Ukujonga kwiiNyulo zakho
Iintlobo zeeurotransmitter eziliqela (izithunywa zamakhemikhali kwingqondo) zidityaniswe kwi- fibromyalgia (i-FMS) kunye nesifo esingapheliyo sisifo ( ME / CFS ). Ngelixa uva okunye malunga ne-serotonin kunye ne-norepinephrine, abanye abaninzi bangabikho kwemali.
I-GABA kunye ne-glutamate bobabini zibonakala zidityaniswe kwi-FMS nakwi-ME / CFS. Izinga likaGlutamate okanye umsebenzi ubonakala uphakamileyo, ngelixa amazinga e-GABA okanye umsebenzi ubonakala uphantsi.
I-glutamate ivuselela-kwaye ingakwazi ukugqithisa-ingqondo yakho, ngelixa uGABA iyancipha. Ukungalingani kwabo kungabangela uxanduva, ubuncinane kwinqanaba, ngenxa yokuxhalabisa ezihambelana nale miqathango kunye nezinye iimpawu. (Ngaphezulu koko, khangela iGABA & Glutamate: Icandelo 1. )
Ukutshintshwa komsebenzi walezi zintsholongwane kunokuncedisa ukunciphisa iimpawu.
Ukutya kunye neZongezelelo zeGABA / i-Glutamate Umsebenzi
Izibonelelo zokuguqula umsebenzi we-GABA kunye ne-glutamate yakho engqondweni azizange zifundwe ngokukodwa kwi-FMS kunye ne-ME / CFS, kodwa sinalo ulwazi olubanzi malunga nabo.
Ifom ye-GABA ifumaneka njengongezelo. Nangona kunjalo, uluvo lwangonyango lwangoku kukuba aludluli umqobo we-brain-brain (BBB) kwaye ngoko akwenzi nto ukulungisa ukungalingani kwe-neurotransmitter.
Ngokudlulileyo, unako ukwandisa imveliso yeGABA ngokunyusa i-glutamate, ekubeni umzimba wakho usebenzisa i-glutamate ukuvelisa iGABA.
Ukwandisa umkhiqizo we-glutamate, kunokunceda ukongeza izandulela-phambili ze-glutamate (izinto umzimba wakho ezisebenzisayo ukuzenza) kwi-regimen yakho yokutya okanye yokuncedisa.
Abanye abahamba phambili baquka:
- 5-HTP : Umzimba wakho uguqula i-5-HTP ibe yi-serotonin, kwaye i-serotonin inokunyusa umsebenzi we-GABA. I-5-HTP yindlela yokwenza i-tryptophan, efumaneka kwi-turkey. Nangona kunjalo, imithombo esekelwe kukutya ye-tryptophan ayicingi ukuba iwele iBBB ngendlela ye-5-HTP.
- I-Glutamine: Umzimba wakho uguqula le-amino acid kwi-glutamate. I-Glutamine ifumaneka kwifomu yokuncedisa kwaye ikhona kwenyama, intlanzi, amaqanda, ubisi, ingqolowa kunye nemifuno.
- I-Taurine: Le nino-amino acid sele iboniswe kwiigulane ukuguqula amanqanaba engqondo yeGABA kunye ne-glutamate. Ungayithatha ifom ye-supplement kwaye uyifumane ngokwemvelo kwenyama kunye nevenkile zaselwandle. I-Taurine isoloko idibaniswa kwiziphuzo zamandla.
- I-Theanine : Lo mboniso we-glutamate ubonakala kuthotywa umsebenzi we-glutamate kwingqondo ngokuthintela i-receptors ngeli xesha likhuthaza amazinga e-GABA. Itholakala ngokwemvelo kwitheyi kwaye iyafumaneka njengokongeza.
Iprobiotic ebizwa ngokuba nguLacbabacillus rhamnosus inokuguqula umsebenzi we-GABA kwingqondo yakho, ngokutsho kwe-2011. Abaphandi bathi iigundane ezitya iibhaktheriya zinamaqondo aphantsi okuxhalaba xa zifakwa kwiimeko ezixinzelelekileyo. Nangona kunjalo, le nto idinga uphando olungakumbi ngaphambi kokuba libe yinconywa.
Ngaphambi kokuba uqale ukuvelisa ezintsha okanye wenze utshintsho oluthile lokutya, xela ugqirha kunye nekhemistiki malunga neengozi ezinobungozi kunye nokusebenzisana kwezidakamizwa . Ukuze ufumane ulwazi malunga nokuqalisa izixhobo, jonga: Izinto ezi-7 ofuna ukuzazi malunga neZongezelelo .
Iziyobisi ezenza i-GABA ne-Glutamate umsebenzi kwiBrain
Amachiza amaninzi okwangoku kuthengiswa kwemisebenzi yengqondo yeGABA kunye ne-glutamate.
