Kusasa kusasa ukuthetha, kodwa unyango olunomdla lunokuthi lube khona
Uphando lwaseCanada olupapashwe kwi- New England Journal of Medicine lubonisa ukuba abantu abane-syndrome yezilwanyana ezizimeleyo ukuya kwi- multiple sclerosis (ebizwa ngokuba yi-CIS) abayithatha i-antibiotic minocycline inokuba nomngcipheko omncinci wokuba ne-multiple sclerosis.
Ngokuqinisekileyo, kukho isibheno esikhulu sokuthatha i-minocycline njengonyango lwe-CIS, njengoko ingabizi, kulula ukuyithatha (yile myeza yomlomo), kwaye ineprojekthi ekhuselekileyo yokhuseleko.
Sekunjalo, ufanisa njani nezinye izifo eziguqula izifo ezifana neBetaseron okanye iAvonex? Ukongezelela, isifundo esibonisa ukusebenza kwayo simncinci, kufuneke ukuba kunzima izilingo ezinzulu ukwenzela ukuba kuqinisekiswe inzuzo yayo ngokwenene.
Makhe sijonge ngokubhekiselele kule nkunkuma ekhulayo. Ngoxa kunokwenzeka okanye kungasebenzi, ukuqonda "kutheni" emva kwendlela i-antibiotic inokuthintela ngayo ukuphuhliswa kwe-MS kukuthakazelisa ngokwalo.
I-Minocycline njenge-Treatment Potential ye-CIS
Ngaphambi kokuba uthathe isifundo kwisifundo se-minocycline njengonyango lwe-CIS, kubalulekile ukuqonda ukuba yintoni i-syndrome ye-kliniki ehlukileyo kwi-MS, kunye nendlela i-minocycline inokuthi ithathwa ngayo njengonyango onokuthi lunakho.
Yintoni i-Clinic Isolated Syndrome?
I-syndrome ye-Clinically isolation kuya kwi-multiple sclerosis, okanye i-CIS, ibhekisela kubantu abafumana "iimpawu ezinjenge-MS" ubuncinane ubuncinane kwiiyure ezingama-24, kwaye ezi zimpawu zingaphaya okanye zingangqinelani nezilonda ezibonwe kwi-MRI.
Umqhatyathi kukuba ngaphandle kwesi siqendu sokuqala, akukho zikhokelo ezenziwa ngumntu onokudlulela kwi-MS ngaphambili, mhlawumbi ngembali yabo okanye nge- MRI yabo (akukho zilonda zengqondo ezihlobene ne-MS).
Ngamanye amazwi, umntu akakwazi ukufumana ubungqina bonyango okanye u-radiographic ngokwaneleyo ukufumana ukuxilongwa kwe-MS.
Olunye umngeni ngokufumanisa i-CIS kukuba ugqirha kufuneka aqinisekise ukuba iimpawu zomntu "ezinjenge-MS" (umzekelo, i- optic neuritis ) ngokwenene ngenxa yokulahlekelwa kwe-myelin-isithintelo sokukhusela phezu kweeseli zesisongela engqondweni nasemgodleni.
Oku kungadinga ukuvavanywa okungakumbi njengokwenza i- lumbar puncture okanye ukukhutshwa kwamathuba , kunye nokulawula ezinye iimeko ze-MS ezifana nokusuleleka okanye ezinye izifo ezizimele (umzekelo, i-systemic lupus erythematosus).
Yilapho izinto ezinokuthi zikhohlakele, njengokuba i-neurologist isetyenzisile isigwebo sayo ukuqinisekisa ukuba umntu onesifo se-syndrome e-kliniki ayilungele ukufumana unyango ngeyeza lokuguqula izifo.
Ngokuqhelekileyo, unyango lunconywa ukuba umntu onesiCIS unemirhobho ebonisa izilonda ezibonakalayo kwi-MS.
Yintoni i-Minocycline?
I-Minocycline yintsholongwane, ngoko ke imishanguzo esetyenziswa ukukhusela ukukhula kweebhaktheriya. Isetyenziselwa ukuphatha uninzi lweemeko zonyango ezifana ne-acne, okanye imiphunga, ubulili, kunye nezifo zesikhumba.
