Ukuphulukiswa kweZonyango eziPhakamisayo kubonisa isithembiso
Sibanzi
I-Naltrexone yiyilisi ebonisa ukuba, kwi-dose eqhelekileyo ye-50 ukuya ku-100 mg, ibimbela iziphumo ze-opioids. Kwimeko ephantsi kakhulu, abanye abaphandi bakholelwa ukuba isixhobo esinokuthi sincede abantu abane- fibromyalgia nesifo esingapheliyo ; Izifo ezivuthayo / izibilini ezibandakanya i-sclerosis ezininzi, isifo esiyinkimbinkimbi yesifo seengingqi kunye nesifo sikaCrohn; kunye nezinye izifo ezinxulumene nomzimba, njenge- HIV / AIDS .
I-dose e-low-naltrexone (i-LDN) isisiza esingabizi kakhulu esele sithengisa imarike, esiye savuyisa ngokusetyenziswa kwayo. Uphando luhamba ngokukhawuleza, nangona kunjalo, mhlawumbi kuba akukho mxhaso omkhulu wezezimali.
I-LDN isebenza njani?
Abaphandi abayiqondi ngokucacileyo indlela yokusebenza yonyango. Abanye abaphandi bathi i-LDN ivimbela i-receptors ethile kwi-system ye-nerror eyenza iimpawu ze-fibromyalgia kunye nesifo esingapheliyo.
Olunye u bungqina lubonisa ukuba i-LDN isebenza njenge-anti-inflammatory kwiinkqubo eziphakathi kunye neendlela zephersi, mhlawumbi ngokunciphisa umsebenzi weeseli ezikhethekileyo ezibizwa ngokuba yi-microglia.
Uphando lukwabonisa ukuba i-LDN inokukunceda ukusetyenzisa ukukhusela isimiso somzimba, oko kukuthi kutheni kubonakala ngathi kubancedisa abantu abanokuzimela kunye nezinye izifo zokhuseleko lwe-immune.
Funda kabanzi malunga nokuvuvukala kunye nokuzimela komzimba kwi-fibromyalgia kunye nesifo esingapheliyo:
KwiFibromyalgia
Uchungechunge lweeSunivesithi zaseStanford luye lwabonisa iziphumo ezintle-ngokumalunga neepesenti ezingama-30 zokuhla kweempawu ezifaniswa ne-placebo. Abaphandi bathi iziphumo zihle kakhulu kubantu abanamaxabiso aphezulu, okubonisa ukuphendula okuvuthayo emzimbeni.
(Izinga eliphezulu liyakubonisa imeko ejongene nayo njengoko ingaqhelekanga kwi-fibromyalgia.)
Iziphumo zibonisa ukuba izidakamizwa ziyakunyamezela.
Nangona kunjalo, ezi zifundo ziye zincinci kwaye kufuneka kwenziwe umsebenzi omningi ngaphambi kokuba siyazi ukuba i-LDN ikhuselekile kwaye isebenzayo kule meko.
I-LDN ayiyi-FDA evunyelwe i-fibromyalgia kodwa ngamanye amaxesha ibhalwe ngaphandle-ilebula.
Isifo Sokunyamekela Sokugula
Kuze kube ngoku, i-LDN ayizange ifundwe ngokugula okungapheliyo. Nangona kunjalo, oogqirha kunye nezigulane bathi zisebenzise ngempumelelo.
Ngobungqina bwakutshanje obonisa ukuba unobungozi obungapheliyo kwi-syndrome engapheliyo kunye nefuthe le-LDN enokubakho ukuvuvukala kwinkqubo yeentlanzi, sinokubona ukuba kutheni le yonyango olululo kwabanye.
Njengoko i-fibromyalgia, i-LDN ngamanye amaxesha ibhalwe ngaphandle-ilebula yokugula okungapheliyo.
Isistim
Ukusetyenziswa ekuphatheni i-fibromyalgia okanye i-chronic fatigue syndrome, i-naltrexone ngokuqhelekileyo inikwe ama-4.5 mg okanye ngaphantsi. Ngokuqhelekileyo, uza kuqala kwi-1.5 mg, usebenze ufike ku-3 mg, uze ukwandise ukuya kwi-4.5.
