Ukujoliswa kwamaseli e-Myelin-Ukuvelisa isinyathelo esilandelayo kwi-MS Therapy
Iindlela ezikhoyo zonyango ngokubhekiselele kwi- multiple sclerosis zijolise kumzimba womzimba womzimba. Ngoxa befunyenwe ukunciphisa inani kunye nobukhulu be-MS kwakhona, akukho nonyango ye-MS, ukuze abantu baqhubeke nokukhubazeka xa isifo sabo siqhubeka.
Kodwa ngoku iingcali zihlola iindlela ezijoliswe kwi-myelin-ingubo ekhuselekileyo ejikeleze i-nerve fibers ewonakele kwi-MS.
Masiqwalasele ngakumbi indima ye-myelin kwi-multiple sclerosis, kwaye ukulungiswa kwayo kungabuyisela njani umsebenzi we-neurological kunye nokunciphisa okanye ukuyeka ii-MS kwiindlela zayo.
Umsebenzi we-Myelin kwi-Multiple Sclerosis
Ngomntu onempilo, iiseli zesisindo zithumela iimpembelelo komnye nomnye ngefayibhile encinci enamathele emzimbeni weselonda. Ezi zicwangciso ezincinci zibizwa ngokuba yi-axons kwaye zizungezwe ngamanqatha, emhlophe emzimbeni othiwa i-myelin. Ukukhonza njengomkhuseli okanye ukhuselo, i-myelin ivumela iimpembelelo zentliziyo ukuba zihambe ngokukhawuleza nangempumelelo.
Kwi- multiple sclerosis , iintsholongwane zomzimba zomzimba zihlasela i-myelin (kwaye ekugqibeleni i-axon nayo) kwingqondo yabo kunye / okanye umgca weconongo. Ukuhlaselwa okuphindaphindiweyo kwi-myelin ekugqibeleni kukukhokelela ekubhenqeni. Xa i-myelin inqabile, iimpembelelo zentsholongwane azikwazi ukuhanjiswa ngokufanelekileyo-zihamba zihamba ngokukhawuleza okanye zingekho. Ekugqibeleni, ama-axons aphelile (alahlekelwe amandla abo okusebenza) ngenxa yelahleko engapheliyo ye-myelin, ekhokelela ekufeni kwe-cell cell.
Ngokuxhomekeka kwimeko apho i-myelin ye-nervous central ihlaselwa khona, iimpawu ezifana nokuphazamiseka kwengqondo, iingxaki zombono, ukuxhamla, kunye neengxaki zesibindi ziqala ukubonakalisa. Yingakho iimpawu ze-MS zihluka ngokubanzi ukusuka komnye umntu ukuya kwelinye, njengoko indawo yokuhlaselwa kwe-myelin ihluka phakathi kwenkqubo ye-nervous central.
Ukongezelela kwiindawo ezichaseneyo zokuhlaselwa kwe-immune system kwi-brain kunye nomgogodla, ixesha lokuhlaselwa alinakuqikelelwa-nangona, iingcali zifumene iimeko ezinokubangela uxinzelelo okanye ixesha lokugqibela.
Ukulungisa i-Myelin: Isinyathelo esilandelayo kwi-MS Therapy
Nangona iimeko ezikhoyo zokuguqula izifo ze-MS zijolise kwindlela yokukhusela isistim somzimba somntu ekuhlaseleni i-myelin, ngoku izazinzulu zikhangele indlela i-myelin enokuyilungisa ngayo emva kokuba yonakaliswe ngumzimba wokuzivikela. Ithemba kukuba ukuba i-myelin isilungiswa, umsebenzi we-neurological unomntu ungabuyiselwa, kwaye umntu we-MS unokuyeka ukugqithisa (okanye ubuncinci).
Iindaba ezilungileyo kukuba ezinye izifundo sele zibonise ukuba ukugcina nokubuyisela i-myelin ejikeleze i-axons inokunyusa isantya se-cells. Ekubeni ukukhubazeka komntu we-MS kuxhunyiwe kwizinga lokufa kweeselferensi, ngokulungisa i-myelin nokukhusela iiseliti zamagulane, iingcali zethemba lokuba sinokuyeka ukunyuka kokukhubazeka kubantu abane-MS.
Uphando lwe-MS olusuka kwi-Myelin Repair
Uphando lokubuyisela umsebenzi nokulungisa i-myelin kwi-sclerosis ezininzi kusekuqaleni kakhulu. Nangona kunjalo, kuyonwaba kwaye kusenokwenzeka ukuba isinyathelo esiseduze ekupheleni kwe-MS kanye nonke.
Omnye umncinci, isigaba sesi-II sifundo kwiYunivesithi yaseCalifornia eSan Francisco senziwa kwiNdibano ye-American Academy of Neurology. Kule sifundo, i-anti-counter-counter-anti-antibiotic medicine ebizwa ngokuba yi-clemastine yahlolwa ukuba ibone ukuba ingayithuthukisa i-myelin kwi-brains yabantu abane-MS.
