I-oxybate ye-sodium iyisithako esisebenzayo kwi-Xyrem yezilwanyana ezinokuxhamla, efunyenwe i- fibromyalgia (FMS) kwaye ngamanye amaxesha isetyenzisiwe ngaphandle kwe-label ye-FMS kunye nesifo esingapheliyo sokugula ( ME / CFS ).
Esi sidakamizwa sinomngcipheko wokulutha nokuxhatshazwa, ngoko kuhlulwa njengezinto ezilawulwa yiShedyuli III. Oko kuthetha ukuba kutholakala kuphela kubantu abadibana neemfuno ezifanelekileyo zokufaneleka, kwaye oogqirha kufuneka bajonge ukusetyenziswa kwawo ngokuthe ngqo.
I-oxidium ye-sodium yindlela ye-gamma-hydroxybutyrate (GHB), eyaziwa nangokuthi "izidakamizwa zokudlwengulwa komhla."
Oko Kukwenza
I-oxybate ye-sodium yinkqubo yesistim ephazamisayo ecinga ukuba kukunceda ufikelele kwisigaba esiphezulu sesi-3 kunye nesigaba se-4 sokulala. Okwamanje ivunyiwe e-US ukwenzela ukunciphisa ubuthongo bemini kunye ne-cataplexy (ukulahlekelwa ngokukhawuleza kwamandla emisipha) kubantu abano-narcolepsy.
Ubuthongo obunzima bukholelwa ukuba buthathaka kwi-FMS kunye ne-ME / CFS, obangela ukulala okungapheliyo .
I-Fibromyalgia kunye neSyndy Syndrome
I-FDA ngo-2010 ichithe i-sodium oxbate njengonyango kungekhona ngenxa yokuba ayisebenzi, kodwa ngenxa yokuba i-arhente ixhalabele ngemiphumo yomphakathi yokwenza izidakamizwa ezinobungozi zifumaneke kwizigidi zabantu.
Uvavanyo lwezonyango kwi-FMS luye lwabonisa rhoqo ukuba izidakamizwa zinokuphucula kakhulu umgangatho wobuthongo kwaye zinciphise intlungu. Isifundo se-2013 (Spaeth) saphetha ukuba sasinesiprofayili esihle sexesha elide lokhuseleko.
Ucwaningo lwe-2010 (iSpitzer) luphakanyisile ukuba lunokusebenza ngempumelelo kwi-ME / CFS, kodwa oku bekuyi-first study yeli gciwane kwi-ME / CFS.
Isistim
I-oxybate ye-sodium ithathwa kwifom egazini, ixutywe ngamanzi. Isiqalo sokuqala sokuqala kwezigulane ezine-narcolepsy ngu-4.5 grams ngobusuku, zihlukaniswe zibe zi-2 ezilinganayo. Abantu bavame ukusebenza kufikelela kuma-6-9 amagremu ebusuku, kusekho kumayeza angama-2 alinganayo.
Ngokuqhelekileyo, izigulane zikwacetyiswa ukuba zilungiselele zombini izilingo uze uzibeke kwindawo yokulala, uze uthathe owokuqala xa uhleli embhedeni. Unokudinga iwashi ye-alamu ukuvusa okwesibini. Esi sidakamizwa sisebenza ngokukhawuleza, ngoko kufuneka uhlale embhedeni xa usithathileyo.
Imiphumela
Yeka ukusebenzisa i-sodium oxybate kwaye ufumane uncedo lwezonyango ngokukhawuleza ukuba unempawu zendlela yokuphendula, njengoku:
- Ukuphefumula okunzima
- Iimbuzi
- Ukuvuvukala ubuso, imilomo, ulwimi okanye umqala
Yeka ukusebenzisa i-sodium oxbate kwaye ubize ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi, equka:
- Hallucinations
- Ukudideka okukhulu
- Ukuphefumula okungapheliyo
- Ukulala
- Ukuvuka kudidekile ebusuku
Ezinye iziphumo ezichaphazelekayo zingabonakali kakhulu, kuquka:
- Ukutshitshiswa
- Paranoia
- Iingxaki zokulawula izibilini okanye isisindo
- Ukuxinezeleka
- Isihlunu okanye ukuhlanza
- Ukuphelelwa kwesidlo
- Runny ekhaleni okanye ukudibanisa kwamanzi kunye nesifo somqala
- Ubungqina okanye ukubetha
- Ukugubha
- Umbono ongezantsi
Kunokwenzeka ukuba ube nemiphumo ecaleni engaboniswa apha. Qinisekisa ukuxoxa ngemiphumo emibi kunye nogqirha wakho.
Ukufumana i-Sodium Oxybate
Oogqirha banokumisela i-sodium oxbate off-label if they choose. Nangona kunjalo, ngenxa yobungozi, akulula ukuthola i-sodium oxybate.
Ukuze ufumane oko, ugqirha wakho kufuneka akubhalise kwinkqubo ekhethekileyo.
Umrhumo uya kwi-pharmacy kuphela e-US evunyelwe ukuyizalisa, kwaye ikhempiki ihambisa iyeza kuwe.
Ukuba ufuna ukuzama i-sodium oxbate, xela ugqirha wakho. Kodwa, khumbula ukuba abanye oogqirha abanokungazilungeli ukuyibeka.
Imithombo:
Upapasho lweNIH NO. 04-5326.
NgoJuni 2007, i-US Food and Drug Administration, "Ukuphila neFibromyalgia" .
URussell IJ, et al. Ubuhlungu. NgoMeyi ka-2011; 152 (5): 1007-17. I-sodium oxybate iyanciphisa intlungu, ukukhathala, nokuphazamiseka kokulala kunye nokuphucula ukusebenza kwi-fibromyalgia: iziphumo ezivela kwisifundo se-weekbo esilawulwa ngeeveki ezili-14.
Spaeth M, et al. Iziganeko zezifo ze-rheumatic. 2012 Juni; 71 (6): 935-42. I-sodium oxbate therapy inikezela ukuphucuka kwamaninzi kwi-fibromyalgia: iziphumo zesigaba samazwe angama-3 esilingo.
Spaeth M, et al. Uphando lwe-arthritis kunye neyeza. 2013 uNgo-11; 15 (6): R185. Ukunyamezela kwexesha elide kunye nokugcinwa kweempendulo zokwelapha kwi-sodium oxybate kwiphando lokukhulisa iilebuli ezivulekileyo kwizigulane ezine-fibromyalgia.
I-Spitzer AR, u-Broadman M. Pain. 2010 Jan-Feb; 10 (1): 54-9. Unyango lwe-narcoleptiform yokugula ubuthongo kwi-syndrome engapheliyo kunye ne-fibromyalgia ene-sodium oxbate.
I-Staud R. Iingcamango zengcali kwi-pharmacotherapy. Ngo-Agasti ka-2011; 12 (11): 1789-98. I-sodium oxbate yokunyanga kwe-fibromyalgia.
Swick TJ. Uphuhliso lwezokwelapha kwizifo ze-musculoskeletal. Ngo-Agasti ka-2011; 3 (4): 167-78. I-oxybate ye-sodium: iindlela ezinokuthi zonyango zonyango zonyango lwe-fibromyalgia syndrome.