Ukhuseleko kunye nento omele uyibukele xa uthatha i-Tysabri
I-Tysabri yenzelwe abantu abaneendlela zokubuyiselwa kwakhona ze-MS kwaye ilawulwa njenge-infusion (inikezwe nge-vein yakho) kanye emva kweentsuku ezingama-28. Ngokuqhelekileyo kunikwe izigulane ezingaphenduliyo kwezinye izifo zentsholongwane ye-MS (intsingiselo yesifo sabo siyaqhubeka sibi kakhulu) okanye abangazange bakwazi ukunyamezela ezinye iindlela zokwelapha ze-MS, ngokuqhelekileyo ezibangelwa yimiphumo eyingozi okanye eyingozi.
Ingozi ye-PML kunye neTysabri
Umngcipheko omkhulu (kodwa ogqithiseleyo) wokuthatha i-Tysabri yi-PML (i-letiencephalopathy eqhubekayo ye-multifocal leukoencephalopathy), eyona ntsholongwane ebungozi obubangelwa yi-JC. Abantu basengozini enkulu yokufumana i-PML ukuba bathatha amanye amayeza anciphisa amandla abo omzimba xa bethatha iTysabri. Eminye imingcipheko emibini yonyusa amathuba omntu wokuphuhlisa i-PML kuquka ukuthabatha iTysabri iminyaka engaphezu kwembini kunye / okanye ukuvavanya ukunyusa i-JC virus antibody.
Umntu ongekho kule miba emithathu yengozi ine-1 / 50,000 ithuba lokuphuhlisa i-PML ngelixa i-Tysabri. Kodwa ukuba zonke izinto ezinobungozi zikhona, ingozi ibe malunga ne-11-13 / 1000. Ukuba umntu uvavanya nje ukuvavanya i-JC virus antibody (akukho nezinye izinto ezinobungozi) ingozi yabo yokuphuhlisa i-PML i malunga ne-1/1000.
Ukumisela umngcipheko womntu wokuphuhlisa i-PML, oogqirha baya kuhlola ukuhlolwa kwegazi ku-antibody kwi-JC virus ngaphambi kokumisela i-Tysabri kunye neenyanga ezintandathu ngelixa umntu ethatha iTysabri.
Ngokusekelwe kwiziphumo, ugqirha uza kuhlaziya umngcipheko / inzuzo yokuthatha iTysabri nesigulane. Ukongeza, oogqirha baya kufumana iMRI (ukuhlula iimpawu ze-MS zangaphambili kwiimpawu ze-PML ezizayo) ngaphambi kokuqala i-Tysabri.
Ukubeka iliso kwi-PML njengoMonde kwiTysabri
Njengesigulane, ukuba uthatha iTysabri, kubalulekile ukuqhagamshelana nogqirha wakho ngokukhawuleza ukuba uhlakulela nayiphina impawu ephathelene ne-PML.
Oku kunokuba lukhohlisayo njengoko iimpawu ezininzi ze-PML zilinganisa abo be-MS. Imizekelo yeempawu ze-PML ziquka:
- ubuthakathaka obuthathaka kwelinye icala lomzimba
- ukuxhamla
- umbono utshintsho
- utshintsho lwabantu
- iingxaki ngokucinga, imemori, kunye nokuqhelanisa okukhokelela ekudidekeni
Ezinye Iimpembelelo Zemizila Ephakathi kunye Nezilumkiso zeTysabri
Iziphumo eziqhelekileyo zeTysabri ziquka
- ukukhathala
- intloko
- ukusuleleka kwindlela yomchamo okanye inkqubo yokuphefumula
- vaginitis
- isifuba okanye isisu esiswini
- ukuxinezeleka
- isifo sohudo
- ukukhawuleza
- intlungu okanye iintlungu.
I-Tysabri inokubangela ukuba umonakalo wesibindi, onokufunyanwa ngokuhlolwa kwegazi. Izibonakaliso neempawu zokulimala kwesibindi ziquka ukuphuka kwesikhumba kunye namehlo, ukukhathala okukhulu, ukucabisa, kunye nokuhlanza, okanye umchamo omnyama.
