Ingxaki eqhelekileyo yamayeza e-Parkinson's Medicine
Ukutshintshwa kwe-dopamine ngendlela ye-carbidopa / levodopa yonyango yenye yezilwanyana ezinonophelo ezisekelwe kwi-neurology kwaye ivumela izigulane nge- Parkinson isifo esithile ekuphumeni kwabo kunye nokunyaniseka. Kodwa, ngezinye iinkqubo, ukutshintshwa kwe-dopamine kuza nemiphumo emibi. Okuziwayo kakhulu kwezi zinto ziquka ukuxhamla (ukunyakaza okukhulu) okanye iindawo zokucoca.
I-Dopamine dysregulation syndrome (i-DDS) yinto enye ingxaki enokwenzeka, eyenzeka malunga neepesenti ezingama-4 zezigulane kwiyeza zokwenza i-dopaminergic.
Iimpawu zeDopamine Dysregulation Syndrome
Uphawu oluqhelekileyo lwe-dopamine dysregulation lufuna ukunyanzela amayeza e-Parkinson njenge- carbidopa / levodopa . Nangona kungekho zibonakaliso ezikhoyo (njengothutho okanye ukungqongqo), isigulane sinokuziva ukuba siyayifuna imithi. Abanye bazama ukufanisa iimpawu zabo ze-Parkinson okanye baqhelise abahlobo okanye amalungu omndeni ukuze bafumane imithi efunwayo-le yindlela enqwenela ngayo isifiso.
Ukongezelela, abantu abane-dopamine dysregulation syndrome banokuziva becala okanye bexakekile, kwaye ngaphandle kweyeza, banokuziva becinezelekile okanye bexinzekile. Kwakhona, iingxaki zokulawula iimpembelelo, ezifana nokugembula okanye ukuthenga, ukuphazamiseka kokutya okanye ezinye iziphathamandla zokulahla, zingenzeka, ngenxa ye-dopamine dysregulation.
Ukuziphatha okulula okulula, okufana nokuqokelela izinto okanye ukubeka izinto ngokunyanisekileyo kumgca, kunokubonakala. Iimpawu ezinzulu ezinjenge-psychosis nazo zinokwenzeka kule syndrome
Yintoni eyenza i-Dopamine Dysregulation Syndrome?
I-Dopamine idibene nenkqubo yomvuzo kwisiseko se-lobes yangaphambili, kubandakanywa nommandla we- ventral .
Enyanisweni, iziyobisi eziluthayo, ezifana ne-cocaine, zikhuthaza ukukhululwa kwe-dopamine kule ndawo. Umsebenzi weDopamine kule ndawo yengqondo ikholwa ukuba ibangela i-dopamine dysregulation syndrome. Oko kuthethwa, iindlela ezichanekileyo aziqondi kakuhle. Ngaphezu koko, ukuba i-dopamine ibaluleke kakhulu kokubambisana kunye nenkqubo yomvuzo, mhlawumbi kuyamangalisa ukuba i-DDS ayiqhelekanga.
Xa isilwanyana esilwayo sisinikwe, inkqubo yomvuzo inokuhlala kwisixa semvuzo, efuna ukuba luninzi lube nefuthe elifanayo. Siyazi ukuba oku kunjalo nonyango lwe-dopamine kwi-Parkinson-i-doses ezinkulu zizakufuneka ekugqibeleni zifuna impembelelo efanayo. Nangona ezinye zezi zinto zinokwenzeka ngenxa yokunyuka kwesifo, ezinye iingcali zenzululwazi ukuba ngaba le mfuno ekhuphukayo ingabonakalisa uhlobo lokuhlala, oluya kwindlela yokuvuza, lunokubangela uhlobo lokufuna.
Ngubani Ofumana I-Dopamine Dysregulation Syndrome?
Ubuninzi be-DDS bubonisa ukuba abaninzi abantu banokukhuselwa nxamnye neengxaki, ngelixa abanye banokuba nemingcipheko yokuphuhlisa ingxaki. Amadoda anesifo sokuqala asenokuba ngumngcipheko ophezulu. Ukuziphatha okunyanzelekileyo kwangaphambili, okufana nokusetyenziswa kakubi kweziyobisi, ngenye yeyona mingcipheko enkulu.
I-Dopamine Dysregulation Syndrome iphathwa njani?
Ngenxa yokuba izigulane ezine-DDS zinexilongo kwiziyobisi ezifuna ukuba zisebenze, unyango olungcono lubandakanya ama-dopamine angqongqo okanye i-dopamine agonists (amayeza asebenze i-dopamine receptors). Impawu zokudityaniswa kwemida ziya kuncipha njengoko umthamo weyeza unciphisa. Njengoko kunye nezinye izilingo, kufuneka kuxhaswe inkxaso yoluntu ekuncedeni ukuqinisekisa ukuba imithi ithathwa njengoko imiselweyo kwaye ilawula ezinye iindlela zokunyanzelisa. Kwiimeko ezinzima, i-antipsychotics inokuba luncedo ekulawuleni ulwaphulo okanye ingqondo, nangona oku kwandisa umngcipheko wesifo sePasinson.
Okukwintsusa
I-Dopamine yintsholongwane engumngcipheko ochaphazela ukunyakaza kwethu, ukukhuthazwa kwethu, kunye nendlela yethu yokuvuza ngendlela esingasayiqondi ngayo, nangona sifundo samashumi eminyaka. Nangona i-dopamine dysregulation syndrome ayiqhelekanga kwisifo se-Parkinson, inokuthi ifikeleleke, kwaye ingenelelo elungileyo lusekuqaleni kwaye luxhaswe ngugqirha womntu ochaphazelekayo, umkhathaleli kunye / okanye abathandekayo.
Imithombo:
Cilia, R., et al. (2014). I-Dopamine dysregulation syndrome kwisifo sikaPasinson: ukusuka kwinkqubo yokubonakalisa i-neuropsychological to the management and outcome-term. I-Journal ye-Neurology, i-Neurosurgery, ne-Psychiatry , 85 (3): 311-8.
Evans, AH, Lees, AJ (uAgasti 2004). I-Dopamine dysregulation syndrome kwisifo sikaParkinson. Iingcamango zangoku kwi-Neurology , 17 (4): 393-8.
Lawrence, AD, Evans, AH, Lees, AJ (Oktobha 2003). Ukusetyenziswa ngokunyanzeliswa kwe-dopamine yonyango yokutshintshwa kwesifo kwisifo sikaParkinson: iifom zemivuzo ziye zaphela? I-Lancet Neurology , 2 (10): 595-604.
Pezzella, FR, et al. (NgoJanuwari 2005). Ubuninzi kunye neempawu zekliniki ze-homeostatic disysregulation kwisifo se-Parkinson. "UMv. Ukungavumelani 20 (1): 77-81.