Esinye sezibonelelo ezongezelelekileyo ezifundwa ngokubanzi kwi-PCOS yabantu i-inositol. Kwaye sinesizathu esihle: zombini i-Myo (MYO) kunye ne-d-Chiro-inositol (DCI) i-inositol iintlobo ziye zaboniswa ukuphucula ezininzi iinkalo ze-PCOS. Ezi zinzuzo ziquka ukuphucula i- cholesterol , i-insulin, i- androgens kunye nesisindo. Abasetyhini abathatha i-inositol babika izifiso ezincinci.
Okugqwesileyo kubo bonke, i-MYO iboniswe ukukhulisa i-fertility ngokuphucula umgangatho weqanda nokubuyisela rhoqo ukuhamba kwexesha kunye nokunciphisa umngcipheko wesifo sikashukela.
Ngoxa iintlobo zombini ze-MYO ne-DCI zinikeza iintlobo ezininzi kubasetyhini abane-PCOS, uphando olutsha ngoku lubonisa ukuba ludibanisa le ntlobo ezimbini, kumlinganiselo wendalo womzimba obonisa inzuzo enkulu.
Yintoni i-Inositol?
I-Inositol ilungu le-vitamini ze-B kunye necandelo le membrane yeseli. I-Inositol ifumaneka kwizidlo ezifana neziqhamo, iimbotyi, iinkozo kunye namantongomane kwaye zenziwa ngumzimba. Nangona kukho iintlobo ezithoba ze-inositol, yi-MYO kunye ne-DCI ezibonise izibonelelo ezingcono kwi-PCOS. Kungenxa yokuba kukholelwa ukuba abafazi abane-PCOS banakho ukukhubazeka emzimbeni wokukwazi ukusebenzisa i-MYO ne-DCI, negalelo ekukhuseni kwe-insulin . Umsebenzi we-MYO kunye ne-DCI njengabathunywa besibini abathumela iimpawu ezibandakanya umgaqo-insulin.
Izinzuzo zeMyo neD-Chiro Inositol ezidibeneyo
I-MYO ne-DCI zi-molecule ezihlukeneyo ezisebenza ngokwahlukileyo emzimbeni.
I-DCI yenziwe kwi-MYO xa ifunwa . Umzimba ugcina umlinganiselo we-plasma oqhelekileyo we-MYO ukuya ku-DCI we-40: 1. Umlinganiselo we-MYO ukuya kwi-DCI kwi-follicular fluid iphezulu-100: 1. Iifolumu ezinama- oocyte aphezulu zixinzelelo oluphezulu kakhulu lwe-MYO.
Ukungalingani komlinganiselo oqhelekileyo we-MYO ukuya kwi-DCI kunokuchaphazela umgangatho weqanda.
Xa i-DCI yodwa ilawulwa kwii-dosage eziphezulu (600-2400 mg ngosuku) kwafunyaniswa kukuchaphazela kakubi umgangatho we-oocyte kunye nempendulo ye-ovari. Ngaphezu koko, i-dose ephezulu ye-DCI (kunye nokulinganisa okungaphezulu kwe-MYO ukuya kwi-DCI), ukugqithisa ngakumbi umgangatho we-oocyte kunye nokuphendula kwe-ovari .
I-MYO ibhalwe ngokucacileyo ukuba iphakame ku-DCI ekuphuculeni ukungqinanga kwe-insulin, ikhwalithi yeqanda kunye nokunciphisa umngcipheko wesifo sikashukela kubantwana besifazane abane-PCOS. Nangona kunjalo, xa i-MYO idibene ne-DCI kwisilinganiselo esiphezulu, iziphumo ezilungileyo ziyabonakala.
Kuphando olupapashwe kwiphepha le- Archives of Gynecology kunye ne-Obstetrics , abafazi abane-PCOS abangena kwi-IVF baphathwa ngokuhlanganiswa kwe-MYO ne-DCI kwisilinganiselo se-physiologic esingu-40: 1 okanye 500 mg we-DCI yodwa. Ulwaphulo oluhlangeneyo lukwazi ukuphucula umgangatho we-oocyte kunye nobungqingili, kunye nokukhula kokukhulelwa, kubonisa ukuba i-MYO idlala indima ebalulekileyo kwi-ovary kuma-PCOS amabhinqa kunye neenzuzo ze-MYO kunye ne-DCI kwisilinganiselo esiphezulu.
Kwesinye isifundo esashicilelwe kulo nyaka kwiNgxelo yeYurophu yezoNyango kunye ne-Pharmacological Sciences , abafazi abangaphezu kwamandla amaninzi kunye ne-PCOS bafumana i-MYO ne-DCI okanye i-MYO yedwa kwinyanga ezintandathu. Ekupheleni konyango, ukuxhaswa okuhlangeneyo kunye ne-MYO kunye ne-DCI kwakusebenza ngempumelelo ekunciphiseni iiparameter zeempawu ezinxulumene neqela le-MYO.
Ababhali baphetha ngokuthi "ukulawulwa okuhlangeneyo kwe-MI kunye ne-DCI kwisilinganiselo se-plasma ratio (40: 1) kufuneka kuthathwa njengendlela yokuqala yokuhamba kwi-PCOS.
Yintoni Omele Uyazi Ngokuthatha Inositol?
