Utyando lweSymptomatic of Polycystic Ovary Syndrome
I-Polycystic ovary syndrome (i-PCOS) yimeko eyinkimbinkimbi echaphazela malunga neepesenti ezili-10 zabafazi abaneminyaka yobudala yokuzala. Abasetyhini abane-PCOS banokufumana iimpawu ezahlukahlukeneyo ukususela kwiinguqulelo zemoya kunye neemeko zesikhumba (i-acne, ubuninzi beenwele zobuso) kwixesha elingavumelekanga kunye neengxaki zokuzala.
Amachiza asebenzisa i-PCOS enenjongo yokunciphisa iimpawu zesifo.
Ngoxa okwangoku akukho unyango lwe-PCOS, unganciphisa umphumo wesifo ngokugcina indlela yokuphila enempilo nokulawula iimpawu ngokusetyenziswa ngokuchanekileyo kweziyobisi.
Amachiza asetyenziselwa ukuLawula ukuSesikweni
I-PCOS ibonakaliswe yinto engafanelekiyo ye-hormonal engabangela ixesha elidlulileyo (i- oligomenorrhea ) okanye amaxesha angabikho ( amenorrhea ). Ezi zitenxo nezinye izikhokelo ze-hormonal zinganciphisa ikhono lomfazi lokukhulelwa. Iyeza unyango lijolise ekulawuleni i-hormone ukubuyisela ngcono umjikelezo oqhelekileyo wokuya esikhathini.
Ezi zikhetho ezimbini ezisetyenziswa ngokuqhelekileyo ziipilisi zokulawula ukuzalwa kunye neProvera, zombini ezo zilawula umjikelezo wakho wokuya esikhathini ngokubonelela ngeprogesterone umzimba wakho ufuna. Ngokulawula ama-hormone, i-uterine lining can be shed more frequently, ukukhusela ukunyuka kwama-tissus okubangelwa ngamaxesha angabikho okanye angaqhelekanga.
I-glucophage (metformin), isishukela se-diabetes, inikeza inzuzo emibini yokunciphisa ukunganyangeki kwe-insulin okubonakalayo kubasetyhini abane-PCOS ngelixa bephucula ukuhamba kwexesha.
Amachiza asetyenziswa ukunyanga ukungafihli
Ukungasebenzi kwe-hormonal echaphazelekayo ye-PCOS kunokubangela ukungavumelekanga okanye ukungabikho kwe-ovulation (ukuvuthwa). Iindidi zamachiza zingasetyenziselwa ukunyanga oku, ukuphucula umgangatho weeqanda (i-oocyte) kunye ne-ovulation.Iimpawu zonyango, unyango lokuqala lubandakanya izidakamizwa zokuzala iComid (i-clomiphene citrate) kunye ne-Femara (letrozole).
Ngelixa iComomid isetyenziswa ngokubanzi ekuphuculeni i-ovulation, i-Femara inokusebenza bhetele kubasetyhini abane-PCOS njengoko ingavuki amazinga e-estrogen okanye ikhulise umngcipheko wokubeleka ezininzi kwizinga elifanayo njengeClomid.
Iinkqubo ezahlukeneyo zonyango zingasetyenziselwa ukuvuselela i-ovulation, kuquka:
- I-follicle evuselela i-hormone (FSH) , ekhuthaza ukukhula kweqanda
- I-hormone yeLuteinizing (LH), ebangela ukukhululwa kweqanda kwi-ovary
- I-chorionic gonadotropin (HCG) , eqinisekisa ukuvuthwa kweqanda
- I-Estrace (estrogen) , eyilungiselela isibeletho ukuba ifumane iqanda
- Provera (progesterone) , eyilungisa isisu sokufakelwa
- I-Menopur (i-menotropins), ehambisa i-FSH kunye ne-LH ngokujola
- I-Bravelle (urofollitropin), ekhupha i-FSH ngejoza
Okwangoku, isongezelelo se-hormonal, i- inositol , iboniswe ekuphuculeni i-oocyte kunye nobungqingili bebumba xa kukhula izinga lokukhulelwa kwabasetyhini abane-PCOS.
Amachiza Okunyanga Ukunyanzelwa Kwe-Insulin
Phantse ama-50 ekhulwini kwabasetyhini abane-PCOS baya kuhlakulela isifo sikashukela okanye isifo seswekile emva kweminyaka engama-40. Ngaphezu koko, basengozini enkulu yokuhlakulela isifo sikashukela, isifo esibangelwa yimpembelelo yokukhangela i-glucose (ushukela) ngexesha lokukhulelwa.
