Iimveliso ze-Vitamin A, ezibandakanya i-retinol kunye ne-Retin-A, ibizwa ngokuba "ngumgangatho wegolide" wokunakekelwa kwesikhumba sokuguga, ukunceda isikhumba sakho sibonakale sincinane kwaye sibhebhezele. Kodwa ezi zithako zenziwe njani, kwaye zinokuphumelela njani ekuphatheni imibimbi kunye nekhukhu eliguga?
IVithamini ebalulekileyo
Ukubaluleka kwe-vitamin A kwimpilo yethu kwafunyanwe ekuqaleni kwekhulu lama-20, ngokufunyanwa kwendima yayo ekusebenzeni kwembungu.
Ukususela ngoko, kufunyenwe ukuba ngumdlali oyintloko kungekhona nje ekuveliseni, kodwa nangombono, ukukhula, kunye nokwahlukana kweesellu kunye nokwanda. Ngenxa yokuba inceda ukuveliswa kweeseli ezimhlophe zegazi, i-vitamin A iyimfuneko kwi-immune system.
I-Vitamin A yaziwa nangokuthi i-retinol, kunye neziphumo zayo (nokuba zendalo okanye ezenziwe) zibizwa ngokuba ngama-retinoids. Ngenxa yokuba le vithamini ayikwazi ukuhlanganiswa ngumbutho, kufuneka idliwe ekudleni-mhlawumbi ngemithombo yezilwanyana, njengezikhupha zeqanda, intlanzi, isibindi, inyama, okanye imithombo yemifuno, njengemifuno enemibala emnyama kunye neentyatyambo, amathanga, kunye neetamatato.
Uncedo kuKhukhu eliguga
Isikhundla samanje seVitamin A njengesikhumba esilukhulayo sisimangalisa kwiminyaka yee-1980 xa abaphandi bafumanisa ukuba i-tretinoin (i-brand name Retin-A) incedise ukukhulisa i-collagen kwimichiza xa isetyenziswe kwi- topical to skinaged skin ukukhanya kwi-ultraviolet ukukhanya ukusuka elangeni.
Ukuhambelana nokufunyaniswa kwaba ngugqirha ogqitywa ngabagqirha bechaza i-tretinoin ye-acne ukuba izigulane zinekhanda elincinci, kunye nemibimbi embalwa. Emva koko uTretinoin wafunyanwa ephazamisa i-enzymes eyenza iqulethe i-collagen kwisigxina sebala kunye nokukhuthaza ukwenziwa kwe-collagen entsha.
Ukususela ngoko, i-retinoids sele yaziwa ngokuba yi "golide yezinga" yeemveliso ezichasayo ezichasayo, ngokubhekiselele kubhali be-2003 ukuphononongwa kuphando olupapashwe kwi- Journal of Drugs in Dermatology .
Okulungileyo, Okubi kunye Ne-Ugly yaseTretinoin
I-Tretinoin kwiindawo ezahlukahlukeneyo (ngokuqhelekileyo i-0.01 - 0.1%) sele ifundwe ngokusisigxina kwixesha elifutshane kunye nexesha elide, ngokubhekiselele ekuhlaziyweni kwexesha elide lika-2006 lweeNtsholongwane zoKliniki ekuguga .
Ngoxa i-vitamin A esetshenzisiweyo esetyenziselwa unyango lwe-acne, i-isotretinoin (igama legama elibizwa ngokuba yi- Accutane ), liye linceda izigulana zinekhanda elincinci, elingu-pinker, i-isotretinoin yomlomo inomngcipheko omkhulu weziphene zokuzalwa. Nangona i-tricinoin ye-headical engakhange iboniswe kwizifundo ukuba ibe nesongelo esifanayo, ezinye iingxelo zecala zicebise ukukhubazeka kwabazali phakathi kwabasetyhini basebenzisa i-tretinoin elukhumbeni lwabo kwi-trimester yokuqala yokukhulelwa. Abasetyhini ke balumkiso malunga nokusebenzisa le mveliso ngelixa bekhulelwe.
Abasebenzisi abakhulu besikhalazo banalo malunga ne-tretinoin yempembelelo ecaleni ngoku eyaziwa njenge-retinoid dermatitis, ebandakanya ubomvu, ukucaphukisa kunye nokukhawuleza okungakhula ngokukhawuleza okanye kwiiveki ezimbalwa zokuqala unyango. Oogqirha bahlala becetyiswa ukuba baqale ngexilongo ephantsi (0.01 - 0.025%), kwaye bayisebenzise ngemali encinci yonke imihla.
