Option Treatment for Fibromyalgia
NgoJanuwari 14, 2009, i-FDA yamkela i-Savella (i-milnacipran HCl) yolawulo lwe- fibromyalgia . U-Savella uhlelwa njenge-serotonin ekhethiweyo kunye ne-norepinephrine emibini ye-inhibitor. Isilwanyana sele sisetyenziswe iminyaka emininzi eYurophu nakwi-Asiya ukuphatha ukudandatheka.
Yintoni i-Serotonin ekhethiweyo kunye ne-Norepinephrine Dual Reuptake Inhibitor?
Njenge-serotonin ekhethiweyo kunye ne-norepinephrine ye-rearptake inhibitor, eyaziwa nangokuthi yi-SSNRI, i-Savella yandisa i-norepinephrin kunye nomsebenzi we-serotonin kwingqondo.
Kwi-tube ye-test, i-Savella ibonakala ibe nempembelelo eninzi kwimisebenzi ye-norepinephrine. Oku kubalulekile kwizigulane ze-fibromyalgia kuba iqondo le-norepinephrine eliphantsi licingelwa ukuba linxulumene nentlungu eninzi kunye nobunzima bokuqonda ("inkohlakalo yengqondo").
I-Savella inikwa njani?
I-Savella ilawulwa ngamanani amabini ahlukeneyo ngosuku. Isilinganiselo sonyuka ngokunyuka kwikhosi yeveki yokuqala ukuya kwi-dose ephakanyisiweyo ye-100 mg / ngosuku.
I-Savella ifumaneka njenge-12.5 mg, i-25 mg, i-50 mg kunye neepilisi ze-100 mg. Ngomhla wokuqala, uthatha i-12.5 mg kanye. Kwiintsuku ezi-2 ukuya kwe-3, uthatha i-12.5 mg / kabini imihla ngemihla. Ngeentsuku ezine ukuya ku-7, uthatha ama-25 mg / kabini imihla ngemihla. Emva komhla wesi-7, umthamo oqhelekileyo ngowama-50 mg / kabini imihla ngemihla. Ezinye izigulana zingadinga i-200 mg / ngosuku - kwaye ezinye zifuna i dose ephantsi ukuba zineentlungu (impempo).
I-Savella eyenziwa njani kwiimvavanyo zecliniki?
Ukhuseleko kunye nokusebenza kwe-Savella kwakunqunywe ukusuka kwiziphumo zezilingo ezimbini zesigaba se-III e-US Kwakukho izigulane ezingaphezu kwe-2,000 ezine-fibromyalgia ezibandakanyekayo kwizifundo.
Ukungqinelana kwe-Savella
I-Savella iyaphikisana (ayifanele isetyenziswe) kwizigulane ezine-glaucoma ezincinci ezingalawulwayo. I-Savella akufanele isetyenziswe zizigulane ezithatha ii-MAOI (i-monoamine oxidase inhibitors), ezisetyenziswa ngokudandatheka. I-Savella ayivunyelwe ukusetyenziswa kubantwana.
Izilumkiso ezinxulumene no-Savella
Izigulane ezimiselweyo i-Savella kufuneka ziqaphele ezi zilumkiso kunye nezilumkiso ezilandelayo:
- Ukugqithisa iimpawu zokudandatheka kunye nokuzibulala kubonakala ku-Savella
- I-Serotonin syndrome (isisombululo esisongela ubomi esibangela ukuba umzimba ube ne-serotonin kakhulu) inokwenzeka.
- Ukuphakanyiswa kwegazi kunye nezinga lentliziyo lingahle lenzeke ngo-Savella.
- Izigulane ziye zaxelwa kwiigulana ezithatha i-Savella.
- I-Hepatotoxicity ibixelwe (izigulane ezinokusetyenziswa kakhulu kotywala okanye isifo esingasasigxina sesibindi kufuneka sigweme i-Savella).
- Iimpawu zokurhoxeka zenzeke ukuba i-Savella ayinqunywanga kancane kancane.
- I-Savella inokunyusa umngcipheko wokuphuma kwamanzi ngakumbi kwizigulane ezithatha ii-NSAID , i- aspirin , okanye ezinye iziyobisi ezichaphazela ukuphuma kwegazi.
- Kukho amazinga aphezulu ezenzakaliso ze-genitourinary kunye nokusetyenziswa kwe-Savella.
U-Savella ukhethwe njenge-Agent Category C, ebonisa ukuba izingozi ezibangelwa ngumntwana kwisifundo sezilwanyana. Umenzi we-Savella uthi akukho zifundo ezaneleyo okanye ezilawulwa kakuhle eziye zaxelwa kwabasetyhini abakhulelweyo, ngoko ke kufuneka kusetyenziswe ngexesha lokukhulelwa kuphela ukuba iinzuzo ezinokuthi zilungele ukubeka ingozi kwi-fetus.
Izifundo ezilawulwayo zikaSasella azizange zenziwe kumama oongikazi.
Iimpawu eziqhelekileyo kunye neziganeko ezimbi
Isisindo, intloko, ukuqhwala, ukuxakeka, ukulala, ukugaya, ukunyuka, ukuhlanza, ukunyakaza, kunye nomlomo owomileyo yimpendulo engathandekiyo i-Savella.
Imithombo:
I-Savella yokuLawulwa kolwazi. Savella.com. 01/08/2009.
http://www.allergan.com/assets/pdf/savella_pi
EMilnacipran (Savella), Option Treatment for Fibromyalgia. I-P & T (i-Pharmacy & Therapeutics) P T. 2010 ngoMeyi; 35 (5): 261-266.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873711/