I-N-acetylcysteine, eyaziwa nje nge-NAC, inamandla anqwenela i-antioxidant enokunika uncedo kubasetyhini abaneengxaki ze- polycystic ovary syndrome (i-PCOS). Eyaziwayo eYurophu kwiminyaka emininzi njengenyusa yokukhusela umzimba kwaye njengonyango oluthatywayo lwe-bronchitis, i-NAC ikhulayo njengonyango oludibanisayo lwabasetyhini abaneengxaki ze-PCOS. Nazi iinqununu ezintlanu zeNAC kubasetyhini abaneemeko.
Ukuxhobisa
Kuba malunga nama-70 ekhulwini kwabasetyhini abane-PCOS abanesifo sokungabikho, iNAC inganinika ithemba. Ukuphononongwa ngokuchanekileyo kunye nokuhlaziywa kweemeta ezipapashwe kwiNcwadi ye-Obstetrics kunye ne-Gynecology ibhekisele kwiinzuzo ze-NAC kwizilingo ezisi-8 ezilawulwa ngandlela-thile ezibandakanya abafazi abangama-910 abane-PCOS. Ukuhlaziywa kubonisa ukuba i-NAC inikezele ukuphucula okuphuculweyo ekuphuculeni i-ovulation, ukukhulelwa kunye nokuphila kwamazinga okuzalwa xa kuthelekiswa ne-placebo yodwa.
I-NAC iboniswe ukuba ineenzuzo ezifanayo njenge- metformin ekuphuculeni isantya sokukhulelwa, ukuvuthwa ngokukhawuleza, kunye nokuphucula ukuhamba kwimizi kubantwana besifazane abane-PCOS.
Kubafazi abachasene ne-clomid, i-NAC inokunceda ekuphuculeni ukuzala kwabo. Kwiphononongo epapashwe kwi-European Journal ye-Obstetrics, iGynecology, kunye ne-Biological Reproductive, yabona ukuba abasebenzisi be-NAC babenamazinga angama-9 aphakamileyo ovulation kunye namaxesha aphindwe amahlanu aphezulu okukhulelwa kwabasetyhini abaxhatshaziweyo kunokuba befaniswe ne-placebo.
Uphucula ukukhuselwa kwe-insulin
I-NAC ikhulayo njengeyona ndlela inokuthenjelwa kwabasetyhini abane-PCOS ukuphucula amanqanaba abo e-insulin. Isenzo esibalulekileyo se-NAC kukukhusela i-insulin receptors kunye nempembelelo yokufunyanwa kwe-insulin kumaseli e-pancreas. Ngenxa yoko, i-NAC inokuphucula ukukhuselwa kwe-insulin.
Nangona i-FDA ingavunyelwe ukusetyenziswa kwayo, i-metformin isala imithi echazwe ngokuqhelekileyo ukunceda abasetyhini abane-PCOS abanokuxhatshazwa kwe-insulin. Ucwaningo oluninzi lufanise iNAC kunye ne-metformin kubasetyhini abane-PCOS. Abafazi abathatha i-NAC babonisa iziphumo ezifanayo kwi-metformin ekuphuculeni ukuxhatshazwa kwe-insulin kunye nokunciphisa amanqanaba e-cholesterol , kwaye ngaphandle kokufumana iziphumo eziqhelekileyo zesisu esisemgangathweni esenza ukuba i-metformin ibangele.
Ukubuyisela iHormone Balance
Inzuzo engamangalisa yeNAC kukuba inako ukunciphisa amanqanaba e-androgen kwaye ilawulwe imijikelezo yokuya esikhathini . Ekufundeni kwabo, i-Oner kunye noogxa babo abafazi abanomdla nge-PCOS ukuthatha i-metformin (500 mg, kathathu ngokuphindaphindiweyo) okanye i-NAC (600 mg kathathu imihla ngemihla) kwiiveki ezingama-24. Bobabini unyango lubangele ukunciphisa okuphawulekayo kwinqanaba le-hirsutism, i-testosterone yamahhala, kunye nokungahambi komzimba.
Ukulwa nokuvutha
Abasetyhini abane-PCOS baye baboniswa ukuba banamazinga aphezulu okuxinzezeleka koxinzelelo kunabesifazana ngaphandle kwe-PCOS. Amanqanaba aphezulu okuxinzezeleka kwengcinezelo angonakalisa iiseli kwaye akhuthaze ukuvuvukala okubhekiselele kwimimandla ye-PCOS. Njenge-antioxidant enamandla, i-NAC isebenza ukulwa noxinzelelo lwe-oxidative kunye nokunciphisa ukuvuvukala.
Unceda Isibindi Sakho
Ngamanye amaxesha abafazi kunye ne-PCOS bahlakulela isifo sesibindi esingaselunxila.
Olu hlobo lwesifo sesibindi esinamafutha lungabangela ukuphuma kwe-insulin ephezulu kunye ne-triglyceride kwaye ungatshintshwa nokuguqulwa kokutya kwakho.
I-NAC iboniswe ukunceda ukuphucula isibindi esinamafutha kwi-PCOS. Uphando olupapashwe kwi- Hepatitis Monthly lubonise ukuba abafazi abane-PCOS abaye baphathwa nge-NAC (1200 mg / imihla ngemihla) kwinyanga ezintathu babonisa ukuphucula okukhulu ekunciphiseni iimvavanyo zentsholongwane, isibonakaliso sesibindi esinamafutha.
Ngokubanzi, i-NAC yongezelelo elongezelelweyo lokutya elinikezelayo elibonelela ngeenzuzo ezininzi kubasetyhini abane-PCOS. Ukuba unomdla wokuzama i-NAC ukubona ukuba kuya kukunceda ukhulelwe okanye unciphise imiphumo ye-PCOS enjenge-fatty liver kunye nokuxhatshazwa kwe-insulin, thetha nogqirha wakho kunye ne-dietitian obonayo isondlo sokunquma ukuba yeyiphi i dose efanelekileyo kuwe .
> Imithombo:
> Javanmanesh F. Uthelekiso phakathi kweempembelelo ze-metformin kunye ne-N-acetyl cysteine (NAC) kwezinye iimpawu zesifo kunye ne-endocrine yabasetyhini abane-polycystic ovary syndrome. Gynecol Endocrinol. 2015 Dec 10: 1-5.
> Manouchehr Khoshbaten. I-N-Acetylcysteine Iphucula Umsebenzi Wobungozi Kwizigulane Ngezifo ezingenalo Utywala. Hepat Mon. 2010; 10 (1): 12-16.
> Oner G et al. I-Clinical, i-endocrine kunye nemiphumo ye-metformol ye-metformin ne-N-acetyl-cysteine kubasetyhini abane-polycystic ovary syndrome. I-Euro J Obst Gynecol Biol. Novemba 2011; 159 (1): 127-131.
> I-Thakker D. N-acetylcysteine ye-polycystic ovary syndrome: ukuphononongwa ngendlela echanekileyo kunye nokuhlaziywa kwemeta yezilingo ezilawulwa ngononophelo. I-Obstet Gynecol Int. 2015; 2015: 817849.