Ukutshintshwa kwi-gel ukuya kwisiseko se-cream esikhonkco kungaphinda kunciphise ukrakra isikhumba. Emva kokuba ukunyamezela kuye kwakhiwa, ukusebenzisa i-tretinoin imihla ngemihla kunye / okanye ukusebenzisa i-dose egxininiswe ngakumbi kunokulawulwa ngakumbi.
Ukubuyisela Imifanekiso
I-Tretinoin ibonakala iphumelele kakhulu ekunciphiseni imigca emihle yobuso kunye nemibimbi, ukunciphisa ubuqhophololo, isikhumba esifakwe ngombala, kunye nokuphucula iingubo ezingenalo. Ingathabatha inyanga ezimbalwa ukuba ezi ziphumo zikhangeleke, kwaye iziphumo zixhomekeke kwintsholongwane, oku kuthetha ukuba iziphumo ezinamandla zizisa iziphumo ezibonakalayo ngokukhawuleza. Ngokomzekelo, ngelixa i-0.05% ingqinisiso inganciphisa kakhulu imiphumo ye-photohotel, ngoko kuya kuba sesigamu selo (okanye i-0.025%), kodwa okokugqibela kuya kufuna ixesha elide.
Ingqwalaselo engaphantsi kwama-0.01% ayizange iboniswe ukunceda isikhumba esenziwe ngesikrini.
Ezinye izinto ezichaphazela ukuba imisebenzi ye-tretinoin iquka njani i-genetics, umgangatho ngamnye wesikhumba, kunye nobukhulu bephotodamage.
Amanye amaVithamini A ayenzayo
I-Tretinoin inamandla okubangela ukucaphukisa isikhumba kunye nokuhlulwa kwayo njengesilwanyana (kufuna i-prescription) kuye kwaphazamisa uphando olunzulu ngabavelisi bezonyango kunye nabaxuba kwiimveliso ezincinci. Phakathi kwala ma-retinol, retinaldehyde, kunye ne-retinyl palmitate. I-Retinol iguqulwa ibe yi-tretinoin elukhumbeni, nangona i-concentration engumphumo i-1/1000 kuphela ye-tretinoin (kwaye ngoko ingacasuliyo) xa isetyenziswe ngokusemgangathweni.
Iimveliso ezininzi ze-vitamin A eziphuhlisiwe kwiimarike ezichasene nokuguga ziyimpahla efanelekileyo-ngaphandle kophando olupapashwe kwiimagazini ze-scholarly - kwaye ke kunzima ukuhlaziya.
Okukwintsusa
Iimveliso zeVithamini A ezinjengeengqungquthela ze-tretinoin ziye zaboniswa ukunciphisa imibimbi, ubomvu, kunye nokuguqulwa okungafaniyo, nangona (ngokungaqhelekanga) kunokubangela ubomvu nokucaphukisa ngexesha elifutshane. Ukuba ufuna ukuzama ukutshintshisa ukubeka isithombe, qhagamshelana nomboneleli wakho wezempilo okanye ubone i-dermatologist ye-odokotela. Iimveliso ezingaphezulu kwee-counter-containing containing derivatives ziyakwazi ukusebenza ngesikhumba esidala, nangona imiphumo yabo ingabonakali kakhulu, kwaye iyanzima ukuqinisekisa.
Imithombo:
Ukuguga kwintsholongwane. I-National National Institutes of Health Medline Information Sheet Sheets. http://www.nlm.nih.gov/medlineplus/ency/article/004014.htm
UKockaert M, uNeumann M. Systemic, kunye neziyobisi zamathambo ezikhukhumba. J Izidakamizwa zeDermatol. 2003 Agasti; 2 (4): 435-41.
U-Siddharth Mukherjee, Usuku luka-Abhijit, uVandana Patravale, uHans Christian Korting, uAlexander Roeder, noGünther Weindl. I-Retinoids kwonyango lokuguga kwelaphu: ukujonga ngokubanzi ukusebenza kweeklinikhi nokukhuseleko. Ukukhulelwa kweKliniki. 2006 uDisemba; 1 (4): 327-348
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
I-Vitamin A. IiNational Institutes of Health Medline Information Sheet. http://www.nlm.nih.gov/medlineplus/druginfo/natural/964.html