Abanye abantu baphatha nge-NSAID bathathe iProton Pump Inhibitor
Iproton pump inhibitors, ebizwa ngokuba ngamachiza e-PPI, yinkalo yeziyobisi ezimiselwe ukunyangwa kwegazi, i-GERD (igastroesophageal reflux disease), izilonda , okanye ezinye iimeko ezinxulumene nesisu esiswini. Iproton pump inhibitors isebenza ngokukhusela i-enzyme eyimfuneko yokwenza i-asidi esiswini. Ngokuthintela i-enzyme, ukuveliswa kwe-asidi kuyancipha.
Iproton Pump isebenza njani?
Ipompo yeproton ilamleksi efumaneka kwezinye iiseli zesisu (iiseli zeparietal). Ukusebenza njengomshini we-molecule, ipompu ipompo ithatha ion potassium ion ngaphandle kwesisu kwaye iyitshintsha nge-acidic i-hydrogen ion. Ngokubeka i-hydrogen ions kwisisu sakho, ipompo yeproton ikwandisa i-asidi yesisu sakho. I-acid isisu iyimfuneko ukuncedisa ukuphuka ukutya kunye nokuncedisa ukugaya. Kodwa i-asidi eninzi, ingabacaphukisa i-esophagus, ibangele i-indigestion okanye i-heartburn, kwaye inganciphisa ukuphilisa izilonda zesisu. Xa i-asidi engaphezu kwemali iba yingxaki, izidakamizwa zeproton pump inhibitor zivame ukumiselwa ukuvala ipompo yeproton.
Isizathu sokuba abanye abantu abaneArthritis bachongwe i-PPIs
Abantu abaninzi abane- arthritis bathabatha izidakamizwa ezichasene nezidakamizwa (anti-inflammatory drugs) (i-NSAID) ukulawula ukuvutha kunye nentlungu ehambelana nezifo ezidibeneyo. Nangona ii-NSAID zihlala ziyimpatho ye-arthritis esebenzayo, iziyobisi zidibaniswa nobutyhefu besisu.
Le nkcenkceshe yintloko ngenxa ye-prostaglandin inhibition ye-NSAID. Abantu abathatha ii-NSAID okanye ii-NSAID ezininzi, abantu asebekhulile, okanye abo abaneembali zesifo sesilonda okanye isisu sokugaya esiswini basengozini enkulu yeengxaki ezivela kwi-NSAID.
Ukunciphisa umngcipheko weengxaki zesisu, abantu abane-arthritis bangacetyiswa ukuba bathathe i- COX-2 inhibitor (umzekelo, i- Celebrex ), okanye i-NSAID yendabuko (umzekelo, i- naproxen , ibuprofen ) kunye ne-misoprostol okanye i-proton pump inhibitor.
I-Misoprostol kufuneka ithathwe ngamaxesha amaninzi ngosuku, ingabangela uhudo, kwaye ingabangela ukulahleka kwamathambo, umsebenzi wexesha elide, okanye iziphene zokuzalwa-ngoko, izidakamizwa zePPI zikhethwa ngokuqhelekileyo. Kukho kwakhona iVimovo , isiza esibandakanya i-NSAID (naproxen) kunye ne-PPI (esomeprazole) kwipilisi enye.
Ukuhlanganiswa kweziyobisi zePPI kunye ne-NSAID akuyimfuneko kuzo zonke iimeko. Izidakamizwa zePPI ziyenziwa ngokugqithiseleyo. Izidakamizwa ze-PPI, zipapashwa kakhulu kwaye zikhuthazwa kubo bobabini kunye nabogqirha, ziye zasetyenziselwa ukhathaza isisu esichukumisayo okanye ukuguqulwa kwamanzi xa kukho izixazululo ezingaphezulu kwee-counter, eziquka i-antacids (i-Maalox, i-Mylanta, i-TUMS) okanye i-H2 blockers (iTagamet, i-Pepcid, ne-Zantac ), kuya kukwanela.
Kukho izikhokelo ezixhasayo ezikunceda ukulawula i-NSAID inetyhefu:
- Thatha i-NSAID enye ngexesha, kungekhona ii-NSAID ezininzi.