Unokuzibuza ukuba ukuthatha i-minocycline kunokuncedisa njani umntu engozini yokuphuhlisa i-MS. Ewe, izazinzulu ziye zafumanisa i-minocycline ukuba ibe nezinto ezichasayo, ngoko kuya kunciphisa inkqubo yomzimba womntu, ngaphezu kokuthintela ukusasazeka kweebhaktheriya.
Kungenzeka ukuba ipropati echasayo ye-minocycline ibangelwa ukukwazi ukuguqula ibhaktheriya emanzini omntu ngenxa yokuba ezi bhaktheriya zidlala indima ephambili ekulawuleni umzimba womzimba womntu.
I-Minocycline ikholelwa ukuba ithintela ukufuduka kwamaseli athile omzimba omzimba ahlasela i-myelin engqondweni nasemgodleni.
Ekugqibeleni, uphando lubonisa ukuba i-minocycline inokukhusela iisensi zeentsimbi ngokuthintela ukufa kwazo. Le yindlela enye apho ingabazuzisa abo abane-CIS.
Yintoni Eyayityhilwa Ngalo Mxholo?
Ngaphezulu kweminyaka engama-4, aba-142 abathathi-nxaxheba be-CIS abavela kwiiklinikhi ezi-12 zaseCanada ze-MS babethelwe ngokukhawuleza ukuba bafumane i-100mg ye-minocycline kabini ngosuku okanye indawo ye-placebo.
Bonke abathathi-nxaxheba bafumene iimpawu zabo zokuqala zeCIS ezinsukwini eziyi-180 ngaphambi kokuqala isifundo. Uninzi lwabathathi-nxaxheba ngababhinqa (ama-68 ekhulwini), kwaye oku kufana neCIS (ixhaphake kakhulu kubasetyhini), kunye nobudala obuphakathi kweminyaka engama-36.
Olu pho nonongo lwaluyimpumputhe, lithetha ukuba abathathi-nxaxheba okanye abaphandi babengazi ukuba bafumana i-minocycline okanye indawo ye-placebo.
Abathathi-nxaxheba baqhubeka bethatha imithi (okanye i-placebo) de kube ngaba bafumene i-MS okanye kwiinyanga ezingama-24 emva kokuba baqale bathathe i-minocycline (okanye i-placebo).
Iziphumo zabonisa ukuba emva kweenyanga ezintandathu emva kokuba abathathi-nxaxheba bathathe i-minocycline, iipesenti ezingama-33 zenze i-MS, xa kuthelekiswa nama-61 ekhulwini abathathi-nxaxheba bathatha indawo ye-placebo. Lo umehluko owehlayo malunga neepesenti ezingama-28 zepesenti.
Emva kokulungiswa kwenani lezilonda ze-MS ezisemgangathweni, ulwahlulo lwaluhla ukuya kuma-18.5 ekhulwini, oluya luphosakele. Isizathu salolu lungiso kukuba imigaqo yokuhlola i-MS yahlaziywa ngexesha lekhosi yezifundo. Ngokwe-criteria ehlaziyiweyo ye-McDonald ka-2010, umntu unokufumanisa ukuba une-MS ukuba unobungqina bemi-MS yezilonda zesifo sengqondo, nangona bebengenayo impawu ehambelana nalezo zilonda.
Nangona ingozi yokuguqulwa kwi-CIS ukuya kwi-MS yayincinci kakhulu kulabo bathatha i-minocycline kwiinyanga ezintandathu xa kuthelekiswa ne-placebo, ngelanga, oku kungagcinwa kwiinyanga ezingama-24.
I-Minocycline iyithelekisa njani kwezinye iindlela zokwelapha ze-CIS?
Iziphumo zolu cwaningo zifana nezinye iindlela zonyango ezisetyenziselwa i-CIS njenge-Betaseron (i-interferon beta-1b), i-Avonex (i-interferon beta-1a), kunye ne-Aubagio (i-teriflunomide), ithetha ngeenyanga ezi-6, ezi zonyango zibonisa ingozi efana nayo yokuphuhlisa NKSK.
Nangona kunjalo, akukho ntloko ekhondweni yokuvavanya i-minocycline kwenye yezinto ezilapha ngasentla, ngoko kusengaphambili ukuba uxelele indlela efaniswa ngayo.
