Iimpawu zoMlomo we-Oral Leukoplakia (OHL)

Izilonda zomlomo zingabonakaliswa kweNtsholongwane kaGawulayo

I-leukoplakia enoboya (eyaziwa nangokuthi i-leukoplakia enomlomo, okanye i-OHL) ibonakala isilonda somlomo kumntu ogxininiswe ngumzimba, obonakalisa iimpawu ezimhlophe kwicala lolwimi kunye nesimo "sesithandwa". Ngenye yezifo zomlomo ezininzi ezinokuchaphazela rhoqo abantu abane-HIV, ngokuqhelekileyo xa inani le- CD4 lomntu lihlahla ngaphantsi kweeseli 200 / mL.

I-OHL ibangelwa yi-Epstein Barr igciwane (EBV), intsholongwane yeentsapho ze-herpes ezichaphazela phantse abantu abangama-95%, nangona ininzi iya kuba ne-immunity immunity ekhusela intsholongwane ukuba ibonakalise ngokubonakalayo. Nangona kunjalo, kubantu abaneNTSHOLONGWANE KAGAWULAYO, umsebenzi okhuselweyo we-immune ochaphazelekayo unentsholongwane uvumela i-OHL ithuba lokukhula. Ngaloo ndlela, kuthathwa njengentsholongwane echaphazelekayo ye- HIV (OI) .

Izilonda ze-OHL zinobungozi kwaye azibangeli ezinye iimpawu. Kunoko, le mqathango ibonisa ukuba umntu unqabile ukukhusela ngokukhuselana nokukhusela kwamanye ama-OIs. Ngokuqhelekileyo, i-OHL ibonakala ngokuphindaphindiweyo kumadoda kunabasetyhini, kwaye ayifumaneki kubantwana.

Ngaphambi kokufika kwe- antiretroviral therapy (i-ART) , i-OHL yayigxininisa ngokunyanisekileyo ukuqhubela phambili kwisifo sexesha elide, apho amaninzi angama-47% aqhubela phambili kwi- HIV ukuya kwi-AIDS kwiminyaka emibini.

Namhlanje, kunye nokuqaliswa kokuqala kwe-ART, iziganeko ze-OHL ziye zahla kakhulu, ngokungafani nezinye izifo zomlomo ezinxulumene ne-HIV ezinamandla kwaye zikhoyo kumazinga aphezulu e-CD4.

Okwangoku, uphando olutshanje luye lwabonisa ukuba ukutshaya , ngokubambisana nokubalwa kwe-CD4, kubangela ukunyuka kwamaxesha amabini emngciphekweni we-OHL.

Uxilongo, unyango kunye nokukhusela i-OHL

I-OHL izilonda ziyahluka ngobukhulu. Iingeniso zingabonakala kunye okanye kumacala omabini olwimi okanye ngaphakathi kwehlathini. Abaqhelekanga ababuhlungu ngaphandle kokuba kukho isibini, isifo sesifo.

Ngamanye amaxesha, izilonda zinokubonakala ziphantsi, okwenza kube nzima ukuhlula ukusuka kwezinye, izifo ezifanayo. Nangona kunjalo, ngokungafani ne- candidiasis yomlomo (thrush) , i-OHL ayikwazi ukukhutshwa ngokukhawuleza ukusuka kulwimi. Oku, kunye ne-lesion's nameake appearance, ngaba iimpawu eziphambili ze-OHL kubantu abane-HIV.

Nangona uvavanyo lweklinikhi ludla ngokwaneleyo ukuxhasa uxilongo olungileyo, uphando oluthile lubonisa ukuba ukuya kwi-17% yeemviwo ezibonwayo ayilunganga. Ukuba kuyimfuneko, ukuxilongwa okucacileyo kungenziwa kunye novavanyo lwezinto ezincinci kunye nezinye iindlela zokuxilonga ukuqinisekisa ukusuleleka kwe-EBV.

Ngenxa yokuba i-OHL lesion iyingozi, akukho nonyango efunekayo. Nangona kunjalo, kwezinye iimeko-ikakhulukazi abo abane-CD4 ephezulu-dose-dose-high-dose Zovirax (i-acyclovir) inokukunceda ukulungisa imeko. Nangona kunjalo, ukuphindaphinda kwe-OHL kuphakamileyo xa unyango lwe-acyclovir luyekile ngaphandle kokuba umsebenzi we-immune uvuselelwe.

I-OHL inokuphindaphinda kwakhona xa unyango lwe- HIV lungakhuselanga kwaye imishanguzo ye- antiretroviral yesigulane ayifanelekanga ekulawuleni i-HIV.

Uthintelo lwe-OHL luxhomekeke kakhulu kwi-diagnostic yokuqala kwaye unyango lwe-HIV, kunye nezikhokelo zamanje zase-US zikhuthaza ukuqaliswa kwe-ART kwii-CD4 zokubala phakathi kwama-350 kunye nama-cell / mL, kunye nakwii-CD4 zibalo ezingaphezulu kweeseli / mL.

Ukuyeka ukubhema kukhuthazwa kakhulu ukukhusela ukubonakala kwe-OHL, kunye nezinye izinto ezininzi ezinxulumene neHIV kunye ne-HIV.

_Imithombo:

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_{I-Cherry-Pepper, G .; UDaniels, uC .; Uluhlu, V. okqhubekayo. "Imbonakalo yomlomo ngexesha le-HAART." . Umbhalo weNational Medical Association. NgoFebruwari 2003: 95 (iSongezelelo 2): 21S-32S.}

_{I-Chattopadhyay, A .; Caplan, D .; Slade G; okqhubekayo. "Isiganeko somlomo we-candidiasis kunye ne-leukoplakia enomlomo osweleyo abantu abadala abane-HIV eNorth Carolina." I-oral Oral Med Oral Medal Pall Oral Radiol Endod. Ugqirha lwe-Oral Medicine Oral Medicine Oral Pathology Oral Radiology Endodontology . Ja nuwari 2005; 99 (1): 39-47.}

_{I-Chapple, I. kunye ne-Hamburger, J. "Ukubaluleka kwempilo yomlomo kwisifo se-HIV." . Izifo ezithathelwana ngesondo. Agasti 2005; 76 (4): 236-243.}