I-Tysabri nayo ingabangela ukusuleleka kwe-herpes yengqondo, umgudu womgogodla, kunye namadoda. Izibonakaliso neempawu zezi zinto ziquka umkhuhlane, intloko, ukuqina kwentamo, iingxaki zombono, ukudideka, kunye nokuguquka kokuziphatha.
Kuye kubekho iziganeko ezinzima zokuziphendulela ezigulini eziphantsi kweTysabri, ezinye zifuna unyango (nakwiziko lokuhlala esibhedlele). Iimpawu zezi zinto zibandakanya imifuno / ukubetha, ukuphosa, ukutywala, intlungu yesifuba, ukuxubha, ukuphefumula nokuphefumula kwegazi.
Ukongezelela , abantu baseTysabri banokuthi banokungenwa kwezifo kwaye bafanele bathathe amanyathelo okuba baphephe, kubandakanywa nezenzo zokuhlamba izandla kunye nokuphepha abantu abagulayo, xa kunokwenzeka.
Ukubeka iliso ngelixa i-Tysabri
I-Tysabri inokwenziwa kuphela kwiziko lokungena ngaphakathi elibhaliswe kwi-"TOUCH" program. "UKUBA" kumela "iTysabri Outreach: Ukuzibophezela okuManyeneyo kwizeMpilo" kwaye yinkqubo eye yafakwa kwindawo yokuzama ukubamba naziphi na iziganeko ezinokwenzeka ze-PML kumazinga okuqala, kunye nokuzikhusela.
Ukukhulelwa kwiTysabri
I-Tysabri ithathwa ngokuba "inqanaba lokukhulelwa C," oko kuthetha ukuba kubangele ukulimala ekufakeni izifundo kwizilwanyana, kodwa umphumo kubantu awunakwazi. I-Tysabri ayifanele isetyenziswe ngabasetyhini abakhulelweyo kwaye kufuneka imiswe ixesha elithile ngaphambi kokuzama ukukhulelwa (xubusha oku ngogqirha wakho).
Okukwintsusa
Uya kufuneka usebenze ngokusondeleyo kunye nogqirha wakho ukuba anqume ukuba i-Tysabri iyilisi elungileyo. Ukuba ukhetha ukuyithatha, qiniseka ukuba ufunde iileyile yeyeza. Kwakhona, qiniseka ukuba uxoxela imiqondiso kunye neempawu ze-PML, ukusuleleka, ukulimala kwesibindi, kunye nesenzo esichaphazelekayo kunye nodokotela wakho. Qinisekisa ukuba ulandelelwano olufanelekileyo (umz. 3 emva kwe-infusion yokuqala), kwaye bonke oogqirha bakho bayazi ukuba uthatha iTysabri. A
Imithombo:
Krumbholz, M., et al. (2007). Ukunciphisa umonakalo we-Allergic reaction to Natalizumab edibaniswe nokuQala ukuQinisekiswa koTywala. I-Archives ye-Neurology , 64: 1331-1333.
Polman, CH, et al. (2008). Uvavanyo olulinganiselayo lwe-placebo olulawulwa yi-natalizumab lokuphinda luphinde lubuyele kwi-multiple sclerosis. I-New England Journal of Medicine , uMar 2; 354 (9): 899-910.
National Society of MS. (2016). I-MS Izifo-Ukuguqula iMithi .
Rudick, RA, et al. (2006). Natalizumab kunye ne-interferon beta-1a yokubuyiselwa kwesifo se-sclerosis. I-New England Journal of Medicine , uMar 2; 354 (9): 911-23.
US Food and Drug Administration. ITysabri.
INKCAZELO: Ulwazi olukule ndawo lusezinjongo zemfundo kuphela. Akufanele isetyenziswe njengendawo yokunyamekelwa ngumntu ogqirha. Nceda ubone ugqirha wakho ukuze ufumane unyango kunye nonyango malunga nayiphi na impawu okanye imeko yonyango .