I-FDA-Yamkelwe ukususela ngo-2009
I-Savella (i-milnacipran) yavunywa yi-FDA ngoJanuwari 2009 njengonyango lwe- fibromyalgia . Ngaloo xesha, kwakungumuthi omtsha kwi-marketplace yase-US. Ngenxa yokuba intsha, ayikho ifomu yobudala ekhoyo okwamanje.
I-Savella yi-serotonin-norepinephrine reuptake inhibitor, okanye i-SNRI. Ngencazelo, i-SNRI i-anti-depressants. Nangona kunjalo, i-Savella ayivunyelwanga ukudakumba e-US Kuze kube ngoku, i-fibromyalgia iyona kuphela yokusetyenziswa kwayo kuvunyelwe kwilizwe.
Nangona kunjalo, i-milnacipran iyathengiswa eYurophu phantsi kwamagama amanqaku amaninzi, kuquka iDalcipran, Ixel nabanye. Izidakamizwa zaseMilnacipran zifumaneke kwiimarike zangaphandle kwiminyaka engaphezu kweshumi kwaye ziyavunyelwa ukudandatheka kumazwe angaphezu kwama-50.
I-Savella Injani
U-Savella ukwandisa amazinga we-neurotransmitters serotonin kunye ne- norepinephrine , enokuthi iphantsi kubantu abane-fibromyalgia. Oku kubeka kwiklasi efanayo neCymbalta , eyaziwayo yi-FDA-fromyalgia, intlungu e-neuopathic, ukuxinezeleka, kunye nezinye iimeko.
U-Savella, nangona kunjalo, unikwe ingxelo yokwandisa i-norepinephrin ngaphezu kwe-serotonin.
Isicelo Esitsha seMithi ye-Savella, esenziwa ngoDisemba ka-2007, sineenkcukacha ezivela kwizilingo ezimbini zeSigaba III ezibandakanya izigulane ezingama-2,000. Inkampani ithi idatha idlulisele i-Savella yayisebenza ngempumelelo kune-placebo kwaye yayinyamezeleke. Kwakungabikho ukufa ngexesha lezifundo kwaye uninzi lweziphumo zecala zachazwa njengomnene ukuya kumodareyitha.
Uphando lwexesha elide luye lwaxhasa iziphumo zakudala, lubonisa ukuphucuka okukhulu kweempawu, kubandakanywa intlungu, ukukhathala nokulala. Nangona kunjalo, uhlolo luka-2015 luphelile ukuba lusebenza kuphela malunga nama-40 ekhulwini abo bathabatha. (Oku kufana neentengo zokusebenza zeCymbalta kunye nezinye izidakamizwa ze-FDA-approved by fibromyalgia, eLyrica .)
Savella Isisombululo
Isilinganiselo esinconywayo se-Savella singama-100 mg okanye 200 mg ngosuku, ukwahlukana kwamanani amabini. Kuqhelekile ukuba uqale kumlinganiselo omncinci kwaye ngokukhawuleza usebenze kwixabiso elipheleleyo.
Akukhuselekile ukuyeka ngokukhawuleza ukuthatha i-Savella. Ukuba ufuna ukuphuma kwilisi, qiniseka ukuba uthethe ugqirha wakho malunga nenkqubo yokuqhawula ngokufanelekileyo .
I-Effects Side Effects
Njengazo zonke iziyobisi, i-Savella inokubangela ezinye iziphumo ezimbi. Akuyena wonke umntu owenzayo, kodwa kufuneka uqaphele oko bakuyo xa uqala ukusebenzisa le nkunkuma. Ezinye zeziphumo zempembelelo zingaba zinzulu.
