I-ceramide yintlobo yamanqatha afumaneka ngokwemvelo kwi- strumum corneum , ecaleni kwesikhumba. Kanye kunye ne-cholesterol kunye ne-fatty acids yamahhala (ezinye iindidi ezimbini zeempepha ezitholakala ngokwemvelo kwesikhumba sakho), ii-ceramide zinceda ukugcina iiseli zesikhumba ndawonye. I-ceramide ibalulekile ekusebenzeni ngokuqhelekileyo kwendawo yokukhawulela kwesikhumba kwaye idlala indima ephambili ekuncedeni ulusu lwakho lugcina umswakama.
Njengamazinga e-ceramide ehla ngokuguga ngokuqhelekileyo, umqobo wesikhumba unokuphazamiseka, obangela ukubomvu, ukuma, kunye nentlungu.
Ukusetyenziswa kweekeramide
Xa isetyenziswe ngokucacileyo kwesikhumba kwizilwanyana kunye nezinye iimveliso ze-skincare, i-ceramide zithi zikunceda ukubuyisela umqobo wesikhumba, uncedo kunyango lweemeko ezinjenge- eczema kunye ne- psoriasis , ukuphucula isikhumba esomileyo, nokunciphisa ukubonakala kwemigca emihle kunye nezinye iimpawu ukuguga.
Iinzuzo zeekeramide
Nanku ukujonga kwezinye iziphumo zophando eziphambili ekusebenziseni i-ceramide zeengxaki zesikhumba:
Eczema
Eyaziwa nangokuthi i-atopic dermatitis, i-eczema yimeko esenza ukuba isikhumba sibe nomsindo kwaye sitshise. Uphando lubonisa ukuba abantu abane-eczema bangaba namazinga aphantsi eekeramide kwindawo engaphezulu kwesikhumba. Olunye uphando lubonisa ukuba ukusetyenziswa kweemveliso ze-skincare eziqukethe i-ceramide kunokuphucula iimpawu ze-eczema.
Ngokomzekelo we-2016, umzekelo, abaphandi bafumene ukuba i-cream equkethe i-ceramide kunye ne-magnesium yenza ngcono i-skin hydration kwaye yanciphisa ubunzima bezilonda zesikhumba (esomileyo, esinyanisiweyo okanye isikhumba se-scaly) kubantu abane-dermatitis emninzi kuya kwi-moderation, xa kuthelekiswa nekhilimu ye-hydrocortisone kunye ikhefu eliqhelekileyo elisetyenzisiweyo.
Psoriasis
I-Psoriasis iye yadibaniswa namazinga aphantsi ama-ceramide kwizilonda zesikhumba (eziphakanyisiweyo, izibhakabhaka ezibomvu ezihlanganiswe nezikali), okubangelwa ngumsebenzi onqandekileyo wokhuseleko lwesikhumba. Uphando olupapashwe kwiDermatologic Therapy ngo-2015 lwavandlakanya ukusebenza kwe-linoleic-acid-ceramide hydtuosteroid (kunye ne-corticosteroid ye-topic acid kuphela) kubantu abane-psoriasis.
Emva kwexesha lesibhozo zeeveki ezisixhenxe, unyango lweempawu lwaye lwacutha kulabo basebenzisa i-linoleic-acid-ceramide moisturizer.
Isikhumba esikhulayo
Iiceramide zinokukunceda ukukhusela isikhumba esomileyo esikhathele ukuguga, ngokutsho kwiphando elipapashwe kwi- International Journal ye-Immunopathology ne-Pharmacology . Kwiimvavanyo kuma-20 asemasetyhini asempilweni, abalobi beengcali baqaphela ukuba ukusebenzisa i-cream equkethe iikheramni kuncede ekuphuculeni umsebenzi wokunqanda isikhumba kwaye ukwandisa ukuchasana nokukhutshwa kwesikhumba esomileyo.
I-Skin Irritation
Iiceramide zinokukunceda ukukhusela ulusu kwizinto ezithile ezivuthayo, uphando olupapashwe kwi- International Journal of Dermatology lucebisa. Kuvavanyo olwenziwa ngabasetyhini abanempilo enomzimba, abaphandi bafumene ukuba ukusebenzisa i-ceramide equkethe amanzi kwesikhumba kuncede ukuphucula umsebenzi wokukhusela isikhumba, ukwandisa i-skin hydration, nokukhusela ukucasuka okubangelwa ukutyhila kwi-lauryl sulphate, iimveliso zokunyamekela.
Ukuthenga iCeramide
Uninzi lweengcali zinconywa zincoma ukuba ukhethe iimveliso ze-ceramide eziqulethe i-cholesterol kunye ne-fatty acid acids in some ratio. Uphando lubonisa ukuba kufuneka kubekho ukulinganisela kwazo zonke iintlobo ezintathu zeemveliso ukwenzela ukuba umkhiqizo we-ceramide uquletheke ukuphulukisa ulusu.
