I-Angiotensin yokuguqula i-enzyme (ACE) inhibitors yimiyeza yomlomo ephantsi kwengcinezelo yegazi. Ii-inhibitors ze-ACE zisetyenziselwa ukuphatha unyango lwegazi (ukunyuka kwengcinezelo yegazi), isifo se-coronary disease kunye nokuhluleka kwentliziyo, nokukunceda ukulawula ukuqhubela phambili kwesifo sikashukela nesifo sesifo.
Sibanzi
Ezi nkqubo zesifo zihlala zihamba ngesandla; Uxinzelelo oluphezulu lwegazi luqhelekile kubantu abanesifo sikashukela.
Uxinzelelo lwegazi oluphezulu lugalelo ekuphuhliseni i-nephropathy yesifo sikasifo (isifo sesifo).
Ukongezelela, abo abaneesifo seswekile bavame ukufumana iziphumo ezimbi kakhulu (izibhedlele ezinde, ixesha elide lokuphucula kunye nemingcipheko ephezulu yentsholongwane) ukusuka kwiingxaki ezinkulu zeentliziyo. Ngoko ke, ababoneleli-bonyango bayaphatha ingozi yomshukela kwintlanganiso yesifo sikashukela .
Nangona i-ACE inhibitors ingabonakali ngokukhawuleza ishukela legazi, inokufaka isandla ekulawuleni ushukela wegazi ngokunyusa ukuqonda komzimba kwi-insulin. I-insulin inceda umzimba udibanisa i-glucose (iswekile) kwaye uyisusa ukusuka egazini ukuya kwiiseli, apho isebenza njengomthombo wamandla.
Ama-inhibitors amaninzi ase-ACE atholakala e-United States, kuquka neCapoten (captopril), i-Prinivil ne-Zestril (lisinopril), i-Vasotec (i-enalapril), uLotensin (benazepril), i-Altace (ramipril), i-Accupril (i-quinapril), i-Monopril (i-fosinopril), i-Mavik ( trandolapril), Aceon (perindopril) kunye ne-Univasc (moexipril).
Indlela Abasebenza ngayo
I-ACE inhibitors ingcinezelo yegazi ephantsi ngokukhusela umzimba ukuba ungabonakali i-hormone angiotensin II. I-Angiotensin II ibangela i-vasoconstriction (ukunciphisa imithambo yegazi) kunye nokugcinwa kwamanzi, okubangelwa yingozi yengozi. Ngokunciphisa uxinzelelo lwegazi kunye nokugcinwa kwamanzi, i-ACE inhibitors inceda ukulawula ukuhluleka kwentliziyo.
I-ACE inhibitors inokuthintela nokulawula i-nephropathy yesifo sikasifo (isifo sesifo) kunye nokunceda ukulawula i-retinopathy yesifo sikasifo (iingxaki zamehlo). I-ACE inhibitors ayicutyi intliziyo okanye iswekile yegazi ephantsi.
Imbali yokuSebenza
Ii-inhibitors ze-ACE ziye zavunyelwa yi-FDA ukunyanga ingozi yomshukela ophezulu ukususela ngo-1981. Ngokuhamba kwesikhathi, ukusetyenziswa kwe-ACE inhibitor kwandiswe ngokuphawulekayo ukuphatha isifo sengqondo kunye nezimo ezihambelanayo.
Ngubani o fanele aphephe
Abantu abanexinzelelo oluphantsi kakhulu lwegazi (hypotension), okanye ababenokugula okanye ukukhwehlela okuhlobene ne-ACE inhibitors, akufanele basebenzise i-ACE inhibitors. Kwakungekho nabo abane-stenosis ye-renal, abafazi abakhulelweyo nabasetyhini abazama ukukhulelwa.
Abantu abanomonakalo omkhulu wezintso badinga i-dosing ye-ACE inhibitors.
Iimpawu eziPhakathi kunye neengozi
Zonke iipilisi zengcinezelo yegazi zinomngcipheko wokuxilonga, kunye neempawu ezibandakanya ukukhanya okukhawulezileyo, utywala, isisonguluko, ukujuluka kunye nokulahlekelwa kwintliziyo.
Ngokuqhelekileyo, i-ACE inhibitors ingabangela ishukela ephantsi yegazi (i-hypoglycemia). Oku kwenzeka kubantu abanesifo sikashukela abanamazinga e-ishukela egazi alawulwa kakuhle ngokutya kunye namanye amayeza e-antidiabetic.
I-ACE inhibitors ingabangela ukukhwehlela kwabanye abantu. Ukuba oku kwenzeka, kufuneka baxoxe ngale nto kunye nabanikezeli bamanyango, abanokuthi bangene endaweni eyahlukeneyo yegazi.
Olunye Usebenziso 'lweTeksi'
I-ACE inhibitors inokunceda ukukhusela ukuqala kohlobo lwe-2 lweswekile . Ukongezelela, i-ACE inhibitors inganceda ukulawula izitho zentliziyo ezingavamile, ngakumbi xa zisetyenziswe emva kokuhlaselwa kwentliziyo.
I-ACE inhibitors isetyenziswe kwileyibhile kunyango lwezifo ezifana ne-rheumatoid arthritis, migraines, isifo sikaRaynaud kunye ne-Bartter syndrome.
Iingcebiso zeMpilo
I-Angiotensin receptor blockers (ARBs) zifana ne-ACE inhibitors. Abantu abahlukunyezwayo kwi-ACE inhibitors okanye abahlakulela ukukhwehlela ngokuphathelele kwi-ACE inhibitors banokutshintshela kuma-ARB ngempumelelo. Abantu abanesifo sikashukela kufuneka bahlale bexelela ababoneleli ngempilo yabo yonke imirhumo kunye neyeza-counter-counter-counter, kunye nawaphi na amayeza kunye nezongezelelo ezisetyenziswayo ngoku, ngaphambi kokuqala ukuthatha i-ACE inhibitors.
Abantu abakwi-ACE inhibitors kufuneka bahlole ababonelela ngempilo ngaphambi kokuba baqalise nayiphina imithi entsha.
Imithombo:
Bakris, uGeorge L. "Unyango lwe-Hypertension kwi-Diabetes Mellitus." UpToDate.com. Ngomhla wama-11, 2015. UkuPhakamisa .. (ukubhalisa).
Kaplan, Norman M., noBurton D. Rose. "I-ACE Inhibitors kwi-Treatment of Hypertension." UpToDate.com. 2014. UpToDate. (ubhaliso)
UMcCulloch, uDavid K., noRa. Paul Robertson. "Ukubikezela kunye nokuthintela uhlobo lwesifo sikashukela seMelitus." UpToDate.com. 2007. UpToDate. 7 Septemba 2007. (ubhaliso).