I-Estrogen Connection
Ngaba wayesazi ukuba ukuthatha i-migraines kunokunciphisa umngcipheko wakho wokuphucula umdlavuza webele ngexesha elizayo?
Nangona i-migraines kunye nomhlaza wesibele iimeko ezininzi zezokwelapha, kukho enye into ebalulekileyo edibanisa okanye edibanisa nayo-ihomoni yesondo, i-estrogen.
I-Cancer yase-Breast ne-Estrogen
Umdlavuza wesifuba usenzeka xa iiseli zomhlaza eziguqulwayo zikhula zingalawulekiyo, ngokuqhelekileyo kumadada kunye nee-lobules zesisu sebele.
Ukugqithiswa okukhulu kwexesha lokuphila kwi-estrogen kwandisa umngcipheko wesifo somhlaza webele. Ngoko nantoni na eyenza i-estrogen inomzimba inokunyusa umngcipheko wesifo somhlaza webele. Imizekelo yeemeko ezandisa i-estrogen ziquka:
- Inani elide lobomi bexesha lokuya esikhathini (inqanaba ngaphambi kokudala eli-12 ubudala, ukuyeka umva emva kweminyaka yobudala engama-55)
- Ukugqithisa kwe-Postmenopausal, apho i-adipose okanye i-tissue ye-fat eguqulwa ibe yi-estrogen
- IHormone Therapy
Migraines ne-Estrogen
Imvelaphi ye-Migraine iyahluka kubasetyhini ngokusekelwe kwimijikelezo yabo yokuya esikhathini, i-state yabo ye-menopausal, nokuba ingaba bayakhulelwa. Olu tshintsho kwi-freraine frequency and gravity lungahambelana namanqanaba e-estrogen eguqukayo.
Ngokomzekelo, i-migraine imvamisa ikhula ngokukhawuleza ngaphambi okanye ngexesha lokuhamba kwesini ( ukuhamba kwelanga ), xa amanqanaba e-estrogen eyancipha. Ngakolunye uhlangothi, amaninzi amabhinqa anamava okuphucula ama-migraines ngexesha lesibini leesithathu zokukhulelwa, i-estrogen ephezulu.
I-Migraines kunye neCanscer Breast: Uxhumano oluxhatshazayo
Bobabini imigraines kunye nomhlaza wesifuba yi-estrogen edibeneyo, ngoko kuya kuba noqhagamshelwano phakathi kwe-migraine kunye nomngcipheko ophantsi wokuvelisa umdlavuza webele. Enye yezifundo zokuqala ukuhlolisisa olu lwalamano lwalukho kwiCarcer Epidemiology, i-Biomarkers kunye noKhusela.
Olu pho nonongo lufumene ukuba abafazi abane-migraines abazichazayo ngokwabo babenomngcipheko we-33 wokunciphisa umngcipheko wokuvelisa i- hormone-receptor engenazo i-ductal ne-lobular carcinoma kwi-postmenopausal. Noko ke, isifundo asizange sigcine ukusetyenziswa kwe- NSAID , iklasi eqhelekileyo yeyeza elisebenzisayo ukuphatha imigraines-kunye nezifundo eziliqela zicebise ukuba ukusetyenziswa kwe-NSAID kunokwakheka komngcipheko webele webele.
Olunye uphando kwi- Journal of Clinical Oncology lwafumanisa ukuba abafazi be-postmenopausal abane-migraines abazichazelayo babenomngcipheko omncinci womhlaza webele. Olu pho nonongo lufumene umngcipheko we-17 weengcipheko zokuhlakulela umdlavuza we-hormone-receptor. Ukongezelela, lo mngcipheko owenciphekileyo wawuzimeleyo ngokusetyenziswa kwe-NSAID, kunye nokusetyenziswa kotywala kunye ne-caffeine, ezibini ezibangela ukuguquka kwe-migraine .
Ngo-2014, esinye isifundo kwiCcercer Causes and Control sihlolisise iimeko ezingaphezu kwe-700 zesifo somhlaza webele. Abaphandi bafumanisa ukuba xa kuthelekiswa nabasetyhini abangenayo imbali ye-migraines, abafazi abanembali ebanzi ye-migraines (engaphezu kweminyaka engama-30) banomngcipheko ongaphantsi kwama-60 wokuphucula umdlavuza we-estrogen receptor.
Ukongezelela, abafazi ababenomdla wabo wokuqala ngaphambi kweminyaka engama-20 babenomyinge wengozi wokuphucula umdlavuza webele we-estrogen (both ductal and lobular) xa kuthelekiswa nabangewona imigraineurs (amabhinqa).
Ekugqibeleni, abafazi abane- migraine ne-aura babengenakuncinci (malunga nesithathu) ukuhlakulela umdlavuza webele we-estrogen (both ductal and lobular).
Kwi-flip ecaleni kwinqanaba le-2013 kwiCcercer Causes and Control phezu kwama-migraineurs angama-7 angayifumananga naluphi na ulwalamano oluphawulekayo phakathi kwemigraines nomngcipheko wesifo somhlaza.
Ngokuqinisekileyo, zonke ezi zifundo zinokulinganiselwa, kwaye ukuba zikhethwe ngaphandle zingachaza iziphumo zabo ezizodwa. Umfanekiso omkhulu apha kukuba le ngongoma kunye nolwalamano oluthakazelisayo kufuneka luhlolwe ngokusondeleyo.
Ngaphantsi
Khumbula, ikhonkco ibonisa ulwalamano olunokwenzeka okanye umbutho.
Akuthethi ukuba enye imeko yonyango ibangele okanye ikhusele omnye. Izifundo eziqhubekayo eziqhubekayo zifuneka zihlolisise ubudlelwane obuyinkimbinkimbi phakathi komhlaza webele kunye ne-migraines.
Lithetha ntoni Oku?
Qhubeka uhlala usebenza ngokunyamekela kwezempilo. Xoxa ngemingcipheko yakho yomhlaza wesifuba kunye nodokotela wakho. Hlaziya indlela impilo yokuphila, njengokulahleka kwesisindo, inokunciphisa ukuxhatshazwa kwe-migraine ngaphezu kwengozi yomhlaza wesisu.
Imithombo:
I-Dumitrescu R, iCotarla I. Ukuqonda ingozi yomhlaza wesifuba: sihlala kuphi ngo-2005? J Cell Mol Med 2005; 9: 208-21
UHarris RE, uChlebowski RT, uJackson RD, et al. Umhlaza wesifuba kunye nezidakamizwa ezingekho komzimba ezichasayo: iziphumo ezivela kwi-Women's Health Initiative. Cancer Res 2003: 63: 6096-101.
Li CI, Mathes RW, Bluhm EC, Caan B, Cavanagh MF, uClebowski RT. Umlando we-Migraine kunye nomngcipheko webele lomhlaza phakathi kwabafazi be-postmenopausal. J Clin Oncol . 2010 Feb 20; 28 (6): 1005-10.
Mathes RW et al. I-Migraine kubasetyhini be-postmenopausal kunye nomngcipheko wesifo somhlaza webele. I-Cancer Epidemiol Biomarkers Ngaphambili . 2008 17: 3116-3122.
Ubusika ii-AC, i-Rexrode KM, i-Lee IM, i-Buring JE, iTamimi RM, i-Kurth T. Imigraine nomngcipheko wesifo somhlaza wesifuba: umntu oza kuhlola isifundo. Iingxaki Zomdlavuza . 2013 Jan; 24 (1): 81-9.