Njengoko inzululwazi yezokwelapha iqonda ngokubanzi malunga ne- fibromyalgia syndrome (i-FMS), iinkampani zonyango zizabalazela ukuba i-FDA ivume izidakamizwa ezininzi ze-fibromyalgia. Oogqirha banquma ukuba izidakamizwa ezivunyiweyo kunye nohlu olubanzi lwee-label-label ngenxa yokuba zifumene ukuba ziyasebenza.
I-FDA-YENYULWA NGEZIMPUTHO ZEMFUBO YEMFIBROMYALGIA
ULyrica (pregabalin) : NgoJuni 2007, uLyrica waba yiyomfuyo yokuqala ye-FDA-approved fibromyalgia.
Kwizilingo zesikliniki , abantu abaneFMS babonakalise ukuphucuka okukhulu kwiintlungu, ubuthongo, ukukhathala, kunye nomgangatho wobomi . Ekhutshwe yiPfizer, uLyrica uvunyiwe ukuba uphathe intlungu yesifo sesifo sikashukela ne- neuralgia . Isetyenziswe kwakhona, ngokunxulumene nezinye iziyobisi, ukukhusela ukuhluthwa ngokukhawuleza kwintlungu yabantu abadala.
Ingavakala ingavamile, kodwa i-Pfizer ayiqinisekanga ukuba kungani iLyrica isebenza. Yiloo nto ithi kwiwebhusayithi ye-FDA:
Inkqubo yesenzo ayifumanekanga, kodwa kukho idatha ebonisa ukuba inempembelelo ekukhutshweni kwama-neurotransmitter kwingqondo. I-neurotransmitters ziyimichiza engqondweni ehambisa iisignali kwi-neuron enye ukuya kwenye.
I-Cymbalta (duloxetine) : I-FDA evunyelwe i-Cymbalta njengesigqirha se-fibromyalgia ngo-Juni 2008. I-Cymbalta ibalwa njenge-SNRI, okanye i-serotonin-norepinephrine yokubuyisela inhibitor. I-Serotonin kunye ne-norepinephrin zombini i-neurotransmitters edlalwa ngabantu abanokuphelelwa yi-fibromyalgia.
I-SNRI yenza ezininzi zazo zifumaneke kwingqondo.
I-Cymbalta yayisigunyazisiwe yi-FDA yokuphatha uxinzelelo kunye nesifo sengqondo sesifo sikashukela .
Savella (milnacipran) : Isiza esitsha kwiimakethe zase-US, i-Savella yavunywa ngoJanuwari 2009 njenge-drug fibromyalgia. Yenziwe yiHlater Laboratories, Inc. kunye neCypress Bioscience, Inc., i-Savella yinkinga yokuxhatshazwa efana neCymbalta ngaphandle kokuba yilezi ziyobisi lokuqala kwiklasi ukukhuthaza i-norepinephrine ngaphezu kwe-serotonin.
Isicelo Esitsha seMithi , esenziwa ngoDisemba ka-2007, sineenkcukacha ezivela kwizilingo ezimbini zeSigaba III ezibandakanya izigulane ezingama-2,000. Inkampani ithi idatha idlulisele i-Savella yayisebenza ngempumelelo kune-placebo kwaye yayinyamezeleke. Kwakungabikho ukufa kwaye uninzi lweziphumo zecala zachazwa njengomnene ukuya kumodareyitha.
UMilnacipran uthengiswa eYurophu phantsi kwegama elithi Dalcipran no-Ixel. Kuye kwintengiso kwiminyaka elishumi kwaye ivunyiwe ukuxinezeleka kumazwe angaphezu kwama-50.
UKUFUNA UKUSEBENZISWA NJENGOBA I-FIBROMYALGIA DRUGS
I-JZP-6 (i-oxygate ye-sodium) : Izilingo ze-JZP-6 (i-ingredient esebenzayo e-Xyrem) zibonise ukuba ziphucule kakhulu umgangatho wobuthongo kunye neentlungu ezincinci kwizigulane ze-fibromyalgia . I-JZP-6 iyinkqubo yesantya esicinezelayo kwaye icingelwa ukuba incede isigulane sifumane isigaba esicacileyo sigaba 3 kunye nesigaba se-4 sokulala. Isivivinyo sesigaba se-III sesigxina esilongwe ngo-Septemba 2008 kunye ne-Jazz Pharmaceuticals zithumele isicelo esitsha seDrug kwi-FDA ngoDisemba 2009. Iziphumo zezinye izilingo ze-Phase III zilindele, kodwa inkampani ithi iziphumo zixhaswe kwiziphumo ezilungileyo kwangaphambili.
I-Xyrem i-FDA-avunyelwe ukuba i-cataplexy (ukulahleka ngokukhawuleza kokulawula umsila) kunye nokulala ngokugqithiseleyo emini kwizigulane ezinokuxhamla.