Iimfucumfucu, i-creams, i-lotions, i-cleaner, kunye ne-skin care form formes eziqukethe i-ceramide zithengiswa kwiindawo ezininzi zokuthengisa izilwanyana kunye neevenkile ezithwele iimveliso zesikhumba. Ezinye i-ceramide creams kunye ne-moisturizers zifumaneka ngomyalelo.
Khu seleko
Nangona i-ceramide ifumaneka ngokubanzi kwimveliso yokunakekelwa kwesikhumba, asikwazi okwaneleyo malunga nokukhuselwa kweeramide ezithathwe ngomlomo. Amanqanaba aphezulu e-ceramide ahlanganiswe nezifo ezininzi, ezifana nesifo senhliziyo nesifo sikashukela.
Izibonelelo zokutya eziqukethe imithombo yeceramide, njenge konjac, zithi ziphucule umsebenzi wokukhusela isikhumba kwaye zincede zonyango iimeko ezithile zesikhumba.
Nangona kunjalo, ngoku kukho ukungabikho kophando oluxhasa inkxaso ukuba i-ceramide inokuphulukisa ulusu xa isetyenziswe kwifom yesongezelelo somlomo.
Unokufumana iingcebiso ekusebenziseni izongezo apha , kodwa de kube sisazi ngakumbi, izongezelelo ze-ceramide zomlomo zifanele zigwenywe.
ILizwi
I-ceramide ikhona kwiindawo ezininzi zokunyusa iimveliso kunye neemveliso ze-skincare. Nangona uphando olongezelelweyo lufunekayo kwimpembelelo yokuphulukisa kwiimeko ezifana ne-psoriasis, ukusebenzisa i-moisturizer kunye ne-ceramide kunokunceda ukukhupha isikhumba esomileyo nokunciphisa ukuchithwa okuhambisana nesikhumba esomileyo.
Ukuba unempilo yesikhumba, xhaphaza udokotela wakho ukuba ukhangele ukuba iimveliso ze-ceramide ezifanelekileyo zilungele uhlobo lwakho lolusu kwaye uncedo lokukhetha umkhiqizo.
Ukongeza kwii-ceramide zengqungquthela, inani leemveliso zendalo, ezifana neoli neemanzi ze- argan , zinokukhusela kunye nesikhumba esomileyo nokukhuthaza ukuphulukiswa kweemeko ezithile zesikhumba.
> Imithombo:
> Di Marzio L, uCinque B, Cupelli F, De Simone C, Cifone MG, Giuliani M. Ukwandiswa kwamanqanaba e-skin-ceramide kwizifundo ezidala emva kwexesha elifutshane lokusetyenziswa kwe-bachingia sphingomyelinase ukusuka eStreptococcus thermophilus. Int J Immunopathol Pharmacol. 2008 Jan-Mar; 21 (1): 137-43.
> Huang HC, Chang TM. I-Ceramide 1 kunye ne-ceramide 3 isenzo se-synergistically kwi-skin hydration kunye ne-transepidermal yamanzi ukulahleka kwe-sodium lauryl sulphate-ekhutshisayo isikhumba. Int J Dermatol. 2008 Aug; 47 (8): 812-9.
> Koppes SA, uCharles F, uLammers L, et al. Ukusebenza kweCream equkethe iCeramide ne-Magnesium kwiNyango yoLungile ukuya kwi-Dermatitis ye-Aicic Dermatitis: I-Trial-blind, i-Double-blind, i-Emollient- ne-Hydrocortisone. Acta Derm Venereol. Ngo-2016 uNgo-2; 96 (7): 948-953.
> Liu M, Li X, Chen XY, Xue F, Zheng J. I-Topical isicelo se-linoleic acid-ceramide ene-moisturizer ibonisa iimpawu zokwelapha kunye nokukhusela i-psoriasis vulgaris: ityala elilawulwa ngokungahleliwe. Dermatol Ther. 2015 uNgo-Dec; 28 (6): 373-82.
> Ukuziphendulela: Ulwazi oluqulethwe kule ndawo lujoliswe kwiinjongo zemfundo kuphela kwaye alithathi indawo yeengcebiso, ukuxilongwa okanye unyango ngumgqirha onikwe ilayisenisi. Akunakuthetha ukukhusela zonke iindlela zokulondoloza, ukusebenzisana kwezidakamizwa, iimeko kunye nemiphumo emibi. Kufuneka uncede unyango lwangonyango ngokukhawuleza kuyo nayiphi na imiba yempilo uze ubonane nodokotela wakho ngaphambi kokusebenzisa elinye iyeza okanye wenze utshintsho kwi-regimen yakho.