I-Antiinflammatories: Iingozi kunye nokuqwalasela
Xa unesifo se- fibromyalgia (FMS) kunye nesifo esingapheliyo sesifo ( ME / CFS ), unokugqiba ukuthatha amayeza amaninzi ahlukeneyo, kuquka amachiza aqhelekileyo entlungu. Nangona oko kunokukunceda uzive usebenze bhetele, kunokunokuba yingozi. Ihlawulela ukuyiqonda ngokwenene iziyobisi ezikhoyo kuwe.
Zininzi iintlobo zee-painkillers zifumaneka kwi-counter (OTC), kwaye ipesenti enkulu yethu inikwe i-penicillers yesigulane ngexesha elithile kwisifo sethu.
Ezi ziyobisi zinezingozi zabo kunye nemiphumo emihle, kwaye abanye banokusebenzisana kakubi namanye amayeza.
Enye yezona ntlobo eziqhelekileyo ze-painkillers izidakamizwa ezichasayo. Uhlobo oluqhelekileyo olusetyenziswayo lokulwa nezidakamizwa lubizwa ngokuba yi-NSAID, emele imithi engeyiyo-stteroidal anti-inflammatory. I-OTC i-NSAID ezigqithisayo ziquka:
- Advil, Motrin (ibuprofen)
- Aleve, Naprosyn (naproxen)
- Bayer, Bufferin, Excedrin (aspirin)
Ezi zi yobisi zifumaneka nakwiimpawu zamandla. I-NSAID kuphela iquka ii:
- Relafen (nabumetone)
- Feldene (piroxicam)
- Orudis (ketoprofen)
- I-Voltaren (i-diclofenac)
- ILodine (etodolac)
- Celebrex (celecoxib)
Uninzi lwethu siqhelana nokusetyenziswa kwe-NSAID ukunciphisa intlungu ebangelwa ukuvuvukala. Nangona kunjalo, ezinye i-NSAID zinokunciphisa intlungu ngokuthintela i-enzyme ethile eyingxenye yomphendule womzimba wakho kwi-stimuli ebuhlungu. Akucaci ukuba ngaba le ndlela isebenza ngokubhekiselele kwiintlobo zentlungu engaqhelekanga ezihambelana neFMS .
Ngenxa yesi sizathu, ukuhamba kunye noogqirha kukumisela i-NSAID ezimbalwa kwaye kunoko umyalelo wokusebenzisa iziyobisi ezisebenza kwinkqubo yesantya ephakathi, apho iintlungu zethu zikholelwa ukuba zivela. Ngokweziphumo zophando olushicilelwe ngo-2013 umxholo we-European Journal of Medicine.
Ezinye iingcaphephe zibonisa ukuba ukuvutha kudlala indima ephambili kwi-ME / CFS .
Ngaba i-FMS iyakrokra , nangona kunjalo? Ngokuqhelekileyo kuthethwa ngathi ayikho, kodwa isifundo esibhaliweyo nguGinevra Liptan, MD, sichaza ukuba siquka ukuvuvukala kwe-fascia.
Kungakhathaliseki ukuba yintoni indima yokuvuvukala kule miqathango, siyazi ukuba abaninzi abantu bathabatha ii-NSAID kwiintlungu ezihlobene ne-FMS kunye ne-ME / CFS, kwaye ezinye zezi zigulo nazo zithathe i-NSAID kwezinye iingxaki zezokwelapha ezibandakanya ukuvuvukala.
Iingozi zeNSAID
Ngelixa unako ukufumana ii-NSAID kumakhaya amaninzi kwaye uthenge phantse naphi na, zisenayo ingozi enkulu.
Ngokwe-American Journal of Medicine, abantu abangaphezu kwe-100,000 babhedlele ngenxa ye-NSAID minyaka yonke e-US Ukongezelela, i-15-20,000 ifa minyaka yonke ivela kwiingxaki ezinxulumene ne-NSAID ezifana nezilonda kunye nokuphuma kwamanzi, kunye ne-60% ye-NSAID Abasebenzisi banokuphuhlisa iziphumo zecala lokugaya.
I-NSAID zidibaniswe nomngcipheko okhulayo wokufa kwesifo senhliziyo okanye ukubetha. Ezi ziyobisi zingakhokelela kwiingxaki zesibindi okanye zeengtso, ngokunjalo.
Ukuthatha i-NSAID ezimbini kunye kuyingozi-uphando olwenziwa ngo-2004 olupapashwe kwi-European Journal ye-Clinical Pharmacology lubonise ukuba longeze umngcipheko wokulimala kwesibindi okanye ukungaphumeleli kweengtso ngama-500-600 kwipesenti ngokusetyenziswa kwe-NSAID enye.
Ukusetyenziswa kwexesha elide, njengokuba ungalindela ngesimo esingapheliyo, kunokunyusa le mngcipheko.