Kukho konke, ngelixa i-minocycline ibonakala njengendleko ephantsi kunye neyeza ezikhuselekileyo, uphando oluhlolisisa inzuzo yalo njengonyango lwe-CIS lincinci kwaye lunezinye izilungiso ezinxulumene nokufunda.
Izifundo ezinkulu zisadingeka ukuba zibonwe lo unyango olufanelekileyo kwaye lunempumelelo.
Ngaba Kukho Uphulo Olujongene Nokuthatha iMinocycline?
Unokuzibuza ukuba kukho ukuphazamiseka ukuthatha i-minocycline, njengokungakhathaliseki ukuba kuphephile okanye kungabangela nantoni na. Oku kubalulekile kuba ukunamathela kumachiza emihla ngemihla kunokuba ngumngeni, kwaye ukuba kukwenza uzive ukhululekile, ukubambelela kunokuba nzima nakakhulu.
Iziphumo eziqhelekileyo ezinokuthi zenzeke nge-minocycline ziquka:
- Uhudo
- Utywala okanye ukukhanya
- Intloko
- Ukutshatyalaliswa kwamazinyo (njengokutsalwa kwamazinyo nomlomo)
- Ukuhlonipha ilanga (unokufumana okubi ngaphezu kokushisa kwelanga ngokuqhelekileyo)
- Izifo ezifayilini (umzekelo, izifo zesisu zesisu)
Kukho nezinye iingxaki ezinqabileyo kodwa ezinzima ezingenzeka nge-minocycline njenge- pseudotumor cerebri . Ukongezelela, i-minocycline iyaphikisana nokukhulelwa kunye noongikazi, kwaye inganciphisa ukuphumelela kwamapilisi okulawula ukuzalwa.
Nangona kunjalo, nangona ezi ziphumo zecala zikhankanyiwe, i-minocycline ineprogram epheleleyo yokhuseleko oluhle kwaye abantu bavame ukukwenza kakuhle.
Ewe, njengawo nawaphi na amayeza, kufuneka uxoxe ngokugqithiseleyo nodokotela wakho malunga nobungozi bokuthatha i-minocycline ngokumalunga nenzuzo yayo (ukuba sele ivunyiwe ukuba isebenzise kwi-CIS), kunye nokuphonononga zonke iziphumo zaso.
ILizwi
Ngelixa iziphumo zolu cwaningo luchulumancisayo, yinto nje isinyathelo somntwana kwinqanaba lokuthintela i-MS ngokwenene ukuba kwenzeke kubantu abafunyaniswa ukuba baneempawu zokuqala. Kufuneka uphando olungakumbi kwi-minocycline, ingakumbi njengoko uphando luyaxutyushwa kwiziphumo.
Ngokomzekelo, uphando oluthile lubonisa ukuba i-minocycline enikwe iBeta-Seron ayizange iphuculise ukulawulwa kwezifo kubantu abanokubuyiselwa kwakhona-ukuyeka i-sclerosis. Uphando oluphikisanayo lubonisa ukuba uphando olongezelelweyo lufuneka luyenziwe ngaphambi kokuba i-neurologists iqale ukunika izigulane zabo nge-MS tetracycline antibiotic.
> Imithombo:
> Marcus JF, Waubant EL. Ukuhlaziywa kwi-syndrome yezilwanyana ezizimeleyo kunye neendlela zokuxilonga kwi-multiple sclerosis. Neurohospitalist . Ngo-2013 ngoMatshi; 3 (2): 65-80.
> Metz LM et al. Umlingo we-minocycline kwi-syndrome ye-clinically isolation of multiple sclerosis. N Eng J Med. 2017 Juni 1; 376 (22): 2122-33.
> Multiple Sclerosis Society of Canada. (Meyi 2017). I-Minocycline kwi-Clinic Isolated Syndrome (CIS) FAQ.
> Sørensen PS kunye al. I-Minocycline ifakwe kwi-interferon β-1a kwi-multiple sclerosis: i-RECYCLINE yophando. Eur J Neurol. Ngo-2016 ngoMeyi; 23 (5): 861-70.