Imithi yomlomo ebizwa ngokuthi nguJanuvia (sitagliptin phosphate) ivunyiwe yi-US Food and Drug Administration yokulawula uhlobo lwesifo sikashukela . Ngowokuqala kwiklasi leziyobisi ezibizwa ngokuba yi-DPP-4 inhibitors. I-Januvia iyanciphisa amanqanaba eshukela egazi ngokukhusela i-enzyme eyaziwa ngokuba yi-dipeptidyl peptidase IV okanye i-DPP-4.
Uhlobo luni lwesifo seswekile?
Uhlobo lwe-2 lweswekile, oluye lwaziwa ngokuba ngumntu omdala okanye isifo sikashukela esingaxhomekanga, luyisifo esingasigxina esichaphazela indlela umzimba wakho udibanisa ushukela (i-glucose), umthombo wakho obaluleke kakhulu wombane.
Ngohlobo lwesibini lwesifo sikashukela, umzimba wakho unqanda imiphumo ye-insulin-ihomoni elawula ukunyuka kweswekile kwiiseli zakho-okanye ayivelisi ngokwaneleyo i-insulin ukuze igcine izinga eliqhelekileyo le-glucose.
Okuqhelekileyo kubantu abadala, uhlobo lwesi-2 lwesifo sikashukela luya kubachaphazela ngakumbi abantwana njengoko ukunyuka kwengane kukhula. Akukho naluphi uhlobo lwesifo sikashukela se-2, kodwa unokukwazi ukulawula imeko ngokutya kakuhle, ukusebenzisa, nokugcina ubunzima obunempilo. Ukuba ukutya kunye nokuzivocavoca akwanele ukulawula iswekile yegazi kakuhle, unokufuna unyango lwe-diabetes okanye unyango lwe-insulin.
Njani i-Januvia iSebenza
I-DPP-4 ijongene nokuphula iiproteins ezikhuthaza iiseli ezivelisa i-insulin emva kokutya. Ukuba i-DPP-4 ivinjelwe, ke iiprotheni ziyakwenza kusebenze ukukhululwa kwe-insulin ixesha elide, ngaloo ndlela kunciphisa izinga le-glucose egazini.
I-Januvia ibonise iziphumo ezilungileyo kwizilingo zamva nje ngokubambisana nezinye iziyobisi, ezifana ne-metformin, kunye nazo ngokwazo.
Inqunyelwe uhlobo lwesifo sikashukela kuphela.
Kwabanye abantu, ukutya, ukusetyenziswa, kunye namayeza aqhelekileyo akwanele ukugcina amanqanaba e-glucose egazi kwindawo efanelekileyo. UJanuvia uye waphumelela kwizilingo zekliniki ekuncedeni ukunciphisa xa iindlela zendabuko zingonelanga. Ukutya kunye nokuzilolonga kusekho ukongeza okubalulekileyo ekulawulweni kwezonyango, nangona kunjalo.
UJanuvia usebenza ngokunyusa ukuvuselelwa kwemveliso ye-insulin. Umngcipheko we- hypoglycemia awunakwenzeka kuba u-Januvia usebenza kuphela xa kufuneka. Ngokomzekelo, ukuba akukho glucose egazini, akukho nto eyenziwa ngu-Januvia. Kodwa, emva kokutya xa amazinga e-glucose ephakama, i-Januvia iya kusebenza ukunciphisa elo nqanaba.
Kwakhona, izazinzulu ziye zafumanisa ukuba akukho mngcipheko wokufumana ubunzima kunye noJanuvia, ngokungafani nezinye iyeza zomlomo zesifo sikashukela.
Imiphumela
Imiphumo echaphazelekayo echazwe ngokuqhelekileyo ibandakanya ukusuleleka kwentsholongwane yokuphefumula, umqala womqala, kunye / okanye intloko.
I-Januvia iqhutyelwa ngeentso. Abantu abaye banciphisa umsebenzi we-renal bangadinga ukuba ne-dose yabo ye-Januvia iguqulwe ngugqirha wabo kwiqondo eliphantsi. Umsebenzi weRenal kufuneka uhlolwe ngaphambi kokuthatha iJanuvia.
Umthombo:
US Food and Drug Administration. I-FDA iyavuma unyango olutsha lweSwekile. Oktobha 2006.