I-Oral Flupirtine: Efile eManzini?
Ayikho ixesha elide kwiPayipi?
Isilwanyana esibizwa ngokuba yi-oral flupirtine sasibonisa isithembiso njengonyango olutsha lwe- fibromyalgia emva ko-2008, xa kubonakala ngathi isiza liza kuqala ukulungiswa kwindlela eya kwi-FDA imvume. Nangona kunjalo, ukususela ngaloo ndlela, kubonakala sengathi iwele phantsi kwe-radar.
I-Oral flupirtine ifumaneka eYurophu ukususela kuma-1980. Kulapho, isetyenziselwa ukuphatha intlungu evela kwimithombo emininzi, kuquka ukuhlinzwa, umdlavuza, ukuxhwaleka kunye nesifo sesibindi.
Ingenayo irekhodi ende elide njengeziyobisi ezikhuselekileyo nezichanekileyo.
I-FDA yase-US inikwe i-Adeona Pharmaceuticals isicelo soPhando olutsha lweDrug ukuze iqalise izilingo kwi-fibromyalgia. Igama legama elibizwa ngu-Effirma libhaliswe kulo.
I-Adeona inesivumelwano kunye nePipex Pharmaceuticals ukusebenzela kwi-FDA, kodwa i-website yePipex yangaphambili isele ihambe. U-Adeona ekugqibeleni waguqula igama lakhe kwi-Synthetic Biologics, kwaye u-Effirma akakhankanyi naliphi na kwiwebhusayithi ye-Synthetic. Akukho nto ifakwe kwi-FDA, kwaye akukho zifundo ezintsha ezipapashwe.
Okwangoku, kubonakala ngathi le nkunkuma ifile emanzini ase-US Ludabukile, kuba lihluke kwezinye iipilisi kunye ne-fibromyalgia iziyobisi ngendlela enomdla kwaye inokuba luncedo.
I-Oral Flupirtine isebenza njani
I-Oral flupirtine ayikho i- opiate / i-narcotic , kwaye ayiyi- antidepressant okanye i- anti-seizure , eyenza ihluke kakhulu kwezinye iziyobisi ezisetyenziselwa ukuphatha i-fibromyalgia .
U-Adeona wayexelele ukuba uthembele ukubonisa izilwanyana eziphathwe ngaphezu kweentlungu ze-fibromyalgia, kodwa iphinda iphucule imvakalelo, ukukhathala, iingxaki zokuqonda, ukuphazamiseka kokulala kunye nokusebenza ngokubanzi.
I-Oral flupirtine isebenza ngokuhlukileyo kunamachiza enyango ngokuqhelekileyo ngenxa yendlela ejolise ngayo intlungu ebuchosheni.
Ama-opiates , amaninzi angasebenziyo kubantu abane-fibromyalgia, pha kamisa izinga lakho le-dopamine, elibangela ukuba ujonge. Esikhundleni sokuvalela intlungu, i-opiates yenza ukuba ungakhathazeki kakhulu ngeentlungu.
Ngakolunye uhlangothi, i-Oral flupirtine, inomphumela omnene kwizakhiwo ezithile kwingqondo ebizwa ngokuba yi-NMDA receptors kwaye, ngenxa yoko, iyanciphisa amanqanaba akho e- glutamate . I-Glutamate yi-neurotransmitter eyenza iingqamuzana zakho zengqondo zisebenze.
Izifundo ezishicilelwe ngo-2008 no-2009 (i-Harris) zibonisa ukuba abantu abane-fibromyalgia banokuba namazinga aphakamileyo e-glutamate kwiindawo ezithile zobuchopho kwaye xa amazinga a-glutamate ehla, kunjalo na amanqanaba eentlungu. Oku kwenza ukuba umlomo we-oral flupirtine ube ngumviwa okhangayo kuthi.
Abantu abane-fibromyalgia banexesha elinzima kakhulu ukunyamezela amayeza. Amachiza amaninzi asetyenziswa rhoqo ukusiphatha, okwangoku, enokuluhlu lwexesha elide kunye neziphumo ezinzima kunye nokunyamezela ukunyamezela. Iirekhodi ye-Oral flupirtine yaseYurophu njengezikhuseli ezikhuselekileyo ezineempembelelo ezimbalwa zenza kube mnandi. Akunakufuneka uphucule ngokuthe ngcembe kwilisi, mhlawumbi, njengokuba wenzayo kunyango lwangoku lwe-fibromyalgia.
Yintoni ngoku?
Kubonakala ngathi sinethemba kuphela ngoku ukuba i-Synthetic okanye enye inkampani inquma ukuqala uphando nge-oral flupirtine.
Nangona ukuba kukho enye imeko, kuya kusinceda - ukuvunyelwa kwe-FDA kuya kuthetha ukuba kuya kuba semarike e-US kunye noogqirha banokuyilungiselela kwilebula.
Sekunjalo, loo nkqubo ithatha iminyaka. Ngoko ngaphandle kokuba ufuna ukufudukela eYurophu, akubukeka ngathi uya kukwazi ukuthatha umlomo ngomlomo naliphi na ixesha kungekudala.
Imithombo:
Harris RE, et al. Arthritis kunye ne-rheumatism. 2008 Mar; 58 (3): 903-7. Amanqanaba amandla e-glutamate ngaphakathi kwe-insula adibaniswa nokuphucula kwiindawo ezininzi zeentlungu kwi-fibromyalgia.
Harris RE, et al. Arthritis kunye ne-rheumatism. 2009 Oct; 60 (10): 3146-52. I-glutamate ephakamileyo ye-fibromyalgia idibene neentlungu zokulinga.