I-Metformin yisisisi esisoloko sichazwe , ngaphandle kwelebula, ekwenzeni unyango lwe-PCOS kunye nokulawula i-ovulation. Ikwaseklasini yezidakamizwa eziphucula impendulo yeseli kwi-insulin kwaye ilawula iswekile yegazi . Umyalelo wokubhaliweyo weleyile uthetha ukuba i-FDA ayizange ivume ukusetyenziswa kweziyobisi ngokukodwa kuloo mqathango. Kule meko, i-metformin ivunyelwe ukunyangwa kwesifo sikashukela kodwa kungekhona i-PCOS ngokukodwa.
Indlela iMetformin isebenza ngayo
Ngenxa yokuba abaninzi abafazi abane-PCOS banokuxhatshazwa kwe- insulin kunye nesifo sikashukela, kukholelwa ukuba ukuphathwa kwe-insulin ukungasebenzi kunokuthi kube nomthelela kwezinye izitenxo ze-hormone ezihambelana nale meko. Nangona abaphandi bengenakuqinisekiswa kwindlela echanekileyo, kukho ubungqina bokuba uphakamisa le ngqungquthela: ezinye iingcaphephe zibonise ukuba abafazi abathatha inhlanganisela ye-metformin kunye ne-clomid (isicatshulwa esisetyenziselwa ukunyusa ama-ovatory women) Impendulo engcono kwiimpawu zonyango kunezo zithatha i-clomid yedwa. Abanye abafazi abane-PCOS, ingakumbi abo abanesifo se-insulin, banokubona ixesha eliqhelekileyo lokuthatha i-metformin ngokunjalo.
Isilinganisi seMetformin
Imilinganiselo ephakathi kwe-1,500 mg ukuya kwi-2,000 mg yemihla ngemihla iyafana, ngokuxhomekeka kwindlela yokunyamezela kwe-insulin yowesifazane kunye nemingcipheko yeziphumo ezibi. Abafazi abaninzi bathabatha i- metformin ingxelo ingxelo yokuba isisu sithukuthele, isisongulu kunye nesifo sohudo-ngokukodwa ngamanani aphezulu.
Ugqirha unokuncoma ukwandisa i-dosage yakho ngokukhawuleza uze ufike kumlinganiselo obekiweyo ukwenzela ukwandisa ukunyamezela kwakho kwilisi. Abanye oogqirha baya kuncoma ifom yokukhululwa , oku kuthetha ukuba inani elincinci leyeza likhutshwe yonke imini, endaweni yazo yonke kanye kanye njengenxeba elikhutshwa rhoqo.
Kubalulekile ukuthatha imithi yakho njengoko imiselweyo kwaye ugqirha ugqirha wakho ukuba uyafumana nayiphi na imiphumo emibi .
I-Metformin kunye nokuLawula kwangaphambili
Ukongezelela ubunzima bokukhulelwa, abafazi abane-PCOS basengozini yokukhulelwa. Oku kungenxa yokungalingani kwamahomoni kunye namazinga aphezulu e- insulin. Izifundo eziliqela zibonise izinga eliphantsi kakhulu lokukhulelwa kwelabasetyhini kunye ne-PCOS ethatha i-metformin xa kuthelekiswa nabasetyhini abangathathi i-metformin.
I-Metformin neSifo soSwesigqirha
Ngelishwa, abafazi abane-PCOS basengozini enkulu yokuphuhlisa isifo sikashukela (isifo sikashukela ngokukhulelwa). Uphando luxhasa ukusetyenziswa kwe-metformin ekunciphiseni umngcipheko wesifo sikashukela kwi-women's PCOS.
Ukhuseleko lweMetformin ekukhulelweni kokuqala
Ukwazi ukuba inkunkuma inokukunceda ekukhuseleni ukukhulelwa, umbuzo olandelayo udla ngokukhuseleko. Ezi zifundo zikhuthazayo: ngoku, i-metformin ayizange ixhunywe nakweyiphi na impazamo enkulu yokuzalwa okanye intsholongwane yesisu xa ithathwa ngexesha le-trimester yokuqala. Ngokutsho kwiphando elipapashwe kwi- Human Reproduction , iintsana ezizalelwe oomama ezithatha i-metformin azibonisi ukungafani nokukhula kobudala, ubude, ukukhula, okanye ukuphuhliswa kwezentlalo ngexesha leenyanga ezili-18 zokuphila xa kuthelekiswa nabantwana base-US abaqhelekileyo.
Ukuba uceba ukukhulelwa ngelixa uthabatha i-metformin, qiniseka ukuthetha nodokotela wakho ngaphambili malunga noko afuna ukuba ukwenze xa ufumana uvavanyo lokukhulelwa olufanelekileyo. Nangona i-metformin yinto yesigqirha seB, oku kuthetha ukuba ikhuselekile ngokukhulelwa, kukulungele ukuthetha nodokotela wakho kwaye ulandele imiyalelo yakhe. Gcinani engqondweni, bonke ugqirha bahluke, kwaye banecebo labo kwizinto ezilungele wena nomntwana wakho.
Imithombo:
> Begum MR, > Khanam > NN, Quadir E, et al. Ukuthintela isifo sikashukela sesifo sikashukela ngokuqhubela phambili unyango lwe-metformin ekukhulelweni kwabasetyhini abane-polycystic ovary syndrome. I-Journal Obstet Gynaecol Res. 2009; 35 (2): 282-286.
> I-Glueck CJ, i-Goldenberg N, i-Pranikoff J, i-Loftspring M, i-Sieve L, i-Wang P. Ukuphakama, ubunzima kunye nokuphuhliswa kwentlalo-ntlalo kwiinyanga ezili-18 zokuqala zokuphila kubantwana abangama-126 abazalelwa koomama abangama-109 abane-polycystic ovary syndrome I-metformin eqhubekayo ngokukhulelwa. Uluntu > ukuhlawula >. 2004; 19 (6): 1323-1330.
> Khattab S, Mohsen IA, Aboul Foutouh I, et al. Ngaba i-metformin ingakwazi ukunciphisa i-index glycemic diet in pregnancy ukukhusela i-macrosomia (i-ROLO study): > randomized > control control. BMJ. 2012; 345: e5605.
> Kinnunen TI, uRaitanen J, Aittasalo M, uLooto R. Ukukhusela ubunzima obukhulu kakhulu bokufumana isisindo > ukufumana-a > ukuhlalutya okwesibini kwilingo elilawulwa ngokungahleliwe. I-Euro Clinical Nutriti. 2012; 66 (12): 1344-1350.
> Kumar P, Khan K. Imiphumo yokusetyenziswa kwe-metformin kwizigulane ezikhulelwe nge-polycystic ovary syndrome. I-Human Resprod Sciences. 2012; 5 (2): 166-169.
Ukuhlaziywa ngu-Angela Grassi, MS, i-RDN i-PCOS Expert.