Imiphumo ebanjwe kule doji ephantsi ayibonakali kwizinga eliphezulu.
Imiphumela
Ngelixa i-LDN ibonakala iyanyamezelwa kakuhle, iziphumo ezimbi eziziwayo ze-naltrexone ziquka:
- utywala kunye ne syncope (ukuphelelwa amandla)
- intloko
- kulala
- ukuxhalaba nokukhathazeka
- ukulala nokukhathala
- isicathulo, ukuhlanza, isifo sohudo, isisu esiswini / ukutyumla, ukunciphisa ukutya
- intlungu yejoza kunye nokuvuvukala
- intlungu
- ukugqithwa kwemisipha ngokugqithiseleyo
- isifo sokuphefumula esiphezulu
- umqala obuhkungu
Kwizifundo zaseStanford, iziphumo zecala zachazwa njengezinto ezinqabileyo, ezinobunzima, kunye nexesha elide.
Abantu abaneentsholongwane okanye isifo sesibindi bangadinga iimvavanyo ezizodwa okanye ama-dosage ukuze bathathe ngokukhuselekileyo i-LDN. Esi sidakamizwa sinokuba yingozi kumntwana ongakazalwa. Asisazi ukuba ingaba liwela ubisi lwebele.
I-LDN ne-Opioid Painkillers
Kwimilinganiselo emikhulu, i-naltrexone isetyenziselwa ukunqanda abantu abane- opiate (i-narcotic) i-painkillers efana ne- Vicodin (i-hydrocodone acetaminophen) kunye ne- OxyContin (oxycodone) kuba ikhupha impembelelo yabo kwingqondo.
Isiphumo ekusebenziseni i-opiate kumaxabiso aphantsi awaziwa okwamanje, kodwa kuthathwa njengengcamango embi yokudibanisa nala mayeza. Qiniseka ukuba uthethe ugqirha wakho malunga nokuba ungakanani ixesha elide ufanele uchithe kwi-opioids ngaphambi kokuqala i-LDN.
Ngaba Kukulungele?
Ukuba unomdla ekuzameni i-LDN, xela ugqirha wakho malunga neenzuzo kunye neengxaki. Ngelixa abanye oogqirha banika i-LDN kubantu abanezifo kunye nabanye abaninzi, kusenokuba kuthathwa njengonyango olusakhulayo, ngoko ugqirha wakho akanako ukungaqwalasela.
Imithombo:
Ablin JN, uBuskila D. Iingcamango zengcali kumayeza asakhulayo. 2010 Sep; 15 (3): 521-33. Iimpawu zokwelapha ze-fibromyalgia: ukuhlaziywa.
Plesner KB, Vaegter HB, Handberg G. Ugeskrift yeelaeger. 2015 Oct 9; 177 (43): V03150248. Umthamo ophantsi we-naltrexone unyango lweentlungu. [Okubhaliweyo okubhekiselelwe kuyo. Isiqendu kwisiDanish.]
Incinci J, iMackey S. Imithi yezobuhlungu. 2009 Meyi-Juni; 10 (4): 663-72. "Izimpawu ze-Fibromyalgia ziyancitshiswa yi-Low-Dose Naltrexone: Isifundo soPhando."
Omncinane J, et al. Arthritis kunye ne-rheumatism. 2013 Feb; 65 (2): 529-38. I-do-dose ne-naltrexone yonyango yokunyanga kwe-fibromyalgia: ukufunyaniswa kwincinci encinci, engabonakaliyo, ephindwe kabini, engabonakaliyo, e-controls, e-counterboards, e-counterbodies, ekulinganisweni kwamanqanaba eentsuku zonke.
Omncinane J, uParkitny L, McLain D. I-rheumatology yezonyango. 2014 kuMatshi; 33 (4): 451-9. Ukusetyenziswa kwe-do-ne-naltrexone ephantsi (LDN) njenge-anti-inflammatory treatment for inferior pain.