Oko Uphando lubonisa
I-marijuana yonyango iyinkxalabo-entlalweni, ngokusemthethweni, nakwezopolitiko. Nangona kunjalo, ubungqina bobunzululwazi buyaqhubeka bubonisa ukuba kungaba yinkqubo ekhuselekileyo neyinkqubo yeemeko ezininzi zeentlungu, kuquka i- fibromyalgia .
Sinezinye iinguqu ze-tetrahydrocannabinol (THC) kwimarike, leyo yinto enxulumene ne "phezulu" yentsangu.
Iingcaphephe zibonisa ukuba ezinye iifomthi kwisityalo zinokuxabiswa kweempawu zonyango.
Ngaphambi kokuxoxa ngemiphumo ethile yonyango lwezokwelapha kwi-fibromyalgia, kunceda ukwazi okufutshane malunga nento ebizwa ngokuba yi-endogenous cannabinoid, okanye i-endocannabinoid, inkqubo.
Yintoni i-Endocannabinoid System?
"Endogenous" ibhekisela kwizinto ezivela ngaphakathi emzimbeni wakho-into enokuthi ikhona.
"I-cannabinoid" ivela kwigama elithi cannabis, eliyigama lobuchwepheshe lentsimbi ye-marijuana, kwaye libhekiselele kumalungu omzimba wakho osabela kwi-cannabis. Sonke sinomdla wezinto ezingokwemvelo emzimbeni wethu, kwaye ezininzi zingasungulwa ngokutshaya okanye ukungena kwegunju okanye iinguqulelo zokwenziwa kwazo.
Inkqubo ye-endocannabinoid ibandakanyeke kwiinkqubo ezininzi, ezininzi zazo ezaziwa okanye ezichazwayo ukuba ziphosakele kwi-fibromyalgia. Ezi ziquka:
- Amandla e-metabolism
- Umsebenzi wokukhusela umzimba
- Imemori
- Ukucubungula ubuhlungu
- Ukulala
- Impendulo yoxinzelelo
- Ummiselo wokushisa
- Inkqubo ye-nervous system
Iphepha le-2004 malunga neprogram yokugcina i-endocannabinoid ecetywayo ukuba i-fibromyalgia, isifo sengqondo sesifo esilumkileyo, kunye neemeko ezinxulumene nazo ziza kubalwa ngokuthi "i-syndrome ye-endocannabinoid defence syndromes". Kwakhona ikhankanya iingxaki eziphambili zophando malunga nale ngxaki kwi-schizophrenia, i-multiple sclerosis, isifo sikaHuntington, ezinye iziganeko zesifo sika-Parkinson, ezinye iimeko ze-anorexia kunye nokugula okungapheliyo.
Umzimba ophandayo ophando uphakamisa ukuba i-fibromyalgia ingabandakanya ukungaphumeleli kwi-endocannabinoids iphakamisa umbuzo ocacileyo: ukwandisa inani le-cannabinoids emzimbeni kunceda ukuphucula umsebenzi nokunciphisa impawu? Ukuba kunjalo, ziphi iimpawu ezaza kuba unyango lwe-marijuana (okanye ukulinganisa okulinganayo) kunceda ukunciphisa?
Uphando ngeMicuba ne-Fibromyalgia
Ukuhlaziywa kuka-2014 ngophando lwe-marijuana ekuphatheni i-fibromyalgia, kwakunye nezimo ezihambelanayo nezigulane zesifo se-bowel syndrome kunye ne-migraine, cebisa:
- Ukungaphumeleli kwe-Endocannabinoid kudlala indima kule miqathango
- I-Marijuana inokukwazi ukuvimba iindlela zentlungu yomgudu, yendlela kunye neentlungu zesisu
- Amava okliniki axhasa ezi ziphumo
Uphando lubonisa ukuba i-marijuana inokubaluleka kakhulu:
- Ukunciphisa intlungu (kuquka intlungu ye-nociceptive, eyinxalenye ye-fibromyalgia)
- Ukunciphisa ukuqina
- Ukuvuvukala okuphantsi (kubandakanywa nokuvuvukala kwe-myofascial, engadlala indima kwi-fibromyalgia)
- Ukuphucula ukuphumula
- Ukwandisa ukulala
- Ukwandisa iimvakalelo zokuphila
Olunye uphando lwafumanisa ukuba abasebenzisi be-cannabis babenomlinganiselo ophezulu kakhulu wempilo yengqondo kunabasebenzisi. Omnye, ojonge umphumo we-synthetic cannabinoid ebizwa ngokuba yi-nabilone, ubonisa ukuba i-dose ephantsi ebusuku ingaphucula ukulala kwi-fibromyalgia kwaye ingathathwa ngenye indlela kwi-amitriptyline ethandwayo.
