Indlela esebenza ngayo, iimpembelelo zangasese, kunye nokunye
I-Gabapentin yipilisi echazwe ngokuqhelekileyo kwi- fibromyalgia . Itholakala njenge-generic kwaye iyathengiswa phantsi kwegama legama le-Neurontin, i-Horizant, ne-Gralise.
I-Gabapentin ayiyiyo i-FDA evunyelwe ukunyanga le meko, ngoko imiselweyo-ilebula. Isichengiselwano sihambelana nemichiza e- Lyrica (pregabalin) , evunyiwe njengonyango lwe-fibromyalgia.
Enyanisweni, uLyrica ngamanye amaxesha ubizwa ngokuba ngu "nyana waseNeurontin."
I-Gabapentin ihlelwa njengesixhobo sokulwa nesigxina. Isetyenziselwa ukwelapha isifo sokuphuza, ukuphazamiseka kwentsholongwane (intlungu ebuhlungu beentsholongwane ezonakalisiweyo), imilenze yokuphunga imilenze kunye nokutshisa okutshisa.
Intlungu ye-Fibromyalgia ifana ne-neuropathy, kodwa ingaba le meko ibandakanya umonakalo wesondlo kodwa awucaci.
Indlela iGabapentin isebenza ngayo
I-Gabapentin ikholelwa ukuba isebenze ngokutshintsha ukukhululwa kwe- glutamate kunye nezinye i-neurotransmitters engqondweni yakho. Ama-neurotransmitters athumela imiyalezo esuka kwiseli yesa ebuchosheni kwenye.
I-Glutamate inceda ngokwenene kwizinto ezithile, njengokufunda ulwazi olutsha. Kungenxa yokuba iifestile zobuchopho bakho zivuselela kwaye zisebenza.
Uhlobo olunjengomntwana onotshokolethi, nangona kunjalo, ukuba une-glutamate eninzi ejikelezayo phaya phezulu, iiseli zakho zobuchopho zingaphepheka. Oku kungenza zonke iintlobo zezinto zihambelane.
I-Glutamate inomsebenzi omnye, nangona kunjalo.
Kwakhona kunceda ukuhambisa iimpawu zentlungu ebuchosheni kunye nasezintwini. I-glutamate eninzi inokudlala indima kwi- hyperalgesia , eyona nto iguqula umthamo weentlungu.
Ukulwa nemiphumo ye-glutamate, unomnye u-neurotransmitter obizwa nge- gamma-aminobutyric acid (GABA) . Iyancipha iiseli zakho kwaye ihoxisa ubuchopho bakho.
Xa i-GABA kunye ne-glutamate ikhona ngokulingana kunye, izinto zihamba kakuhle.
Ezinye izifo kunye neemeko zingaphazamisa ukulinganisela kwaye uvumele i-glutamate isebenze i-amok. I-Gabapentin ikholelwa ukuba unciphisa ingqondo yakho yokukhululwa kwe-glutamate ukwenzela ukuba iiseli zikwazi ukuzincama kwaye ingqondo yakho ikwazi ukusebenza kangcono.
IGabapentin ngeFibromyalgia
Uphando lubonisa ukuba abantu abane-fibromyalgia banama-glutamate amaninzi kwiindawo ezithile zobuchopho babo, ngoko i-gabapentin isele ibekiwe.
Kodwa ngaba kusebenza? Uphando luxutywe.
Ukuphononongwa kwezimbini zobungqina akuvumelani. Omnye okhululwe ngo-2016 wambona ukuba i-gabapentin yonyango olusebenzayo lwe-fibromyalgia, kodwa enye, eyapapashwa ngo-2017, yabonisa ubungqina obuphantsi nje kuphela.
Ukuhlaziywa kwe-gabapentin ngo-2014 kwi-fibromyalgia ne-neuropathy kubone ukuba malunga nama-35 ekhulwini abathathi-nxaxheba babone intlungu yabo iyancipha ngamancinci ama-50 ngelixa eli liyeza. Kubalulekile ukuba uqaphele, nangona kunjalo, ukuba iipesenti ezingama-21 zabona amaconsi afanayo xa uthatha indawo ye-placebo.
Kwizifundo ngokuthelekisa i-gabapentin ne-pregabalin (isilwanyana eLyrica), kubandakanywa enye epapashwe kwiNcwadi ye-American Medical Association, i- pregabalin ibonakala yenza ngcono.
Ifom ye-gabapentin ikhutshwe ngokuphindaphindiweyo isilingo esincinane eshicilelwe kwi- Pain Practice .
Abaphandi bathi ukuphucula intlungu, ubuthongo kunye nomgangatho wobomi. Oku kwakuyilingo lokuqala, nangona kunjalo, umsebenzi omningi kufuneka uyenze ngaphambi kokuba siqiniseke ngokuqinisekileyo ukuba lukhuselekile kwaye lusebenza ixesha elide.
