I-Biguanides yindlela yokwenza isifo somshukela womlomo esisetyenziselwa ukhathaza uhlobo lwesifo sikashukela, apho i-metformin yikhenkethi yobudala. La machiza asebenza ngokuchaphazela ukuveliswa kwe-glucose ephuma ekutyeni. Azingabangeli u-hypoglycemia kwaye aze ancede kunye nokulahleka kwesisindo kunye namanani e- cholesterol aphantsi. Ziyizona izidakamizwa eziqhelekileyo eziqhelekileyo zolu hlobo lwesifo sikashukela.
- Kwaziwa nangokuthi : i- Metformin, i-Glucophage
- I-Biguanides: Iisisiseko zala mayeza
- I-Metformin : Funda kabanzi malunga nokusetyenziswa kwesilwanyana.
IiMiguanide IiMedi zeSwekile
I-Metformin yi-biguanide ekhoyo ngoku kwiimarike zesifo sikashukela . I-glucophage (metformin) kunye ne-Glucophage XR (i-metformin-release release-are-out) -yona yaziwa kakhulu ngala mayeza. Ezinye iimpawu ezibhalisiweyo ziquka i-Fortamet, i-Glumetza ne-Riomet. Ikwafumaneka kwakhona kwimveliso enxulumene nezinye iziyobisi zeswekile.
Ii-Biguanides zaqala ukuvela kwi-lilac yesiFrentshi, ebizwa ngokuba yi-rue yebhokhwe, iGalega officinalis. Uphando malunga nemiphumo yalo ekunciphiseni i-blood glucose level kuholele ekuphuhlisweni kweemveliso ezinobuthi obuphantsi. Ezinye iziyeza zonyango zingabandakanya esi sityalo, kodwa ukuba usebenzisa isifo sikashukela kufuneka uqaphele ngenxa yokusebenzisana.
Ezinye iintlobo ze-biguanides zaphuhliswa kodwa zihoxiswa kwimarike. Ezi zibandakanya i-phenformin, eyaqalwa ngo-1957 ngexesha elifanayo ne-metformin kodwa ihoxiswa ngasekupheleni kwee-1970 kuba yayidibene nomngcipheko omkhulu we-lactic acidosis.
Le nto, ngelanga, ibulalayo kwisiqingatha seemeko.
I-Buformin yaveliswa eJamani ngo-1957 kodwa ayizange idayiswe eMelika. Kwakhona kwafunyanwa ukuba yengozi yokwanda kwe-lactic acidosis. Isuswe kwiimarike kumazwe amaninzi kodwa isenokufumaneka kwezinye.
Ukongezelela ekusebenziseni kwayo isifo sikashukela, ezinye iintlobo ze-biguanides zisetyenziselwa izidakamizwa ze-malaria, proguanil kunye ne-chlorproguanil.
I-Biguanides isebenza njani ngesifo sikashukela?
I-Metformin isebenza ukulawula isixa seshukela egazini lakho. Akuchaphazeli inani le-insulin oyivelisayo, kodwa landisa ubuhlungu kwi- insulin . Oku kunceda iiseli zakho zithathe i-glucose ekusebenziseni amandla, zinciphisa umkhiqizo we-glucose kwisibindi, kwaye iyanciphisa intlupheko ye-glucose kwigazi lakho. Ukusetyenziswa kwe- glucose emathunjini kuvelisa i-lactic acid, eqhutyelwa esibindi kodwa ingakhokelela kumphumo wecala lwe-lactic acidosis. I-Metformin ayibangeli i-hypoglycemia yeklinikhi, eyona inzuzo ngaphezu kwesinye isilwanyana sesifo sikashukela. Kwakhona akubangeli ukufumana ubunzima kwaye kunemiphumo emihle ekunciphiseni ezinye izinto ezinobungozi bomzimba.
I-Metformin isoloko imiselwe ukuba luhlobo lwe-2 lwesifo sikashukela xa eso sifo singakwazi ukulawulwa yindlela yokuphila yedwa. Ingumuthi womlomo, ngoko unokuthi uthathwe njenge-tablet okanye umbane. Kuxhomekeke kwifomu, kuthathwa kanye emva kwesithathu kathathu imihla. Kukho iifom zokukhululwa ezongezelelweyo kunye neifom ezifunekayo ukuba zithathwe ngokutya. Imiyalelo kufuneka ilandelwe ukusetyenziswa ngokukhuselekileyo kwemveliso nganye.
Njengoko isifo sikashukela siqhubela phambili, i-injulis injections ingadingeka ukulawula iswekile yegazi kunye ne-metformin isasetyenziswa ukuphucula amandla omzimba wokusebenzisa i-insulin.
> Imithombo:
> Bailey CJ, "Biguanides kunye ne-NIDDM," Ukunyamekela ngesifo sikashukela, ngo-Juni Juni, 15 (6) 755-72.
> Metformin, MedlinePlus, iLebhu yeSizwe yeMathala ka-US, 2/15/2015
> Krentz AJ, Bailey CJ. "I-antialabetictic agents (oral anti-agabetic agents): indima yangoku kwi-2 ye-diabetes mellitus." Zi yobisi. 2005; 65 (3): 385-411.