Uphononongo luka-2012 lubhekisele ekusebenziseni i-marijuana kwi-fibromyalgia. Abaphandi bafumanisa ukuba malunga neepesenti ezingama-13 abathathi-nxaxheba basebenzisa izidakamizwa ukuze bancede ukukhulula iimpawu zabo. Phakathi kwezi, iipesenti ezingama-80 zazisetyenziswa ngokungekho mthethweni.
Abaphandi bafumanisa ukuba i-marijuana isebenzise kakhulu kwizigulane ze-fibromyalgia ezinokugula okungagungqiyo kwengqondo. Ubudlelwane phakathi kokusetyenziswa kwegciwane kunye nokugula ngengqondo kule qela akungaziwa.
Ukusebenzisa i-Marijuana kwaye kwaxhaphaka phakathi kwamadoda, abathathi-nxaxheba abangaqeshwanga, kunye nabo bafumana iintlawulo zokukhubazeka.
Imiphumela
Ukuhlaziywa kuka-2011 kuchazwe ukuba i-cannabinoids ibonakala ikhuselekile kwaye idibaniswe nemiphumo emibi okanye eyingcipheko eyayivunyelwe ngokuqhelekileyo, kwaye ukuba isantya sokuphuma ngenxa yemiphumo emibi iphantsi.
Iingxelo ezibiweyo zibandakanya:
- Utywala
- I sizathu
- Umlomo omile
- I-Ataxia (ukulawulwa okunciphise ukunyakaza komzimba)
Nangona kunjalo, uphando lwango-2014 lubonisa ukuba sifuna iimfuno zexesha elide ukwenzela ukuba siyazi ukuba iziphumo ezinobungozi ezide kangakanani, kunye neengozi zokusetyenziswa kakubi kunye nokulutha.
Unyango lweMarijuana
Ezinye iintlobo ze-marijuana zithengiswa kwimarike e-US Ezi zi yobisi ziquka:
- Marinol (dronabinol)
- I-Cesamet (nabilone)
I-marijuana yonyango isemthethweni kumazwe athile. Le fom yesilwanyana inokutshaywa, idliwe (njengempahla ebhaka), okanye iphefumlelwe. Ukutya okanye iifom zenziwe zikhuselekileyo kwaye zilula kuba abanye abantu bazinyamezela.
Ngenxa yokufikeleleka kwayo njengesidakamizwa sokuzonwabisa, abanye abantu bakhetha ukuziphatha ngokugqithisileyo ngamanambu. Oku kuza nemingcipheko yaso, kubandakanywa:
- Ukubanjwa, ukuhlawuliswa nokugwetywa inkohlakalo
- Ukufumana isambuko ngezinto ezinobungozi ezibandakanya
- Ukufumana imveliso engaphantsi
Abantu abasebenzisa inambuzane ngokungekho mthethweni banganqikaza ukuxelela ababoneleli ngezempilo. Oku kungakhokelela kwiingxaki zokusebenzisana kwezidakamizwa okanye, xa kwenzeka ukuphendula kakubi, kubangelwa oogqirha ukuba bangayiqondi kakuhle loo mbandela. Ukuze ukhuseleko lwakho, kufuneka uhlale uzisa ugqirha wakho kunye nekhemistiki malunga nazo zonke iziyobisi ozithathayo.