I-Gabapentin Isisombululo
I-Gabapentin ivame ukuqaliswa kwiqondo eliphantsi kwaye emva koko landa kancane. Qinisekisa ukuba ulandele imiyalelo yakho kagqirha.
Uhlobo lwamanani oqhelekileyo oluphakathi kwe-900 mg kunye ne-1,800 mg imihla ngemihla, lwahlula ngamanani amathathu.
Akufanele uyeke ukuthatha gabapentin ngokukhawuleza. Qiniseka ukuba uthethe ugqirha wakho malunga nenkqubo yokucoca ngokufanelekileyo kwenzalo oyithathayo.
Gabapentin Side Effects
Njengazo zonke iziyobisi, i-gabapentin ihamba nomngcipheko weempembelelo.
Amanye ayenokuba yingozi xa abanye bengabikho.
Ukuba unayo nayiphi na imiphumo elandelayo xa uthabatha i-gabapentin, biza ugqirha wakho ngokukhawuleza:
- ubuthathaka obunzima bokukhathala
- ubuhlungu besisu esiswini
- iintlungu zesifuba
- ukukhwehlela okutsha okanye ukuqhubela phambili kunye nomkhuhlane
- ukuphefumula
- ukubetha okukhulu okanye ukugubha
- ukuhamba kwamehlo okukhawuleza, okuya phambili nokuphuma
- intlungu okanye ubunzima bokuvuthwa, okanye akukho ukucoca
- umkhuhlane
- umqala obuhkungu
- ukuvuvukala ebusweni okanye ngolwimi
- amehlo avuthayo
- ukukhawuleza
Imiphumo engazange ibangele ukukhathazeka ngokukhawuleza iquka:
- ukukhathala
- ukungcola
- intloko
- ukulala
- ukutyeba kwakho
Abantwana abathatha i-gabapentin banokufumana iziphumo ezichaphazelekayo ezahlukeneyo. Xhalela ugqirha wakho ngokukhawuleza ngokulandelayo:
- utshintsho ku ziphatha
- iingxaki zememori
- ukukwazi ukugxila
- ukungabi nantlungu, ubundlobongela, okanye ubundlobongela
I-Gabapentin ingasabela kakubi nezinye iziyobisi. Qiniseka ukuba ugqirha kunye nekhemistiya bayazi yonke into oyithathayo.
Ngaba iGabapentin Unelungelo Lakho?
Ngobubungqina obubuthathaka kunye nokuxutywa, i-gabapentin inelungelo elilodwa ngaphezu kweLyrica-liyinto enamandla, kwaye ngoko ke kuyabiza kakhulu. Ulwahluko lwamaxabiso lukhokelela abanye abantu ukuba bazame i-gabapentin naphezu kobuthathaka oboniswe kwizifundo.
Kwakhona, sonke senza ngendlela eyahlukileyo kwimichiza. Abanye abantu abahlulekayo kwezinye iziyobisi banokufumana ukukhulula kwi-gabapentin.
Ukuba unomdla ekuzameni i-gabapentin, xela ugqirha wakho malunga nokuxhamla kunye nokuxhamla kweziyobisi kunye nendlela enokuthi ifanele ngayo kwi-regimen yakho yonyango.
> Imithombo:
> I-Calandre EP, i-Rico-Villademoros F, i-Slim M. Apha2delta ligands gabapentin, i-pregabalin kunye ne-mirogabalin: ukuhlaziywa kwe-pharmacology yabo yeklinikhi kunye nokusetyenziswa kweyeza. Uphononongo lweengcali ze-neurotherapeutics. 2016 Nov; 16 (11): 1263-1277.
> Cooper TE, uDerry S, Wiffen PJ, Moore RA. Gabapentin ngeentlungu ze-fibromyalgia kubantu abadala. Isiseko seenkcukacha zeCochrane zokuphononongwa ngokuchanekileyo. 2017 Jan 3; 1: CD012188.
> Moore RA, Wiffen PJ, uDerry S, et al. I-Gabapentin yintlungu engapheliyo ye-neuropathic kunye ne-fibromyalgia kubantu abadala. Isiseko seenkcukacha zeCochrane zokuphononongwa ngokuchanekileyo. 2014 Apr 27; (4): CD007938.
> Moore A, Wiffen P, uKalso E. Izidakamizwa ze-Antiepileptic zeentlungu ze-neuropathic kunye ne-fibromyalgia. JAMA. 2014 Julayi; 312 (2): 182-3.
> North JM, Hong KS, Rauck RL. Impembelelo yendlela entsha yokukhululwa kwe-gabapentin kwiintlungu nokulala kwizifundo ze-fibromyalgia: isifundo se-pilot evulekileyo. Ukusetyenziswa kobuhlungu. 2016 Julayi; 16 (6): 720-9.