Kunconywa ukuba abafazi abane-PCOS bathathe inani elidibeneyo le-MYO (2-4 grams) kunye ne-DCI (50-100mg) kwisilinganiselo se-physiologic esingu-40: 1.
Ngokuqhelekileyo, i-MYO ne-DCI iyakunyamezela kakuhle kodwa ingabangela ishukela ephantsi yegazi , ngakumbi xa uthatha imishanguzo okanye ezinye izongezelelo ezishukela egazini legazi. Njengamaxesha onke, jonga ugqirha wakho ngaphambi kokuba uqale i-inositol.
> Imithombo:
> I-Costantino D, i-Minozzi G, i-Minozzi E, i-Guaraldi C. I-Metabolic nemiphumo yeHormonal ye-Myoinositol kwi-Women With Polycystic Ovary Syndrome: i-Trial-Blind Trial. I-Europ Ukuhlaziya iMed Pharmacol Sci . 2009; 13 (2): 105-110.
> Unfer V, uCarlomagno G, uRizzo P, uRaffone E, uRoseff S. Myo-Inositol Kunokuba iD-Chiro-Inositol inakho ukuphucula umgangatho we-oocyte kwi-Intracytoplasmic Sperm Injection Cycles. Uvavanyo olulindelekileyo, olulawulwayo, oluLungisiweyo. I-Europ Ukuhlaziya iMed Pharmacol Sci. 2011; 15 (4): 452-457.
> Le Donne M, Alibrandi A, Giarrusso R, Lo Monaco I, Muraca U. [Ukutya, i-Metformin kunye ne-Inositol kwi-Womenight Overseight and Obese Women With Polycystic Ovary Syndrome: Impembelelo kwiCandelo loMzimba]. Minerva Ginecologica. 2012; 64 (1): 23-29.
> Venturella R, Mocciaro R, De Trana E, D'Alessandro P, Morelli M, Zullo F. [Uvavanyo lokuguqulwa kwezonyango, i-Endocrinal kunye ne-Metabolical Profile of Patients with PCOS Syndrome Ephathwayo nge-MYO-Inositol]. Minerva Ginecologica. 2012; 64 (3): 239-243.
> Genazzani AD, Prati A, Santagni S, et al. Impendulo ye-insulini eyahlukileyo kuMlawuli we-Myo-Inositol kwi-Obese Polycystic Ovary Syndrome Izigulane. Gynecol Endocrinol. 2012; 28 (12): 969-973.
> Gerli S, uPapaleo E, uFerrari A, uDi Renzo GC. I-Randomized, i-Blind Double Blind Indawo elawulwa yi-Placebo-Controled Trial: Iimpembelelo ze-Myo-Inositol kwiMisebenzi ye-Ovari kunye nezinto eziMetabolic kwi-Women with PCOS. I-Europ Rev Med Pharmacol Sci . 2007; 11 (5): 347-354.
> Raffone E, Rizzo P, Benedetto V. I-Insulin Sensitiser Agents Yodwa kunye neCro-Treatment kunye ne-r-FSH yokukhutshwa kwe-Ovulation kwi-PCOS Women. Gynecol Endocrinol. 2010; 26 (4): 275-280.
> Galazis N, Galazi M, Atiomo W. D-Chiro-Inositol kunye nokubaluleka kwayo kwi-Polycystic Ovary Syndrome: ukuHlola okuHlolo. Gynecol Endocrinol . 2011; 27 (4): 256-62
> Papaleo, E., Unfer, V., Baillargeon, JP, et al. (2007). I-Myo-Inositol kwizigulane ngePolycystic Ovary Syndrome: iNdlela yeNew ye-Ovulation Induction. I-Endocrinology ye-Gynecological, 23 (12): 700-703.
> D 'Anna R, Di Benedetto V, Rizzo P, et al. I-MYO-Inositol May ingavimba isifo sikashukela se-Gestational kwi-PCOS Women. Gynecol Endocrinol. 2012; 28 (6): 440-442.
> Isabella R, uRaffone E. Ngaba i-Ovary idinga i-D-Chiro-Inositol? J Ovarian Res. 2012 Meyi 15; 5 (1): 14.
> Dinicola S1, Chiu TT, Unfer V, Carlomagno G, Bizzarri M. Isizathu seMyoinositol kunye ne-D-Chiro-Inositol Ukwelapha okuhlanganisiweyo ye-Polycystic Ovary Syndrome. J Clin Pharmacol. 2014 Oct; 54 (10): 1079-92.
> I-Nordio M, i-Proietti E. I-Articular Treatment ne-Myoinositol kunye ne-D-Chiro-Inositol iyanciphisa iNengozi yezifo zeMetabolic kwii-PCOS Izigulane ezingaphezu komzimba ngokuthelekiswa ne-Myoinositol Supplementation Alone. Eur Rev Med Pharmacol Sci. NgoMeyi ka-2012; 16 (5): 575-81.
> Colazingari S, Treglia M, Najjar R, Bevilacqua A. Ulwaphulo oluhlangeneyo I-Myoinositol Plus D-Chiro-Inositol, Esikhundleni seD-Chiro-Inositol, iyakwazi ukuphucula iziphumo ze-IVF: Iziphumo ezivela kwi-Trial Controls Trial. I-Arch Gynecol Obstet. 2013 Dec; 288 (6): 1405-11.