Isifo seswekile sisetyenziswe rhoqo ukunciphisa i-glucose kunye namazinga e-insulin kubasetyhini abane-PC-related insulin resistance.
Ukongezelela, ukuguqulwa kokukhetha kwendlela yokuphila, kubandakanywa ukuzivocavoca kunye nokutya okuphantsi kwamafutha kunye noshukela ococekileyo, kuthathwa njengento ephambili kunyango.
Izinketho zemithi ziquka:
- I-glucophage (metformin) , ekwazi ukulawula isifo sikashukela nokuncedisa ukulahleka kwesisindo
- I-Victoza (liraglutide) , isicatshulwa esisetyenziswayo ukulawula ama-insulin namazinga e-glucose
- I-Actos (pioglitazone), iklasi leziyobisi ezisetyenziswayo ukwenzela ukunciphisa iswekile ephezulu yegazi
- I-Avandia (rosiglitazone), isicatshulwa esijoyiweyo kwiklasi efanayo ne-pioglitazone
- I-Avandamet, inhlanganisela ye-rosiglitazone kunye ne-metformin.
Amachiza Okuncedisa Ngokulahlekelwa Kwisisindo
Phantse isiqingatha sabasetyhini abane-PCOS baninzi okanye baninzi.
I-PCOS ayinayo kuphela inxaxheba ekuncedeni ubunzima, yenza kube nzima nakakhulu kubafazi ukuba banciphise umzimba . Ukongezelela ekusebenziseni nasekudleni, amayeza athile asetyenziswa ngokuncedisa ekulahlekeni kwesisindo, nangona bavame ukuza nemiphumo ebalulekileyo.
Izinketho zangoku ziquka:
- I-Xenical (orlistat), isiza esinokuthintela ukuxutywa kwamafutha
- I-Qsymia (i-phentermine / i-topiramate), isithintelo sokutya
- UBelviq (i-lorcaserin), esinye isidlo esinqandayo
- Ukuphambana (naltrexone / bupropion), okungawanqanda ukuthanda ukutya
- I-Saxenda (i-liraglutide) , isetyenziselwa ukunyanga ukuxhatshazwa kwe-insulin kunye nokukhuluphala
- I-Inositol , isongezelelo esingokwemvelo ehambelana nokulahlekelwa kwesisindo kubasetyhini abane-PCOS
Amachiza asetyenziselwa ukujongana noKhuselo lweeNwele zoBuso kunye ne-Acne
Abafazi kunye ne-PCOS bahlala bephakamisa amanqanaba ama-hormone esintu (i-androgens), kuquka ne-testosterone. Umsebenzi wonyango lwe-anti-androgen ngokuthintela ukuhlanganiswa kwala ma hormone kunye nokunciphisa impawu zesibini zesibini, kubandakanya i-hirsutism (ubuninzi bomzimba kunye neenwele zomzimba) okanye ukulahleka kweenwele.
Izinyango zokwelapha ziquka:
- Aldactone (spironolactone) , i-diuretic eneempembelelo ezinxamnye ne-androgenic
- Vaniqa (eflornithine hydrochloride) , i-cream cream esetyenziselwa ukuvimba ubunwele beenwele
- Ipropecia (i-finasteride) , isetyenziswe ngaphandle kwileyibhile ukuphatha ukulahleka kweenwele kwabasetyhini abane-PCOS
Ukongeza kwiinguqu zokukhula kweenwele, i-androgen ngaphezu kweproproduction ingabangela ukuphuhliswa kwe-acne. Le nto ixhaphake ngokuqhelekileyo ngama-creic creams afaka i- benzoyl peroxide , i- salicylic acid , i- retinoids , okanye i- antibiotics .
ILizwi
Ekujonganeni neempawu ze-PCOS, uya kufuneka usebenze nodokotela wakho. Kukho iipilisi ezingafanelekanga ngenxa yeemeko zempilo, ukusebenzisana ngamachiza kunye nezinye izinto. Qinisekisa ukuba uyayiqonda unyango olucebisiweyo kunye nendlela yokuthatha umyalelo ngokufanelekileyo.
Umthombo:
> Kasper DL, uFauci AS, uHauser SL, uLongo DL, uJameson JL, uLolexcalzo J. Harrison i-Principals of Medicine Internal (i-19th edition). ENew York: iMacGraw-Hill Education, 2015.