Fumana uncedo lwezonyango ngokukhawuleza ukuba unayo nayiphi na impawu ezilandelayo:
- isenzo esichukumisayo sokumelana (ukukhawuleza, ukuxubha, ukuphefumula ubunzima, ukuqina kwesifuba, ukuvuvukala ubuso, imilomo okanye ulwimi)
- ukuziphatha okumangalisayo
- izitulo zamanzi okanye zamnyama
- kudideka
- umchamo omnyama
- ukujuluka okukhulu
- ukuphelelwa amandla
- intliziyo ekhawulezayo okanye engaqhelekanga
- umkhuhlane
- bhinqa
- eqhubekayo emqaleni
- ukucoca
- ukulahlekelwa koqhagamshelwano
- iingxaki zememori
- iintlungu okanye ubuthathaka
- ukutshabalalisa, ukukhathazeka, ukunyamezela, ukuhlaselwa, ukugwenxa, ukunyanzeliswa, ukucaphuka, ukugubha, ukungazinzi okanye ukukwazi ukuhlala
- izibonda eziluhlaza
- ebomvu, evuvukileyo, ekhuniweyo okanye ekhanda
- ukuxhamla
- enentloko okanye eqhubekayo entlekweni okanye isisu
- isicupunu esinzima okanye esiqhubekayo
- ukuhlanza okanye urhudo
- inkathazo enzima okanye eqhubekayo yokulala
- intlungu yesisu
- iingcamango zokuzibulala okanye iimpawu zokuziphatha
- ukuthuthumela
- ingxaki yokuchama
- ukuqhwala okanye ukuphuma
- ukuguquka kwengqondo okanye ukuguquka kwengqondo
- ubuthathaka obungavamile
- ukuphuka kwesikhumba okanye amehlo (i-jaundice)
Imiphumo emibi engadingi ingqalelo yonyango ibandakanya:
- ukuqothulwa
- kuncitshiswe umnqweno wesini okanye ukusebenza
- ukungcola
- umlomo owomileyo
- intloko
- ukutshisa
- zanda
- ukulahleka kwesidlo
- isicaphulelo
- i ngxaki yokulala
Kunokwenzeka ukuba iziyobisi zingenelelane. Thetha ugqirha wakho kunye / okanye wekhemisti ngeemeko zakho zonyango kunye nokusebenzisana okunokwenzeka kunye nezinye iziyobisi onokuzithatha.
Ngaba U-Savella Ungakulungele?
Asikwazi ukuba yiyiphi imichiza (s) eya kusinceda size sizame. Ukuba ufuna ukuzama u-Savella, xela ugqirha wakho malunga neenzuzo kunye neengxaki kwaye wenze isigqibo kunye.
Imithombo:
Ahmed M, et al. Umbhalo weyeza zonyango zokulala. 2015 Sep 14. pii: jc-00381-14. Imiphumo ye-milnacipran ekuphazamiseni ubuthongo kwi-fibromyalgia: i-randomized-blind-blind, i-placebo-elawulwa yi-placebo, i-crossover e-two-way.
Cording M, et al. Isiseko seenkcukacha zeCochrane zokuphononongwa ngokuchanekileyo. 2015 Oktobha 20; 10: CD008244. EMilnacipran ngenxa yentlungu e-fibromyalgia kubantu abadala.
I-Mease PJ, i-Palmer RH, i-Wang Y. I-Journal ye-rheumatology yeklinikhi. 2014 Juni; 20 (4): 195-202. Iimpembelelo ze-milnacipran kwimimandla emininzi yokukhathala kunye nobudlelwane bokukhathala kwintlungu kunye nomsebenzi: uhlalutyo oluchongiweyo lwezilingo ezintathu ze-fibromyalgia.
Staud R, et al. Umbhalo weentlungu. Agasti ka-2015; 16 (8): 750-9. Iimpembelelo ze-milnacipran kwiintlungu zeklinikhi kunye ne-hyperalgesia yezigulane ezine-fibromyalgia: iziphumo zeesilingo ezili-6 ezilawulwa ngononophelo.
Vitton O, et al. I-psychopharmacology yabantu. 2004 Oct; 19 Isibonelelo 1: S27-35. Iilingo ezilawulwa yi-plabo-blind blind-controlled control of milnacipran ekunyangeni kwe-fibromyalgia.