Ezinye iziNyango zeNkqubo ze-Endocannabinoid
Uphando lubonisa ukuba ezinye iziyobisi, zombini umyalelo kunye ne-over-counter-counter, zichaphazela inkqubo ye-endocannabinoid. Ezi ziquka:
- Ama-Painkillers (i- acetaminophen , i- NSAID , i- opioids , i-glucocorticoids)
- I-anti-depressants ( amitriptyline , duloxetine )
- Antipsychotics
- Ukuxhalabisa iziyobisi
- Iziyobisi zokulwa ne-anti-seizure ( pregabalin , gabapentin)
Ionyango ezingekho phantsi kweziyobisi ezingaphumelela zibandakanya:
- Ukuhlawula
- Ukuphathwa kwamanzi
- Ukwenza i-Acupuncture
- Izibonelelo
- Amayeza emfuyo
Izinto zokuphila eziquka ukutya kunye nokuzilolonga kungakhokelela ekutshintsheni kwindlela yokugcina i-endocannabinoid. Njengalo naluphina unyango okanye indlela yokulawula, kufuneka uxoxe nodokotela wakho malunga nezinto ezikhethileyo.
Imithombo:
Benyamina A, Reynaud M. La revue du practitioner. 2014 Feb; 64 (2): 165-8. (IsiGaba esiFulentshi. Okubhaliweyo okubhekiselelwe kuyo.) Ukusetyenziswa kwezilwanyana ezivela kwi-cannabis derivatives.
Fiz J, et al. PLoS One. 2011 uMatshi 21; 6 (4): e18440. I-Cannabis isebenzisa kwizigulane ezine-fibromyalgia: umphumo kwiimpawu zokhuseleko kunye nomgangatho ofanelekileyo wezempilo.
ULynch ME, uCampbell F. iBritish Journal ye-pharmacology yeklinikhi. 2011 Nov; 72 (5): 735-44. Iingenabinoids zokunyanga iintlungu ezingapheli komhlaza; ukuphononongwa ngokuchanekileyo kwezilingo ezingenamsebenzi.
McPartland JM. Umbhalo wemizimba kunye nokunyanga kweendlela. 2008 Ngo-Apr; 12 (2): 169-82. Inkcazo ye-endocannabinoid system kwi-fibroblasts kunye nama-myofascial tissues.
McPartland JM, Guy GW, Di Marzo V. PLoS One. 2014 Mar 12; 9 (3): e89566. Ukunyamekela nokutya kwenkqubo ye-endocannabinoid: ukuhlaziywa ngokuchanekileyo kwamanyathelo angenelelo lwekliniki ezilawula inkqubo yokugcina i-endocannabinoid.
Russo EB. Iileta ze-endocrinology ze-Neuro. 2004 Feb-Apr, 25 (1-2): 31-9. Ulwaphulo lwe-endocannabinoid (Clinical deficiency) (i-CECD): Ingaba le ngcamango ingachaza iingenelo zokuthintela i-cannabis kwi-migraine, i-fibromyalgia, i-syndrome kunye nesinye isimo esinganyangekiyo?
USmith SC, Wagner MS. Iileta ze-endocrinology ze-Neuor. 2014; 35 (3): 198-201. Ulwaphulo lwe-endocannabinoid (Clinic deficiency) (i-CEC D) kwakhona kwakhona: ingaba le ngcamango ichaza iingenelo zonyango ze-cannab ku-migraine, i-fibromyalgia, i-syndrome kunye nezinye izimo ezinganyangekiyo?
Ste-Marie PA, et al. Unonophelo lwe-Arthritis kunye nophando. Ngo-Agasti ka-2012; 64 (8): 1202-8. Umbutho we-herbal cannabis usetyenziso lweengxaki zeengqondo kunye nezigulane ze-fibromyalgia.
Ware MA, et al. Anesthesia kunye ne-analgesia. 2010 Feb 1; 110 (2): 604-10. Imiphumo ye-nabilone elele kwi-fibromyalgia: iziphumo zolu vavanyo olulawulwe ngokungenamthetho.