Qaphela: Ngenxa yokusetyenziswa kwayo kakubi, i-Xyrem yinto elawulwa yiShedyuli yeFolda III.
I-Adeona Pharmaceuticals inethemba lokuba u-Effirma avunywe eUnited States ngokokuqala ngqa, kwaye ngo-Ephreli 2008 le nkampani yamenyezela ukuba i-US FDA inikwe iSicelo soPhando olutsha lweDrug. Oku kunika imvume yenkampani ukuqhuba uvavanyo lwe -phasebo olulawulwa yi- Phase II lwe-Phase II lwe -placebo e- Effirma njengonyango lwe-FMS.
I-Oral flupirtine ivunyiwe kwiYurophu iminyaka engaphezu kwe-25. Kulapho, isetyenziselwa ukuphatha intlungu evela kwimithombo emininzi, kuquka ukuhlinzwa , umdlavuza, ukuxhwaleka kunye nesifo sesibindi.
U-Adeona, ke, uthemba ukubonisa ukuba uthatha ngaphezu kweentlungu ze-FMS, kodwa kuphucula imvakalelo, ukukhathala, iingxaki zokuqonda, ukuphazamiseka kokulala kunye nokusebenza ngokubanzi.
EZINYE IZINDLELA ZEZIBHOMYALGIA
Ukuxhatshazwa kweengxaki: Abachasayo baphakamisa amanqanaba eekhemikhali ezithile kwingqondo, kubandakanya i- neurotransmitter serotonin kunye ne-hormone yokucindezeleka i-norepinephrine-bobabini baphantsi kubantu abanexinzelelo okanye i-FMS.
- I-Reuptake Inhibitors ezimbini: Eli klasi liquka iCymbalta ne-Savella. Eminye imizekelo yalezi zonyango yi: venlafaxine nefazodone.
- I-Tricyclic Anti-depressants : Ukuba ithathwa ebusuku, ezi ziyobisi zingancedisa abantu abane-FMS bafumane ubuthongo obuhle. Bakwandisa nemiphumo ye-endorphins ekubulaleni ubuhlungu kunye nokuncedisa izihlunu ezinzima . Ezinye i-tricyclic antidepressants eziqhelekileyo ezisetyenziswa ukuphatha i-FMS ziquka: amitriptyline, doxepin kunye ne-nortriptyline.
- I-Serotonin Reuptake Inhibitors (i- SSRI s): Ezi ziyobisi zifumana ingqondo ukuba ikhulule i-serotonin engaphezulu, eyanceda ukulawula ubuthongo, kwaye ngamanye amaxesha kunceda abantu abane-FMS bazive bekhathele kwaye bafumane ukukhululeka kwezinye iimpawu. Nangona kunjalo, banokuphazamisa ubuthongo. Imizekelo yama-SSRI: i-fluoxetine, i-paroxetine kunye ne-sertraline.
Zonke iyeza ezichazwe apha zinemiphumo emibi kwaye zingabangela iimeko ezinzulu zokwelapha ukuba unqande ukubatha ngokukhawuleza. Kubalulekile ukuhlala unxibelelwano nodokotela wakho ukuxoxa ngeengxaki okanye utshintsho lwezilingo.
EZIKHULULEKILEYO / IARAROTICS NJENGOBA I-FIBROMYALGIA IZINTO
Uphononongo lubonisa ukuba i-opiates ayinakusebenza ngokumalunga nentlungu ye-FMS. Nangona kunjalo, abaninzi abantu babika ukuba banceda, kwaye ezi ziyobisi zihlala zimiselwe.
Ama-opiates / izidakamizwa ziquka:
- UVicodin (i-hydrocodone acetaminophen)
- I-Percocet (oxycodone acetaminophen)
- OxyContin (oxycodone)
Ukujongana noyiko loxhatshazo lwe-opiate kunye nomlutha, uMbutho we-American Pain ukhuphe izikhokelo zoogqirha.
IINKCUKACHA ZENGXELO NOKUSEBENZA IMISEBENZI
- Qiniseka ukuba ugqirha uyazi malunga nazo zonke iziyobisi kunye nezongezelelo zondlo ozithathayo. Thetha ugqirha okanye umseli-mveliso malunga nemiphumo emibi kunye nokunxibelelana kakubi.
- Ukubona uluhlu lweempembelelo kunye nokusebenzisana kwezidakamizwa , kunye nolunye ulwazi oluninzi, jonga i-Drugs.com okanye i-RxList.com.
- Ukuba unempembelelo embi kumachiza, qiniseka ukuba ubalise kwi-FDA Iinkcukacha zoKhuseleko kunye neNkqubo yokuBika ingxelo yeNgehlakalo.
Umthombo:
Upapasho lweNIH NO. 04-5326.
US Food and Drug Administration. "Ukuphila ngeFibromyalgia"