I-Gonadotropin Ikhupha iHormone Agonists (GnRH)
Umbuzo: Yintoni i-Gonadotropin ekhupha ii-hormone Agonists (GnRH)?
Impendulo: I-Gonadotropin yokukhulula i-hormone agonists (GnRH) luhlobo lonyango oluthintela i-ovulation ngokuyeka ukuveliswa kwe-estrogen kunye neprogesterone.
I-Gonadatropin-Ukukhupha iHormone yi-hormone eyenziwa ngokwemvelo emzimbeni. Ikhutshwa yi-hypothalamus kwaye ilawula ukukhutshwa kwe-horlicone evuselela i-hormone (i-FSH) kunye ne-hormone ye-luteinizing (LH) esuka kwintsimbi ye-pituitary.
Ezi iHmmoni ze-FSH kunye ne-LH zivuselela ukuveliswa kwe-estrogen kunye ne-progesterone kuma-ovari. Olu luhlobo olubizwa ngokuba yi-hypothalamic pituitary ovarian axis elawula umjikelezo wakho wokuya esikhathini.
Ukuze i-axis isebenze kakuhle kwaye ibangele i-ovulation GnRH kufuneka ikhutshwe ngendlela ye-pulsatile. Ukuba le meksi isebenza ngokufanelekileyo uza kuba namaxesha aqhelekileyo ukuba awuzange ukhulelwe xa uvula.
Iklasi lamachiza eyaziwa ngokuthi i-GnRH agonists ixhaphaza le mfuno yokufundwa kwe-GnRH. Amachiza aphumela ekukhuthazeni okuqhubekayo kwintsimbi ye-pituitary. Ekuqaleni kukho ukugqitywa okufutshane kweFSH kunye ne-LH ukukhululwa kodwa ke ingxube ye-GnRH engeyiyo i-pulsatile ibangela ukuba i-pituitary gland iqale ukuvelisa i-FSH ne-LH, ekugqibeleni iguqula ukuveliswa kwe-hormone kwi-ovary.
Ama-agonist amathathu aseGnRH aqhelekileyo asetyenziswa kwiinkqubo zonyango zi:
Lupron- leuprolide
Zoladex- goserelin
Synarel- nafarelin
I-Leuprolide kunye ne-goserelin zilawulwa yijokeki kwiiyure nganye kwiiveki ezi-4 okanye kwiiveki ezili-12 ngelixa i-nafarelin ilawulwa yinkonzo yamanzi engama-1-2 ngamaxesha ngamaxesha. Abaninzi abasetyhini baya kuba nokunyanzeliswa kwamaqanda abo ngeeveki ezi-4 kwaye phantse bonke abafazi baya kuthatha iiveki ezi-8 zonyango.
Ngenxa yokuba i-GnRH igonists ikhuphe okwesikhashana ukuveliswa kwama-ovari we-estrogen kunye neprogesterone le klasi yonyango isetyenziselwa ukuphatha imimiselo ethile kubasetyhini abaxhomekeke kwi-estrogen kunye ne-progesterone. Ezi ziquka:
Endometriosis
I-Uterine Fibroids
Ukulawulwa kokuphuma kwindoda enzima
I-Premenstrual syndrome ye-Premenstrual / Premenstrual disysphoria disorder
Unyango lokungenzi lutho
Kukho ubungqina obubonisa ukuba i-GnRH igonists inokukunceda nokugcina i-ovarian functionin bafazi besenza i-chemotherapy yomhlaza wesifuba.
Ezi zonyango ziyinkqubo enonophelo yonyango. Ngelishwa banemiphumo emibi kakhulu. Ngenxa yokuba banqanda ukuveliswa kwamaqanda akho ama-hormone iimiphumo ezichaphazelekayo ze-GnRH agonists zixelisa iimpawu zokunquma kwesisu. Ezi ziphumo ziquka:
Ukutshisa okufudumele- okuqhelekileyo kubalwe kuma-80% wabasetyhini
Ukuma komzimba
Ukunciphisa libido
Intloko
Ukukhathala
Ukuphazamiseka kwemizwelo
Ukunciphisa isisitye samaminerali
Kuyacaca ukuba iimpawu ze-menopausal ziyinto engathandekiyo kodwa into echaphazelekayo yempembelelo yecala kukuba ilahleko leethambo lomnwaba. Ngokuqhelekileyo ukulahlekelwa kwethambo kuguqulwa emva kokuba unyango luyekile kodwa kwinani elincinci labasetyhini eli lahleko lokulahlekelwa kwethambo alinakuze liphinde lifumane ngokupheleleyo.
Ukuthintela ukulahlekelwa kwethambo ehambelana noGnRH unyango wakho ugqirha uya kubeka iprogesin okanye udibaniso lwe-estrogen kunye neprogesin.
Oku kwaziwa ngokuba yongeza kwakhona unyango kwaye iboniswe ukuba isebenze ekukhuseleni ukulahlekelwa kwethambo ehambelana nokusetyenziswa kwe-GnRH. Kwakhona kunokukunceda ukunciphisa ubunzima bokutshisa okutshisayo.
Ukuhlaziywa ngu-Andrea Chisholm MD
Magnon N.Gonadotropin ikhulula i-hormone agonists: Ukwandisa i-vistas; I-Indian Journal Endocrinology Metabolism. 2011 ngo-Oktobha-Dec; 15 (4): 261-267