Yintoni enokuyilindela xa uthatha i-Betaseron
Abantu abane- MS -reitting-recting, okanye i-RRMS, ngokuqhelekileyo benze izigqibo zabo zonyango ngokusekelwe kwingcebiso yabo ngugqirha, kunye nokukhathazeka ngokulula, iziphumo ezibi, kunye neendleko. Olunye unyango lwe-interferon oluvunyiweyo yi-FDA yokuphatha ukubuyela kwakhona kwi-MS ngu-Betaseron.
Isiseko kwi-Betaseron Therapy
I-Betaseron (i-Interferon beta-1b) sele isetyenziswe kwiimarike ixesha elide kunanoma yiphina inyango yokuguqula isifo.
Inika i-dose ephezulu yeveki yazo zonke i- interferons , kwi-250mcg / dose, inikwe yonke imihla. I-subcutaneous (intsingiselo yokuba ifakwe kwi-fat fat right under the skin) kwaye ayihambisani ne-pH, ngokuchasene ne-Avonex (i-intramuscular, ithetha injected into muscle) kunye neRebif (nayo iphantsi, kodwa i-acidic, i-injection buhlungu). Uninzi lwezigulisa zenza iindawo ezibomvu kwiindawo zokuxhatshazwa kunye neBetaseron, apho, kwiimeko ezinqabileyo, zingaba zilonda.
I-Betaseron iza kunye neempawu eziqhelekileyo ezinxulumene ne-interferon, ezifana nezifo, ikakhulukazi ekuqaleni kwonyango. Ekubeni kunikwa yonke imihla, oku kwenza kube nzima kubantu abasebenza ixesha elizeleyo okanye mhlawumbi kufuneka babe "ekuhambeni" rhoqo, ngokuchasene neAvonex (kanye kanye ngeveki i-dosing) okanye iCopaxone (engeyi-interferon, ngoko akukho mkhuhlane ezifanayo). Nangona kunjalo, iBetaseron iza nehedyuli yokubhaliweyo (intsingiselo yezigulane ziqala kwiqondo elincinci kwaye zanda kancane kancane), ezithathwa ukuba zinciphise kakhulu iziphumo zecala.
I-Betaseron idinga ukuba izigulane zifumane igazi ngokukhawuleza ukuba lijonge umsebenzi wesibindi kunye nokubala kweeseli zegazi.
Oluthe nkcukacha ezithe nkcukacha ngeBetaseron Therapy
I-Betaseron yenzelwe abantu abane-RRMS kunye ne-progressive-relapsing MS (i-PRMS). Kwakhona kuvunyelwe ukuba kusetyenziswe kubantu abaye bafumana umcimbi we-MS kunye nemiqondiso ye-MRI ehambelanayo ne-MS.
Ukusebenza ngokufanayo kuzo zonke i-CRAB (iCopaxone, Rebif, Avonex, i-Betaseron iziyobisi) - malunga nokunciphisa okwesithathu ukubuyiswa kwakhona xa kuqhathaniswa ne-placebo ngaphezu kweminyaka emibini. Uphando lubonisa ukuba kukho ubungqina bokuba i-interferons ye-dose ephezulu (i-Betaseron neRebif) inokusebenza ngokuthe kancinci ekukhuseleni ukubuyela kwakhona nokunciphisa izilonda kune-dose ephantsi (Avonex). Ngoxa i-Betaseron, iimvavanyo zegazi kufuneka zenziwe rhoqo emva kweenyanga ezintathu zonyaka wokuqala ukujonga ubungakanani bamaseli egazi kunye nomsebenzi wesibindi. Emva konyaka, banokuncitshiswa rhoqo emva kweenyanga ezine.
I-Betaseron inikwa yonke imihla (izihlandlo ezili-14 ngenyanga) njenge-subcutaneous (phantsi kwesikhumba) injola, edlalwa ngumgulane ngokwabo okanye ilungu lentsapho. Inaliti imfutshane kunendlela yokwelashwa kwe-intramuscular (.5 intshi ukuya kweyoku-1. ukuya kwi-intshi eziyi-1,25) kwaye i-gauge eyi-27, elungileyo. I-Betaject 3 ifowuni yokufakelwa ngokuzenzekelayo inikezelwa.
