Iyini indima yayo?
Ukuvuvukala kwesinye sezizathu eziqhelekileyo zentlungu, kodwa ngaba kudibene nentlungu ye- fibromyalgia ?
Indima yokuvuvukala kule mqathango ibe yintloko yophando kunye neengxoxo iminyaka emininzi. Enyanisweni, imeko ebizwa ngokuba yi "fibrositis," oku kuthetha "ukuvuvukala kwezicubu." Ngexesha, nangona kunjalo, ukungabikho kokuvuvukala kubangela ukuba uluntu lwentlalo lubone i-fibromyalgia ("i-fibrous-tissue and muscle pain") njengexesha elichanekileyo.
Emashumi ambalwa emva kamva, nangona kunjalo, sithatha ukubheka okwesibini ukuvuvukala kule meko, ngenxa yomsebenzi okhulayo womsebenzi ucetyiswa ukuba unokudlala indima, emva kwayo yonke into. Lo mgca wophando ungakhokelela ekuqondeni kangcono ukugula kunye nokhetho olunonyango lwezokwelapha.
Kutheni Kudideka?
Oogqirha bekholelwa ukuba i-fibromyalgia yayingesi sifo sokuvuvukala ngenxa yokuba singabonakali njengezifo ezininzi ezivuthayo. Iimbumbano azibonakali zivuvukile okanye zishushu. Uvavanyo oluqhelekileyo lokumakisha okuvuthayo, olubonakalisa amanqanaba aphezulu kwizifo ezifana ne- lupus kunye ne- arthritis , ngokuqhelekileyo ibonakalisa amanqanaba aqhelekileyo okanye aphakanyisiweyo kuphela kwi-fibromyalgia. Ngo-2012, abaphandi bafunda i-myopathies ephazamisayo (iimeko zentlungu) ebizwa ngokuba yi-fibromyalgia "imopathy yamanga."
Ukongezelela, izidakamizwa ezichasayo-zombini i-corticosteroids kunye ne- non-steroidal anti-inflammories (ii-NSAID) -zihlala zingasebenzi ekunciphiseni ubuhlungu be-fibromyalgia .
Ngoko ivelaphi imeko yokuvuvukala?
I-Case for Inflammation
Kwiminyaka yakutshanje, abaphandi baye bafunda okuninzi malunga nenxaxheba yokuvuvukala kwimeko.
Ngentwasahlobo ka-2017, i- Journal of Pain Research yashicilele isifundo esakhangela kwiiprotheni eziyi-92 ezahlukileyo ezaziwa ukuba zihlobene nokuqhaqha.
Abaphandi bathi "yinkalo enkulu kakhulu yokufunda iprofilenti yezigulane ze-FM ukuya kutsho." Baxele ubungqina obunzulu bokuvuvukala. Akunjalo kuphela, kodwa ubungqina bubonisa ukuvuvukala kwinkqubo yesistim ephakathi (ubuchopho kunye neentsholongwane zentambo yomgogodla) kunye ne-systemic.
Lo msebenzi uqinisekisile uphando olwangaphambili olubonisa ukuba ezinye iamolekyu ezivela kumzimba wokuzivikela, ezibizwa ngokuthi i- cytokines , ziphezulu kubantu abane-fibromyalgia. Exhasa uxolo lokuba le meko ibandakanya ukuxilongwa kwe-immune dysregulation.
Inkqubo yesiseko yomnyoba ine-immune system, ihluke kuwo wonke umzimba, kwaye uphando lubonisa amanqanaba aphakamileyo ama-molecular immune abizwa ngokuthi yi-chemokines, ngokunjalo.
Ucwaningo olwenziwa ngo-2010 ngu-Genevra Liptan, MD, lubonisa ukuba lube yintlawu-yincinci engqameneyo yeethambo ezixhamlayo kwiinkalo zangaphakathi-ezivuthayo kwi-fibromyalgia. Umphandi ugqiba ukuba ukungabikho komsebenzi kunye nokuvuvukala kunokuthi kukukhokelela ekumvezweni okuphakathi , okukholelwa ukuba yinto ebalulekileyo yokugula.
Ukwaziswa okusemgangathweni kwenzeka xa inkqubo yentsholongwane ephakathi iqhutyiswa ngamandla kwaye iphendulela phezulu kwi-input, kubandakanywa intlungu kunye nezinye izinto ezifunyenwe zizifo zakho, njengokukhanya , isandi kunye nezivumba .
Kukholelwa ukuba ubuncinci kubangelwe zizibonakaliso zentlungu eqhubekayo ebhobhoza ingqondo kunye nentambo yomthambo.
Uphononongo olwenziwa ngo-2012 kwi- Neuroimmunomodulation luphande indima yenkqubo enokutsha kunye nokunyanzeliswa kwe-fibromyalgia. Abaphandi bafumanisa ukuba kwakukho isimo esivuthayo esabonakala sibophelelwe kwisigqibo esingavumelekanga sokunyamezela. Akwazanga ukufumanisa ukuba ukuvuvukala kwakhokelela ekubandezelekeni kokunyanzeliswa okanye ngokuphambene.