Kule sifundo, abantu abangama-50 abane-MS kunye ne-optic nerve damage banikezwa ngokucoca ngomlomo kabini ngosuku okanye ipilisi ye-placebo iintsuku eziyi-150. Emva kweentsuku eziyi-90 zale mihla 150, abathathi-nxaxheba batshintshe imithi, kuthetha ukuba abo bafumene i-clemastine ekuqaleni bafumana indawo ye-placebo kunye ne-vice-versa.
Abathathi-nxaxheba bafumana iziphumo ezibonakalayo ezibonakalayo, ezibonisa ukuhanjiswa kwegama ukusuka kwi-retina yelihlo ngokusebenzisa i-nertic optic kwi-cortex ebonakalayo-ummandla wengqondo owenza imifanekiso, okanye ngamanye amagama, uguqula oko ubona kwimifanekiso.
Iziphumo zityhila ukuba ukulibaziseka kwizinto ezibonakalayo ezikhutshwayo zancitshiswa nge-1.9 millisecond kweso ngelixa abantu baphathwa ngayo nge-clemastine. Ukunciphisa ukutshatyalaliswa kokutshatyalaliswa kweentsholongwane kubonisa ukuba ukulungiswa kwe-myelin kuqhutywe kwindlela yokuguqula i-optic.
Omnye umgca wokufundwa kweso sifundo kukuba i-dose ye-clemastine yayiphezulu kuneyona dose ephakamileyo ephakanyisiwe, ngoko akumangalisi kukuba, kubangele ukukhathala kwabathathi-nxaxheba.
Ubunokwenzeka bokuMilana-Ukulungisa iMithi kwiimvavanyo zakuqala
Ezinye izifundo zokuqala zifumana izigulane okanye ziqhubeka ngokuphathelele imishanguzo enokukunceda ukuvuselela i-myelin kunye nokukhusela iiseliti zesistim kwinkqubo ye-nervous central.
Ngokomzekelo, izilingo zeSigaba 1 (kakhulu kakhulu) ziqhutyelwa ku-Olesoxime noGananbenz.
I-Guanabenz (iyeza ngaphambili elivunyiweyo yi-FDA yokuphatha uxinzelelo lwegazi eliphezulu) lufunyenwe kwizifundo zezilwanyana ukwenzela ukwandisa ukusinda kweeseli ezivelisa i-myelin (ebizwa ngokuthi i-oligodendrocyte). Kuye kwafunyaniswa ukunciphisa inani lamajoni omzimba aqokelelwa kwingqondo kunye nomthambo womgudu.
Olunye unyango oluthiwa yi- Olesoxime , olwakusungulwa ngokusesikweni ukunyanga i- amyotrophic lateral sclerosis , luye lwafunyanwa kokukhawuleza ukuvuthwa kweeseli ezivelisa i-myelin kwingqondo kunye nomgudu wokugcoba nokunyusa umlenze.
I-Quetiapine yi-antipsychotic e-atypical efunyenwe ukuba ivuselele iipropati kwiimpawu zezilwanyana ze-MS. Kukholelwa ukukhusela nokukhuthaza ukukhula kweeseli zesisindo ezenza i-myelin (i-oligodendrocyte) kwaye zivimbele amaseli omzimba achaphazelekayo ekuhlaselweni kwe-myelin e-MS.
Ukongeza kwimeko yokulungisa i-myelin kubantu abane-MS, njenge-antipyychotic ye-atypical, inokufumana inzuzo eyongezelelweyo yokunyanga iingxaki zengqondo kunye nokungabikho kwe-MS. Ukufundwa kwenzululwazi kokubili kokubuyisela-MS kunye ne-MS eqhubekayo iyaqhubeka.
ILizwi
Ingcamango yokuba isilwanyana sinakho ukukhuthaza ukulungiswa kwe-myelin kwinkqubo yesantya ephakathi. Ibonisa ukuba ubuchopho buyakwazi ukuzilungisa, buyisele umsebenzi we-neurological oye waphazamiseka okanye walahleka.
Oko kuthethwa, konke oku kusekuntsha kwaye kusasa kakhulu. Ngoko ngelixa sithandeka kwabo bethu nge-MS, zama ukuhlala unomonde njengoko uphando luqhubeka.
> Imithombo:
> Harlow DE, Honce JM, iMasvalle AA. Ukunyangwa kwe-Remyelination kwi-multiple sclerosis. Front Neurol. 2015; 6: 257.
> Nave KA. I-Myelination kunye nenkxaso ye-troph of axx long. Nar Rev Neurosci. Ngo-2010 kuMatshi; 11 (4): 275-83.
> I-MS Society Society. (Epreli 2016). I-Antihistamine ibonisa ubungqina bokuvuselela i-Myelin Ukulungiswa kwiSigaba esincinci sesiFundo se-MS.
> Zhornitsky S et al. I-Quetiapine fumarate ukwenzela unyango lwe-multiple sclerosis: jolisa kwi-myelin ukulungiswa. CNS Neurosci Ther . 2013 Oct; 19 (10): 737-44.