Ezinye zeengxaki ezivela kwi-NSAID zisenokubangelwa ziziganeko zabantu kwii-OTC iziyobisi. Basenokucinga ukuba ababalulekanga okanye abanobungozi kwaye ke bangabonakali ukuba basebenzise ugqirha okanye othemistiki. Kubalulekile ukuba abaqeqeshi bezempilo bazi yonke into oyithathayo, kuquka ne-OTC iziyobisi kunye nezongezelelo zokutya, ngoko banokukunceda ukuba ugweme iingxaki ezinzulu.
I-NSAID Effects Side & Interactions
Ukongeza kwiingozi ezi ngasentla, ii-NSAID zingabangela iziphumo ezininzi zecala. Ezizona ziqhelekileyo zi:
- I sizathu
- Ukuvutha
- Uhudo
- Ukutyunjwa
- Ukunciphisa ukutya
- Rash
- Utywala
- Intloko
- Ukulala
Ezinye zeziphumo zempembelelo (ingxaki yokugaya, ukungcola, intloko, ukulala) ziyimpawu eziqhelekileyo ze-FMS kunye ne-ME / CFS. Xa uqala ukuthatha iNSAID entsha, kubalulekile ukuba uqaphele nayiphi na inguqu kwiimpawu ezingenzeka ngenxa yonyango.
Ii-NSAID zinokusebenzisana kakubi kunye nezinye iziyobisi, ngoko qi niseka ukuba uthethe ugqirha wakho kunye nekhemisti malunga nawo onke amayeza akho.
Ngenxa yokuba i-NSAID iyanciphisa amandla okugawula igazi lakho, kunokuba yingozi ukudibanisa kunye nama-antiticoagulants (abagcini begazi) njenge-Coumadin (warfarin).
Ukuba unyango lwe- hypertension (uxinzelelo lwegazi oluphezulu), kufuneka ukwazi ukuba ii-NSAID zingenza iyeza lakho lingasebenzi kakuhle.
Ukunciphisa Ingozi Yakho
Ngokutsho kwe-FDA, ukukhusela impilo yakho kufuneka usebenzise i-NSAID kuphela njengoko imiselweyo, kwisebe eliphantsi kakhulu, kunye nexesha elifutshane njengokuba unakho.
Xa intlungu yakho ingapheliyo, loo ndululo yokugqibela inzima ukuyenza. Qinisekisa ukubika nayiphi na ukwanda kwimiphumo emibi kumgqirha wakho. Ugqirha wakho angathanda ukubeka uphawu lwamagqabantshi enyama yesibindi ukuba uthatha ii-NSAID ixesha elide.
Ukubhema ugwayi kunye nokusela utywala kunokunyusa umngcipheko wezilonda ezinxulumene ne-NSAID okanye iingxaki eziphazamisayo, zombini ezo zinto zingabangela isiteleka ngaphandle kokulumkisa kwaye kunokukubulala. Qiniseka ukuba ugqirha uyazi malunga nokutshaya nokusetyenziswa kotywala.
ILizwi
Wena kunye nogqirha wakho kufuneka unqume kunye nokuba ii-NSAID zifanelekile, ngokusekelwe kukuxilonga kwakho, iimpawu, jikelele kwimpilo kunye neendlela zokuphila. Kubalulekile ukuba uqaphele ukuba enye i-NSAID inokusebenza kangcono kunabanye, ngoko kungathatha ukuhlolwa ngamachiza ahlukeneyo ukuphumeza iziphumo ezilungileyo.
Ukuba ungaziva i-NSAID iphumelela ekunciphiseni intlungu yakho, xela ugqirha malunga neendlela ezinokwenzeka kwaye ulinganise umngcipheko malunga nezibonelelo.
Imithombo:
Carruthers BM, kunye. al. Umbhalo weyeza lwangaphakathi. 2011 Oct; 270 (4): 327-38. i-doi: 10.1111 / j.1365-2796.2011.02428.x. I-Myalgic encephalomyelitis: Iingqinisiso zamazwe ngamazwe.
Clinard F, kunye. al. Umbhalo waseYurophu we-pharmacology yeklinikhi. 2004 Juni; 60 (4): 279-83. Umbutho phakathi kokusetyenziswa kweendlela ezininzi ze-NSAID kunye neengozi eyingozi yokuphendula iziyobisi. Icala / engekho ityala lokufunda kwisiFundo seFrancis Pharmacovigilance system.
Kovac SH, kunye. al. Arthritis kunye ne-rheumatism. 2008 Feb 15; 59 (2): 227-33. Umbutho wekhwalithi yempilo enxulumene nempilo kunye nokusetyenziswa kabini kwemithi kunye ne-over-counter-anti-anti-inflammatory drugs.
Liptan GL. Umbhalo wemizimba kunye nokunyanga kweendlela. NgoJan 2010; 14 (1): 3-12. UFascia: ikhonkco elahlekileyo ekuqondeni kwethu kwi-pathology ye-fibromyalgia.
Wolfe F, et al. Umbhalo waseYurophu weentlungu. 2013 Ngo-Apr; 17 (4): 581-6. Iipatheni ezide ze-analgesic kunye neziphambili zokusetyenziswa kweziyobisi kunye nokusebenza okuhambelanayo kwi-fibromyalgia.