Ukubaluleka kweeNzame zeNgcebiso zichazwa ngokubeka kunye nabemi
Umlinganiselo we- CD4 / CD8 uvavanyo lokuxilongwa komzimba womntu , ukuthelekisa inani le " CD4 T-cell " kweso "yokhuseli" i-CD8 T-cell. Uvavanyo lokuhlaziya lusetyenziswe ukucacisa inkqubo yesifo, njengokuba xa umntu enesifo se- HIV .
Ukuqonda indlela i-CD4 kunye ne-CD8 T-cells ezisebenzisana ngayo
I-CD4 ne-CD8 zimbalwa iintlobo ezimbini ezahlukeneyo ze-glycoprotein ezifunyenwe kwi-T-cell kunye nezinye i-lymphocytes (iklasi yamaseli egazi amhlophe ephambili kwi-immune system).
Ii-CD4 T-cell zibhekwa "ngabancedisi" kuba yizo ezibangelwa impendulo yokuzivikela ngomzimba xa zijongene ne-pathogen (i-agent engathinteliyo).
Xa oko kwenzeka, i-CD8 "i-suppressor" i-T-cell isebenze ukuhlaselwa nokubulala ezo zifo. Benza ngoko ngokuvala umsebenzi we-CD4 xa kufikelelwe iimpendulo ezaneleyo zokuzivikela.
Umlinganiselo weCD4 / CD8 uthathwa njengesiqhelo xa uphakathi kwe-1.0 no-4.0. Ngomntu onempilo oguqulela kuma-30-60% kwi-CD4 T-cell kunye nee-10-30% ze-CD8 T-cell.
Nangona kunjalo, xa umntu ekhulelwe ngentsholongwane kaGawulayo , ngokuqhelekileyo ukuhla kwe-30% kwinani lama-CD4 T-seli njenge-HIV ijolise la sele kwaye ichithe inani labo. Ngokwahlukileyo, ii-CD8 T-seli ziya kukhula ngokubanzi ngama-40% ngethuba, nangona amandla abo okunciphisa intsholongwane ziya kugxotha ixesha elide njengoko zilula ezimbalwa ii-CD4 T-cell ukuba zenze impendulo efanelekileyo.
Xa unyango lwe-antiretroviral (ART) luqaliswa ngexesha elifanelekileyo kumntu onentsholongwane kaGawulayo, umlinganiselo ngokuphindaphindiweyo uya kubuya oqhelekileyo.
Nangona kunjalo, ukuba unyango lulibazisekile, amandla omzimba wokubuyisela kwakhona ii-CD4 T-cell eyancipha, kwaye isilinganiselo sisoloko siphantsi kwe-1.0.
Oko i-CD4 / CD8 Ratio isitshela yona
Ixabiso le-CD4 / CD8 elithengiswayo lithathwa njengento efanelekileyo ekulawuleni i-HIV ngaphezu kweminyaka engama-20 edlulileyo, xa kwakuninzi imishanguzo ye-antiretrovirals engaphantsi ekhoyo ekuphatheni i-HIV.
Nangona iyakubonisa ukuba usulele ukusuleleka kwintsholongwane yokufa kunye nokuxhomekeka kokufa kwe- AIDS , ukugxininiswa kakhulu namhlanje kugcinwe ukugcina ukunyanzelwa kwe-virus (njengoko kulinganiswa ngumthamo wentsholongwane yomntu) ukuze kuphuculwe ukunyuka kwesifo kwaye kugweme ukuphuhliswa kwe-HIV ukumelana .
Xa kuthethwa oko, ukugxila okugxininiswayo kubeka kwi-CD4 / CD8 enamandla kwi- HIV yabantu abadala . Uphando lwezonyango olutsha luye lwacetyiswa ukuba izigulane kwi-ART esebenzayo, kunye ne-CD4 / CD8 ephantsi, inomngcipheko ophezulu wokungabikho kwe-HIV kunye nokufa.
Kukho ezinye iindawo apho umlinganiselo we-CD4 / CD8 ungasetyenziswa. Ngophando lwe-epidemiological, lunokusetyenziswa njengexabiso elithile lokulinganisa i-virulence (oko kukuthi, amandla okwenza utyholongwane obangela izifo) ze-HIV kwiindawo ezahlukeneyo okanye kwixesha elide.
Ingasetyenziselwa ukuxela ubungqina be- IRIS (ukukhuselwa kwesifo sokugonywa kwamagciwane) apho ngamanye amaxesha kwenzeka xa umntu eqala unyango lwe-antiretroviral. Ukuba ubuncinane be-CD4 zibalo kwaye buhamba kunye nomlinganiselo ophantsi we-CD4 / CD8 ungaphantsi kwe-0.20, umcimbi wezehlakalo ze-IRIS ukwandisa kakhulu.
Ngokufanayo, uphando lucebise ukuba inani eliphantsi le-CD4 / CD8 kwiintsana ezizalwe ngabafazi abanentsholongwane kaGawulayo liqikelela ukuba ngaba umntwana uya kuba ngu- seroconvert (kuqinisekiswe ukuba unentsholongwane kaGawulayo) , ngokunokwenzeka ukuba ukwanda ngokukhawuleza xa umlinganiselo ungaphantsi kwe-1.0.
Oku kungabandakanyeka ngokukodwa kumazwe asathuthuka apho inani lokuthunyelwa komama ukuya komntwana liye lancipha ngokuphawulekayo kodwa inani le-HIV elikhulelwe ngabantwana abane-HIV lihlala liphezulu.
Imithombo:
Mahnke, Y; IGreenwald, J .; DerSimonian, R .; okqhubekayo. Ukwandiswa okukhethiweyo kwezixhobo ze-CD4 ze-Pathogen ezithile ze-HIV-1 ezinegciwane ezine-HIV ezi-1 ezine-immune reconstitution syndrome. Igazi. Matshi 29, 2012; 119 (13): 3105-3112.
Zijenah, L .; Katzenstein, D .; Nathoo, K .; okqhubekayo. "I-lymphocytes phakathi kweentsholongwane kaGawulayo kunye ne-noninfected: umlinganiselo we-CD4 / CD8 njengesixhobo esinokuthi uhlolisise intsholongwane kwiintsana ezingaphantsi kweminyaka emi-2 . " I-Journal of Medicine Translation. 1 kuFebruwari 2005; 3: 6: i-doi: 10.1186 / 1479-5876-3-6.
Seng, R .; Goujard, C .; Krastinova, E .; okqhubekayo. "Impembelelo yokukhula kwe-HIV yentsholongwane yexesha elide kwi-Viremia ye-HIV ngokuphindwa kwexesha elide le-CD4 + kunye ne-CD4 + / CD8 + phakathi kwezigulane kwi-antiretroviral therapy." AIDS . NgoJanuwari 13, 2015; papashwe ngaphambi kokuprinta; INGXELO: 10.1097 / QAD.0000000000000571.