Zininzi ziye zavavanywa kunye / okanye zisetyenziselwa unyango lwe-FMS, kodwa ngaphantsi kwe-ME / CFS.
Ezi zi yobisi zibizwa ngokuba yi-agonists. Ababangela ukuba amanqanaba e- neurotransmitter akhuphuke kodwa kunoko bandise umsebenzi ngokukhuthaza ama-receptors. Ngokwenene, benza ubuchopho bakho basebenzise ngaphezulu kwezinto sele zikhona.
IGABA i-agonists iquka:
- I-Benzodiazepines: Ezi zi yobisi ziphazamisa inkqubo ye-nervous central. Ii-benzodiazepines eziqhelekileyo ziquka i-Ativan (lorazepam), iKlonopin (clonazepam), iValium (diazepam) ne-Xanax (alprazolam). I-Benzodiazepines ngamanye amaxesha imiselwe ukuba i-FMS, ngakumbi xa i- sleepiness and anxiety are present.
- I-Xyrem (i-oxybate oxybate) kunye ne-GHB (i-Gamma-Hydroxybutyric acid): Ezi ziyobisi ezinxulumene nazo zixinzelele inkqubo ye-nervous central. Igama lezitalato le-GHB " lidakamizwa yokudlwengulwa komhla ." I-Xyrem ivunyelwe ezinye iimpawu ze-narcolepsy, kwaye uphando lubonise ukuba lusebenza njengonyango lwe-FMS; nangona kunjalo, i-US Food Management and Drug Administration (FDA) yalilahlile iFMS malunga nokukhathazeka kokukhuseleko.
- I-Nonzo-Benzodiazepine Hypnotics: Le klasi yezilwanyana ifaka imithi elelekileyo yokulala i-Ambien (zolpidem), iNonata (zaleplon) kunye neLunesta (eszopiclone). Ezi zi yobisi zihluke ngokwemvelo kwi-benzodiazepines kodwa zisebenza ngokufanayo. Ezinye izifundo (kuquka i-Gronblad neMoldofsky, ngezantsi) zibonise ukuba le nkcazo yeziyobisi ingaphucula ukulala kwaye mhlawumbi ubuhlungu kwi-FMS. Akukho nanye kula machiza ayenayo ngaphambi kokuba i-FDA ivunywe.
Ngaba iYoga inganda iGABA?
I-Yoga ngokuqhelekileyo ikholelwa ukuba iyancipha. Ingaba iyakwandisa i-GABA engqondweni? Esinye sifundo esincinci sikhombisa ukuba kunokwenzeka. Abaphengululi babika ukuphakama kwama-27 ekhulwini kwi-GABA emva kwe-yoga kumanqanaba asibhozo.
Oku kunjalo kuphela isifundo esisodwa, ngoko ke sifuna uphando olungakumbi malunga nokuba i-yoga iphakamisa ingqondo yeGABA kwaye ingaba yenzayo ngaphezu kwemisebenzi efanayo.
I-Neurotransmitter Dysregulation
Ukuba ukholelwa ukuba uneGABA / glutamate dysregulation, kufuneka uxoxe nodokotela wakho malunga neendlela zokonyango. Khumbula ukuba unyango lwemvelo lunokuba nemiphumo emibi kakhulu.
Funda nzulu:
Imithombo:
Bravo JA, et. al. Iinkqubo ze-academy of science ye-United States of America. 2011 Septemba 20; 108 (38): 16050-5. Ukungena kwe-Lactobacillus uhlobo lulawula ukuziphatha komzwelo kunye ne-central GABA receptor ibonakaliso kwimouse ngokusebenzisa i-vagus nererve.
Jacobs GE, kunye. al. Inkqubela phambili kwi-neuro-psychpharmacology kunye nengqondo yengqondo. 2010 uMbhi 16; 34 (3): 486-91. Amazinga e-Hypothalamic glutamate emva kokuvuselela kwe-serotonergic.
Malemud CJ. I-rheumatology yeklinikhi kunye nokuhlola. 2009 Septemba-Oktobha; 27 (I-Suppl 56): S86-91. Gxila kwiindlela zobuhlungu kunye ne-pharmacotherapy kwonyango ye-fibromyalgia syndrome.
Molchanova SM, i-Oja SS, iSaransaari P. Iinkqubo zentlalo ye-pharmacology yasentshonalanga. 2007; 50: 95-7. Umphumo we-taurine kwiziphumo ze-glutamate, iGABA, glutamine kunye ne-alanine kwi-rat striatum kunye ne-hippocampus.
Spitzer AR, u-Broadman M. Pain Practice. 2010 Jan-Feb; 10 (1): 54-9. Unyango lwe-narcoleptiform yokugula ubuthongo kwi-syndrome engapheliyo kunye ne-fibromyalgia ene-sodium oxbate.