Iimiphumo eziphambili ze-Betaseron Therapy
Imiphumo emibi yeBetaseron ifana neyezinye i-interferon-based therapies ngaphandle kwe-Avonex, engabangela ukuba amaninzi amaninzi angene kwi-injection site.
- Izimpawu ezinjenge-Flu: Impembelelo ebaluleke kakhulu yimiqondiso efana nokukhuhlane. Ezi zibandakanya umkhuhlane, ukuphosa, ukujuluka, izihlungu zomzimba kunye nokukhathala, okudlulileyo iiyure ezingama-24 ukuya kuma-36. Esi siphumo sempembelelo sisoloko sibi kakhulu emva kwejoyi lokuqala kwaye sihlahla kancane kancane ngejoyi ngalinye ukwenzela ukuba abaninzi abantu bafumane okanye banganyamezeleka emva kweenyanga ezintandathu. Inokuncitshiswa ngokuqala ngeqondo eliphantsi kunye nokwandisa umthamo opheleleyo ngokuthe ngcembe, ngaphezu kweeveki ezimbalwa. Ukuthatha ibuprofen okanye i-acetaminophen iiyure ezimbalwa ngaphambi nangemva kunokunceda nangalomphumo wecala.
- Iindawo ezibomvu: Ezi zivame ukuvela kwisiza seenjini, ezingapheli iiveki ezimbalwa. Ezi ziyakwazi ukwehla zibe zilonda (i-injection-site necrosis) kwi-4 pesenti yamatyala. Ukutshintshwa kweziza kunye nokubeka i-compress efudumele kwisayithi ngaphambi kokufaka injini kuyo kunokunceda ukunciphisa le mibala ebomvu.
- Ukulimala kwesibindi: Ukulimala kwe- Hepatic kubandakanywa amanqanaba e-enzyme ephakamileyo yegazi kunye ne-hepatitis. Ukubeka iliso rhoqo kuyadingeka ukukhusela umonakalo ongenakwenzeka okanye oqhubela phambili.
- Igalelo leGazi: I- Betaseron inokubangela ukuncipha kweenombolo zamaseli ebomvu namhlophe, kunye nokunciphisa inani leeplatelet egazini.
- Uxinzelelo kunye neengxaki: I- Betaseron kufuneka isetyenziswe ngokuqaphela kwizigulane ezinexinzelelo kunye nokuxhamla-ezi gulane zifuna ukuhlolwa kweliso.
Ndiyakwazi ukuthatha i-Betaseron xa ndikhulelwe?
U-Betaseron ukhulelwe isigaba C, oko kuthetha ukuba kubangele ukulimala kumathambo kwizifundo zezilwanyana, kodwa umphumo kubantu awungaziwa. Ukuba uceba ukukhulelwa, nceda uxelele ugqirha wakho ngokukhawuleza ukuze uceba isicwangciso kunye xa uvimba. Kwakunyanzeliswa ukuba uncelise xa uthabatha i-Betaseron.
Iinkcukacha zoqhagamshelwano kwiBetaseron
I-Betaseron yenziwe yiBayer HealthCare Pharmaceuticals Inc. Inkqubo yokuxhasa isiguli yeBetaseron ibizwa ngokuba yi-MS Pathways. Bangakwazi ukufikelela kwifowuni ngo-1-800-788-1467, apho unokuxoxa ngemibuzo enayo malunga noBetaseron nomongikazi (obizwa ngokuba ngumhlengikazi we-BETA).
Imithombo:
Ukunakekelwa kwezempilo kweBayer. Isikhokelo seMithi: i-Betaseron .
Durelli L, Verdun E, Barbero P, et al. I-interferon ye-beta-1b yezinye i-interferon nge-weekly beta-1a nge-multiple sclerosis: iziphumo zeminyaka emi-2 efuna ukufundwa ngamanqaku amaninzi (INCOMIN). ULancet 2002; 359: 1453-1460.
IKoppos L, uPolman CH, Freedman MS, et al, kwiQela lokuFundisisa iBENEFIT. Utyando nge-interferon beta-1b ukuguqulwa kokutshintshela kwi-Clinic ecacileyo kunye noMcDonald MS kwizigulane ezinezifo ezizimeleyo. Neurology 2006; 67: 1242-1249.
National Society of MS. (2015). I-MS Izifo-Ukuguqula iMithi .