Ngo-2013, abaphandi baseSpeyin baholwa ngu-MD Cordero bapapasha iingcamango zokuthi ukuvutha kwi-fibromyalgia kunokubangelwa ukungasebenzi kwi-mitochondria (iinxalenye zeeseli zakho ezidiliza izondlo ukuze zenze amandla.) Olunye uphando luka-2010 oluvela eSpain, olupapashwe kwi- Clinical Rheumatology , wabonisa amanqanaba aphakamileyo eeseli-mast-ezikhupha iikhemikhali ezivuthayo ekuphenduleni izinto ezahlukahlukeneyo-elukhumbeni lwabantu abane-fibromyalgia.
Ukuphatha ukuvuvukala kwi-Fibromyalgia
Ekubeni iipilisi eziphambili ze-inflammation-steroids kunye nee-NSAID-sele zibonakaliswe zingenakusebenza ngokumelene nentlungu ye-fibromyalgia, yiyiphi indlela esinokuyenza ngayo ukunciphisa ukuthukuthela kwethu, sinethemba lokuba ngenxa yoko, intlungu yethu?
Ucwaningo lwango-2017 lucebise ukuba isilwanyana esibizwa ngokuba yi -do-ne-naltrexone (LDN) encinci sinokukunceda ukunciphisa amanqaku atshabisayo abonakalayo ekuncedeni ukunciphisa intlungu nezinye iimpawu.
Ucwaningo luka-2010 lukaLindtan ngokuvuvukala okuthabathayo lubonisa ukuba iindlela zokwenza izinto ezijoliswe kwi-fascia zingasebenza. Oku kuquka ukukhutshwa kwe-myofascial ( uhlobo lokusilalisa ) kunye nokuxhaphaza kwimizimba ebizwa ngokuba yiRolfing. Nangona kunjalo, kude kube ngoku, uphando malunga nalezi zonyango luphela. Kwakhona, kuxhomekeka kwiimpawu, abanye abantu abaneli meko abanako ukunyamezela iintlobo ezithile zokuhlalisa.
Uphando olwenziwa ngo-2012 olupapashwe eScandinavia lubonisa ukuba ukuzivocavoca kwamanzi kungaphucula ukulinganisela kwe-cytokine kwi-fibromyalgia, kwaye ngoko ke amanqanaba okuthukuthela aphantsi kunye nentlungu. (Ngaphambi kokuba uqale nawuphi na uhlobo lomzimba, kubalulekile ukufunda ngeendlela ezifanelekileyo zokusebenzisa i-fibromyalgia .)
Abanye abantu abane-fibromyalgia bathi banenhlanhla kunye neengongezelo ezikholelwa ukutshaya. Izongezo ezichasayo ezibandakanyekayo zibandakanya:
Asinakho uphando malunga nokutya okuchasayo kwintambo ye-fibromyalgia, kodwa oogqirha abaninzi bayincoma ukuba kubekho izimo ezivuthayo. Ngenxa yokuba kungekhona abantu abavuthayo abavuthayo, abantu baqala ngokutya ngokukhawuleza, bese bongeza kwakhona uhlobo lokutya ngexesha elinye ukufumana ukuba zeziphi ukutya eziyingxaki.
ILizwi
Njengoko sifunda ngakumbi malunga nendima yokuvuvukala kwi-fibromyalgia, sinokufumanisa iithagethi ezitsha zamachiza kunye nezinye iindlela zokwenza unyango, kwaye oko kunokukhokelela kwiindlela ezingcono zonyango phantsi kwendlela.
Asazi ukuba lukhulu kangakanani indima yokuvuvukala, kodwa nokuba yintoni imbangela okanye umphumo wale meko. Le mibuzo ingaphendulwa njengoko le migqa yophando iyaqhubeka iphandwa.
Imithombo :,
U-Backryd E, uTanum L, uLind AL, uLarsson A, uGordh T.. > 2017 uMar 3; 10: 515-525. i-doi: 10.2147 / JPR.S128508. Ububungqina bobubini bokuvuvukala kunye ne-neuroinflammation kwizigulane ze-fibromyalgia, njengoko zihlolwe yipaneli yamaprotheni ye-multiplex esetyenziswa kwi-cerebrospinal fluid kunye ne-plasma.
Blanco I, et al. Rheumatology yezonyango. 2010 Dec; 29 (12): 1403-12. Ukugqithisa ngokwemvelo kwama-mastocytes e-skin biopsies zezigulane ze-fibromyalgia.
Bote ME, et al. Neuroimmunomodulation. 2012; 19 (6): 343-51. Ingxelo yokunyanzelisa / ukunyanzelisa ingxaki yokudityaniswa kwabasetyhini abane-fibromyalgia.
> Cordero MD, et al. I-Antioxidants & redox ukusayina. 2013 kuMar 1; 18 (7): 800-7. Ngaba ukuvuvukala kwesigxina se-mitochondrial esixhomekeke kwi-fibromyalgia?
> Liptan, GL. Umbhalo wemizimba kunye nokunyanga kweendlela. NgoJan 2010; 14 (1): 3-12. UFascia: Ikhonkco elahlekileyo ekuqondeni kwe-pathology ye-fibromyalgia.