- Sebenzisa i-NSAID yeyona ndlela ephantsi kakhulu yeyona ndlela kunye nexesha elifutshane kunokwenzeka.
- Ungasebenzisi ii-NSAID xa ezinye iinketho zonyango zisebenza (i- analgesics , intra-articular injection ).
- Thatha i-NSAID yakho ngokutya.
- Ungayihoyi impawu zesisu; xubusha nodokotela wakho.
- Abantu abanokuphelelwa ngumlomo, isifo sesilonda sesisu, ukuphuma kwamanzi esisisu, i-aspirin / i-NSAID yokuxhomekeka komzimba, ukunyanzeliswa komfutho wegazi, okanye i-cardiovascular disease kufuneka ziphephe ii-NSAID.
Ukufumaneka
Iipilisi ze-PPI ziyafumaneka zombini kwi-counter-counter and by prescription kuphela, kuxhomekeke kwizinto ozikhethayo. Ngokutsho kweeNgxelo zeBathengi , iziyobisi zilingana ngokubhekiselele ekusebenzeni nasekukhuseleni kodwa zihluke kwiindleko.
- Omeprazole (Prilosec, Prilosec OTC)
- Lansoprazole (Prevacid, Prevacid 24 hr)
- Omeprazole / i-sodium bicarbonate (Zegerid, Zegerid OTC)
- I-Pantoprazole (i-Protonix)
- Esomeprazole (Nexium)
- Dexlansoprazole (Kapidex)
- Rabeprazole (Aciphex)
Ukukhathazeka
Ngaphandle kweempembelelo eziqhelekileyo (intloko yesifo, isifo sohudo), kukho iinkxalabo ezithile zokukhuselwa ezinxulumene neziyobisi zePPI, njenge:
- Umngcipheko ophezulu wokusuleleka
- Ukwanda komngcipheko wokusuleleka kwi-bacterium Clostridium difficile ebangela ukuba uhudo olukhulu
- Umngcipheko wokwanda kwethambo, kuquka ukuphuka kwe-hip, kunye nokusetyenziswa kwexesha elide
- Ukuphuculwa komsebenzi we-Plavix (clopidogrel) ukucutha igazi
- Ukusebenzisana okunokwenzeka kunye nokusebenza okuphantsi kweminye imichiza kunye nezibonelelo
Ngaphantsi
Ayikho into eyahlukileyo kunezinye izilwanyana, izibonelelo kunye neengozi ze-PPIs kufuneka zilinganiswe kwimeko nganye. Abanye abantu abanakho ukufuna izidakamizwa zePPI ukulawula ukunyuka kwenhliziyo okanye i-GERD, nangona zichazwe iziyobisi. Musa ukumisa iziyobisi ngaphandle kokuxoxisana nodokotela wakho kuqala. Ukuyeka ngokukhawuleza kunokunyusa iimpawu.
Abantu abane-arthritis banokukwazi ukunciphisa umngcipheko wezobisi zesisu ezinxulumene ne-NSAID ngaphandle kokuthatha iziyobisi ze-PPI. Khumbula, nangona izidakamizwa zePPI zivumelekile kwiimeko zakho ezithile, ukusetyenziswa okukhuselekileyo kuthatha ukuthabatha kuphela isilwanyana ixesha elide njengoko kuyimfuneko.
> Imithombo:
> Ukusebenzisa i-Proton Pump Inhibitors ukuPhatha i-Heartburn kunye ne-Aclux Acidx. Imibiko yabathengi. Ukuhlaziywa kukaJulayi 2013.
> I-Arthritis ye-Rheumatoid: I-Early diagnosis and Treatment. Cush J et al. Uluhlu lwesithathu. UQhagamshelwano loLwazi, Inc. Copyright 2010.
> Ngaba ii-PPI zineempembelelo zexesha elide? Isikhokelo sezeMpilo sezeMpilo saseHarvard. Fe bruwari 2009.
> IProtton Pump Inhibitors Ulwazi. US FDA. Ukuhlaziywa nge- 4/12/2016.