyroid, ukugcina izinga leTSH liphantsi kakhulu, okanye ngamanye amaxesha linyanzeliswe kumanqanaba angama-0, njengendlela yokukhusela ukuphindaphinda komdlavuza we-thyroid.
> Umthombo:
> I-Tan, iZaldy et. al. Umsebenzi we-Thyroid noMngcipheko wezifo ze-Alzheimer: I-Framingham Study. " IiNgxelo zoLondolozo lwangaphakathi , u-2008; 168 (14): 1514-1520.